Poly(A)-specific RNase(PARN)generates and regulates miR-125a-5p 3’-isoforms,displaying an altered expression in breast cancer

作     者：Luisa Tomasello Shoshanah M.Holub Giovanni Nigita Rosario Distefano Carlo M.Croce 

作者机构：Department of Cancer Biology and GeneticsThe Ohio State UniversityColumbusOHUSA Department of Internal MedicineDivision of HematologyThe Ohio State UniversityColumbusOHUSA 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2024年第9卷第5期

页      面：1805-1807页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：The authors thank the Genomics Shared Resource at The Ohio State University Comprehensive Cancer Center(OSU CCC) Columbus OH.This work was supported by the NCI(NIH)grant R35CA197706 to C.M.Croce 

主　　题：breast cancer advancement 

摘      要：Dear Editor,MicroRNAs(miRNAs)are small non-coding RNAs crucial for post-transcriptional gene regulation,processed from primary miRNA transcripts by Drosha and Dicer.1 Latest advancements in Next Generation Sequencing highlighted the existence of miRNA isoforms(isomiRs)resulting from alternative processing,RNA editing,or post-transcriptional modifications.