检索结果-南通市图书馆

Nanomanufacturing and Metrology 2024年第2期7卷 76-88页

作者： Motoya Yoshikawa Saeko Fujii shotaro Kadoya Tatsuya Sugihara Masaki Michihata Satoru Takahashi Department of Precision Engineering The University of TokyoHongo 7‑3‑1BunkyoTokyo 113‑8656Japan Department of Mechanical Engineering Osaka UniversityYamadaoka 2‑1SuitaOsaka 565‑0871Japan

This study proposes a model for the measurement of microscale liquid film thickness distribution using fluorescence *** interfacial conditions between the tool and the workpiece in mechanical machining are important for understanding these phenomena and *** this study,indentation tests with transparent tools were used to observe interfaces;however,it was challenging to obtain the signal from a thin fluorescent liquid film on smooth and steeply inclined ***,fluorescence-based measurement,such as laser-induced fluorescence,was *** measure the absolute thickness of the thin fluorescent film,calibration of the measurement system is ***,a theoretical model was proposed considering the multiple reflections of excitation light and fluorescence at the inclined surface between the indenter and *** measuring the profile of the surface topography of the indented workpiece and comparing the results with those measured by a surface profiler,the validity of the proposed calibration method and the performance of this measurement system were *** measured surface profiles,including scratches of 2–4μm,were in good agreement,demonstrating the validity of the proposed method.

关键词： Laser-induced fluorescence(LIF) Thickness distribution In-situ measurement Lubricant Mechanical machining

Prion Protein Binds to Aldolase A Produced by Bovine Intestinal M Cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Veterinary Medicine 2015年第3期5卷 43-60页

作者： Yuya Nagasawa Yu Takahashi Wataru Itani Hitoshi Watanabe Yusuke Hidaka shotaro morita Kei Suzuki Kouichi Watanabe Shyuichi Ohwada Haruki Kitazawa Morikazu Imamura Takashi Yokoyama Motohiro Horiuchi Suehiro Sakaguchi Shirou Mohri Michael T. Rose Tomonori Nochi Hisashi Aso Cellular Biology Laboratory Tohoku University Sendai Japan Food Immunology Group Tohoku University Sendai Japan Prion Disease Research Center National Institute of Animal Health Tsukuba Japan Laboratory of Veterinary Hygiene Hokkaido University Sapporo Japan Institute for Enzyme Research The University of Tokushima Tokushima Japan Institute of Biological Environmental and Rural Sciences Aberystwyth University Aberystwyth UK

Microfold (M) cells are a kind of intestinal epithelial cell in the follicle-associated epithelium (FAE) of Peyer’s patches. They can transport antigens and microorganisms to lymphoid tissues. Bovine spongiform encephalopathy (BSE) is a fatal neurodegenerative disorder in cattle. It is linked to variant Creutzfeldt-Jakob disease in humans. Although it is thought that M cells transport the BSE agent, the exact mechanism by which it crosses the intestinal barrier is not clear. We have bovine intestinal epithelial cell line (BIE cells), which can differentiate into the M cell type in vitro after stimulation, and which is able to transport the BSE agent. We show here that M cells are able to incorporate large numbers of PrP coated magnetic particles into intracellular vesicles, which we collected. The results of 2-DE show a specific protein associated with the PrP-coated particles, compared with non-coated particles. This protein was identified as aldolase A, a glycolytic pathway enzyme, using LC-MS/MS analysis. Aldolase A was synthesized and secreted by BIE cells, and increased during M cell differentiation. In the villi of the bovine intestine, aldolase A was detected on the surface of the epithelium and in the mucus droplet of goblet cells. In the FAE of bovine jejunal and ileal Peyer’s patches, aldolase A was localized on the surface and the apical part of the M cells. The binding of rbPrP to aldolase A was clearly detected and inhibited by pre-treatment of anti-aldolase A antibody. Aldolase A was co-stained with incorporated PrPSc in M-BIE cells. These results suggest that bovine M cells and goblet cells synthesize aldolase A, and that aldolase A may have the ability to bind PrP and associate with PrP in cellular vesicles. Therefore, aldolase A-positive M cells may play a key role in the invasion of BSE into the body.

关键词： Peyer’s Patch M Cell BIE Cells Aldolase A PrP Binding Protein

Direct visualization of postoperative aortobronchial fistula on computed tomography

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Radiology 2024年第8期16卷 337-347页

作者： Nanae Tsuchiya Hitoshi Inafuku Satoko Yogi Yuko Iraha Gyo Iida Mizuki Ando Takaaki Nagano shotaro Higa Tatsuya Maeda Yuya Kise Kojiro Furukawa Koji Yonemoto Akihiro Nishie Department of Radiology Graduate School of Medical ScienceUniversity of the RyukyusOkinawa 903-0215Japan Department of Thoracic and Cardiovascular Surgery Graduate School of Medical ScienceUniversity of the RyukyusOkinawa 903-0215Japan Department of Biostatistics School of Health SciencesFaculty of MedicineUniversity of the RyukyusOkinawa 903-0215Japan

BACKGROUND Postoperative aortobronchial fistula(ABF)is a rare complication that can occur in 0.3%-5.0%of patients over an extended period of time after thoracic aortic *** visualization of the fistula via imaging is *** To investigate the relationship between computed tomography(CT)findings and the clinical signs/symptoms of ABF after thoracic aortic *** Six patients(mean age 71 years,including 4 men and 2 women)with suspected ABF on CT(air around the graft)at our hospital were included in this retrospective study between January 2004 and September *** CT findings included direct confirmation of ABF,peri-graft fluid,ring enhancement,dirty fat sign,atelectasis,pulmonary hemorrhage,and bronchodilation,and the clinical course were retrospectively *** proportion of each type of CT finding was *** ABF detection after surgery was found to have a mean and median of 14 and 13 years,*** signs and symptoms were asymptomatic in 4 patients,bloody sputum was found in 1 patient,and fever was present in 1 *** complications of ABF included graft infection in 2 patients and graft infection with hemoptysis in 2 *** the 6 patients,3 survived,2 died,and 1 was lost to *** locations of the ABFs were as follows:1 in the ascending aorta;1 in the aortic arch;2 in the aortic arch leading to the descending aorta;and 2 in the descending *** were directly confirmed by CT in 4/6(67%)***-graft dirty fat(4/6,67%)and peri-graft ring enhancement(3/6,50%)were associated with graft infection,endoleaks and pseudoaneurysms were associated with hemoptysis(2/6,33%).CONCLUSION Asymptomatic ABF after thoracic aortic surgery can be confirmed on chest *** is useful for the diagnosis of ABF and its complications.

关键词： Peri-graft air Aortobronchial fistula Chest computed tomography Postoperative Thoracic endovascular aortic repair Complication Thoracic aorta surgery

Unsteady Behavior of Leading-edge Vortex and Diffuser Stall in a Centrifugal Compressor with Vaned Diffuser

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Thermal Science 2016年第1期25卷 13-21页

作者： Nobumichi FUJISAWA shotaro HARA Yutaka OHTA Graduate Student Graduate School of Fundamental Science and EngineeringWaseda University 3-4-10kuboShinjukuTokyo 169-8555Japan Department of Applied Mechanics and Aerospace Engineering Waseda University 3-4-1 OkuboShinjukuTokyo 169-8555Japan

The characteristics of a rotating stall of an impeller and diffuser and the evolution of a vortex generated at the diffuser leading-edge(i.e., the leading-edge vortex(LEV)) in a centrifugal compressor were investigated by experiments and numerical analysis. The results of the experiments revealed that both the impeller and diffuser rotating stalls occurred at 55 and 25 Hz during off-design flow operation. For both, stall cells existed only on the shroud side of the flow passages, which is very close to the source location of the LEV. According to the CFD results, the LEV is made up of multiple vortices. The LEV is a combination of a separated vortex near the leading-edge and a longitudinal vortex generated by the extended tip-leakage flow from the impeller. Therefore, the LEV is generated by the accumulation of vorticity caused by the velocity gradient of the impeller discharge flow. In partial-flow operation, the spanwise extent and the position of the LEV origin are temporarily transmuted. The LEV develops with a drop in the velocity in the diffuser passage and forms a significant blockage within the diffuser passage. Therefore, the LEV may be regarded as being one of the causes of a diffuser stall in a centrifugal compressor.

关键词： Centrifugal Compressor Vaned Diffuser Rotating Stall Leading-edge Vortex CFD DES

Operator-based Nonlinear Temperature Control Experiment for Microreactor Group Actuated by Peltier Devices

在线全文

学校读者我要写书评

暂无评论

International Journal of Automation and computing 2016年第4期13卷 401-408页

作者： shotaro Kawahata Ming-Cong Deng The Graduate School of Electrical and Electronic Engineering Tokyo University of Agriculture and Technology Tokyo 184-8588 Japan

In this paper, operator-based nonlinear water temperature control for a group of three connected microreactors actuated by Peltier devices is proposed. To control the water temperature of tube in the microreactor, the temperature change of aluminum effects is considered. Therefore, the temperature change of aluminum becomes the part of an input of the tube. First, nonlinear thermal models of aluminum plates and tubes that structure the microreactor are obtained. Then, an operator based nonlinear water temperature control system for the microreactor is designed. Finally, the effectiveness of the proposed models and methods is confirmed by simulation and experimental results.

关键词： Peltier device microreactor nonlinear control nonlinear process modeling operator continuous-time systems.

Helicobacter pylori and gastric mucosa-associated lymphoid tissue lymphoma:Recent progress in pathogenesis and management

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第45期19卷 8181-8187页

作者： shotaro Nakamura Takayuki Matsumoto Department of R/D for Surgical Support System Center for Advanced Medical Innovation Kyushu University Fukuoka 812-8582 Japan Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu UniversityFukuoka 812-8582 Japan Division of Gastroenterology Department of Internal Medicine Iwate Medical University Morioka 020-8505 Japan

Recent progress in the research regarding the molecular pathogenesis and management of gastric mucosa-associated lymphoid tissue (MALT) lymphoma is reviewed. In approximately 90% of cases, Helicobacter pylori (H. pylori) infection plays the causative role in the pathogenesis, and H. pylori eradication is nowadays the first-line treatment for this disease, which leads to complete disease remission in 50%-90% of cases. In H. pylori-dependent cases, microbe-generated immune responses, including interaction between B and T cells involving CD40 and CD40L co-stimulatory molecules, are considered to induce the development of MALT lymphoma. In H. pylori-independent cases, activation of the nuclear factor-κB pathway by oncogenic products of specific chromosomal translocations such as t(11;18)/API2-MALT1, or inactivation of tumor necrosis factor alpha-induced protein 3 (A20) are considered to contribute to the lymphomagenesis. Recently, a large-scale Japanese multicenter study confirmed that the long-term clinical outcome of gastric MALT lymphoma after H. pylori eradication is excellent. Treatment modalities for patients not responding to H. pylori eradication include a “watch and wait” strategy, radiotherapy, chemotherapy, rituximab immunotherapy, and a combination of these. Because of the indolent behavior of MALT lymphoma, second-line treatment should be tailored in consideration of the clinical stage and extent of the disease in each patient.

关键词： Gastric lymphoma, Mucosa-associated lymphoid tissue lymphoma, Helicobacter pylori, Nuclear factor κ B

Local oxynitriding of AZ31 magnesium alloy by atmospheric-pressure plasma treatment at room temperature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2022年第7期10卷 1878-1886页

作者： Kenta Nakazawa Tatsuki Ohashi shotaro Saiki Shoichi Kikuchi Department of Mechanical Engineering Faculty of EngineeringShizuoka University3-5-1JohokuNaka-kuHamamatsu432-8561Japan Graduate School of Integrated Science and Technology Shizuoka University3-5-1 JohokuNaka-kuHamamatsu432-8561Japan

A surface-hardening treatment for AZ31 magnesium alloy using an atmospheric-pressure plasma jet(APPJ)at room temperature was *** is a potential engineering material because it is lightweight;however,magnesium alloys are difficult to heat-treat because of their low flaming *** alloy specimens were irradiated with a localized atmospheric-pressure plasma jet generated by dielectric-barrier discharge for 180 s in *** APPJ excited oxygen and nitrogen molecules in the ambient air,resulting in the formation of an oxynitrided layer;oxygen and nitrogen diffusion layer,on the surface of the magnesium *** hardness and elemental distribution for the treated surface were *** top surface of the APPJ-treated magnesium alloy achieved a maximum hardness of 108 HV,which was~1.7 times greater than that of the untreated *** analysis using an electron-probe microanalyzer revealed strong oxygen and nitrogen signals corresponding to the hardened region of the magnesium alloy,meaning that the hardness increased as a result of the formation of the oxynitrided *** proposed APPJ treatment is a promising approach for locally hardening magnesium alloys without using a heat treatment.

关键词： Magnesium alloy Oxynitriding Atmospheric-pressure plasma jet Hardness Surface modification Diffusion

Synthesis and adsorptivity of acryloylmorpholine resin to various fission product elements in nitric acid media

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2014年第11期57卷 1459-1463页

作者： NISHIDA Tetsuhiro TANAKA shotaro NOGAMI Masanobu Department of Electric and Electronic Engineering Faculty of Science and Engineering Kinki University

A novel silica-supported resin with a cyclic monoamide of polymerized 4-acryloylmorpholine(Silica-AM) was synthesized, and adsorptivity to metal ions of major fission products(FP) was examined in HNO3 and HCl solutions. Silica-AM has a carbonyl oxygen atom outside of the 6-membered morpholine ring, and a cyclic structure that is different than other cyclic monoamide resins we have studied. These include polyvinylpolypyrrolidone(PVPP) and poly-N-vinyl-ε-caprolactam(VEC), both of which have coordinative carbonyl groups included in the ring. Silica-AM was similar to a cyclic monoamide we have reported because it exhibited adsorption to Pd(Ⅱ) and Re(VⅡ) in HNO3 of a particularly low concentration range. Silica-AM has an ether oxygen atom included in the ring as well. Considering the difference in the chemical structures of Silica-AM and other cyclic monoamide resins, it was suggested that oxygen atoms in the carbonyl group and in ether may be main contributors to Silica-AM's respective adsorptions to Pd(Ⅱ) and Re(VⅡ), and Mo(VI) and Zr(IV). Our results imply that the contribution of the two types of oxygen atoms to adsorption is more observable in an HCl system. The contribution of the ether oxygen atom to the adsorption of Pd(Ⅱ) was also suggested from our study on crystal prepared from 4-acetylmorpholine and palladium nitrate.

关键词： monoamide resin acryloylmorpholine FP nitric acid

Effect of fiber-reinforcement on the mechanical behavior of sand approaching the critical state

在线全文

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2022年第4期14卷 1241-1252页

作者： Jakhongirbek Ganiev shotaro Yamada Masaki Nakano Takayuki Sakai Department of Civil Engineering Nagoya UniversityNagoya464-8603Japan Department of Civil Engineering Tohoku UniversitySendai980-8579Japan

Several types of ground improvement methods that employ fiber-reinforcement have been developed in recent years.A series of consolidated drained triaxial compression tests has been conducted here to examine the effect of short fibers on the mechanical properties of Toyoura *** with 0%,0.2%,0.4%,and 1%fiber contents,prepared to yield random distribution,was sheared under several confining pressures and controlled via their initial relative *** test results showed that the maximum and residual deviatoric stresses increased,whereas the volumetric expansion decreased with an increase in fiber *** the stress ratio h(=q/p′)and specific volume changed depending on the fiber content and confining pressure with shear progression,they each reached the same values for a definite fiber content at the end of shearing,independent of initial relative *** other words,the unique critical state line can be found for a definite fiber ***,the greater the fiber content,the larger the slope of the critical state line at the end of ***,as the length of fibers shortened with the same percentage of fiber inclusions in sand,the deviatoric stress and the stress ratio decreased,approaching the shear-strain-volumetric response of unreinforced sand.

关键词： Fiber-reinforced sand Triaxial compression Stress ratio Critical state Relative density

Active Air Venting of Mold Cavity to Improve Performance of Injection Molded Direct Joining

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nanomanufacturing and Metrology 2021年第2期4卷 109-117页

作者： Fuminobu Kimura shotaro Kadoya Yusuke Kajihara Institute of Industrial Science The University of Tokyo4-6-1KomabaMeguro-kuTokyoJapan

A surface micro-/nano-structured metal plate can be joined with an injection molded plastic piece in a mold,which has been named injection molded direct joining(IMDJ).The injected plastic melt infiltrates the micro-/nano-structure,e.g.,a porous structure with micro/nano pores,on the metal plate while flowing in the mold cavity where the metal plate is *** solidification of the plastic,the metal and plastic materials are directly joined via the micro-/nano-structured metal *** air is trapped by the plastic melt,it is easily imagined that the air in the mold cavity prevents the melt plastic from contacting the metal surface and infiltrating the micro-/nano-structure,which could result in poorer joining *** avoid the prevention of the air for the better joining performance,the present study proposes a system actively venting the mold cavity during injection *** apply the active venting to IMDJ,venting and sealing systems were newly *** addition,a system measuring air pressure of the mold cavity was *** proposed system was evaluated by a measurement of joining strengths of IMDJ specimens that were produced under various *** the results,it is concluded that the active venting does not necessarily have a positive effect in any cases:the effect depends on the type of surface micro-/nano-structure.

关键词： Metal-plastic direct joining Micro-/nano-structured surface Injection molding Active venting Mold cavity pressure measurement