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Regeneration of rat corpora cavernosa tissue by transplantation of CD133＋ cells derived from human bone marrow and placement of biodegradable gel sponge sheet

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Asian Journal of Andrology 2017年第2期19卷 203-207页

作者： shogo inoue Katsutoshi Miyamoto Shunsuke Shinmei Koichi Shoji Jun Teishima Kazuhiro Sentani Wataru Yasui Akio Matsubara Department of Urology Hiroshima University Institute of Biomedical and Health Sciences Hiroshima Japan Department of Molecular Pathology Hiroshima University Institute of Biomedical and Health Sciences Hiroshima Japan

The objective is to develop an easier technique for regenerating corpora cavernosa tissue through transplantation of human bone marrow-derived CD133＋ cells into a rat corpora cavernosa defect model. We excised 2 mm× 2 mm squares of the right corpora cavernosa of twenty-three 8-week-old male nude rats. AIginate gel sponge sheets supplemented with 1 × 10^4 CD133＋ cells were then placed over the excised area of nine rats. Functional and histological evaluations were carried out 8 weeks later. The mean intracavernous pressure/mean arterial pressure ratio for the nine rats （0.34258 ± 0.0831） was significantly higher than that for eight rats with only the excision （0.0580±0.0831, P = 0.0238） and similar to that for five rats for which the penis was exposed, and there was no excision （0.37228±0.1051, P = 0.8266）. Immunohistochemical analysis revealed that the nine fully treated rats had venous sinus-like structures and quantitative reverse transcription polymerase chain reaction analysis of extracts from their alginate gel sponge sheets revealed that the amounts of mRNA encoding the nerve growth factor （NGF）, and vascular endothelial growth factor （VEGF） were significantly higher than those for rats treated with alginate gel sheets without cell supplementation （NGF： P= 0.0309; VEGF： P〈 0.0001）. These findings show that transplantation of CD133＋ cells accelerates functional and histological recovery in the corpora cavernosa defect model.

关键词： alginate gel sponge sheet CD133+ cell corpora cavernosa

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Significance of timing of therapeutic line on effectiveness of nivolumab for metastatic renal cell carcinoma

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Current Urology 2023年第1期17卷 52-57页

作者： Jun Teishima Daiki Murata Kazuma Yukihiro Yohei Sekino shogo inoue Tetsutaro Hayashi Koji Mita Yasuhisa Hasegawa Masao Kato Mitsuru Kajiwara Masanobu Shigeta Satoshi Maruyama Hiroyuki Moriyama Seiji Fujiwara Akio Matsubara Department of Urology Graduate School of Biomedical and Health SciencesHiroshima UniversityHiroshimaJapan Department of Urology Hiroshima-City Asa Citizens HospitalHiroshimaJapan Department of Urology Fukuyama Medical CenterFukuyamaJapan Department of Urology Hiroshima General HospitalHatsukaichiJapan Department of Urology Hiroshima Prefectural HospitalHiroshimaJapan Department of Urology Kure Medical Center and Chugoku Cancer CenterKureJapan Department of Urology Miyoshi Central HospitalMiyoshiJapan Department of Urology Onomichi General HospitalOnomichiJapan Department of Urology Higashi-Hiroshima Medical Center Higashi-HiroshimaJapan

Objectives:This study aimed to clarify the significance of therapeutic timing on the effectiveness of nivolumab for treating metastatic renal cell *** and methods:Fifty-eight patients with metastatic renal cell carcinoma treated with nivolumab monotherapy were retrospectively *** who were treated with nivolumab as second-line therapy were included in the second-line group,while the others were included in the later-line *** clinicopathological characteristics,effects of nivolumab,and prognoses of these groups were ***:Twenty and thirty-eight patients were included in the second-line and later-line groups,*** were no significant differences in the distribution of International Metastatic Renal Cell Carcinoma Database Consotium risk and other clinicopathological characteristics between the 2 *** proportion of patients whose objective best response was progressive disease in the second-line group was significantly lower than that in the later-line group(15%vs.50%,p=0.0090).The 50%progression-free survival with nivolumab in the second-line group was significantly better than that in the later-line group(not reached and 5 months,p=0.0018).Multivariate analysis showed that the second-line setting was an independent predictive factor for better progression-free survival(p=0.0028,hazard ratio=0.108).The 50%overall survival after starting nivolumab in the second-line and later-line groups was not reached and 27.8 months,respectively(p=0.2652).Conclusions:The therapeutic efficacy of nivolumab as second-line therapy is expected to be better than that of later therapy.

关键词： Immune checkpoint inhibitor Metastatic renal cell carcinoma Nivolumab Prognostic factor Second-line treatment

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Comparative epidemiology of gastric cancer between Japan and China

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World Journal of Gastroenterology 2011年第39期17卷 4421-4428页

作者： Yingsong Lin Junko Ueda shogo Kikuchi Yukari Totsuka Wen-Qiang wei You-Lin Qiao Manami inoue Department of Public Health Aichi Medical University School of Medicine Aichi 480-1195 Japan Division of Cancer Development System National Cancer Center Research Institute Tokyo 104-0045 Japan Department of Cancer Epidemiology Cancer Institute/Hospital Chinese Academy of Medical Sciences Beijing 100730 China Epidemiology and Prevention Division Research Center for Cancer Prevention and Screening National Cancer Center Research Institute Tokyo 104-0045 Japan

AIM:To clarify the similarities and differences in gastric cancer epidemiology between Japan and ***:A comprehensive literature search of the PubMed database was *** relevant literature published in China was also been *** on incidence and mortality rates in 2008 were obtained from the Cancer Mondial database,published by International Agency for Research on Cancer at http://***/.RESULTS:Gastric cancer remains a significant publichealth burden in both Japan and *** prevalence of Helicobacter pylori(***)colonization is high in the adult populations of both *** evidence from intervention studies in both countries has shown the effectiveness of *** eradication in reduc-ing gastric cancer *** are differences,however,in many aspects of gastric cancer,including patterns of incidence and mortality,trends in the prevalence of *** infection,*** strains,the magnitude of risk of gastric cancer related to *** infection,and associations with dietary *** with China,Japan has seen a more rapid decline in *** infection among *** Japanese cohort studies have dominated the literature concerning the associations between gastric cancer and dietary habits,numerous case-control studies in China suggest a positive association between a high intake of preserved fish and vegetables and gastric cancer *** is a need for a multidisciplinary research approach to understand the interactions between various strains of ***,host factors,and other lifestyle and environmental factors in gastric carcinogenesis in both ***:The shared high incidence of gastric cancer and high prevalence of ***,as well as differences in many aspects of gastric cancer,provide an excellent opportunity to establish Sino-Japanese collaborations.

关键词： Gastric cancer Risk factor Helicobacter pylori Epidemiology

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Dissipative structure for symmetric hyperbolic systems with memory

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Science China Mathematics 2018年第11期61卷 2053-2064页

作者： Shuichi Kawashima shogo Taniue Faculty of Mathematics Kyushu University Graduate School of Mathematics Kyushu University

We study symmetric hyperbolic systems with memory-type dissipation and investigate their dissipative *** treat two cases:memory-type diffusion and memory-type relaxation,and observe that the dissipative structures of these two cases are essentially ***,we show that the dissipative structure of the system with memory-type diffusion is of the standard type,while that of the system with memory-type relaxation is of the regularity-loss type.

关键词： hyperbolic systems memory-type dissipation dissipative structure

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A study on particle breakage behavior during pile penetration process using acoustic emission source location

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Geoscience Frontiers 2020年第2期11卷 413-427页

作者： Wuwei Mao shogo Aoyama Ikuo Towhata Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai 200092China Key Laboratory of Geotechnical and Underground Engineering Ministry of EducationTongji UniversityShanghai 200092China Kiso-Jiban Consultants Co. Ltd.TokyoJapan Department of Civil Engineering University of TokyoTokyoJapan

Particle breakage is a common occurrence in granular systems when the external stress exceeds the individual particle strength.A large number of experimental evidences suggested that particle breakage may significantly influence the soil *** the case of pile foundations,the subsoil below the pile tip experiences considerable high stress and consequently prone to *** to the lack of sufficient understanding on particle breakage mechanism,there is currently no consentaneous theoretical background for particle breakage analysis during the pile penetration *** study aims to clarify the location of particle breakage and its evolving characteristics with the aid of acoustic emission(AE)source location *** spatial distribution of AE hypocenters is interpreted to be associated with the mechanism of particle *** showed that the AE sources were not uniformly distributed,but concentrated within certain zones below the pile *** AE concentration zone was pushed downward with the advancing pile tip,and its distance from the real time pile tip position decreased after certain depth of pile *** location of particle breakage interpreted from AE source location was verified with posttest excavations and the insights on the particle breakage evolution zone were further discussed.

关键词： Acoustic emission Source location Sand Particle breakage Pile

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Locally infiltrative inflammatory fibroid polyp of the ileum:report of a case showing transmural proliferation

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Gastroenterology Report 2018年第2期6卷 144-148,I0003页

作者： shogo Tajima Kenji Koda Department of Pathology Shizuoka Saiseikai General HospitalShizuokaJapan and 2Department of PathologyFujieda Municipal General HospitalShizuokaJapan

Morphologically,an inflammatory fibroid polyp(IFP)is usually centred in the *** of an IFP to the subserosa with destruction of the muscularis propria is exceedingly ***,we describe a 70-year-old woman who presented with right lower abdominal pain but was finally diagnosed with an ***-enhanced computed tomography revealed a target-like structure with a hypovascular mass at the leading edge,which was consistent with intussusception due to a *** surgery,the resected specimen displayed a mass measuring 4×3×3 cmthat was protruding into the ***,the mass was centred in the submucosa,extending up to the mucosal surface and down to the subserosa and *** muscularis mucosae and muscularis propria were destroyed focally.A PDGFRA gene mutation in exon 2(1837_1851 del)that was found in this case,as well as a highly infiltrative growth pattern,strongly supported the neoplastic nature of IFP.

关键词： inflammatory fibroid polyp transmural proliferation subserosa serosa

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PMSSC:Parallelizable multi-subset based self-expressive model for subspace clustering

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Computational Visual Media 2023年第3期9卷 479-494页

作者： Katsuya Hotta Takuya Akashi shogo Tokai Chao Zhang Department of Engineering University of FukuiFukui-shi 910-8507Japan Faculty of Science and Engineering Iwate UniversityMorioka-shi 020-8551Japan

Subspace clustering methods which embrace a self-expressive model that represents each data point as a linear combination of other data points in the dataset provide powerful unsupervised learning ***,when dealing with large datasets,representation of each data point by referring to all data points via a dictionary suffers from high computational *** alleviate this issue,we introduce a parallelizable multi-subset based self-expressive model(PMS)which represents each data point by combining multiple subsets,with each consisting of only a small proportion of the *** adoption of PMS in subspace clustering(PMSSC)leads to computational advantages because the optimization problems decomposed over each subset are small,and can be solved efficiently in ***,PMSSC is able to combine multiple self-expressive coefficient vectors obtained from subsets,which contributes to an improvement in *** experiments on synthetic and real-world datasets show the efficiency and effectiveness of our approach in comparison to other methods.

关键词： subspace clustering self-expressive model big data subsetting

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LOV Domain-Containing Light-Dependent Protein in Arabidopsis F-Box Proteins： Degradation Modules

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Molecular Plant 2012年第3期5卷 573-582页

作者： shogo Ito Young Hun Song Takato Imaizumi Department of Biology Seattle WA 98195-1800 USA University of Washington Seattle WA 98195-1800 USA

Plants constantly survey the surrounding environment using several sets of photoreceptors. They can sense changes in the quantity （= intensity） and quality （=wavelength） of light and use this information to adjust their physiological responses, growth, and developmental patterns. In addition to the classical photoreceptors, such as phytochromes, crypto- chromes, and phototropins, ZEITLUPE （ZTL）, FLAVIN-BINDING, KELCH REPEAT, F-BOX 1 （FKF1）, and LOV KELCH PROTEIN 2 （LKP2） proteins have been recently identified as blue-light photoreceptors that are important for regulation of the circadian clock and photoperiodic flowering. The ZTL/FKF1/LKP2 protein family possesses a unique combination of domains： a blue-light-absorb- ing LOV （Light, Oxygen, or Voltage） domain along with domains involved in protein degradation. Here, we summarize recent advances in our understanding of the function of the Arabidopsis ZTL/FKF1/LKP2 proteins. We summarize the distinct pho- tochemical properties of their LOV domains and discuss the molecular mechanisms by which the ZTL/FKF1/LKP2 proteins reg- ulate the circadian clock and photoperiodic flowering by controlling blue-light-dependent protein degradation.

关键词： blue light LOV domain ZTL FKF1 LKP2 photoperiodic flowering circadian clock Arabidopsis

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Regenerative medicine strategies for chronic complete spinal cord injury

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Neural Regeneration Research 2024年第4期19卷 818-824页

作者： shogo Hashimoto Narihito Nagoshi Masaya Nakamura Hideyuki Okano Department of Orthopedic Surgery Keio University School of Medicine Department of Physiology Keio University School of Medicine

Spinal cord injury is a condition in which the parenchyma of the spinal cord is damaged by trauma or various *** rapid progress has been made in regenerative medicine for spinal cord injury that was previously untreatable,most research in this field has focused on the early phase of incomplete ***,the majority of patients have chronic severe injuries;therefore,treatments for these situations are of fundamental *** reason why the treatment of complete spinal cord injury has not been studied is that,unlike in the early stage of incomplete spinal cord injury,there are various inhibitors of neural ***,we assumed that it is difficult to address all conditions with a single treatment in chronic complete spinal cord injury and that a combination of several treatments is essential to target severe ***,we established a combination therapy of cell transplantation and drug-releasing scaffolds,which contributes to functional recovery after chronic complete transection spinal cord injury,but we found that functional recovery was limited and still needs further ***,for the further development of the treatment of chronic complete spinal cord injury,we review the necessary approaches to the different pathologies based on our findings and the many studies that have been accumulated to date and discuss,with reference to the literature,which combination of treatments is most effective in achieving functional recovery.

关键词： cell transplantation chronic phase complete transection regenerative medicine spinal cord injury

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A novel use of TiO_2 fiber for photocatalytic ozonation of 2,4-dichlorophenoxyacetic acid in aqueous solution

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Journal of Environmental Sciences 2008年第9期20卷 1138-1145页

作者： GIRI Rabindra Raj OZAKI Hiroaki TAKANAMI Ryohei TANIGUCHI shogo New Industrial R & D Center Osaka Sangyo University Department of Civil Engineering Osaka Sangyo University

More efficient oxidation methods are needed to degrade especially newly emerging recalcitrant organic contaminants at low concentrations in the water environment. Reduced photonic efficiency of immobilized TiO2 is a major challenge in TiO2-assisted advanced oxidation processes (AOP). Mineralization of 2,4-dichllorophenoxyacetic acid (2,4-D) in low aqueous solution by O3/UV/TiO2 using the world’s first high-strength TiO2 fiber was investigated and compared with O3, UV/TiO2, and O3/TiO2 in laboratory batch ex...

关键词： dechlorination degradation intermediates radicals TiO2 total organic carbon (TOC)

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