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Enteroaggregative Escherichia aoliisolated from Chinese diarrhea patients with high-pathogenicity island of Yersinia'xs involved in synthesis of siderophore yersiniabactin

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World Journal of Gastroenterology 2005年第37期11卷 5816-5820页

作者： Jing Hu Biao Kan Zhi-Hua Liu shou-yi yu Department of Epidemiology Southern Medical College Guangzhou 510515 Guangdong Province China Department of Genetics Institute of Epidemiology and MicrobiologyChinese Center for Disease Control and Prevention Beijing 102206 China Department of Infectious Diseases Nanfang Hospital Southem Medical College Guangzhou 510515 Guangdong Province China

AIM: To investigate the distribution of 12 high-pathogenicity island (HPI) genes and the relation between HPI genes and expression of yersiniabactin (Ybt) in enteroaggregative ***(EAggEC) isolated from Chinese diarrhea ***: The distribution of 12 HPI genes was investigated by PCR and DNA hybridization in two prototype strains of EAggEC, EAggEC 17-2, EAggEC O42, and 6 clinical EAggEC isolates from China. The production of siderophore Ybt in HPI-positive strains was detected by reporter gene bioassay to determine the relation between HPI genes and expression of Ybt. Flow cytometry was used to detect fluorescent signal of the reporter strain that could designate production of ***: Seven strains were HPI-positive and one strain was HPI-negative. Six of the seven HPI-positive strains were inserted into asnT-tRNA site. Moreover, seven EAggEC HPI-positive strains revealed enhanced fluorescence signal but the EAggEC HPI-negative strain did not. However, there was a difference in Ybt expression condition and level among these seven EAggEC HPI-positive strains. Although UFT073 strain, the prototype strain of uropathogenic ***(UPEC), carried the complete HPI core part, we did not detect the expression of Ybt in ***: EAggEC HPI-positive strains can express the Ybt system, but the presence of HPI core part does not mean the functional expression of Ybt.

关键词： High-pathogenicity island Enteroaggregative Escherichia colt, Yersiniabactin

Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： Xiao-yu Zhao Juan-Han yu yi-Hua Wang yi-Xin Liu Lu Xu Lin Fu Ning yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

Single-cell transcriptomic profiling reveals ZEB1-mediated regulation in microglial subtypes and the impact of exercise on neuroinflammatory responses

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Traditional Medicine Research 2025年第2期10卷 55-64页

作者： Jin-Fang Wu yi-Sheng Chen yu-Chun Xie Department of Rehabilitation Medicine Jiangsu Province Geriatric HospitalNanjing 210024China Fujian Key Laboratory of Toxicant and Drug Toxicology Medical CollegeNingde Normal UniversityNingde 352100China Central Laboratory Jiangsu Province Geriatric HospitalNanjing 210024China

Background:This study aims to identify distinct cellular subtypes within brain tissue using single-cell transcriptomic analysis,focusing on specific biomarkers that differentiate cell types and the effects of traditional and exercise ***:Four samples were analyzed:older control(OC),older exercise(OE),younger control(YC),and younger exercise(YE).Single-cell RNA sequencing was used to distinguish cellular subtypes through their biomarker *** visualization included violin and t-SNE plots to illustrate biomarker expression across cell clusters such as oligodendrocytes,microglia,and ***,BV2 cells were exposed to amyloid-beta fragments to simulate Alzheimer’s disease,assessing the impact of exercise-induced cellular ***:Distinct cellular subtypes were identified:oligodendrocytes(MBP,St18),microglia(Dock8),and astrocytes(Aqp4,Gpc5).Sample OE was predominantly oligodendrocytes,while YE had more astrocytes,inhibitory neurons,and Canal-Retzius *** showed a significant presence of Olfm3+ganglion ***1 gene knockout revealed changes in SMAD family gene expression,which regulate *** stress levels were also ***:This profiling enhances our understanding of brain cellular functions and interactions,potentially informing targeted therapies in neurological *** may influence brain cell immune responses and cell death pathways by regulating specific gene expressions,offering new insights for treating neuroinflammation and degeneration.

关键词： single-cell transcriptomics brain tissue cellular subtypes biomarker expression neuronal diversity

Success of intravenous immunoglobulin and steroids in managing severe COVID-19 following lung transplantation:A case report

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World Journal of Transplantation 2025年第1期15卷 178-184页

作者： Yen-shou Kuo Kuan-Hsun Lin ying-yi Chen yuan-Ming Tsai Ti-Hui Wu Hsu-Kai Huang Tsai-Wang Huang Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114202Taiwan

BACKGROUND Coronavirus disease 2019(COVID-19)pneumonia with severe septic shock and acute respiratory distress syndrome(ARDS)are critical illnesses for patients following *** immunoglobulin(IVIG)plays a role in both immune support and inflammation control,especially in immunocompromised *** case report describes the first successful experience using IVIG and pulse steroids to manage this critical condition following lung *** SUMMARY A 65-year-old male patient reported a history of chronic obstructive pulmonary disease and poor lung function and received bilateral sequential lung ***,he developed COVID-19 pneumonia,severe septic shock,and *** recovered from this critical condition after empirical antibiotics administration and veno-venous extracorporeal membrane oxygenation,in addition to IVIG and pulse *** IVIG is a valuable adjunct in managing severe sepsis in lung transplant recipients after COVID-19 *** aim,for the first time,to report the success of such a management approach for COVID-19 ARDS and sepsis in the post-lung transplant *** further investigations,this is a starting point for wider analysis of such an approach in this setting and consequently helps guide clinical practice for such a challenging patient population moving forward.

关键词： COVID-19 Septic shock Intravenous immunoglobulin Lung transplantation Post-transplant complications Case report

Research progress of m^(6) A methylation in prostate cancer

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Asian Journal of Andrology 2023年第2期25卷 166-170页

作者： shou-yi Zhang yu Zeng Department of Urology The Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyang 110042China

N^(6)-methyladenosine(m^(6)A)is a ubiquitous RNA modification in *** modification is“written”by methyltransferases and then“read”by m^(6)A-binding proteins,followed by a series of regulation,such as alternative splicing,translation,RNA stability,and RNA *** last,the modification is“erased”by demethylases.m^(6)A modification is essential for normal physiological processes in mammals and is also a very important epigenetic modification in the development of *** recent years,cancer-related m^(6)A regulation has been widely studied,and various mechanisms of m^(6)A regulation in cancer have also been *** this review,we summarize the changes of m^(6)A modification in prostate cancer and discuss the effect of m6A regulation on prostate cancer progression,aiming to profile the potential relevance between m^(6)A regulation and prostate cancer *** studies on m^(6)A regulation in prostate cancer may uncover the potential role of m^(6)A methylation in the cancer diagnosis and cancer therapy.

关键词： epigenetic N^(6)-methyladenosine methylation molecular biology prostate cancer

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World Journal of Clinical Cases 2025年第6期13卷 24-29页

作者： Wen-Jin yuan yi-Juan Zheng Bing-Rong Zhang yi-Jie Lin You Li Yan-Yan Qiu Xue-Ping yu Department of Infection Disease Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian provinceFujian Medical University Affiliated First Quanzhou HospitalQuanzhou 362000Fujian ProvinceChina

BACKGROUND Hydroxyurea,an antimetabolite,is frequently prescribed for various hemato-logical disorders,and its common side effects include gastrointestinal problems,cutaneous or mucosal lesions and pyrexia/*** SUMMARY This study reports the case of a 67-year-old woman who developed recurrent abdominal pain after 10 years of continuous hydroxyurea therapy for primary *** revealed an ileocecal *** discontinuing hydroxyurea therapy for 6 months,follow-up colonoscopy showed a significant reduction in the *** We consider cecal ulcers as a rare complication of hydroxyurea therapy which typically resolves upon stopping the drug.

关键词： Hydroxyurea Ulcer Abdominal pain Thrombocythemia Colonoscopy Case report

Air combat decision-making of multiple UCAVs based on constraint strategy games

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Defence Technology（防务技术） 2022年第3期18卷 368-383页

作者： shou-yi Li Mou Chen yu-hui Wang Qing-xian Wu College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjing211100China

Game theory can be applied to the air combat decision-making problem of multiple unmanned combat air vehicles(UCAVs).However,it is difficult to have satisfactory decision-making results completely relying on air combat situation information,because there is a lot of time-sensitive information in a complex air combat *** this paper,a constraint strategy game approach is developed to generate intelligent decision-making for multiple UCAVs in complex air combat environment with air combat situation information and time-sensitive ***,a constraint strategy game is employed to model attack-defense decision-making problem in complex air combat ***,an algorithm is proposed for solving the constraint strategy game based on linear programming and linear inequality(CSG-LL).Finally,an example is given to illustrate the effectiveness of the proposed approach.

关键词： Game theory Time-sensitive information Constraint strategy games Polytope strategy games Multiple UCAVs Air combat decision-making

Harmonic Current′s Coupling Effect on the Main Motion of Temper Mill Set

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Journal of Central South University 2000年第3期12卷 162-164页

作者： HE Jian-jun yu shou-yi ZHONG Jue College of Information Science and Engineering Central South UniversityChangsha 410083China College of Mechanical and Electrical Engineering Central South UniversityChangsha 410083China

The paper probes into a probable condition that causes temper mill chatter from aspect of electromechanical coupling of complex electromechanical system, and mainly studies the effect of temper mill electrical driving system harmonic current on the main motion of temper mill set. Aiming at the electrical driving system of CM04 temper mill, the effect of harmonic current is analyzed and evaluated according to different load. Combining the features of CM04 temper mill′s structure and its working state, the paper discusses in every detail how the harmonic current in main circuit, which can be regarded as a disturbance via feedback control circuit , influences main motion of temper mill set.

关键词： electromechanical coupling temper mill harmonic current rolling mill chatter

Phase-mediated controllable intramolecular and intermolecular photocycloadditions assisted by supramolecular templates

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Science China Chemistry 2022年第6期65卷 1129-1133页

作者： yi-shou Wang Li-ying Sun Yao-yu Wang ying-Feng Han Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education Xi’an Key Laboratory of Functional Supramolecular Structure and MaterialsCollege of Chemistry and Materials ScienceNorthwest UniversityXi’an710127China

Understanding and controlling supramolecular template effect assembly via a photochemical reaction in different solid and solution phases is one of the main topics in photochemistry. Here, an interesting case of phase-mediated controllable intramolecular/intermolecular photochemical [2+2] cycloadditions assisted by supramolecular templates was demonstrated. Direct irradiation of the complexes in solution yields intramolecular photoproducts exclusively, whereas exposure of the solid powder sample under the same conditions yields intermolecular dinuclear species quantitatively. The nature of the phase and supramolecular interaction affects the geometrical arrangements of the metallacycles, leading to different cycloaddition products under photoirradiation. The crystal structures of different products were investigated by single-crystal X-ray diffraction, nuclear magnetic resonance(NMR) spectrometry, and electrospray ionization mass spectrometry(ESI-MS).

关键词： N-heterocyclic carbene photochemical cycloaddition template synthesis topochemistry stacking interactions

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