Is there diversity among UGT1A1 polymorphism in Japan?

作     者：Michiya Kobayashi Shoichi Hazama Kenichi Takahashi Koji Oba Naoko Okayama Mitsuaki Nishioka Yuji Hinoda Masaaki Oka Ken Okamoto Hiromichi Maeda Daisuke Nakamura Junichi Sakamoto Hideyuki Mishima 

作者机构：Department of Human Health and Medical Sciences Kochi Medical School Nankoku 783-8505 Japan Department of Digestive Surgery and Surgical Oncology (Surgery Ⅱ) Yamaguchi University Graduate School of Medicine Ube Yamaguchi 755-8505 Japan Department of Surgery Aomori Prefectural Central Hospital Aomori 030-8553 Japan Translational Research and Clinical Trial Center Hok-kaido University Hospital Sapporo 060-8638 Japan Division of Laboratory Yamaguchi University Hospital Ube Yamaguchi 755-8505 Japan Department of Oncology and Laboratory Medicine Yamaguchi University Graduate School of Medicine Ube Yama-guchi 755-8505 Japan Tokai University School of Medicine Is-ehara Kanagawa 259-1131 Japan Young Leaders Program in Healthcare Administration Nagoya University Graduate School of Medicine Nagoya 466-8550 Japan Department of Surgery Osaka National Hos-pital Osaka 565-0871 Japan 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2012年第4卷第7期

页      面：170-175页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071007[理学-遗传学] 

基　　金：Supported by The Non-profit Epidemiological and Clinical Research Information Network Organization 

主　　题：UGT1A1 gene Polymorphism Diversity 

摘      要：AIM: To investigate into the diversity of UGT1A1 polymorphism across three different districts in Japan and highlight genetic differences among the population in Japan. METHODS: We enrolled 50 healthy volunteers from each of the Yamaguchi (western part of Japan), Kochi(southern part of Japan) and Akita (northern part of Japan) prefectures. Blood samples (7 mL) were collected from each participant and stored in EDTA for subsequent genotyping by fragment size analysis, direct sequencing and TaqMan assay of UGT1A1*28, UGT1A7*3/UGT1A9*22 and UGT1A1*93/UGT1A1*6/ UGT1A1*27/UGT1A1*60/UGT1A7 (-57), respectively. RESULTS: The only statistically significant differences in allele polymorphisms among the group examined were for UGT1A1*6. The Akita population showed more UGT1A1*6 heterozygosity (P = 0.0496). CONCLUSION: Our study revealed no regional diversity among UGT1A1, UGT1A7 or UGT1A9 polymorphisms in Japan.