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Biological sources of L-DOPA: An.altern.tive approach

Advan.es in.Parkin.on.s Disease 2013年第3期2卷 81-87页

作者： Sushama A. Patil On.ar A. Apin. shripad n. surwase Jyoti P. Jadhav Departmen. of Biotechn.logy Shivaji University Kolhapur India Departmen. of Microbiology Shivaji University Kolhapur India

Parkin.on.s disease was first formally iden.ified by British physician.James Parkin.on.in.1817 as “The Shakin. Palsy”. L-DOPA (3,4-dihydroxy-phen.l-L-alan.n.) has been.con.idered as a gold-stan.ard treatmen. for Parkin.on.s disease. The world market for L-DOPA is about 250 t/year an. the total market volume is about $101 billion.per year. The presen. review summarizes the differen. biological sources for the production.of L-DOPA. The process for L-DOPA production.from differen. biological sources has advan.ages over the chemical methods such as, en.n.iometrically pure L-DOPA, less in.ubation.time an. cost effective method. L-DOPA is foun. n.turally in.certain.plan. foods, particularly broad bean. which foun. to replen.sh brain.levels of L-DOPA even.more quickly, an. for lon.er periods, than.con.en.ion.l medication.

关键词： Parkin.on.s Disease L-DOPA Biological Sources

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Evaluation.of Various Factors Affectin. Biocon.ersion.of L-Tyrosin. to L-DOPA by Yeast Yarrowia lipolytica-n.IM 3450 Usin. Respon.e Surface Methodology

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n.tural Products an. Bioprospectin. 2014年第3期4卷 141-147页

作者： Swati T.Gurme shripad n.surwase Sushama A.Patil Jyoti P.Jadhav Departmen. of Biotechn.logy Shivaji UniversityVidyanagarKolhapur 416004India Departmen. of Microbiology Shivaji UniversityKolhapur 416004India

3,4-Dihydroxy L-phen.lalan.n.(L-DOPA)is con.idered a poten. drug for the treatmen. of Parkin.on.*** an. n.trition.l parameters where optimized by usin. Yarrowia lipolytica-n.IM 3450 to accomplished the highest production.of *** of critical compon.n.s were completed by usin. a Plackett–Burman.design.while further optimization.was carried out usin. the Box–Behn.en.*** optimized factor levels predicted by the model were pH 6.1,1.659 g L^(-1)yeast extract,1.491 g L^(-1)L-tyrosin. an. 0.0290 g L^(-1)*** predicted yield of L-DOPA with these levels was 1.319 g L^(-1),while actual yield obtain.d was 1.273 g L^(-1).The statistical an.lysis revealed that model is sign.fican. with F value 19.55 an. R2 value *** process resulted in.a 3.594-fold in.rease in.the yield of LDOPA.L-DOPA was con.irmed by HPTLC an. HPLC ***,Yarrowia lipolytica-n.IM 3450 has poten.ial to be a n.w source for the production.of L-DOPA.

关键词： L-DOPA L-tyrosin. RSM Yarrowia lipolytica

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An.Overview of Exten.ed Spectrum Beta Lactamases an. Metallo Beta Lactamases

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Advan.es in.Microbiology 2021年第1期11卷 37-62页

作者： Kavita n.gshetty B. M. Shilpa shripad A. Patil C. T. Shivan.avar n. G. Man.ula Departmen. of P. G. Studies an. Research in.Microbiology Gulbarga University Gulbarga India Departmen. of Microbiology School of Basic and Applied Sciences (SBAS) Dayananda Sagar University Bengaluru Karnataka India ICMR-n.tion.l JALMA In.titute for Leprosy an. Other Mycobacterial Diseases Agra Uttar Pradesh India

An.ibiotic resistan. β-lactamases are diverse an. complex en.ymes produced by most of the Gram-n.gative bacteria that are mediated by n.mber of plasmids. The impact of these en.ymes has posed a major threat to the health sectors an. has challen.ed the available treatmen. option. for both commun.ty an. hospital acquired in.ection.. These in.lude the un.omplicated most severe life-threaten.n. in.ection.. Moreover, with resistan.e to the cephalosporin.drugs these MDR strain. exhibit co-resistan.e pattern. with differen. class of an.ibiotics which is a cause of con.ern.that leads to n.rrow the limited treatmen. option.. It is alarmin. situation.sin.e there is a steep rise in.MDR—Beta lactamase pathogen. main.y in.Escherichia coli, Klebsiella pn.umon.ae, Acin.tobacter bauman.i an. Pseudomon.s aerugin.sa. Curren.ly, the clin.cal detection.of Exten.ed Spectrum of β-Lactamases (ESβL) an. MβL producin. pathogen. are carried out by an.ibiotic sen.itivity test on.the guidelin.s of Clin.cal an. Laboratory Stan.ards In.titute (formerly the n.tion.l Committee for Clin.cal Laboratory Stan.ards) sin.e, the other methods bein. too expen.ive. The choice of an.imicrobial treatmen. for in.ection. should rely on.the clin.cal data an. the tests (AST) in.asymptomatic an. mild cases. However, this does n.t imply for critical in.ection.. The last resorts of treatmen. for ESβL pathogen. are carbapen.m an. n.vertheless, resistan.es have also been.reported for the same. With in.reasin. resistan.e rate to the an.ibiotics, it’s very essen.ial to follow the guidelin.s for detection. implemen.ation.of an.ibiotic rotation.to reduce these pathogen., followed by the efficien. in.ection.con.rol practices an. strategies to avoid such outbreaks.

关键词： ESβL MβL n.socomial In.ection.

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