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Four new eremophilendiolides from Ligularia atroviolacea

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Chinese Chemical Letters 2007年第1期18卷 59-61页

作者： shu yun shi Di Yao Wu Xun Gong Hua Peng Rong Ping Zhang Chang Xin Zhou Xiao Jiang Hao Zhong Jian Jia Joachim Stockigt Yu Zhao Department of Traditional Chinese Medicine and Natural Drug Research College of Pharmaceutical Sciences Zhejiang University Hangzhou 310031 China College of Pharmacy Kunming College of Medicine Kunming China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 China Lehrstuhl fiir Pharmazeutische Biologie lnstitut fur Pharmazie Johannes-Gutenberg Universitiit Mainz D-55099 Mainz Germany

From Ligularia atroviolacea, four new eremophilendiolides, 81$-hydroxy-eremophil-3,7 （11）-dien-12,8α（14,6α）-diolide （1）, 8β-methoxy-eremophil-3,7（11）-dien-12,8α（14,6α）-diolide （2）, 8α-hydroxy-eremophil-3,7（11）-dien-12,8lβ（14,6α）-diolide （3） and eremophil-3,7（11）,8-trien-12,8 （14,6α）-diolide （4）, as well as a known diolide （5） were isolated. Their structures were elucidated on the basis of 1D and 2D NMR as well as ESI-MS spectral data.

关键词： Phytochemical examination Sesquiterpene Eremophilendiolide Ligularia atroviolacea

Two new compounds from Zingiber officinale

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Chinese Chemical Letters 2007年第10期18卷 1247-1249页

作者： Yu Zhao Qiao Feng Tao Rong Ping Zhang Chang Xin Zhou Hui Dou shu yun shi Ye Cheng Xiao Lian Li Sun Su Zeng Ke Xin Huang Xiao Dong Zhang Xiao Kun Li Department of Traditional Chinese Medicine and Natural Drug Research College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China College of Pharmacy Kunming College of Medicine Kunming 650031 China Pharmacy School of Wenzhou Medical College Wenzhou 325035 China

A new cyclic diarylheptanoid, 1,5-epoxy-3-hydroxy-1-（3-methoxy-4,5-dihydroxyphenyl）-7-（4-hydroxyphenyl）-heptane （1）, as well as a new monoterpene, 10-O-β-n-glucopyranosyl-hydroxy cineole （2） were isolated from the rhizomes of Zingiber officinale. The structures of compounds 1 and 2 were established based on their spectral data. In addition, the antioxidant activities of these compounds were also measured.

关键词： Diarylheptanoid Monoterpene Zingiber officinale Antioxidant

One chloro-furoeremophilanoid and two new natural dimers from Ligularia atroviolacea

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Chinese Chemical Letters 2008年第11期19卷 1319-1322页

作者： Jun Zhao Hao Wu Ke Xin Huang shu yun shi Hua Peng Xian Feng Sun Liu Rong Chen Qun Xiong Zheng Qi Jun zhang Xiao Jiang Hao Joachim Stockigt Xiao Kun Li Yu Zhao Jia Qu Department of Traditional Chinese Medicine and Natural Drug Research College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China Key Laboratory of Southern Zhejiang TCM R＆D Pharmacy School of Wenzhou Medical College Wenzhou 325035 China School of Chemical Engineering Central South University Changsha 410083 China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 China

Three new compounds, including one chloro-furoeremophilanoid （1）, one eremophiladiolide （2）, a rare dimer of nor- furoeremophilanoid, ligulatrovine A （3）, and a known furoeremophilanolide （4）, were isolated from Ligularia atroviolacea. The structures of compounds 1-4 were elucidated by spectroscopic methods including 1D and 2D NMR experiments as well as X- ray diffraction study.

关键词： Natural scsquilcrpene Eremophiladiolidc Dimcr Chloro-furanocrcmophilanc X-ray Ligularia atroviolacea

Improved survival ratios correlate with myeloid dendritic cell restoration in acute-on-chronic liver failure patients receiving methylprednisolone therapy

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Cellular & Molecular Immunology 2012年第5期9卷 417-422页

作者： Juan Zhao Ji-Yuan Zhang Hong-Wei Yu Yu-Lan He Jing-Jing Zhao Juan Li Yue-Ke Zhu Qin-Wei Yao Jin-Huan Wang Hai-Xia Liu shu-yun shi Zheng-Sheng Zou Xiang-Sheng Xu Chun-Bao Zhou Fu-Sheng Wang Qing-Hua Meng Department of Hepatology Beijing You An HospitalCapital Medical UniversityBeijingChina Research Center for Biological Therapy The Institute of Translational HepatologyBeijing 302 HospitalBeijingChina Department of Infectious Disease Beijing 302 HospitalBeijingChina juan Zhao and Ji-Yuan Zhang contributed equally to this work.

Acute-on-chronic liver failure （ACLF） is a severe life-threatening complication. Liver transplantation is the only available therapeutic option; however, several limitations have restricted its use in patients. The use of corticosteroids as an optional therapy for ACLF has received a great deal of interest. The rationale behind its use is the possible role of the immune system in initiating and perpetuating hepatic damage. In order to assess the relationship between myeloid dendritic cells （mDCs） and the efficacy of methylprednisolone （MP） treatment for hepatitis B virus （H BV）-associated ACLF patients, we recruited 30 HBV-associated ACLF patients who had received MP treatment at lO-day intervals; 26 patients received conservative medical （CM） management as a control. The functionality of DC subsets was lower in these ACLF patients compared with healthy subjects. In addition, compared with survivors, dead/transplanted patients had lower functional mDC in both groups. Furthermore, a decreased numbers of mDC at baseline was associated with high mortality of ACLF patients. Importantly, MP treatment resulted in a significant decrease in 28-day mortality, and all MP patients exhibited an initial rapid decrease in circulating mDC numbers within 10 days of MP treatment. Subsequently, MP survivors displayed a continuous increase in mDC numbers accompanied by a decrease in total bilirubin levels by more than 30%. However, MP dead/ transplanted patients lacked these sequential responses compared with survivors. This evidence suggests strongly that the higher mDC numbers at baseline and the recovery of mDC number at the end of treatment may represent a prognostic marker for favorable response to corticosteroid treatment in ACLF patients.

关键词： acute-on-chronic liver failure methylprednisolone myeloid dendritic cells plasmacytoid dendritic cells

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-yun Zhao De-En Xu Ming-Lei Wu Ji-Chuan Liu Zi-Ling shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

Laser direct writing of flexible multifunctional airflow sensors on the Kevlar fabric

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Nano Research 2025年第1期18卷 443-454页

作者： Wei Wang Zi-Qing Chen Yong-Qi Li Yu-Long Wang Mei-Chen Liu yun-Bo Ruan Yang Zhang shu-Juan Liu Qiang Zhao College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China State Key Laboratory of Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Nanjing University of Posts and TelecommunicationsNanjing 210023China Zhe Jiang Topsun Logistic Control CO. LTD.Yuhuan 317600China Department of Rehabilitation Medicine School of Acupuncture-Moxibustion and Tuina and School of Health Preservation and RehabilitationNanjing University of Chinese MedicineNanjing 210023China

The growing interest in flexible devices has emerged as a global trend due to their advantages in flexibility,lightweight structure,and wearability,addressing the limitations of traditional *** wearable airflow sensors have been previously reported,the development of flexible fabric-based airflow sensors capable of functioning in environments with open flames—critical for fire rescue operations—has yet to be explored,largely due to the poor fire resistance of conventional *** this work,we first present a flexible,wearable,and multifunctional airflow sensor with excellent fire-resistant properties,fabricated through a simple direct laser writing *** sensor maintains airflow detection capabilities even in the presence of open ***,the fabrication of fabric-based sensors involves complex procedures such as carbon materials doping or vapor-phase deposition,leading to lengthy preparation cycles and high ***,fabric-based devices are inherently prone to *** address these challenges,we introduce twice-vertical laser-induced graphene(TVLIG)as a sensitive and reliable component for fire-resistant airflow *** resulting TVLIG/Kevlar fabric can be integrated into various garments,particularly protective suits,to form sensitive and fire-resistant airflow sensors capable of detecting airflow velocity and direction in both two-dimensional(2D)and three-dimensional(3D)spaces during fire ***,the TVLIG patterns can be expanded to multifunctional platforms,such as glucose detection for injured individuals,offering further applications in rescue *** functional expansion reduces the burden on rescue personnel and streamlines device *** its outstanding sensing capabilities,fire resistance,and expandability,the developed flexible airflow sensor shows great potential for various real-world rescue scenarios,promising advancements in wearable sensing technology for rescue enginee

关键词： flexible airflow sensor direct laser writing twice-vertical laser-induced graphene fire accident rescue Kevlar fabric

The liquefaction and displacement of saturated sand under horizontal vibration loading by a cylinder

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The liquefaction and displacement of saturated sand under ho...

第十二届中国海岸工程学术讨论会

作者： ZHANG Jin-lai1, LU Xiao-bing1, WANG shu-yun1, shi Zhong-min2 (1 Institute of Mechanics, Chinese Academy of Sciences, Beijing, 100080 2 . Research Center of China Ocean Oil Co., Beijing 100027,)

In this paper we investigated the responses of saturated sands under horizontal vibration loading translated by a cylinder. It is shown that the saturated sand liquefies gradually since the vibration

关键词： Liquefaction saturated sand vibration loading cylinder.

来源： cnki会议评论

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六棱菊提取物对醋氨酚致小鼠肝损伤的影响

世界华人消化杂志 2010年第7期18卷 711-715页

作者：伍义行郝冰洁胡少青施树云王建国杨雷香赵昱中国计量学院生命科学学院药学系浙江省杭州市310018 浙江大学药学院浙江省杭州市310053 浙江大学医学院附属第一医院传染病诊治国家重点实验室浙江省杭州市310003

目的:探讨六棱菊提取物(LAE)对药物性肝损伤的抑制作用.方法:采用FolinCiocalteu和HPLC方法对LAE的主要成分进行定量分析;通过预防给药探讨LAE对大剂量(1000mg/kg)醋氨酚引起的小鼠中毒死亡的影响;运用醋氨酚引起的小鼠急性肝损伤模型评... 详细信息

目的:探讨六棱菊提取物(LAE)对药物性肝损伤的抑制作用.方法:采用FolinCiocalteu和HPLC方法对LAE的主要成分进行定量分析;通过预防给药探讨LAE对大剂量(1000mg/kg)醋氨酚引起的小鼠中毒死亡的影响;运用醋氨酚引起的小鼠急性肝损伤模型评价LAE大(200mg/kg)、中(100mg/kg)、小(50mg/kg)剂量对药物性肝损伤的抑制作用.结果:FolinCiocalteu法测定结果表明LAE的总酚含量为56.5gGAE/100g提取物;HPLC分析结果显示LAE的主要成分为是二咖啡酰奎尼酸类化合物,其含量为53.0%.醋氨酚中毒保护试验表明,LAE在100mg/kg剂量下对大剂量醋氨酚所致小鼠死亡有明显抑制作用.药效评价结果显示:LAE在50、100和200mg/kg剂量下灌胃给药,均能明显降低肝损伤小鼠血清AST和ALT水平,其中100和200mg/kg剂量具有显著性影响;病理组织学检测表明,模型组小鼠肝组织呈现以中央静脉为中心的放射状坏死和脂肪变性,LAE大、中、小剂量组小鼠肝损伤均有一定程度的改善.结论:六棱菊对醋氨酚所致的药物性肝损伤具有较强的抑制作用.二咖啡酰奎尼酸类化合物可能是六棱菊保肝作用的主要物质基础.

关键词：六棱菊二咖啡酰奎尼酸类化合物醋氨酚保肝作用

PRECONDITIONING HIGHER ORDER FINITE ELEMENT SYSTEMS BY ALGEBRAIC MULTIGRID METHOD OF LINEAR ELEMENTS

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Journal of Computational Mathematics 2006年第5期24卷 657-664页

作者： yun-qing Huang shi shu Xi-jun Yu Hunan Key Laboratory for Computation and Simulation in Science and Engineering Institute for Computational and Applied Mathematics Xiangtan University Xiangtan 411105 China Laboratory of Computational Physics Institute of Applied physics and Computational Mathematics Beijing 100088 China

We present and analyze a robust preconditioned conjugate gradient method for the higher order Lagrangian finite element systems of a class of elliptic problems. An auxiliary linear element stiffness matrix is chosen to be the preconditioner for higher order finite elements. Then an algebraic multigrid method of linear finite element is applied for solving the preconditioner. The optimal condition number which is independent of the mesh size is obtained. Numerical experiments confirm the efficiency of the algorithm.

关键词： Finite element Algebraic multigrid methods Preconditioned Conjugate Gradient Condition number.