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Simulation of wave scattering over a floating platform in the ocean with a coupled CFD-IBM model

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Theoretical & Applied Mechanics Letters 2024年第3期14卷 157-161页

作者： Pengxuan Luo Jingxin Zhang Yongyong cao Shaohong song School of Naval Architecture Ocean&Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China MOE Key Laboratory of Hydrodynamics Shanghai Jiao Tong UniversityShanghai 200240China Shanghai city Tou waterway construction Co. LTDShanghai 200092China

A numerical study of linear wave scattering over a floating platform has been simulated by an efficient numericalmodel in this *** non-hydrostatic model is used to simulate the free surface and the uneven *** thesolid body modelling,the immersed boundary method(IBM)is implemented by introducing a virtual boundaryforce into the momentum equations to emulate the boundary *** implementation enhances theability of the model to simulate interactions between waves and floating structures.A numerical case involvingwave interactions with a floating platform is studied to validate the numerical *** simulating the wavepropagation,the numerical model captures the variation of the wave scattering very well,which verifies theperformance of the numerical model and the robust strategy of the IBM.

关键词： Non-hydrostatic model Immersed boundary method Wave structure interaction Floating platform

Deep neural network based on multi-level wavelet and attention for structured illumination microscopy

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Journal of Innovative Optical Health Sciences 2024年第2期17卷 12-23页

作者： Yanwei Zhang song Lang Xuan cao Hanqing Zheng Yan Gong School of Biomedical Engineering(Suzhou)Division of Life Sciencesand Medicine University of Science and Technology of China Hefei Anhui230026P.R.China Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences Suzhou Jiangsu 215163P.R.China School of Physical Science and Technology Suzhou University of Science and Technology Suzhou Jiangsu 215009P.R.China

Structured illumination microscopy(SIM)is a popular and powerful super-resolution(SR)technique in biomedical ***,the conventional reconstruction algorithm for SIM heavily relies on the accurate prior knowledge of illumination patterns and signal-to-noise ratio(SNR)of raw *** obtain high-quality SR images,several raw images need to be captured under high fluorescence level,which further restricts SIM’s temporal resolution and its *** learning(DL)is a data-driven technology that has been used to expand the limits of optical *** this study,we propose a deep neural network based on multi-level wavelet and attention mechanism(MWAM)for *** results show that the MWAM network can extract high-frequency information contained in SIM raw images and accurately integrate it into the output image,resulting in superior SR images compared to those generated using wide-field images as input *** also demonstrate that the number of SIM raw images can be reduced to three,with one image in each illumination orientation,to achieve the optimal tradeoff between temporal and spatial ***,our MWAM network exhibits superior reconstruction ability on low-SNR images compared to conventional SIM *** have also analyzed the adaptability of this network on other biological samples and successfully applied the pretrained model to other SIM systems.

关键词： Super-resolution reconstruction multi-level wavelet packet transform residual channel attention selective kernel attention

Unraveling the nexus between cellular senescence and malignant transformation:a paradigm shift in cancer research

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Cancer Biology & Medicine 2024年第7期21卷 541-546页

作者： Xiaoyu song Xiyan Liu Qiqiang Guo Hongde Xu Liu cao The College of Basic Medical Science Health Sciences InstituteChina Medical UniversityShenyang 110122China Key Laboratory of Cell Biology of Ministry of Public Health Key Laboratory of Medical Cell Biology of Ministry of EducationKey Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors of Ministry of EducationLiaoning Province Collaborative Innovation Center of Aging Related Disease Diagnosis and Treatment and PreventionChina Medical UniversityShenyang 110122China

Cellular senescence, a natural process wherein cells cease division and undergo irreversible growth arrest, has long captivated the curiosity of scientists because of its many implications in aging and disease. Recent research has shed light on the nexus between cellular senescence and malignant transformation, thus leading to a paradigm shift in understanding cancer development and progression.

关键词： malignant cancer transformation

Effect of Incoming Vortex on Secondary Flows in Turbine Cascades with Planar and Non-Axisymmetric Endwall

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Journal of Thermal Science 2024年第1期33卷 138-157页

作者： cao Zhiyuan WANG Chuxuan song Zhigao GAO Xi ZHAO Wei LIU Bo School of Power and Energy Northwestern Polytechnical UniversityXi'an 710072China National Key Laboratory of Science and Technology on Aerodynamic Design and Research Northwestern Polytechnical UniversityXi'an 710072China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100080China School of Aeronautics and Astronautics University of Chinese Academy of SciencesBeijing 100080China

Non-Axisymmetric Endwall Profiling(NAEP) is commonly utilized in turbines to eliminate secondary ***,most of the NAEP methods consider a single-blade row environment without incorporating the effect of the stage *** paper aims to investigate the influence mechanism of the incoming vortex on the endwall secondary flow structures of NAEP in a highly loaded turbine *** model the incoming vortex in a stage environment,this study considers a half-delta wing as the vortex generator at the upstream of the turbine *** NAEP is then carried out for a highly loaded turbine cascade with an in-house numerical optimization design platform subject to no incoming *** simulation is also carried out under the influence of the incoming vortex for the turbine cascades with both planar and non-axisymmetric *** paper furthers investigated the pitchwise effect of the incoming vortex on the near endwall secondary *** results indicate that the NAEP effectively improves the endwall secondary flow of the turbine cascade,where the total pressure loss coefficient and the secondary kinetic energy(SKE) are reduced by 7.3%,and 45.7%,*** is further seen that with the incoming vortex,the NAEP achieves a considerable control effect on the endwall secondary flow of the turbine *** incoming vortex,the NAEP can still achieve considerable control effect on the endwall secondary flow of the turbine cascade;the averaged reductions of loss coefficient and SKE are 7.8% and 14.2%,*** some pitchwise locations,incoming vortex can suppress the convection of cross-passage flow toward the suction corner greatly and reduce the loss coefficient of the baseline *** incoming vortex at 4/7 pitch impinged right at the blade leading edge,leading to the generation of low-momentum fluid,which increased the size and the strength of the horseshoe *** all the pitchwise locations,NAEP can suppress the seco

关键词： non-axisymmetric endwall secondary flow incoming vortex passage vortex stage environment

Access to advanced sodium-ion batteries by presodiation:Principles and applications

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Journal of Energy Chemistry 2024年第5期92卷 162-175页

作者： Shihao Zhang Ruoyu cao Xiangjun Pu Along Zhao Weihua Chen Chunhua song Yongjin Fang Yuliang cao College of Chemistry and Molecular Sciences Hubei Key Laboratory of Electrochemical Power SourcesWuhan UniversityWuhan 430072HubeiChina College of Chemistry&Green Catalysis Center Zhengzhou UniversityZhengzhou 450001HenanChina Shenzhen Janaenergy techonulogy Co. Ltd.Shenzhen 518000GuangdongChina School of Chemistry and Chemical Engineering Jiangsu University of TechnologyChangzhou 213001JiangsuChina Zonergy Corporation NO.68 Fucang RoadYantan DistrictZigong 643030SichuanChina

Sodium-ion batteries(SIBs)are expected to offer affordability and high energy density for large-scale energy storage ***,the commercial application of SIBs is hurdled by low initial coulombic efficiency(ICE),continuous Na loss during long-term operation,and low sodium-content of cathode *** this scenario,presodiation strategy by introducing an external sodium reservoir has been rationally proposed,which could supplement additional sodium ions into the system and thereby markedly improve both the cycling performance and energy density of *** this review,the significance of presodiation is initially introduced,followed by comprehensive interpretation on technological properties,underlying principles,and associated approaches,as well as our perspectives on present inferiorities and future research ***,this contribution outlines a distinct pathway towards the presodiation methodology,of significance but still in its nascent phase,which may inspire the targeted guidelines to explore new chemistry in this field.

关键词： Presodiation Increased coulombic efficiency High reversible capacity Sodium ion batteries

Strategic Study on the Development of Space Science in China and Proposals for Future Missions

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空间科学学报 2024年第4期44卷 699-703页

作者： WANG Chi song Tingting LI Ming cao song National Space Science Center Chinese Academy of SciencesBeijing 100190

Since 2011,the Chinese Academy of Sciences(CAS)has implemented the Strategic Priority Program on Space Science(SPP).A series of scientific satellites have been developed and launched,such as Dark Matter Particle Explorer(DAMPE),Quantum Experiments at Space Scale(QUESS),Advanced Space-based Solar Observatory(ASO-S),Einstein Probe(EP),and significant scientific outcomes have been *** order to plan the future space science missions in China,CAS has organized the Chinese space science community to conduct medium and long-term development strategy studies,and summarized the major scientific frontiers of space science as“One Black,Two Dark,Three Origins and Five Characterizations”.Five main scientific themes have been identified for China’s future breakthroughs,including the Extreme Universe,Space-Time Ripples,the Panoramic View of the Sun and Earth,the Habitable Planets,and Biological&Physical Science in *** science satellite missions to be implemented before 2030 are proposed accordingly.

关键词： Space science Space missions Space exploration

Identification of transient receptor potential channel genes and functional characterization of TRPA1 in Spodoptera frugiperda

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Journal of Integrative Agriculture 2024年第6期23卷 1994-2005页

作者： Yutong Zhang Hangwei Liu song cao Bin Li Yang Liu Guirong Wang State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China Institute of Evolution and Ecology School of Life SciencesCentral China Normal UniversityWuhan 430079China

Spodoptera frugiperda is a highly destructive pest that has become a global problem due to its robust reproductive and migratory *** receptor potential(TRP)channels,which constitute a vast ion channel family,play pivotal roles in sensing the external environment and maintaining internal homeostasis in *** channels have been widely investigated for their critical roles in regulating various insect behaviors in recent *** this study,we identified 15 TRP gene loci encoding 26 transcripts in the genome of *** and analyzed their expression profiles at different developmental *** results revealed that *** possesses four TRPC genes,six TRPA genes,one TRPM gene,two TRPV genes,one TRPN gene,and one TRPML gene,while a canonical TRPP is ***,the SfruTRPA1 was functionally characterized using the Xenopus oocyte expression *** results showed that SfruTRPA1 is activated by temperature increases from 20 to 45℃,and there is no significant desensitization after repeated stimuli within the same temperature ***,SfruTRPA1 is activated by certain natural chemicals,including allyl isothiocyanate(AITC)and cinnamaldehyde(CA).These findings provide valuable insights to the TRP genes in ***.

关键词： Spodoptera frugiperda transient receptor potential channel expression profile TRPA1 Xenopus oocyte

Targeted metabolomics reveals the aberrant energy status in diabetic peripheral neuropathy and the neuroprotective mechanism of traditional Chinese medicine JinMaiTong

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Journal of Pharmaceutical Analysis 2024年第2期14卷 225-243页

作者： Bingjia Zhao Qian Zhang Yiqian He Weifang cao Wei song Xiaochun Liang Department of Traditional Chinese Medicine Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing100730China Institute of Basic Medicine Sciences Chinese Academy of Medical SciencesBeijing100005China Medical Research Center Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing100730China

Diabetic peripheral neuropathy (DPN) is a common and devastating complication of diabetes, for which effective therapies are currently lacking. Disturbed energy status plays a crucial role in DPN pathogenesis. However, the integrated profile of energy metabolism, especially the central carbohydrate metabolism, remains unclear in DPN. Here, we developed a metabolomics approach by targeting 56 metabolites using high-performance ion chromatography-tandem mass spectrometry (HPIC-MS/MS) to illustrate the integrative characteristics of central carbohydrate metabolism in patients with DPN and streptozotocin-induced DPN rats. Furthermore, JinMaiTong (JMT), a traditional Chinese medicine (TCM) formula, was found to be effective for DPN, improving the peripheral neurological function and alleviating the neuropathology of DPN rats even after demyelination and axonal degeneration. JMT ameliorated DPN by regulating the aberrant energy balance and mitochondrial functions, including excessive glycolysis restoration, tricarboxylic acid cycle improvement, and increased adenosine triphosphate (ATP) generation. Bioenergetic profile was aberrant in cultured rat Schwann cells under high-glucose conditions, which was remarkably corrected by JMT treatment. In-vivo and in-vitro studies revealed that these effects of JMT were mainly attributed to the activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK) and downstream peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α). Our results expand the therapeutic framework for DPN and suggest the integrative modulation of energy metabolism using TCMs, such as JMT, as an effective strategy for its treatment.

关键词： Diabetic peripheral neuropathy JinMaiTong Energy metabolism Targeted metabolomics Adenosine monophosphate-activated protein kinase

C_(Ar)-Br bond cleavage via cooperative EnT/NHC catalysis: mild access to indolines

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Science China Chemistry 2024年第3期67卷 922-927页

作者： Yi-Xiong Dong cao-Bo Li Ming-Lei Jin Zhong-Hua Gao song Ye Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and FunctionCAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The cooperative visible-light mediated and NHC-catalyzed dearomative arylation-acylation of N-(2-bromobenzoyl)indoles with aldehydes was developed, affording the corresponding highly functionalized polycyclic indolines in moderate to good yields with exclusive diastereoselectivities. Mechanism investigations support the activation of CAr-Br bond via visible-light mediated energy transfer(EnT) and the following single-electron-transfer(SET) with Breslow intermediate under NHC catalysis to give key aryl radical and ketyl radical. This protocol demonstrates the cleavage of CAr-Br bond under mild cooperative EnT/NHC catalysis.

关键词： energy transfer N-heterocyclic carbenes photocatalysis aryl radicals indolines