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Secondary Prevention Following Coronary Artery Bypass Surgery: A Pilot Study for Improved Patient Education

作者： (新西兰)苏巴斯·钱德拉·穆克帕德亚(Subhas Chandra mukhopadhyay)

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International Journal of Clinical Medicine 2012年第4期3卷 286-294页

作者： Jeffrey B. Kramer Patricia A. Howard Brian J. Barnes Bashar Ababneh Purna mukhopadhyay Mazda Biria Gregory F. Muehlebach Emmanuel Daon George L. Zorn William A. Reed James L. Vacek Cardiovascular Division Department of Internal Medicine School of Medicine The University of Kansas Medical Center Kansas City Kansas Cardiovascular Division Department of Internal Medicine School of Medicine.The University of Kansas Medical Center Kansas City Kansas Department of Biostatistics School of Medicinel The University of Kansas Medical Center Kansas City Kansas Department of Pharmacy Practice School of Pharmacy The University of Kansas Medical Center Kansas City Kansas Mid-America Thoracic and Cardiovascular Surgeons The University of Kansas Medical Center Kansas City Kansas Mid-America Thoracic and Cardiovascular Surgeons The University of Kansas Medical Center Kansas City Kansas.

Background: Sustained positive outcomes after coronary artery bypass grafting (CABG) requires risk factor modification and secondary prevention medications. Much attention has been focused on planning at hospital discharge;however longer-term patient compliance is not well described. Hypothesis: A follow-up multidisciplinary educational program improves disease understanding, motivation to reduce cardiovascular risk, and secondary prevention medication prescribing following hospital discharge. Methods: Using a prospective, randomized, controlled design, patients undergoing CABG completed surveys over a year period, assessing disease understanding and motivation. Four to six weeks after CABG, intervention subjects completed a one-time educational program with a multidisciplinary team. The primary endpoint was a composite score of reduced risk factors, medication use, and awareness of prescribed medications. Secondary endpoints evaluated survey scores and medication use rates. Wilcoxon Rank Sum and Chi Square tests compared data between specific time points. Generalized estimating equations and linear contrasts of the parameter estimates compared data at the three time points. Results: The final analysis included 98 subjects (Intervention = 49, Control = 49). The composite score was not different between groups (I = 12.8 ± 4.5 points, C = 12.7 ± 4.9 points, p = 0.9405). Improvements were noted in understanding and motivation in the entire cohort, but these changes were not influenced by the intervention. Medication prescribing declined at 3 and 12 months after CABG without significant differences between the groups. Conclusions: Disease understanding, motivation to reduce risk, and medication use are robust at hospital discharge but the latter declines with time and was not improved by our intervention. These findings are concerning and warrant further study.

关键词： Secondary Prevention Coronary Artery Disease Coronary Artery Bypass

A child with Erysipelothrix-beware of the little known

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Asian Pacific Journal of Tropical Biomedicine 2012年第6期2卷 503-504页

作者： Chiranjay mukhopadhyay Hitesh Shah KE Vandana Frenil Munim Sandeep Vijayan Department of Microbiology Kasturba Medical College Manipal University Department of Orthopaedics Kasturba Medical College Manipal University

Erysipelothrix rhusiopathiaeis an established animal pathogen while the zoonotic infections in humans are rarely reported. Infections occur after exposure to animals or animal products that are mostly occupational in adults. Here we report in a child for the first time septic arthritis and osteomyelitis without an identifiable risk factor. A 5-year-old male child was admitted with pain in the left hip joint and inability to bear weight on the limb. Clinical examination followed by radiological and magnetic resonance imaging was suggestive of septic *** rhusiopathiaegrew from peroperative joint specimen. The infection was resolved following arthrotomy, joint lavage and antibiotic therapy.

关键词： Erysipelothrix rhusiopathiae Osteomyelitis Septic arthritis

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数据策略、管理、技术共建当代营销

现代广告 2019年第5期 12-12页

作者： Kajal mukhopadhyay 威瑞森(美国)

大数据营销在过去也被叫做数据库营销,广告主采用这种营销方式的历史已经不短了。它主要用来进行分段和定位,广告主在B2B或B2C模式下均可创建消费者洞察。另外,广告主还主要通过大数据手段,用正确的信息在正确时间和地点发现消费者,减... 详细信息

大数据营销在过去也被叫做数据库营销,广告主采用这种营销方式的历史已经不短了。它主要用来进行分段和定位,广告主在B2B或B2C模式下均可创建消费者洞察。另外,广告主还主要通过大数据手段,用正确的信息在正确时间和地点发现消费者,减少媒介浪费,提高营销表现。当前,行业对大数据营销的解读主要有两种:一是利用大数据改进营销,包括改进行为、态度、人口、心理分段、高效定位和策略营销.

关键词：数据营销

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Immunogenicity, Safety and Efficacy Comparison of Wockhardt’s Biosimilar Insulin Glargine—Glaritus®with Reference Product— Lantus®: Study Protocol &Early Data Trends

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Open Journal of Endocrine and Metabolic Diseases 2018年第8期8卷 157-166页

作者： S. K. Sharma A. K. Ajmani P. Khosla P. mukhopadhyay G. Bhatia K. G. Prakash G. Chhaya P. D. Supe V. Pavithran H. Bora R. Jain S. Ingole A. Shah Diabetes Thyroid and Endocrine Centre Jaipur India BL Kapoor Hospital Delhi India Sir Ganga Ram Hospital Delhi India Institute of Post Graduate Medical Education and Research Kolkata India Medipoint Hospitals Pvt. Ltd. Pune India Bangalore Medical College and Research Institute Bangalore India Sanjivani Supers Peciality Hospital Ahmedabad India Supe Heart and Diabetes Hospital and Research Centre Nashik India KVM Hospital Kerala India Downtown Hospital Guwahati India Wockhardt Ltd. Mumbai India

Objective: Present Phase IV Trial is aimed at evaluating the immunogenicity, safety, and efficacy of Wockhardt’s insulin glargine, Glaritus®in comparison with reference insulin glargine, Lantus®in subjects with type 2 diabetes mellitus (T2DM), inadequately controlled on oral hypoglycaemics. Setting: A head-to-head, prospective, open-label, parallel group, randomized, Phase IV, non-inferiority study over 6 months treatment conducted in 10 centres in India. Participants: Considering 20% drop-out rate, 180 subjects of either sex, age 18 - 55 years, diagnosed with T2DM with body mass index (BMI) 18 - 38 kg/m2 and HbA1c levels 8.0% - 10.0% inadequately controlled by 1 or more oral hypoglycaemics and according to investigator needed glargine treatment were enrolled in the study. Interventions: Subjects self-administered insulin glargine (Glaritus®or Lantus®) subcutaneously once daily for 6 months. Treatment in Glaritus®arm was continued till 12 months. Percentage change in anti-insulin antibody (AIA) titre and HbA1C was ascertained at every 3 months interval. The tests were performed at accredited central laboratory. Treat-to-target dose titration: Starting doses of Glaritus®and Lantus®was 10 units (or 0.2 units/kg) once daily. The target fasting blood glucose was 70 to 130 mg/dL. Daily glargine dose was titrated by ±10% based on average of last 3 FBG values being out of target range and presence of nocturnal hypoglycemia. Early data trends: First interim analysis was planned once 100 subjects complete visit 8 (6 months treatment). By then, 119 subjects (78 males and 41 females) with mean age 46.3 years were enrolled, of which 90 (75.6%) subjects had evaluable data. The results of analysis indicated trend of comparability between Glaritus®and Lantus®at the end of 6 months in terms of immunogenicity (% change in AIA titre from baseline, −10.52 ± 23.06 vs. 0.48 ± 63.95), glycemic control (change in HbA1c from baseline, −1.09%

关键词： Insulin Antibodies Immunogenicity Insulin Glargine Biosimilar HbA1c

大麻素受体1通过多种机制促进肝细胞癌的发生和进展

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临床肝胆病杂志 2015年第6期31卷 935-935页

作者：杨坤王崇 mukhopadhyay B 吉林大学第一医院肝病科

【据《Hepatology》2015年5月报道】题：大麻素受体1通过多种机制促进肝细胞癌的发生和进展（作者mukhopadhyay B等）肝细胞癌（HCC）的死亡率高且治疗方法有限。内源性大麻素与肝大麻素1受体相互作用（CB1Rs）诱导参与有丝分裂的细胞... 详细信息

【据《Hepatology》2015年5月报道】题：大麻素受体1通过多种机制促进肝细胞癌的发生和进展（作者mukhopadhyay B等）肝细胞癌（HCC）的死亡率高且治疗方法有限。内源性大麻素与肝大麻素1受体相互作用（CB1Rs）诱导参与有丝分裂的细胞周期蛋白,包括叉头框M1,可促进再生的肝细胞增殖。由于该蛋白在肝癌组织中高表达,有助于其发生、发展过程,来自美国国立卫生研究院的mukhopadhyay B等分析了小鼠及人类肝癌中内源性大麻素系统/CB1R。出生后二乙基亚硝胺诱导野生型小鼠8个月建立肝癌模型。观察连续磁共振成像,在CB1R（-/）小鼠或外周拮抗剂处理的野生型小鼠体内发现较少和较小的肿瘤全基因组转录组分析显示CBlR依赖、肿瘤诱导的CBIR，及其内源性配体大麻素和一些肿瘤促进基因，包括Grb2的作用以及ForkheadboxM1和其下游的目标，即色氨酸催化吲哚胺2，3-双加氧酶在肝脏表达上调。

关键词：肝细胞癌大麻素受体肝癌模型二乙基亚硝胺内源性大麻素野生型小鼠磁共振成像拮抗剂肝细胞增殖细胞周期蛋白

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印度拉贾斯坦Phalwadi-Positara地区白钨矿、辉钼矿、钼钨钙矿和硅铍钇矿的新产状

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地球与环境 1982年第10期 28-28页

作者： A.K.mukhopadhyay ,邱维时

在印度拉贾斯坦Phalwadi-Positara地区的Erinpura花岗岩及其伴生的酸性岩脉中现已圈出白钨矿、辉钼矿、钼钨钙矿和硅铍钇矿的重要矿化点。 1975年在区域地球化学勘探过程中,在该地区部分地方发现了含钨、锡的流水异常。本简讯就是根据... 详细信息

在印度拉贾斯坦Phalwadi-Positara地区的Erinpura花岗岩及其伴生的酸性岩脉中现已圈出白钨矿、辉钼矿、钼钨钙矿和硅铍钇矿的重要矿化点。 1975年在区域地球化学勘探过程中,在该地区部分地方发现了含钨、锡的流水异常。本简讯就是根据随后的野外研究及对一些地质单元的紫外线检查和地球化学取样做出的。

关键词：辉钼矿钼钨钙矿硅铍钇矿硫化矿物钨酸钙矿钼矿物硅酸盐矿物 Phalwadi-Positara 花岗岩体白钨矿钙钨矿钨矿物拉贾斯坦南亚印度

ΔF508纯合子囊性纤维化患者的超重及肥胖

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世界核心医学期刊文摘（儿科学分册） 2006年第2期2卷 31-31页

作者： Kastner-Cole D. Palmer C. N. A. Ogston S. A. S. mukhopadhyay 虎小毅(译) 不详 Maternal and Child Health Sciences Ninewells Hospital Dundee DD2 1PS United Kingdom

Overweight (9% ) and obesity (1% ) in patients with cystic fibrosis homozygous for the Δ F508 mutation (CFΔ F508) were non-trivial. Children with CFΔ F508, in contrast to the general population, showed a positive a... 详细信息

关键词：囊性纤维化纯合子肥胖超重患者体重指数正常人群正相关肺功能

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