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实验力学国际会议

作者： shoichi kobayashi Depatment of Construction Eng. Fukui Univ. of Tech. Fukui 910-8505 Japan

＜正＞ A non-contact measurement technique of Rayleigh wave velocity is proposed. In the non-contact measurement system, a laser Doppler velocimeter is used to detect wave motions. With above technique, the relationship between Rayleigh wave velocity and stress for an aluminum alloy 5052 and steel SS400 is determined, and the results are in good agreement with that obtained by contact measurement method.

关键词： Rayleigh wave velocity laser Doppler velocimeter stress-acoustic coefficient sing-around method non- contact measurement.

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新稻田除草剂吡嘧黄隆

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农药 1990年第5期25卷 42-42页

作者： shoichi kobayashi 陈春生

吡嘧黄隆是日本日产化学工业公司1982年发现的磺酰脲类除草剂,用于移栽和直播水稻,芽前和芽后使用,对多种一年生和多年生稻田杂草有优异的防效,用量极低。1984年,其0.

关键词：吡嘧黄隆稻田除草剂磺酰脲

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Repetitive administration of cultured human CD34+cells improve adenine-induced kidney injury in mice

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World Journal of Stem Cells 2023年第4期15卷 268-280页

作者： Takayasu Ohtake shoichi Itaba Amankeldi A Salybekov Yin Sheng Tsutomu Sato Mitsuru Yanai Makoto Imagawa Shigeo Fujii Hiroki Kumagai Masamitsu Harata Takayuki Asahara Shuzo kobayashi Regenerative Medicine The Center for Cell Therapy&Regenerative MedicineShonan Kamakura General HospitalKamakura 247-8533KanagawaJapan Kidney Disease and Transplant center Shonan Kamakura General HospitalKamakura 247-8533KanagawaJapan Regenerative Medicine Shonan Research Institute of Innovative MedicineKamakura 247-8533KanagawaJapan Kamakura Techno-science Inc. Kamakura 248-0036Japan Advanced Medicine Science Tokai University School of MedicineIsehara 259-1193Japan Department of Pathology Sapporo Tokushukai HospitalSapporo 004-0041Japan Department of Pathology Sapporo Medical CenterSapporo 004-0041Japan Human Life CORD Japan Inc Chuo-ku 103-0012TokyoJapan Cell Processing and Cell/Genome Analysis Center The Center for Cell Therapy&Regenerative MedicineShonan Kamakura General HospitalKamakura 247-8533KanagawaJapan Kidney Disease and Transplant Center Shonan Kamakura General HospitalKamakura 247-8533KanazawaJapan

BACKGROUND There is no established treatment to impede the progression or restore kidney function in human chronic kidney disease(CKD).AIM To examine the efficacy of cultured human CD34+cells with enhanced proliferating potential in kidney injury in *** Human umbilical cord blood(UCB)-derived CD34+cells were incubated for one week in vasculogenic conditioning *** culture significantly increased the number of CD34+cells and their ability to form endothelial progenitor cell colony-forming *** tubulointerstitial injury of the kidney was induced in immunodeficient non-obese diabetic/severe combined immunodeficiency mice,and cultured human UCB-CD34+cells were administered at a dose of 1×106/mouse on days 7,14,and 21 after the start of adenine *** Repetitive administration of cultured UCB-CD34+cells significantly improved the time-course of kidney dysfunction in the cell therapy group compared with that in the control *** interstitial fibrosis and tubular damage were significantly reduced in the cell therapy group compared with those in the control group(P<0.01).Microvasculature integrity was significantly preserved(P<0.01)and macrophage infiltration into kidney tissue was dramatically decreased in the cell therapy group compared with those in the control group(P<0.001).CONCLUSION Early intervention using human cultured CD34+cells significantly improved the progression of tubulointerstitial kidney *** administration of cultured human UCB-CD34+cells significantly improved tubulointerstitial damage in adenine-induced kidney injury in mice via vasculoprotective and anti-inflammatory effects.

关键词： Chronic kidney disease CD34+cell Adenine Tubulointerstitial injury Quality and quantity control culture Umbilical cord blood

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Efficacy and safety of endoscopic submucosal dissection for gastric tube cancer:A multicenter retrospective study

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World Journal of Gastroenterology 2021年第11期27卷 1043-1054页

作者： Takuya Satomi Seiji Kawano Tomoki Inaba Masahiro Nakagawa Hirokazu Mouri Masao Yoshioka shoichi Tanaka Tatsuya Toyokawa Sayo kobayashi Takehiro Tanaka Hiromitsu Kanzaki Masaya Iwamuro Yoshiro Kawahara Hiroyuki OkadaDepartment of Gastroenterology and Hepatology Department of Gastroenterology and Hepatology Okayama University Graduate School of MedicineDentistryand Pharmaceutical SciencesOkayama 700-8558OkayamaJapan Department of Gastroenterology Kagawa Prefectural Central HospitalTakamatsu 760-8557KagawaJapan Department of Endoscopy Hiroshima City Hiroshima Citizens HospitalHiroshima 730-8518HiroshimaJapan Department of Gastroenterology and Hepatology Kurashiki Central HospitalKurashiki 710-8602OkayamaJapan Department of Gastroenterology and Hepatology Okayama Saiseikai General HospitalOkayama 700-8511OkayamaJapan Department of Gastroenterology National Hospital Organization Iwakuni Clinical CenterIwakuni 740-8510YamaguchiJapan Department of Gastroenterology National Hospital Organization Fukuyama Medical CenterFukuyama 720-8521HiroshimaJapan Department of Internal Medicine Fukuyama City HospitalFukuyama 721-8511HiroshimaJapan Department of Pathology Okayama University HospitalOkayama 700-8558OkayamaJapan Department of Practical Gastrointestinal Endoscopy Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558OkayamaJapan

BACKGROUND Recent improvements in the prognosis of patients with esophageal cancer have led to the increased occurrence of gastric tube cancer(GTC)in the reconstructed gastric ***,there are few reports on the treatment results of endoscopic submucosal dissection(ESD)for *** To evaluate the efficacy and safety of ESD for GTC after esophagectomy in a multicenter *** We retrospectively investigated 48 GTC lesions in 38 consecutive patients with GTC in the reconstructed gastric tube after esophagectomy who had undergone ESD between January 2005 and December 2019 at 8 institutions participating in the Okayama Gut Study *** clinical indications of ESD for early gastric cancer were similarly applied for GTC after *** specimens were evaluated in 2-mm slices according to the Japanese Classification of Gastric Carcinoma with curability assessments divided into curative and non-curative resection based on the Gastric Cancer Treatment *** characteristics,treatment results,clinical course,and treatment outcomes were *** The median age of patients was 71.5 years(range,57-84years),and there were 34 men and 4 *** median observation period after ESD was 884 d(range,8-4040 d).The median procedure time was 81 min(range,29-334 min),the en bloc resection rate was 91.7%(44/48),and the curative resection rate was 79%(38/48).Complications during ESD were seen in 4%(2/48)of case,and those after ESD were seen in 10%(5/48)of *** survival rate at 5 years was 59.5%.During the observation period after ESD,10 patients died of other *** there were differences in the procedure time between institutions,a multivariate analysis showed that tumor size was the only factor associated with prolonged procedure *** ESD for GTC after esophagectomy was shown to be safe and effective.

关键词： Endoscopic submucosal dissection Gastric tube Gastric cancer Esophagectomy Multicenter study Retrospective study

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Is there diversity among UGT1A1 polymorphism in Japan?

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World Journal of Gastrointestinal Oncology 2012年第7期4卷 170-175页

作者： Michiya kobayashi shoichi Hazama Kenichi Takahashi Koji Oba Naoko Okayama Mitsuaki Nishioka Yuji Hinoda Masaaki Oka Ken Okamoto Hiromichi Maeda Daisuke Nakamura Junichi Sakamoto Hideyuki Mishima Department of Human Health and Medical Sciences Kochi Medical School Nankoku 783-8505 Japan Department of Digestive Surgery and Surgical Oncology (Surgery Ⅱ) Yamaguchi University Graduate School of Medicine Ube Yamaguchi 755-8505 Japan Department of Surgery Aomori Prefectural Central Hospital Aomori 030-8553 Japan Translational Research and Clinical Trial Center Hok-kaido University Hospital Sapporo 060-8638 Japan Division of Laboratory Yamaguchi University Hospital Ube Yamaguchi 755-8505 Japan Department of Oncology and Laboratory Medicine Yamaguchi University Graduate School of Medicine Ube Yama-guchi 755-8505 Japan Tokai University School of Medicine Is-ehara Kanagawa 259-1131 Japan Young Leaders Program in Healthcare Administration Nagoya University Graduate School of Medicine Nagoya 466-8550 Japan Department of Surgery Osaka National Hos-pital Osaka 565-0871 Japan

AIM: To investigate into the diversity of UGT1A1 polymorphism across three different districts in Japan and highlight genetic differences among the population in Japan. METHODS: We enrolled 50 healthy volunteers from each of the Yamaguchi (western part of Japan), Kochi(southern part of Japan) and Akita (northern part of Japan) prefectures. Blood samples (7 mL) were collected from each participant and stored in EDTA for subsequent genotyping by fragment size analysis, direct sequencing and TaqMan assay of UGT1A1*28, UGT1A7*3/UGT1A9*22 and UGT1A1*93/UGT1A1*6/ UGT1A1*27/UGT1A1*60/UGT1A7 (-57), respectively. RESULTS: The only statistically significant differences in allele polymorphisms among the group examined were for UGT1A1*6. The Akita population showed more UGT1A1*6 heterozygosity (P = 0.0496). CONCLUSION: Our study revealed no regional diversity among UGT1A1, UGT1A7 or UGT1A9 polymorphisms in Japan.

关键词： UGT1A1 gene Polymorphism Diversity

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