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Signal Transduction and Targeted Therapy 2024年第5期9卷 1805-1807页

作者： Luisa Tomasello shoshanah m.holub Giovanni Nigita Rosario Distefano Carlo m.Croce Department of Cancer Biology and Genetics The Ohio State UniversityColumbusOHUSA Department of Internal medicine Division of HematologyThe Ohio State UniversityColumbusOHUSA

Dear Editor,microRNAs(miRNAs)are small non-coding RNAs crucial for post-transcriptional gene regulation,processed from primary miRNA transcripts by Drosha and Dicer.1 Latest advancements in Next Generation Sequencing highlighted the existence of miRNA isoforms(isomiRs)resulting from alternative processing,RNA editing,or post-transcriptional modifications.

关键词： breast cancer advancement

Soil fungal and prokaryotic community structure exhibits differential short-term responses to timber harvest in the Pacific Northwest

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Pedosphere 2020年第1期30卷 109-125页

作者： Rachel E.DANIELSON megan L.mCGINNIS Scott m.holub David D.mYROLD Department of Crop and Soil Science Oregon State UniversityCorvallis OR 97331-7306(USA) United State Forest Service Helena-Lewis and Clark National Forest2880 Skyway DriveHelena MT 59602(USA) Weyerhaeuser Company PO Box 275Springfield OR 97477(USA) Department of Land Airand Water ResourcesUniversity of CaliforniaDavis CA 95616USA

Conventional clear-cut timber harvest is a widespread industrial practice across the Pacific Northwest;however,information regarding how these practices impact soil microbial community structure at the regional scale is *** evidence of consistent and substantial impact of harvest on soil microbial functional profiles across the region(despite a range of environmental conditions),the objective of this study was to determine the extent to which harvest also influences the structure of prokaryotic and fungal soil microbial communities,and how generalized these trends are throughout the geographic *** soil samples were collected one year before and after harvest across nine second-growth Douglas-fir forests in the Pacific *** community DNA was extracted from the soils,and high-throughput targeted gene sequencing of the 16 S r RNA gene for prokaryotes and the internal transcribed spacer(ITS)gene for fungi was *** diversity was consistently and significantly higher after harvest;it was moderately so for fungal communities(+14.6%),but only marginally so for prokaryotic communities(+2.0%).Similarly,on average,a greater proportion of the variation in the community structure of fungi(20.1%)at each site was associated with forest harvest compared to that of prokaryotes(13.2%).Overall,the greatest influence of timber harvest on soil microbial communities appeared to be a relative depletion of ectomycorrhizal fungi,with a concomitant enrichment of saprotrophic *** the short-term responses of soil microbial communities across the region,particularly those of tree root-associated symbionts,may aid our understanding of the role soil microbial communities play in ecological succession.

关键词： clear-cut Douglas-fir forest ectomycorrhizal fungi forest soil microbial community microbial diversity root-associated symbiont saprotrophic fungi

State of FAIRness in ESFRI Projects

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Data Intelligence 2020年第1期2卷 230-237,316页

作者： Peter Wittenburg Franciska de Jong Dieter van Uytvanck massimo Cocco Keith Jeffery michael Lautenschlager Hannes Thiemann margareta Hellstrom Ari Asmi Petr holub max Planck Computing and Data Facility Gießenbachstraße 285748 GarchingGermany CLARIN ERIC CLARIN ERIC Drift 10Utrecht 3512 BSThe Netherlands EPOS ERIC Via di Vigna Murata 605Rome 00143Italy Keith G Jeffery Consultants FaringdonUK DKRZ Ringgold standard institution Bundesstr.45aHamburgHamburg 20146Germany Department of Physical Geography and Ecosystem Ringgold standard institutionLund UniversityScienc Sölvegatan 12Lund 22362Sweden University of Helsinki Ringgold Standard Institution–Institution of Atmospheric and Earth System Sciences P.O.Box 64Helsinki 00014Finland BBmRI-ERIC Neue Stiftingtalstrasse 2/B/6 Graz 8010Austria

Since 2009 initiatives that were selected for the roadmap of the European Strategy Forum on Research Infrastructures started working to build research infrastructures for a wide range of research *** important result of the strategic discussions was that distributed infrastructure scenarios were now seen as“complex research facilities”in addition to,for example traditional centralised infrastructures such as *** this paper we look at five typical examples of such distributed infrastructures where many researchers working in different centres are contributing data,tools/services and knowledge and where the major task of the research infrastructure initiative is to create a virtually integrated suite of resources allowing researchers to carry out state-of-the-art *** analysis shows that most of these research infrastructures worked on the Findability,Accessibility,Interoperability and Reusability dimensions before the term“FAIR”was actually *** definition of the FAIR principles and their wide acceptance can be seen as a confirmation of what these initiatives were doing and it gives new impulse to close still existing *** initiatives also seem to be ready to take up the next steps which will emerge from the definition of FAIR maturity *** from these infrastructures should bring in their 10-years’experience in this definition process.

关键词： Infrastructure FAIR metrics GO FAIR matrix

DIAGNOSTICS OF POWER AND ANAEROBIC CAPACITY IN ROWERS

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DIAGNOSTICS OF POWER AND ANAEROBIC CAPACITY IN ROWERS

溶血、肝酶升高及低血小板计数综合征与脂肪酸氧化障碍是否缺乏的相关性

The 2004 Pre-Olympic Congress

作者： Gabrys T Szmatlan-Gabrys U holub m Plewa m Ficek K Academy of Physical Education Galen medical Center

＜正＞Introduction Hagerman et al（1978）studied energetics of rowers’work on 2000m distance performed on rowing cycle ergometer and found that anaerobic glycolytic metabolism constitutes a leading source of energy during the initial 30-90 and the final 60-90 seconds of *** far only a few papers concerning diagnostics of rowers’anaerobic capacity have been published[Klusiewicz,2001].Present studies show that only 20%of rower’s work is of anaerobic type,yet it is still a sphere of work requiring the precise diagnostics in the

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世界核心医学期刊文摘（儿科学分册） 2005年第6期1卷 6-7页

作者： holub m. Bodamer O. A. Item C. Stckler-lpsiroglu 李开 Department of Paediatrics University Hospital Vienna Whringer Gürtel 18-20 A-1090 Vienna Austria

Aim: Fatty acid β-oxidation defects comprise a heterogeneous group of disorders that may precipitate acute life threatening metabolic crises particularly during catabolic episodes. Several studies have demonstrated a possible association between fatty acid β-oxidation defects, including long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency and severe pregnancy complications. However, the precise percentage of women with haemolysis, elevated liver enzymes, low platelets (HELLP) syndrome associated with foetal fatty acid β-oxidation defects is not known. methods: We carried out amulticentre retrospective study on 88 infants, born to women with HELLP syndrome. Acylcarnitine profiles from blood dried on filter paper cards were analysed by tandem mass spectrometry for the diagnosis of fatty acid β-oxidation defects. In addition, we screened for the common long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency mutation using a standard restriction fragment length polymorphism polymerase chain reaction method. Results: None of the infants studied carried the common long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency mutation. There was no evidence of fatty acid β-oxidation defects, including long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency, as expected by unremarkable acylcarnitine profiles, while three infants with fatty acid β-oxidation defects were diagnosed in the control group. Conclusions: Neither foetal long-chain 3- hydroxyacyl-CoA dehydrogenase deficiency, including heterozygosity for the common long-chain 3-hydroxyacyl- CoA dehydrogenase deficiency mutation, nor fatty acid β-oxidation defects in general are a major risk factor for HELLP syndrome in Austria.

关键词：肝酶升高脂肪酸氧化障碍 β氧化妊娠并发症代谢性疾病脱氢酶基因肉毒碱羟氨腹内缺失性

methods for a blind analysis of isobar data collected by the STAR collaboration

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Nuclear Science and Techniques 2021年第5期32卷 43-50页

作者： J.Adam L.Adamczyk J.R.Adams J.K.Adkins G.Agakishiev m.m.Aggarwal Z.Ahammed I.Alekseev D.m.Anderson A.Aparin E.C.Aschenauer m.U.Ashraf F.G.Atetalla A.Attri G.S.Averichev V.Bairathi K.Barish A.Behera R.Bellwied A.Bhasin J.Bielcik J.Bielcikova L.C.Bland I.G.Bordyuzhin J.D.Brandenburg A.V.Brandin J.Butterworth H.Caines m.Calderon de la Barca Sanchez D.Cebra I.Chakaberia P.Chaloupka B.K.Chan F-H.Chang Z.Chang N.Chankova-Bunzarova A.Chatterjee D.Chen J.Chen J.H.Chen X.Chen Z.Chen J.Cheng m.Cherney m.Chevalier S.Choudhury W.Christie X.Chu H.J.Crawford m.Csanad m.Daugherity T.G.Dedovich I.m.Deppner A.A.Derevschikov L.Didenko X.Dong J.L.Drachenberg J.C.Dunlop T.Edmonds N.Elsey J.Engelage G.Eppley S.Esumi O.Evdokimov A.Ewigleben O.Eyser R.Fatemi S.Fazio P.Federic J.Fedorisin C.J.Feng Y.Feng P.Filip E.Finch Y.Fisyak A.Francisco L.Fulek C.A.Gagliardi T.Galatyuk F.Geurts A.Gibson K.Gopal X.Gou D.Grosnick W.Guryn A.I.Hamad A.Hamed S.Harabasz J.W.Harris S.He W.He X.H.He Y.He S.Heppelmann S.Heppelmann N.Herrmann E.Hoffman L.holub Y.Hong S.Horvat Y.Hu H.Z.Huang S.L.Huang T.Huang X.Huang T.J.Humanic P.Huo G.Igo D.Isenhower W.W.Jacobs C.Jena A.Jentsch Y.Ji J.Jia K.Jiang S.Jowzaee X.Ju E.G.Judd S.Kabana m.L.Kabir S.Kagamaster D.Kalinkin K.Kang D.Kapukchyan K.Kauder H.W.Ke D.Keane A.Kechechyan m.Kelsey Y.V.Khyzhniak D.P.Kikoła C.Kim B.Kimelman D.Kincses T.A.Kinghorn I.Kisel A.Kiselev m.Kocan L.Kochenda L.K.Kosarzewski L.Kramarik P.Kravtsov K.Krueger N.Kulathunga mudiyanselage L.Kumar S.Kumar R.Kunnawalkam Elayavalli J.H.Kwasizur R.Lacey S.Lan J.m.Landgraf J.Lauret A.Lebedev R.Lednicky J.H.Lee Y.H.Leung C.Li C.Li W.Li W.Li X.Li Y.Li Y.Liang R.Licenik T.Lin Y.Lin m.A.Lisa F.Liu H.Liu P.Liu P.Liu T.Liu X.Liu Y.Liu Z.Liu T.Ljubicic W.J.Llope R.S.Longacre N.S.Lukow S.Luo X.Luo G.L.ma L.ma R.ma Y.G.ma N.magdy R.majka D.mallick S.margetis C.markert H.S.matis J.A.mazer N.G.minaev S.mioduszewski B.mohanty I.mooney Z.moravcova D.A.morozov m.Nagy J.D.Nam md.Nasim K.Nayak D.Neff J.m.Nelson D.B.Nemes m.Nie G.Nigmatkulov T.Niida L.V.Nogach T.Nonak Christian University AbileneTX 796992 AGH University of Science and Technology FPACSCracow 30-059Poland Alikhanov Institute for Theoretical and Experimental Physics NRC"Kurchatov Institute" MoscowRussia 117218 Argonne National Laboratory ArgonneIL 60439 American University of Cairo New CairoNew Cairo 11835Egypt Brookhaven National Laboratory UptonNY 11973 University of California BerkeleyCA 94720 University of California DavisCA 95616 University of California Los AngelesCA 90095 University of California RiversideCA 92521 Central China Normal University Wuhan 430079 University of Illinois at Chicago ChicagoIL 60607 Creighton University OmahaNE 68178 Czech Technical University in Prague FNSPEPrague 11519Czech Republic Technische Universitat Darmstadt Darmstadt 64289Germany ELTE Eotvos Lorand University Budapest 1117Hungary Frankfurt Institute for Advanced Studies FIAS Frankfurt 60438Germany Fudan University Shanghai 200433 University of Heidelberg 69120 HeidelbergGermany University of Houston HoustonTX 77204 Huzhou University Huzhou 313000 Indian Institute of Science Education and Research(IISER) Berhampur 760010India Indian Institute of Science Education and Research(IISER)Tirupati Tirupati 517507India Indian Institute Technology PatnaBihar 801106India Indiana University BloomingtonIN 47408 Institute of modern Physics Chinese Academy of SciencesLanzhou 730000 University of Jammu Jammu 180001India Joint Institute for Nuclear Research DubnaRussia 141980 Kent State University KentOH 44242 University of Kentucky LexingtonKY 40506-0055 Lawrence Berkeley National Laboratory BerkeleyCA 94720 Lehigh University BethlehemPA 18015 max-Planck-Institut fur Physik 80805 MunichGermany michigan State University East LansingMI 48824 National Research Nuclear University mEPhI MoscowRussia 115409 National Institute of Science Education and Research HBNIJatni 752050India National Cheng Kung University Tainan 70101 Nuclear Physics Institute of the CAS Rez 25068Czech Republic Ohio State University

In 2018,the STAR collaboration collected data from^(96)_(44)Ru+^(96)_(44)Ru and^(96)_(40)Zr+^(96)_(40)Zr at√^(S)NN=200 Ge V to search for the presence of the chiral magnetic effect in collisions of *** isobar collision species alternated frequently between 9644 Ru+^(96)_(44)Ru and^(96)_(40)Zr+^(96)_(40)*** order to conduct blind analyses of studies related to the chiral magnetic effect in these isobar data,STAR developed a three-step blind analysis *** are initially provided a"reference sample"of data,comprised of a mix of events from the two species,the order of which respects time-dependent changes in run *** tuning analysis codes and performing time-dependent quality assurance on the reference sample,analysts are provided a species-blind sample suitable for calculating efficiencies and corrections for individual≈30-min data-taking *** this sample,species-specific information is disguised,but individual output files contain data from a single isobar *** run-by-run corrections and code alteration subsequent to these corrections are allowed at this *** these modifications,the"frozen"code is passed over the fully un-blind data,completing the blind *** a check of the feasibility of the blind analysis procedure,analysts completed a"mock data challenge,"analyzing data from Au+Au collisions at√^(S)NN=27 Ge V,collected in *** Au+Au data were prepared in the same manner intended for the isobar blind *** details of the blind analysis procedure and results from the mock data challenge are presented.

关键词： Blind analysis Chiral magnetic effect Heavy-ion collisions

Distribution and mode of occurrence of radionuclides in phosphogypsum derived from Aqaba and Eshidiya Fertilizer Industry,South Jordan

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Chinese Journal Of Geochemistry 2010年第3期29卷 261-269页

作者： Al-Hwaiti m.S. Zielinski R.A. Bundham J.R. Ranville J.F. Ross P.E. Environmental Engineering Department Al-Hussein Bin Talal University USGS DenverCO 80225USA Environmental Science and Engineering Division Colorado School of Mines

Phosphogypsum (PG) is a by-product of the chemical reaction called the "wet process" whereby sul-phuric acid reacts with phosphate rock (PR) to produce phosphoric acid, needed for fertilizer production. Through the wet process, some impurities naturally present in the PR become incorporated in PG, including U decay-series radionuclides, are the main important concern which could have an effect on the surrounding environment and pre-vent its safe utilization. In order to determine the distribution and bioavailability of radionuclides to the surrounding environment, we used a sequential leaching of PG samples from Aqaba and Eshidiya fertilizer industry. The results showed that the percentages of 226Ra and 210Pb in PG are over those in the corresponding phosphate rocks (PG/PR), where 85% of the 226Ra and 85% of the 210Pb fractionate to PG. The sequential extraction results exhibited that most of 226Ra and 210Pb are bound in the residual phase (non-CaSO4) fraction ranging from 45%-65% and 55%-75%, respectively, whereas only 10%-15% and 10%-20% respectively of these radionuclides are distributed in the most labile fraction. The results obtained from this study showed that radionuclides are not incorporated with gypsum itself and may not form a threat to the surrounding environment.

关键词：天然放射性核素磷石膏化肥工业赋存状态 226Ra 反应产物化肥生产周围环境

measurement of away-side broadening with self-subtraction of flow in Au+Au collisions at √sNN=200 GeV

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Chinese Physics C 2020年第10期44卷 59-67页

作者： L.Adamczyk J.R.Adams J.K.Adkins G.Agakishiev m.m.Aggarwal Z.Ahammed I.Alekseev D.m.Anderson A.Aparin E.C.Aschenauer m.U.Ashraf F.G.Atetalla A.Attri G.S.Averichev V.Bairathi K.Barish A.Behera R.Bellwied A.Bhasin J.Bielcik J.Bielcikova L.C.Bland I.G.Bordyuzhin J.D.Brandenburg A.V.Brandin J.Butterworth H.Caines m.Calderón de la Barca Sánchez D.Cebra I.Chakaberia P.Chaloupka B.K.Chan F-H.Chang Z.Chang N.Chankova-Bunzarova A.Chatterjee D.Chen J.H.Chen X.Chen Z.Chen J.Cheng m.Cherney m.Chevalier S.Choudhury W.Christie X.Chu H.J.Crawford m.Csanád m.Daugherity T.G.Dedovich I.m.Deppner A.A.Derevschikov L.Didenko X.Dong J.L.Drachenberg J.C.Dunlop T.Edmonds N.Elsey J.Engelage G.Eppley S.Esumi O.Evdokimov A.Ewigleben O.Eyser R.Fatemi S.Fazio P.Federic J.Fedorisin C.J.Feng Y.Feng P.Filip E.Finch Y.Fisyak A.Francisco L.Fulek C.A.Gagliardi T.Galatyuk F.Geurts A.Gibson K.Gopal D.Grosnick W.Guryn A.I.Hamad A.Hamed S.Harabasz J.W.Harris S.He W.He X.H.He S.Heppelmann S.Heppelmann N.Herrmann E.Hoffman L.holub Y.Hong S.Horvat Y.Hu H.Z.Huang S.L.Huang T.Huang X.Huang T.J.Humanic P.Huo G.Igo D.Isenhower W.W.Jacobs C.Jena A.Jentsch Y.JI J.Jia K.Jiang S.Jowzaee X.Ju E.G.Judd S.Kabana m.L.Kabir S.Kagamaster D.Kalinkin K.Kang D.Kapukchyan K.Kauder H.W.Ke D.Keane A.Kechechyan m.Kelsey Y.V.Khyzhniak D.P.Kikoła C.Kim B.Kimelman D.Kincses T.A.Kinghorn I.Kisel A.Kiselev m.Kocan L.Kochenda L.K.Kosarzewski L.Kramarik P.Kravtsov K.Krueger N.Kulathunga mudiyanselage L.Kumar S.Kumar R.Kunnawalkam Elayavalli J.H.Kwasizur R.Lacey S.Lan J.m.Landgraf J.Lauret A.Lebedev R.Lednicky J.H.Lee Y.H.Leung C.Li W.Li W.Li X.Li Y.Li Y.Liang R.Licenik T.Lin Y.Lin m.A.Lisa F.Liu H.Liu P.Liu P.Liu T.Liu X.Liu Y.Liu Z.Liu T.Ljubicic W.J.Llope R.S.Longacre N.S.Lukow S.Luo X.Luo G.L.ma L.ma R.ma Y.G.ma N.magdy R.majka D.mallick S.margetis C.markert H.S.matis J.A.mazer N.G.minaev S.mioduszewski B.mohanty I.mooney Z.moravcova D.A.morozov m.Nagy J.D.Nam Nasim md K.Nayak D.Neff J.m.Nelson D.B.Nemes m.Nie G.Nigmatkulov T.Niida L.V.Nogach T.Nonaka A.S.Nunes G.Odyniec A.Ogawa Abilene Christian University AbileneTexas 79699 AGH University of Science and Technology FPACSCracow 30-059Poland Alikhanov Institute for Theoretical and Experimental Physics NRC"Kurchatov Institute" Moscow 117218Russia Argonne National Laboratory ArgonneIllinois 60439 American University of Cairo New Cairo 11835New CairoEgypt Brookhaven National Laboratory UptonNew York 11973 University of California BerkeleyCalifornia 94720 University of California DavisCalifornia 95616 University of California Los AngelesCalifornia 90095 University of California RiversideCalifornia 92521 Central China Normal University WuhanHubei 430079 University of Illinois at Chicago ChicagoIllinois 60607 Creighton University OmahaNebraska 68178 Czech Technical University in Prague FNSPEPrague 11519Czech Republic Technische Universität Darmstadt Darmstadt 64289Germany ELTE Eötvös Loránd University BudapestHungary H-1117 Frankfurt Institute for Advanced Studies FIAS Frankfurt 60438Germany Fudan University Shanghai 200433 University of Heidelberg Heidelberg 69120Germany University of Houston HoustonTexas 77204 Huzhou University HuzhouZhejiang 313000 Indian Institute of Science Education and Research(IISER) Berhampur 760010India Indian Institute of Science Education and Research(IISER)Tirupati Tirupati 517507India Indian Institute Technology PatnaBihar 801106India Indiana University BloomingtonIndiana 47408 Institute of modern Physics Chinese Academy of SciencesLanzhouGansu 730000 University of Jammu Jammu 180001India Joint Institute for Nuclear Research Dubna 141980Russia Kent State University KentOhio 44242 University of Kentucky LexingtonKentucky 40506-0055 Lawrence Berkeley National Laboratory BerkeleyCalifornia 94720 Lehigh University BethlehemPennsylvania 18015 max-Planck-Institut für Physik Munich 80805Germany michigan State University East LansingMichigan 48824 National Research Nuclear University mEPhI Moscow 115409Russia National Institute of Science Education and Research HBNIJatni 752050Indi

High transverse momentum(pT)particle production is suppressed owing to the parton(jet)energy loss in the hot dense medium created in relativistic heavy-ion *** of energy at low-to-modest pT has been difficult to measure,owing to large anisotropic *** report a data-driven method for background evaluation and subtraction,exploiting the away-side pseudorapidity gaps,to measure the jetlike correlation shape in Au+Au collisions at √sNN=200 GeV in the STAR *** correlation shapes,for trigger particles pT>3GeV/c and various associated particle pT ranges within 0.5medium created in central heavy-ion collisions.

关键词： di-hadron correlations jet heavy-ion