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Insect Science 2022年第5期29卷 1299-1308页

作者： Meryem Behri Haruki Teshima Keisuke Kutsuwada shoko Nakatake Mari H.Ogihara DeMar Taylor Graduate School of Life and Environmental Sciences University of TsukubaTsukubaIbarakiJapan Animal Breeding and Reproduction Research Division Institute of Livestock and Grassland ScienceNational Agriculture and Food Research OrganizationTsukubaIbarakiJapan

Initiation of vitellogenesis by blood feeding is essential for egg maturation in ticks.Nutrients derived from the blood meal are utilized by female ticks to synthesize the yolk protein precursor vitellogenin(Vg).Engorged Ornithodoros moubata ticks can synthesize Vg whether mated or virgin,thus O.moubata is an excellent model for studying the relative roles of blood feeding and mating in tick vitellogenesis.Injection of rapamycin into engorged O.moubata resulted in a reduction of ovarian growth and yolk accumulation in the oocytes of mated females.OmVg expression in the midgut and fat body and protein concentrations in the hemolymph significantly decreased in mated ticks after injection with rapamycin,indicating that inhibition of the nutrient-sensing target of rapamycin(TOR)pathway disrupts egg maturation at the levels of Vg expression and synthesis.These results suggest that the TOR-signaling pathway induces vitellogenesis in response to nutritional stimulation after a blood meal in O.moubata and is functionally independent of the mating-induced pathway.

关键词： Ornithodoros moubata target of rapamycin ticks vitellogenesis vitellogenin

A Series of Soluble Planar Oligorylenes up to Hexarylene

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Chinese Journal of Chemistry 2023年第9期41卷 1023-1027页

作者： Ryuichi Fujita shoko Yoshida Haruka Kano Kyohei Matsuo Hironobu Hayashi Hiroko Yamada Naoki Aratani Division of Materials Science Nara Institute of Science and Technology(NAIST)8916-5 Takayama-choIkoma 630-0192Japan

Preparation of large rylenes often needs the use of solubilizing groups along the rylene backbone,which results in the distortion of the skeleton and thus broadening of the absorption spectrum.In this work,we successfully synthesized 2,5,8,16,19,22-hexakis[2,6-bis(tri-fluoromethyl)phenyl]hexarylene(H)by using an oxidative fusion reaction of perylene trimer in 5%yield.The product is soluble in common organic solvents and could be purified with column chromatography.Single-crystal X-ray diffraction analysis revealed that the hexarylene core is not disturbed by the substituents very much and is almost planar.The longest absorption of H exhibits a sharp peak at 831 nm and an on-set at 875 nm in toluene with a small full-width-at-half-maximum(FWHM)of 660 cm^(-1).The molar extinction coefficient is as large as 131,000 M^(-1)cm^(-1).The substituents could not perturb the electronic properties of the hexarylene because aryl groups are perpendicular to the hexarylene core and the carbon atoms at 2,5,16,19-positions have negligible coeffi-cients on its HOMO and LUMO,estimated by theoretical calculations.As a result,the hexarylene having less absorption at the visible light region was stable enough in solution under the LED room light for more than 1 week.This strategy gives a useful guideline to establish the near-infrared materials that exhibit stability under ambient conditions.

关键词： Oligorylenes Undistorted skeleton Near infrared absorption Crystal structure Effective conjugation length

To Gate, or Not to Gate： Regulatory Mechanisms for Intercellular Protein Transport and Virus Movement in Plants

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Molecular Plant 2011年第5期4卷 782-793页

作者： shoko Ueki Vitaly Citovsky Institute of Plant Science and Resources Okayama University 2-20-1 Chuo Kurashiki Okayama 710-0046 Japan Department of Biochemistry and Cell Biology State University of New York Stony Brook NY 11794-5215 USA

Cell-to-cell signal transduction is vital for orchestrating the whole-body physiology of multi-cellular organ- isms, and many endogenous macromolecules, proteins, and nucleic acids function as such transported signals. In plants, many of these molecules are transported through plasmodesmata （Pd）, the cell wall-spanning channel structures that interconnect plant cells. Furthermore, Pd also act as conduits for cell-to-cell movement of most plant viruses that have evolved to pirate these channels to spread the infection. Pd transport is presumed to be highly selective, and only a limited repertoire of molecules is transported through these channels. Recent studies have begun to unravel mechanisms that actively regulate the opening of the Pd channel to allow traffic. This macromolecular transport between cells comprises two consecutive steps： intracellular targeting to Pd and translocation through the channel to the adjacent cell. Here, we review the current knowledge of molecular species that are transported though Pd and the mechanisms that control this traffic. Generally, Pd traffic can occur by passive diffusion through the trans-Pd cytoplasm or through the membrane/lu- men of the trans-Pd ER, or by active transport that includes protein-protein interactions. It is this latter mode of Pd trans- port that is involved in intercellular traffic of most signal molecules and is regulated by distinct and sometimes interdependent mechanisms, which represent the focus of this article.

关键词： Plasmodesmata cell-to-cell transport plant viruses transcription factors

日本高等融合教育支持体系建设及启示——以日本筑波大学为例

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现代特殊教育 2024年第10期 28-35页

作者：何橙棋黄金峰陈俞安宫本昌子日本筑波大学人间综合科学学术院日本筑波3058572 日本筑波大学人间系日本筑波3058572

为构建共生社会,以“消除非公平差别对待,提供合理便利”为核心理念,由文部省领导,国家公立大学牵头试点,日本建立了自上而下的多阶段高等融合教育支持体系,涵盖残障大学生日常生活、学业、就业支持等领域。借鉴其经验,中国可根据国情,... 详细信息

为构建共生社会,以“消除非公平差别对待,提供合理便利”为核心理念,由文部省领导,国家公立大学牵头试点,日本建立了自上而下的多阶段高等融合教育支持体系,涵盖残障大学生日常生活、学业、就业支持等领域。借鉴其经验,中国可根据国情,制定具体的高等融合教育政策方针,以各高校学工部为指导中心,加强高校融合教育管理,加快师资培养,建立学生支持队伍,以进一步促进高等融合教育的发展。

关键词：高等教育融合教育残障大学生支持体系

Systemic hemodynamics in advanced cirrhosis: Concerns during perioperative period of liver transplantation

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World Journal of Hepatology 2016年第25期8卷 1047-1060页

作者： Tomohide Hori Yasuhiro Ogura Yasuharu Onishi Hideya Kamei Nobuhiko Kurata Motoshi Kainuma Hideo Takahashi Shogo Suzuki Takashi Ichikawa shoko mizuno Tadashi Aoyama Yuki Ishida Takahiro Hirai Tomoko Hayashi Kazuko Hasegawa Hiromu Takeichi Atsunobu Ota Yasuhiro Kodera Hiroyuki Sugimoto Taku Iida Shintaro Yagi Kentaro Taniguchi Shinji Uemoto Department of Transplant Surgery Nagoya University Hospital Department of Intensive Care Unit Nagoya University Hospital Second Department of Surgery Nagoya University Hospital Department of Transplant Surgery Kyoto University Hospital First Department of Surgery Mie University Hospital

Advanced liver cirrhosis is usually accompanied by portal hypertension. Long-term portal hypertension results in various vascular alterations. The systemic hemodynamic state in patients with cirrhosis is termed a hyperdynamic state. This peculiar hemodynamic state is characterized by an expanded blood volume, high cardiac output, and low total peripheral resistance. Vascular alterations do not disappear even long after liver transplantation(LT), and recipients with cirrhosis exhibit a persistent systemic hyperdynamic state even after LT. Stability of optimal systemic hemodynamics is indispensable for adequate portal venous flow(PVF) and successful LT, and reliable parameters for optimal systemic hemodynamics and adequate PVF are required. Even a subtle disorder in systemic hemodynamics is precisely indicated by the balance between cardiac output and blood volume. The indocyanine green(ICG) kinetics reflect the patient's functional hepatocytes and effective PVF, and PVF is a major determinant of the ICG elimination constant(kICG) in the well-preserved allograft. The kICG value is useful to set the optimal PVF during living-donor LT and to evaluate adequate PVF after LT. Perioperative management has a large influence on the postoperative course and outcome; therefore, key points and unexpected pitfalls for intensive management are herein summarized. Transplant physicians should fully understand the peculiar systemic hemodynamic behavior in LT recipients with cirrhosis and recognize the critical importance of PVF after LT.

关键词： Liver cirrhosis Portal hypertension Liver transplantation Indocyanine green Hyperdynamic

HISTORY AND PRESENT STATE OF TRANSLATIONAL ELECTRO-OPTICAL APPLICATIONS TO MEDICINE

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Journal of Innovative Optical Health Sciences 2008年第1期1卷 1-15页

作者： BRITTON CHANCE shoko NIOKA Department of Biochemistry and Biophysics University of Pennsylvania PA USA Britton Chance Center for Biomedical Photonics Wuhan National Lab for Optoelectronics Huazhong University of Science and Technology WuhanChina

This paper reviews the history of the optoelectric devices applied to biomedical sciences in 20th century.It describes history of Vacuum tubes and Spectroscopies with the author’s personal experiences,especially doublebeam spectroscopy.Further,the present developments of Near Infra Red(NIR)devices are described in translational biomedical applications.It includes particulary micro optoelectronics developments and present status of NIR breast cancer detection.Lastly,intrinsic molecular biomarkers are discussed especially NIR measurements of angiogenensis,hypermetabolism and heat production for cancer detection.

关键词： History vacuum tube double beam spectrometer NIR Biomarker

Charge transfer between biogenic jarosite derived Fe^3＋ and TiO2 enhances visible light photocatalytic activity of TiO2

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Journal of Environmental Sciences 2017年第4期29卷 256-267页

作者： Mahabubur Chowdhury Sipiwe shoko Fransciuos Cummings Veruscha Fester Tunde Victor Ojumu Flow Process and Rheolofy Centre Cape Peninsula University of Technology South Africa Department of Chemical Engineering Cape Peninsula University of Technology South Africa Electron Microscope Unit University of the Western Cape South Africa

In this work, we have shown that mining waste derived Fe^3＋can be used to enhance the photocatalytic activity of TiO2. This will allow us to harness a waste product from the mines, and utilize it to enhance TiO2 photocatalytic waste water treatment efficiency. An organic linker mediated route was utilized to create a composite of TiO2 and biogenic jarosite. Evidence of Fe／O／Ti bonding in the TiO2/jarosite composite was apparent from the FTIR, EFTEM, EELS and ELNEFS analysis. The as prepared material showed enhanced photocatalytic activity compared to pristine TiO2, biogenic jarosite and mechanically mixed sample of jarosite and TiO2 under both simulated and natural solar irradiation. The prepared material can reduce the electrical energy consumption by 4 times compared to pristine P25 for degradation of organic pollutant in water. The material also showed good recyclability. Results obtained from sedimentation experiments showed that the larger sized jarosite material provided the surface to TiO2 nanoparticles, which increases the settling rate of the materials. This allowed simple and efficient recovery of the catalyst from the reaction system after completion of photocatalysis. Enhanced photocatalytic activity of the composite material was due to effective charge transfer between TiO2 and jarosite derived Fe^3＋as was shown from the EELS and ELNEFS. Generation of OHU was supported by photoluminesence（PL） experiments.

关键词： Biogenic jarosite TiO2 photocatalysis Charge transfer Organic pollutant Visible light responsive Water treatment

Exploring the Lives of Mothers Raising Children with Autism Spectrum Disorder in Japan

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Open Journal of Nursing 2023年第2期13卷 167-180页

作者： Azusa Kawakami shoko Mano Yoko Shibuya Department of Nursing Nara Medical University Kashihara Nara Japan Department of Nursing Setsunan University Hirakata Osaka Japan

Background: Examining the lives that mothers experience and build will allow us to deepen our understanding of children with ASD and their mothers and facilitate developing support methods. The study aimed to examine the lives of mothers raising children with autism spectrum disorder (ASD) and investigate their sources of support. Method: We conducted a qualitative inductive study using semi-structured interviews to identify characteristics of the lives that mothers have created. Results: Semi-structured interviews were conducted with 11 mothers having children with ASD. The analysis comprised three stages of coding and yielded eight categories. The lives of these mothers contained three themes: preoccupation with parenting children with ASD and their siblings;evolving mother;and using social resources. Mothers engaged in “assessing the characteristics, growth, and changes in the child with ASD”, had a “preoccupation with parenting children with ASD”, and were “thinking about the future of the child with ASD”, and “having goals and plans for parenting” while having “consideration toward the child’s siblings”. During this process, mothers experienced “changes in perspective or approach” and created lifestyles while “receiving help from people around them” and engaged in the “use of social resources”. Conclusions: To avoid becoming preoccupied with parenting and being burdened by their lifestyle, mothers require social support to monitor their perceptions. Furthermore, the utilization of social resources requires the supporting individuals to understand the characteristics of children with ASD, provide appropriate information, and assist in decision-making.

关键词： Autism Spectrum Disorder Mothers Raising Children

A NOVEL TIME-SHARED FLUOROMETER GIVES THE MITOCHONDRIAL REDOX STATE AS THE RATIO OF TWO COMPONENTS OF THE RESPIRATORY CHAIN OF THE ANIMAL AND HUMAN BUCCAL CAVITY WITH QUANTITATIVE MEASURES OF THE REDOX ENERGY STATE

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Journal of Innovative Optical Health Sciences 2010年第4期3卷 235-245页

作者： BRITTON CHANCE shoko NIOKA AQUO JENQ-RUEY HORNG University of Pennsylvania Philadelphia PA 19104USA South Taiwan University 1 Nantai RoadYong KangTainan 71005Taiwan

The source of energy for life is the tissue mitochondria and they demand a complex chain of biochemicals to ensure proper physiological function.Classically,the blood levels,and not the tissue levels of these metabolites,are determined by expensive and time-consuming biochemical analyses.Since the tissue mitochondria are the consumers of the substrates of glycolysis and of fatty acid metabolism,their redox state is a unique accessible monitor of tissue metabolism and its blockade due to toxins.

关键词： Redox state mitochondria optical methods fluorometer

Estrogen and oxytocin involvement in social preference in male mice:a study using a novel long-term social preference paradigm with aromatase,estrogen receptor-αand estrogen receptor-β,oxytocin,and oxytocin receptor knockout male mice

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Integrative Zoology 2018年第6期13卷 698-710页

作者： Mumeko C.TSUDA Kazuyo NAGATA shoko SAGOSHI Sonoko OGAWA Laboratory of Behavioral Neuroendocrinology University of TsukubaTsukubaIbarakiJapan

Certain aspects of social behavior help animals make adaptive decisions during encounters with other animals.When mice choose to approach another conspecific,the motivation and preference behind the interaction is not well understood.Estrogen and oxytocin are known to influence a wide array of social behaviors,including social motivation and social preference.The present study investigated the effects of estrogen and oxytocin on social preference using aromatase(ArKO),estrogen receptor(ER)α(αERKO),ERβ(βERKO),oxytocin(OTKO),oxytocin receptor(OTRKO)knockout and their respective wild-type(WT)male mice.Mice were presented with gonadally-intact versus castrated male(IC),intact male versus ovariectomized female(IF),or intact male versus empty cage(IE)stimuli sets for 5 days.ArWT showed no preference for either stimuli in IC and IF and intact male preference in IE,but ArKO mice preferred a castrated male or an ovariectomized female,or had no preference for either stimulus in IC,IF and IE stimuli sets,respectively,suggesting reduced intact male preference.αandβWT mice preferred a castrated male,showed no preference,and preferred an intact male in IC,IF and IE,respectively.αERKO mice displayed similar modified social preference patterns as ArKO,whereas the social preference ofβERKO mice remained similar toβWT.OTWT preferred a castrated male whereas OTKO,OTRWT and OTRKO mice failed to show any preference in IC and none showed preference for either stimuli in IF.Collectively,these findings suggest that estrogen regulates social preference in male mice and that impaired social preference in oxytocin-deficient mice may be due to severe deficits in social recognition.

关键词： aromatase estrogen receptor oxytocin receptor social motivation social preference