Japanese apricot improves symptoms of gastrointestinal dysmotility associated with gastroesophageal reflux disease

作     者：Takao Maekita Jun Kato Shotaro Enomoto Takeichi Yoshida Hirotoshi Utsunomiya Hideyuki Hayashi Toshiko Hanamitsu Izumi Inoue Yoshimasa Maeda Kosaku Moribata Yosuke Muraki Naoki Shingaki Hisanobu Deguchi Kazuki Ueda Mikitaka Iguchi Hideyuki Tamai Masao Ichinose 

作者机构：Department of GastroenterologySchool of MedicineWakayama Medical University Department of Japanese ApricotMinabe Town Office Department of Health WelfareMinabe Town Office 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2015年第21卷第26期

页      面：8170-8177页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Japan Society for the Promotion of Science  JSPS  (25460933) 

主　　题：Japanese apricot Umeboshi Gastroesophagealreflux disease Frequency Scale for Symptomsof gastroesophageal reflux disease Dysmotility 

摘      要：AIM: To investigate the effects of Japanese apricot(JA) consumption on gastroesophageal reflux disease(GERD)-related ***: Participants included individuals living in Minabe-cho,a well-known JA-growing region,who received specific medical check-ups by the local community health service in ***-related symptoms were examined in 1303 Japanese individuals using a validated questionnaire,the Frequency Scale for Symptoms of GERD(FSSG),which consists of 7 questions associated with acid reflux symptoms and 5 questions asking about gastrointestinal dysmotility *** question was answered using a 4-point scale,with higher scores indicating more severe GERDrelated *** were divided into two groups according to their intake of dried and pickled JA: daily intake(≥ 1 JA daily)(392 subjects) and none oroccasional intake( 1 JA daily)(911 subjects).FSSG scores were compared between subjects who consumed JA daily and those who did ***,subjects were stratified by age,gender and Helicobacter pylori(***) status for ***: Those who ate JA daily were significantly older than those who did not(60.6 ± 10.5 years vs 56.0 ± 11.0 years,P 0.001).Total FSSG scores were significantly lower in subjects with daily JA intake than in those with none or only occasional intake(2.13 ± 3.14 vs 2.70 ± 3.82,P = 0.005).In particular,subjects who consumed JA daily showed significantly improved FSSG dysmotility scores compared with subjects who did not(1.05 ± 1.58 vs 1.46 ± 2.11,P 0.001).In contrast,the FSSG reflux score did not differ between subjects with and without daily intake of JA(1.08 ± 1.90 vs 1.24 ± 2.11,P = 0.177).Subanalysis indicated that improvement in dysmotility by JA intake was specifically observed in non-elderly(1.24 ± 1.68 vs 1.62 ± 2.22,P = 0.005) and ***-negative subjects(0.99 ± 1.58 vs 1.57 ± 2.06,P 0.001).GERD patients(total FSSG score ≥ 8) were less frequently observed among subjects with daily intake of JA as