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Ki-67 Change in Anthracyline-containing Neoadjuvant Chemotherapy Response in Breast Cancer

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Current Medical Science 2024年第1期44卷 156-167页

作者： Zi-guo YANG Le-hao REN Feng WANG Pi-lin WANG Wen-yan WANG shu-ye LIN Department of General Surgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of Critical Care Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Cancer Research Center Beijing Chest HospitalCapital Medical University/Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China

Objective Anthracycline-containing regimens are irreplaceable in neoadjuvant chemotherapy(NAC)for breast cancer(BC)at ***,30% of early breast cancer(EBC)patients are resistant to anthracycline-containing chemotherapy,leading to poor prognosis and higher ***-67 is associated with the prognosis and response to therapy,and it changes after *** A total of 105 BC patients who received anthracycline-containing NAC were ***,the optimal model of Ki-67 was selected,and its predictive efficacy was ***(IHC)was used to determine the estrogen receptor(ER),progesterone receptor(PR),and human epidermal growth factor receptor 2(HER-2)status and Ki-67 *** in situ hybridization(FISH)was used to verify the HER-2 when the IHC score was 2+.Results The post-NAC Ki67 level after treatment with anthracycline drugs was lower than pre-NAC Ki-67(19.6%±23.3%vs.45.6%±23.1%,P<0.001).Furthermore,patients with the Ki-67 decrease had a border line higher pathological complete response(pCR)rate(17.2%vs.0.0%,P=0.068),and a higher overall response rate(ORR)(73.6%vs.27.8%,P<0.001),when compared to patients without the Ki-67 *** ΔKi-67 and ΔKi-67%were valuable markers for the prediction of both the pCR rate and *** area under the curve(AUC)for ΔKi-67 on pCR and ORR was 0.809(0.698-0.921)and 0.755(0.655-0.855),respectively,while the AUC for ΔKi-67% on pCR and ORR was 0.857(0.742-0.972)and 0.720(0.618-0.822),*** logistic regression model 1 revealed thatΔKi-67 was an independent predictor for both pCR[odds ratio(OR)=61.030,95% confidence interval(CI)=4.709-790.965;P=0.002]and ORR(OR=10.001,95%CI:3.044-32.858;P<0.001).Multivariate logistic regression model 2 revealed thatΔKi-67%was also an independent predictor for both pCR(OR=408.922,95%CI=8.908-18771.224;P=0.002)and ORR(OR=5.419,95%CI=1.842-15.943;P=0.002).Conclusions The present study results suggest thatΔKi67 andΔKi67%are candidate predictor

关键词： breast cancer change in Ki-67 neoadjuvant chemotherapy anthracycline,response

Coupling and characterization of a Si/SiGe triple quantum dot array with a microwave resonator

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Chinese Physics B 2024年第9期33卷 139-143页

作者： shun-Li Jiang Tian-Yi Jiang Yong-Qiang Xu Rui Wu Tian-Yue Hao shu-Kun ye Ran-Ran Cai Bao-Chuan Wang Hai-Ou Li Gang Cao Guo-Ping Guo CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Origin Quantum Computing Company Limited Hefei 230088China

Scaling up spin qubits in silicon-based quantum dots is one of the pivotal challenges in achieving large-scale semiconductor quantum *** satisfy the connectivity requirements and reduce the lithographic complexity,utilizing the qubit array structure and the circuit quantum electrodynamics(cQED)architecture together is expected to be a feasible scaling scheme.A triple-quantum dot(TQD)coupled with a superconducting resonator is regarded as a basic cell to demonstrate this extension *** this article,we investigate a system consisting of a silicon TQD and a high-impedance TiN coplanar waveguide(CPW)*** TQD can couple to the resonator via the right double-quantum dot(RDQD),which reaches the strong coupling regime with a charge–photon coupling strength of g0/(2p)=175 ***,we illustrate the high tunability of the TQD through the characterization of stability diagrams,quadruple points(QPs),and the quantum cellular automata(QCA)*** results contribute to fostering the exploration of silicon-based qubit integration.

关键词： triple-quantum dot strong coupling circuit quantum electrodynamics (cQED) scalable siliconbased cQED architectures

Freshening of the Intermediate Waters in the Northern South China Sea over the Past Six Decades

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Journal of Tropical Meteorology 2024年第1期30卷 42-50页

作者：陈栩洋王东晓舒业强成里京范双双 School of Marine Sciences Sun Yat-Sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)ZhuhaiGuangdong 519082 China State Key Laboratory of Tropical Oceanography South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301 China International Center for Climate and Environment Sciences Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029 China

The properties of salinity in the South China Sea(SCS),a significant marginal sea connecting the Pacific and Indian Oceans,are greatly influenced by the transport of fresh water flux between the two ***,the long-term changes in the intermediate water in the SCS have not been thoroughly studied due to limited data,particularly in relation to its thermodynamic *** study utilized reanalysis data products to identify a 60-year trend of freshening in the intermediate waters of the northern South China Sea(NSCS),accompanied by an expansion of low-salinity *** study also constructed salinity budget terms,including advection and entrainment processes,and conducted an analysis of the salinity budget to understand the impacts of external and internal dynamic processes on the freshening trend of the intermediate water in the *** analysis revealed that the freshening in the northwest Pacific Ocean and the intensification of intrusion through the Luzon Strait at intermediate levels are the primary drivers of the salinity changes in the ***,a weakened trend in the intensity of vertical entrainment also contributes to the freshening in the *** study offers new insights into the understanding of regional deep sea changes in response to variations in both thermodynamics and oceanic dynamic processes.

关键词： freshening South China Sea salinity of the intermediate water salinity budget analysis Luzon Strait transport

邻苯二甲酰亚胺−多奈哌齐杂合物的合成及活性评价

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药学学报 2024年第3期59卷 651-660页

作者：王军杰穆叶舒洪琛罗稳河南大学淮河医院河南开封475004 河南大学天然药物与免疫工程重点实验室河南开封475004 河南大学药学院河南开封475004

本文设计合成了一系列邻苯二甲酰亚胺−多奈哌齐杂合物(5a~e,6a~l)作为选择性的乙酰胆碱酯酶(AChE)抑制剂。结果表明,部分化合物具有较强的AChE抑制活性,半数抑制浓度(IC50)达到纳摩尔范围,优于对照药物加兰他敏和他克林,与多奈哌齐相近... 详细信息

本文设计合成了一系列邻苯二甲酰亚胺−多奈哌齐杂合物(5a~e,6a~l)作为选择性的乙酰胆碱酯酶(AChE)抑制剂。结果表明,部分化合物具有较强的AChE抑制活性,半数抑制浓度(IC50)达到纳摩尔范围,优于对照药物加兰他敏和他克林,与多奈哌齐相近。其中6k对AChE的抑制活性最强,IC50值为0.13μmol·L^(-1)。酶动力学及分子对接结果表明化合物6k能够同时作用于AChE的催化活性位点和外周结合位点。部分化合物能够抑制AChE诱导的β-淀粉样蛋白聚集。另外,吸收、分布、代谢和排泄预测结果显示化合物6k符合Lipinski类药五规则且具有较高的油水分配系数。这些化合物特别是6k可以作为双功能的先导物进行更加深入的活性研究。

关键词：邻苯二甲酰亚胺多奈哌齐胆碱酯酶 β-淀粉样蛋白阿尔茨海默症

绿色金融政策与企业ESG表现——基于绿色金融改革创新试验区的准自然实验

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金融论坛 2024年第7期 59-69页

作者：胡剑波叶树张宽元贵州财经大学经济学院上海财经大学公共经济与管理学院上海200082 西安交通大学经济与金融学院

本文以2015-2021年中国A股上市公司数据为研究样本,将绿色金融改革创新试验区视为准自然实验,运用渐进倍差法考察其政策效应。研究发现:(1)绿色金融改革创新试验区能显著提升企业ESG表现,这一结论在通过交叠倍差法检验以及一系列稳健性... 详细信息

本文以2015-2021年中国A股上市公司数据为研究样本,将绿色金融改革创新试验区视为准自然实验,运用渐进倍差法考察其政策效应。研究发现:(1)绿色金融改革创新试验区能显著提升企业ESG表现,这一结论在通过交叠倍差法检验以及一系列稳健性检验后依然有效。(2)绿色金融改革创新试验区通过降低债务融资成本和提高研发创新水平有效提升企业ESG表现,同时加剧重污染企业融资约束,缓解非重污染企业融资约束。(3)试验区的政策效应随着企业所处行业性质、地域市场环境以及企业自身数字化水平等发生变化,企业ESG表现存在显著差异。

关键词：绿色金融政策效应企业ESG

带有信息的区间删失数据下AFT模型的参数估计

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数理统计与管理 2024年第1期43卷 58-65页

作者：王淑影刘舒也张亚男程云飞长春工业大学数学与统计学院吉林长春130012

在生存分析研究中,多数文章假定感兴趣的失效时间和删失时间是独立的,但这一假设在实际情况中未必合理。如果忽略失效时间与删失时间的相依性,可能会导致错误的结论。所以本文考虑在带有信息的K型区间删失数据下,采用基于两步估计的极... 详细信息

在生存分析研究中,多数文章假定感兴趣的失效时间和删失时间是独立的,但这一假设在实际情况中未必合理。如果忽略失效时间与删失时间的相依性,可能会导致错误的结论。所以本文考虑在带有信息的K型区间删失数据下,采用基于两步估计的极大似然估计方法对误差项服从标准正态分布的加速失效时间模型(accelerated failure time model,AFT)进行参数估计。同时还进行了数值模拟以验证提出方法的有效性。最后,应用所提出的方法分析艾滋病的临床试验数据。

关键词：加速失效时间模型带有信息的K型区间删失数据极大似然估计法

BIM 5D在机场工程建设精细化管控中的关键应用

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智能建筑与智慧城市 2024年第6期 80-82页

作者：叶舒帆福建兆翔机场建设有限公司

随着机场工程建设的发展模式由数量增长转向质量提升,传统的工程管理模式已难以满足新的需求。引入BIM 5D数字化建造模式可以显著提升机场工程管理水平。文章从建设方的角度探讨了BIM 5D在机场工程管理中的关键应用,包括进度、质量、安... 详细信息

随着机场工程建设的发展模式由数量增长转向质量提升,传统的工程管理模式已难以满足新的需求。引入BIM 5D数字化建造模式可以显著提升机场工程管理水平。文章从建设方的角度探讨了BIM 5D在机场工程管理中的关键应用,包括进度、质量、安全和成本的综合管理。通过WBS分解结构、数字模型管理、进度管理、质量评定、安全管理和计量支付六大功能,实现机场项目的精细化管控。通过对具体机场项目案例的分析,展示了BIM 5D的应用效果,并指出其在未来发展的潜力。

关键词： BIM 5D 工程管理精细化管控 BIM技术

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基于CKB/p53信号通路探讨白花丹醌对人肝癌细胞增殖和凋亡的影响

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中国中药杂志 2024年第9期49卷 2345-2354页

作者：周凤玲袁彬叶一娴邓舒烨马静刘红马远征韦燕飞广西中医药大学基础医学院广西南宁530200 广西高校中药神经-代谢及免疫药理重点实验室广西南宁530200 广西中医药大学第一附属医院广西南宁530024

基于CKB/p53信号通路研究白花丹醌对人肝癌Huh-7细胞增殖和凋亡的影响及其作用机制。将白花丹醌1~12μmol·L^(-1)处理Huh-7细胞,进行细胞增殖和活性cell counting kit-8(CCK-8)实验,确定1、3、6μmol·L^(-1)为低、中、高浓度用于后续... 详细信息

基于CKB/p53信号通路研究白花丹醌对人肝癌Huh-7细胞增殖和凋亡的影响及其作用机制。将白花丹醌1~12μmol·L^(-1)处理Huh-7细胞,进行细胞增殖和活性cell counting kit-8(CCK-8)实验,确定1、3、6μmol·L^(-1)为低、中、高浓度用于后续实验。采用规律成簇的间隔短回文重复序列(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白(CRISPR-associated proteins,Cas)-9基因编辑技术敲除Huh-7细胞中的脑型肌酸激酶(creatine kinase,brain type,CKB)基因;CKB过表达慢病毒转染Huh-7细胞上调CKB的表达。通过平板克隆实验检测细胞增殖;流式细胞术检测细胞凋亡;实时荧光定量PCR(quantitative real-time PCR,qRT-PCR)检测CKB的mRNA表达情况;蛋白免疫印迹(Western blot,WB)实验检测CKB、p53、双微体同源基因2(mouse double minute 2 homolog,MDM2)、B淋巴瘤细胞瘤2(B-cell lymphoma 2,Bcl-2)、Bcl-2相关X蛋白(Bcl-2 associated X protein,Bax)和半胱天冬酶(caspase)-3蛋白表达水平。结果显示白花丹醌显著抑制Huh-7细胞增殖,诱导细胞凋亡。与对照组比较,白花丹醌组凋亡水平显著升高,而白花丹醌联合凋亡抑制剂组凋亡水平显著降低。白花丹醌可显著下调CKB、Bcl-2和MDM2蛋白表达水平,上调p53、Bax和caspase-3蛋白表达水平。敲除CKB基因后,Huh-7细胞增殖能力降低,凋亡率升高,Bcl-2和MDM2蛋白表达水平降低,p53、Bax和caspase-3蛋白表达水平升高。上调CKB表达后,Huh-7细胞增殖能力增强,Bcl-2和MDM2蛋白表达水平升高,p53、Bax和caspase-3蛋白表达水平降低。而白花丹醌可逆转过表达CKB对Huh-7细胞增殖和凋亡的作用。该实验表明,白花丹醌可显著抑制Huh-7细胞的增殖能力,其机制可能是通过抑制CKB表达,激活p53信号通路,调控线粒体相关凋亡蛋白的表达,最终诱导细胞凋亡。

关键词：肝癌白花丹醌 CKB p53信号通路增殖凋亡

Advanced experimental methods toward understanding biophysicochemical interactions of interfacial biomolecules by using sum frequency generation vibrational spectroscopy

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Science China Chemistry 2014年第12期57卷 1646-1661页

作者： ye shu Ji LUO Yi Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemical Physics University of Science and Technology of China Synergetic Innovation Center of Quantum Information & Quantum Physics University of Science and Technology of China

Sum frequency generation vibrational spectroscopy(SFG-VS)has been demonstrated to be a powerful technique to study the interfacial structures and interactions of biomolecules at the molecular *** most previous studies mainly collected the SFG spectra in the frequency range of 1500–4000 cm-1,which is not always sufficient to describe the detailed interactions at surface and *** knowledge of the complex biophysicochemical interactions between biomolecules and surface requires new ideas and advanced experimental methods for collecting SFG vibrational *** introduced some advanced methods recently exploited by our group and others,including(1)detection of vibration modes in the fingerprint region;(2)combination of chiral and achiral polarization measurements;(3)SFG coupled with surface plasmon polaritons(SPPs);(4)imaging and microscopy approaches;and(5)ultrafast time-resolved SFG *** technique that we integrated with these advanced methods may help to give a detailed and high-spatial-resolution 3D picture of interfacial biomolecules.

关键词： protein cholesterol 3D interfacial structures fingerprint region amide III chiral polarization surface plasmon polaritons time-resolved