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AF1q inhibited T cell attachment to breast cancer cell by attenuating Intracellular Adhesion Molecule-1 expression

Journal of Cancer Metastasis and Treatment 2019年第3期4卷 20-31页

作者： Jino Park Jae Yeon Hwang Alexandra Thore Soojin Kim Tomiteru Togano shotaro Hagiwara Juw Won Park William Tse James Graham Brown Cancer Center University of Louisville School of MedicineLouisvilleKY 40202USA Division of Blood and Bone Marrow Transplantation Department of MedicineUniversity of Louisville School of MedicineLouisvilleKY 40202USA Department of Computer Science and Computer Engineering University of LouisvilleLouisvilleKY 40292USA Division of Haematology National Center for Global Health and MedicineTokyo 162-8655Japan Division of Haematology Tokyo Women’s Medical UniversityTokyo 162-8666Japan

Aim: To investigate whether AF1q, overexpressed in metastatic cells compared with the primary tumor cells, plays a pivotal role in breast cancer metastasis. Methods: To investigate whether AF1q has a responsibility in the acquisition of a metastatic phenotype, we performed RNA-sequencing (RNA-Seq) to identify the gene signature and applied the Metacore direct interactions network building algorithm with the top 40 amplicons of RNA-Seq. Results: Most genes were directly linked with intercellular adhesion molecule-1 (ICAM-1). Likewise, we identified that ICAM-1 expression is attenuated in metastatic cells compared to primary tumor cells. Moreover, overexpression of AF1q attenuated ICAM-1 expression, whereas suppression of AF1q elicited the opposite effect. AF1q had an effect on ICAM-1 promoter region and regulated its transcription. Decreased ICAM-1 expression ;affected the attachment of T cells to a breast cancer cell monolayer. We confirmed the finding by performing the analysis on Burkitt's lymphoma. Conclusion: Attenuation of ICAM-1 by AF1q on tumor cells disadvantages host anti-tumor defenses through the trafficking of lymphocytes, which affects tumor progression and metastasis.

关键词： MLLT11 AF1q intercellular adhesion molecule-1 breast cancer metastasis RNA-sequencing

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Transnasal and standard transoral endoscopies in the screening of gastric mucosal neoplasias

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World Journal of Gastrointestinal Endoscopy 2011年第8期3卷 162-170页

作者： Hiroya Nakata shotaro Enomoto Takao Maekita Izumi Inoue Kazuki Ueda Hisanobu Deguchi Naoki Shingaki Kosaku Moribata Yoshimasa Maeda Yoshiyuki Mori Mikitaka Iguchi Hideyuki Tamai Hiroya Nakata Nobutake Yamamichi Mitsuhiro Fujishiro Jun Kato Masao Ichinose Department of Gastroenterology School of Medicine Wakayama Medical University Wakayama City Wakayama 641-0012 Japan Nakata Medical Clinic Wakayama 641-0006 Japan Department of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo 113-8655 Japan

AIM: To compare the diagnostic performances of transnasal and standard transoral esophagogastroduodenoscopy (EGD) in gastric cancer screening of asymptomatic healthy subjects. METHODS: Between January 2006 and March 2010, a total of 3324 subjects underwent examination of the upper gastrointestinal tract by EGD for cancer screening, with 1382 subjects (41.6%) screened by transnasal EGD and the remaining 1942 subjects (58.4%) by standard transoral EGD. Clinical profiles of the screened subjects, detection rates of gastric neoplasia and histopathology of the detected neoplasias were compared between groups according to the stage of Helicobacter pylori (H. pylori)-related chronic gastritis. RESULTS: Clinical profiles of subjects did not differ significantly between the two EGD groups, except that there were significantly more men in the transnasal EGD group. During the study period, 55 cases of gastric mucosal neoplasias were detected. Of these, 23 cases were detected by transnasal EGD and 32 cases by standard transoral EGD. The detection rate for gastric mucosal neoplasia in the transnasal EGD group was thus 1.66%, compared to 1.65% in the standard transoral EGD group, with no significant difference between the two groups. Detection rates using the two endoscopies were likewise comparable, regardless of H. pylori infection. However, detection rates when screening subjects without extensive chronic atrophic gastritis (CAG) were significantly higher with standard transoral EGD (0.70%) than with transnasal EGD (0.12%, P < 0.05). In particular, standard transoral EGD was far better for detecting neoplasia in subjects with H. pylori-related non-atrophic gastritis, with a detection rate of 3.11% compared to 0.53% using transnasal EGD (P < 0.05). In the screening of subjects with extensive CAG, no significant differences in detection of neoplasia were evident between the two endoscopies, although the mean size of detected cancers was significantly smaller and the percentage o

关键词： Transnasal endoscopy Gastric cancer Gastric adenoma Atrophic gastritis Helicobacter pylori Cancer screening

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Japanese apricot improves symptoms of gastrointestinal dysmotility associated with gastroesophageal reflux disease

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World Journal of Gastroenterology 2015年第26期21卷 8170-8177页

作者： Takao Maekita Jun Kato shotaro Enomoto Takeichi Yoshida Hirotoshi Utsunomiya Hideyuki Hayashi Toshiko Hanamitsu Izumi Inoue Yoshimasa Maeda Kosaku Moribata Yosuke Muraki Naoki Shingaki Hisanobu Deguchi Kazuki Ueda Mikitaka Iguchi Hideyuki Tamai Masao Ichinose Department of Gastroenterology School of MedicineWakayama Medical University Department of Japanese Apricot Minabe Town Office Department of Health Welfare Minabe Town Office

AIM: To investigate the effects of Japanese apricot(JA) consumption on gastroesophageal reflux disease(GERD)-related ***: Participants included individuals living in Minabe-cho,a well-known JA-growing region,who received specific medical check-ups by the local community health service in ***-related symptoms were examined in 1303 Japanese individuals using a validated questionnaire,the Frequency Scale for Symptoms of GERD(FSSG),which consists of 7 questions associated with acid reflux symptoms and 5 questions asking about gastrointestinal dysmotility *** question was answered using a 4-point scale,with higher scores indicating more severe GERDrelated *** were divided into two groups according to their intake of dried and pickled JA: daily intake(≥ 1 JA daily)(392 subjects) and none oroccasional intake(< 1 JA daily)(911 subjects).FSSG scores were compared between subjects who consumed JA daily and those who did ***,subjects were stratified by age,gender and Helicobacter pylori(***) status for ***: Those who ate JA daily were significantly older than those who did not(60.6 ± 10.5 years vs 56.0 ± 11.0 years,P < 0.001).Total FSSG scores were significantly lower in subjects with daily JA intake than in those with none or only occasional intake(2.13 ± 3.14 vs 2.70 ± 3.82,P = 0.005).In particular,subjects who consumed JA daily showed significantly improved FSSG dysmotility scores compared with subjects who did not(1.05 ± 1.58 vs 1.46 ± 2.11,P < 0.001).In contrast,the FSSG reflux score did not differ between subjects with and without daily intake of JA(1.08 ± 1.90 vs 1.24 ± 2.11,P = 0.177).Subanalysis indicated that improvement in dysmotility by JA intake was specifically observed in non-elderly(1.24 ± 1.68 vs 1.62 ± 2.22,P = 0.005) and ***-negative subjects(0.99 ± 1.58 vs 1.57 ± 2.06,P < 0.001).GERD patients(total FSSG score ≥ 8) were less frequently observed among subjects with daily intake of JA as

关键词： Japanese apricot Umeboshi Gastroesophagealreflux disease Frequency Scale for Symptomsof gastroesophageal reflux disease Dysmotility

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关于“绞拧机”计划和“缝合”计划的档案信息

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近现代国际关系史研究 2017年第1期 241-246页

作者：近藤翔太郎丁何昕子日本京都大学首都师范大学历史学院

2015年夏天,我在位于马里兰大学帕克分校的美国国家档案馆进行了为期两个月的文献研究,研究的重点包括:RG341'绞拧机'计划报告(Wringer Project Reports),RG319非个人文件(impersonal files)和RG319个人文件(personnel files)。肯尼迪... 详细信息

2015年夏天,我在位于马里兰大学帕克分校的美国国家档案馆进行了为期两个月的文献研究,研究的重点包括:RG341'绞拧机'计划报告(Wringer Project Reports),RG319非个人文件(impersonal files)和RG319个人文件(personnel files)。肯尼迪时期颁布的1998年《纳粹战争罪行档案解密法案》(Nazi War Crimes Records Disclosure Act)

关键词：日本战俘战俘遣返战俘营反情报

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Tool wear estimation method in milling process using air turbine spindle rotation-control system equipped with disturbance force observer

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International Journal of Hydromechatronics 2018年第3期1卷 1-1页

作者： Tomonori Kato Tatsuki Otsubo Kohei Shimazaki shotaro Matsuguchi Yusuke Okamoto Takanori Yazawa Fukuoka Inst Technol Fac Engn Dept Intelligent Mech Engn Higashi Ku 3-30-1 Wajiro Higashi Fukuoka 8110295 Japan

The authors investigate a disturbance-compensating and energy-saving control method for air turbine spindles equipped with a rotation control system designed for use in ultra-precision *** controllability and energy-conserving characteristics of the proposed method using the proposed pneumatic regulating device,called a high-precision quick-response pneumatic pressure regulator,were demonstrated experimentally ***,the proposed rotation-controlled air turbine spindle is first ***,the proposed rotation-controlled air turbine spindle is set to a milling machine and applied to the milling of an alloy tool steel,to gain data and validate the effectiveness of the in-process tool wear estimation method that have been recently developed and proposed by the ***,to evaluate the possibility of applying the proposed estimation method to three-dimensional milling,milling experiments where the air turbine spindle is set at a 45°incline were conducted and the results indicate a high possibility of the proposed method.

关键词： disturbance-compensating energy-saving control system designed

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Alpha-fetoprotein and des-gamma-carboxy-prothrombin at twenty-four weeks after interferon-based therapy predict hepatocellular carcinoma development

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World Journal of Hepatology 2015年第27期7卷 2757-2764页

作者： Satoshi Shakado shotaro Sakisaka Kazuaki Chayama Takeshi Okanoue Joji Toyoda Namiki Izumi Akihiro Matsumoto Tetsuo Takehara Akio Ido Yoichi Hiasa Kentaro Yoshioka Hideyuki Nomura Yoshiyuki Ueno Masataka Seike Hiromitsu Kumada Department of Gastro-enterology and Medicine Faculty of Medicine Fukuoka University Department of Gastroenterology and Metabolism Applied Life Sciences Graduate School of Biome-dical and Health SciencesHiroshima University Center of Gastroenterology and Hepatology Saiseikai Suita Hospital Department of Gastroenterology and Hepatology Sapporo Kousei Hospital Department of Gastroenterology and Hepatology Musashino Red-Cross Hospital Department of Medicine Shinshu University School of Medicine Department of Gastroenterology and Hepa-tology Osaka University Graduate School of Medicine Department of Gastroenterology and Hepatology Kagoshima University Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine Department of Liver Biliary Tract and Pancreas Diseases Fujita Health University the Center for Liver Disease Shin-Kokura Hospital Department of Gastroenterology Yamagata University Department of Gastroenterology Faculty of Medicine Oita University Department of Hepatology Toranomon Hospital

AIM: To investigate risk factors for development of hepatocellular carcinoma(HCC) in patients with hepatitis C virus-related liver cirrhosis(LC-C).METHODS: To evaluate the relationship between clinical factors including virological response and the development of HCC in patients with LC-C treated with interferon(IFN) and ribavirin, we conducted a multicenter, retrospective study in 14 hospitals in Japan. All patients had compensated LC-C with clinical or histological data available. HCC was diagnosed by the presence of typical hypervascular characteristics on computed tomography and/or magnetic resonance ***: HCC was diagnosis in 50(21.6%) of 231 LC-C patients during a median observation period of 3.8 years after IFN and ribavirin therapy. Patients who developed HCC were older(P = 0.018) and had higher serum levels of pretreatment alpha-fetoprotein(AFP)(P = 0.038). Multivariate analysis revealed the following independent risk factors for HCC development: history of treatment for HCC [P < 0.001, odds ratio(OR) = 15.27, 95%CI: 4.98-59.51], AFP levels of ≥ 10 ng/m L(P = 0.009, OR = 3.89, 95%CI: 1.38-11.94), and des-γ-carboxy prothrombin(DCP) levels of ≥ 40 m AU/mL at 24 wk after the completion of IFN and ribavirin therapy(P < 0.001, OR = 24.43, 95%CI: 4.11-238.67).CONCLUSION: We suggested that the elevation of AFP and DCP levels at 24 wk after the completion of IFN and ribavirin therapy were strongly associated with the incidence of HCC irrespective of virological response among Japanese LC-C patients.

关键词： Des-γ-carboxy prothrombin Hepatocellular carcinoma

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Novel risk markers for gastric cancer screening: Present status and future prospects

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World Journal of Gastrointestinal Endoscopy 2010年第12期2卷 381-387页

作者： shotaro Enomoto Takao Maekita Hiroshi Ohata Kimihiko Yanaoka Masashi Oka Masao Ichinose Second Department of Internal Medicine Wakayama Medical University

Initial identification of populations at high risk of gastric cancer (GC) is important for endoscopic screening of GC. As serum pepsinogen (PG) test-positive subjects with progression of chronic atrophic gastritis (CAG) show a high likelihood of future cancer development, this population warrants careful follow-up observation as a high-risk GC group. By combining the PG test with Helicobacter pylori (HP) antibody titers, the HP-related chronic gastritis stage can be classified, thus identifying not only a GC high-risk group but also a low-risk group. Among PG test-negative patients without CAG, those with high serum PG Ⅱ levels and HP antibody titers are thought to have severe gastric mucosal inflammation and the risk of diffuse-type GC is also high. Meanwhile, in gastric mucosae obtained by endoscopic biopsy, HP infection induces aberrant DNA methylation in CpG islands in multiple gene regions and the extent of methylation clearly correlates with GC risk. By quantifying aberrant DNA methylation in suitable gene markers, we can determine the extent of the epigenetic field for cancerization. These novel concepts and risk markers will have many clinical applications in gastrointestinal endoscopy, including more efficient endoscopic GC screening and a strategic approach to metachronous multiple GCs after endoscopic treatment.

关键词： Gastric cancer Screening Risk Pepsinogen Helicobacter pylori DNA methylation

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Steakhouse syndrome causing large esophageal ulcer and stenosis

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World Journal of Gastrointestinal Endoscopy 2011年第5期3卷 101-104页

作者： shotaro Enomoto Kazuyuki Nakazawa Kazuki Ueda Yoshiyuki Mori Yoshimasa Maeda Naoki Shingaki Takao Maekita Uki Ota Masashi Oka Masao Ichinose Department of Gastroenterology School of MedicineWakayama Medical University811-1 KimiideraWakayama CityWakayama 641-0012Japan Department of Gastroenterology Nishimurakai Koyo Hospital40 TsuhadaWakayama CityWakayama 640-8315Japan Ota Medical Clinic 424-1 OtaWakayama City640-8323 WakayamaJapan

A 66-year-old man developed dysphagia during dinner and was evaluated 2d later in our hospital because of persistent *** gastrointestinal endoscopy showed no impacted food,but advanced esophageal cancer was suspected based on the presence in the upper esophagus of a large irregular ulcerative lesion with a thick white coating and *** imaging studies were performed to evaluate for metastases,revealing circumferential esophageal wall thickening and findings suggestive of lung and mediastinal lymph node ***,dysphagia symptoms and the esophageal ulcer improved after hospital admission,and histopathological examination of the esophageal mucosa revealed only nonspecific *** the timeof symptom onset,the patient had been eating stewed beef tendon(Gyusuji nikomi in Japanese) without chewing *** ulceration due to steakhouse syndrome was therefore *** lung lesion was a primary lung cancer that was surgically *** rare,steakhouse syndrome can cause large esophageal ulceration and stenosis,so care must be taken to distinguish this from esophageal cancer.

关键词： Esophageal stenosis Esophagus Ulcer Dysphagia Steakhouse syndrome

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Diazepam during endoscopic submucosal dissection of gastric epithelial neoplasias

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World Journal of Gastrointestinal Endoscopy 2012年第3期4卷 80-86页

作者： Yosuke Muraki shotaro Enomoto Mikitaka Iguchi Toru Niwa Takao Maekita Takeichi Yoshida Kosaku Moribata Naoki Shingaki Hisanobu Deguchi Kazuki Ueda Izumi Inoue Hideyuki Tamai Jun Kato Mitsuhiro Fujishiro Masao Ichinose Second Department of Internal Medicine Wakayama Medical University Department of Endoscopy and Endoscopic Surgery Faculty of MedicineUniversity of Tokyo

AIM:To investigate risk factors and adverse events related to high-dose diazepam administration during endoscopic submucosal dissection for gastric ***:Between February 2002 and December 2009,a total of 286 patients with gastric epithelial neoplasia underwent endoscopic submucosal dissection in our *** achieve moderate sedation,5-7.5 mg of diazepam was administered intravenously by *** additional administration of 2.5-5 mg diazepam was performed if uncontrollable body movement of the patient was *** patients were classified into groups based on the required diazepam dose:low-dose (≤ 17.5 mg,n=252) and high-dose (> 17.5 mg,n=79).RESULTS:Differences between the low-and highdose diazepam groups were observed in lifetime alcohol consumption (0.30 ± 0.48 vs 0.44 ± 0.52 tons,P=0.032),body weight (58.4 ± 10.3 vs 62.0 ± 9.9 kg,P=0.006),tumor size (15 ± 10 vs 23 ± 18 mm,P < 0.001),lesion location (P < 0.001) and the presence of ulcerative findings (14/238 vs 18/61,P < 0.001).Multivariate analysis identified all five variables as independently related to required diazepam *** terms of adverse reactions to diazepam administration,paradoxical excitement was significantly more frequent in the high-dose diazepam group (P < 0.001).CONCLUSION:Intermittent administration of diazepam enabled safe completion of gastric endoscopic submucosal dissection except in patients who were alcohol abusers or obese,or who showed complicated lesions.

关键词： Diazepam Endoscopic submucosal dissection Gastric epithelial neoplasias Moderate sedation Non-anesthesiologists

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A case of chronic pancreatitis in which endoscopic ultrasonography was effective in the diagnosis of a pseudoaneurysm

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World Journal of Gastrointestinal Endoscopy 2012年第7期4卷 335-338页

作者： Kazuhiro Fukatsu Kazuki Ueda Hiroki Maeda Yasunobu Yamashita Masahiro Itonaga Yoshiyuki Mori Kosaku Moribata Naoki Shingaki Hisanobu Deguchi shotaro Enomoto Izumi Inoue Takao Maekita Mikitaka Iguchi Hideyuki Tamai Jun Kato Masao Ichinose Second Department of Internal Medicine Wakayama Medical University811-1 Kimiidera Wakayama City Wakayama 641-0012 Japan

Endoscopic ultrasonography (EUS) was performed on a patient being treated for chronic pancreatitis because a submucosal tumor was observed in the stomach during gastrointestinal endoscopy. As internal pulsa- tile blood flow on Doppler was present, the diagnosis of an aneurysm was made. The pseudoaneurysm of the left gastric artery was embolized with histoacryl and lipiodol and the splenic artery was embolized with coils at the location of the pseudoaneurysm to prevent hemorrhage. Follow up EUS confirmed the cessation of blood flow from the pseudoaneurysm. Clinicians encountering a gastric submucosal tumor-like protrusion in a patient with chronic pancreatitis should use EUS to investigate the possibility of a pseudoaneurysm, which must be treated as quickly as possible once identified.

关键词： Chronic pancreatitis Endoscopic ultraso- nography Pseudoaneurysm

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