Production of the yolk protein precursor vitellogenin is mediated by target of rapamycin (TOR) in the soft tick Ornithodoros moubata (Acari: Argasidae)
作者机构:Graduate School of Life and Environmental SciencesUniversity of TsukubaTsukubaIbarakiJapan Animal Breeding and Reproduction Research DivisionInstitute of Livestock and Grassland ScienceNational Agriculture and Food Research OrganizationTsukubaIbarakiJapan
出 版 物:《Insect Science》 (昆虫科学(英文版))
年 卷 期:2022年第29卷第5期
页 面:1299-1308页
核心收录:
学科分类:0710[理学-生物学] 07[理学] 09[农学]
基 金:supported by Grants-in-Aid 16K08094 to DT from the Japan Society for the Promotion of Science(JSPS) Japan
主 题:Ornithodoros moubata target of rapamycin ticks vitellogenesis vitellogenin
摘 要:Initiation of vitellogenesis by blood feeding is essential for egg maturation in *** derived from the blood meal are utilized by female ticks to synthesize the yolk protein precursor vitellogenin(Vg).Engorged Ornithodoros moubata ticks can synthesize Vg whether mated or virgin,thus *** is an excellent model for studying the relative roles of blood feeding and mating in tick *** of rapamycin into engorged *** resulted in a reduction of ovarian growth and yolk accumulation in the oocytes of mated *** expression in the midgut and fat body and protein concentrations in the hemolymph significantly decreased in mated ticks after injection with rapamycin,indicating that inhibition of the nutrient-sensing target of rapamycin(TOR)pathway disrupts egg maturation at the levels of Vg expression and *** results suggest that the TOR-signaling pathway induces vitellogenesis in response to nutritional stimulation after a blood meal in *** and is functionally independent of the mating-induced pathway.