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益气养阴通络汤联合贝那普利治疗糖尿病肾病疗效及对血清TGF-β1、VEGF指标影响

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中华中医药学刊 2024年第3期42卷 238-242页

作者：陈仕银胡朋海口市人民医院中医科海南海口570000

目的探讨益气养阴通络汤联合贝那普利治疗糖尿病肾病(diabetic nephropathy,DN)的疗效及对转化生长因子-β_(1)(transforming growth factor-β_(1),TGF-β_(1)),血管内皮生长因子(vascular endothelial growth factor,VEGF)影响。方法选取2019年10月—2021年10月医院收治的DN病人94例,随机分为对照组(n=48)和观察组(n=46)。入院后两组病人均实施生活方式相关的指导,包括体质量控制、运动、戒烟酒等,给予脂质的代谢紊乱相关纠正、血糖控制、血压等基础的治疗,对照组实施盐酸贝那普利片的口服治疗,观察组则在此基础上实施益气养阴通络汤治疗,两组持续治疗4周。对比两组临床疗效、尿微量白蛋白(microalbumin,mALB)、尿白蛋白肌酐比(urine albumin creatine ratio,UACR)、β_(2)微球蛋白(β_(2)-microglobulin,β_(2)-MG)水平、中医证候评分、血清同型半胱氨酸(homocysteine,Hcy)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-6(Interleukin-6,IL-6)、血清TGF-β_(1)和VEGF及空腹血糖(fasting plasma glucose/fasting blood glucose,FPG)、餐后2 h血糖(2 hour postprandial blood glucose,2 h PG)和糖化血红蛋白(glyeosylated hemoglobin,HbAlc)指标变化。结果治疗前两组mALB、UACR、β_(2)-MG指标间无统计学意义(P>0.05);治疗后两组mALB、UACR、β_(2)-MG指标较治疗前显著降低(P<0.05);并且观察组降低较明显(P<0.05);观察组治疗总有效率较对照组明显较高(P<0.05);治疗后两组主症评分、次症评分和中医证候总评分明显降低(P<0.05);且观察组降低较明显(P<0.05);治疗后两组血清Hcy、TNF-α、IL-6指标明显降低(P<0.05);且观察组降低较明显(P<0.05);治疗后两组血清TGF-β_(1)和VEGF指标较治疗前明显降低(P<0.05);且观察组降低较明显(P<0.05);治疗后两组FPG、2 h PG和HbAlc指标较治疗前明显降低(P<0.05);且观察组降低较明显(P<0.05)。结论采用益气养阴通络汤联合贝那普利治疗DN具有较好的临床疗效,可降低血清TGF-β_(1),VEGF指标,降低蛋白尿水平。

关键词：益气养阴通络汤贝那普利糖尿病肾病临床疗效血清TGF-β1 VEGF

陈氏黑药膏联合五神汤治疗急性期下肢丹毒的临床观察及对炎症因子的影响

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四川中医 2024年第5期42卷 155-159页

作者：王臬陈诗吟张洁上海市中医医院治未病科上海200071 上海市中医医院中医外科上海200071 上海市中医医院中医特色诊疗中心上海200071

目的:观察陈氏黑药膏联合五神汤治疗急性期下肢丹毒的临床观察及对炎症因子的影响。方法:选择2021年2月~2023年2月在上海市中医医院治未病科接受治疗的85例丹毒患者,采用随机数表法分为试验组(n=43)和对照组(n=42)。两组均基础给予阿莫... 详细信息

目的:观察陈氏黑药膏联合五神汤治疗急性期下肢丹毒的临床观察及对炎症因子的影响。方法:选择2021年2月~2023年2月在上海市中医医院治未病科接受治疗的85例丹毒患者,采用随机数表法分为试验组(n=43)和对照组(n=42)。两组均基础给予阿莫西林胶囊及五神汤口服,对照组给予金黄膏治疗,试验组给予陈氏黑药膏治疗。1周为1疗程,比较两组临床疗效、白细胞计数(WBC)、中性粒细胞百分比(N%)、C反应蛋白(CRP)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)、下肢外周径差、红肿范围、中医证候积分。结果:试验组治愈7例,显效23例,有效11例,无效2例,痊愈率16.28%,痊愈显效率69.77%,总有效率95.34%;对照组治愈3例,显效11例,有效21例,无效7例,痊愈率7.14%,痊愈显效率33.33%,总有效率83.33%。两组比较,试验组痊愈显效率明显优于对照组(P0.05);治疗后,两组白细胞计数、CRP、IL-6、TNF-α均下降,试验组降低效果显著优于对照组(P0.05),但试验组下降趋势较对照组明显;试验组与对照组均能缩小患者红斑面积,试验组疗效显著优于对照组(P<0.01);两组均能改善中医证候积分,试验组疗效显著优于对照组(P<0.01);治疗期间,对照组不良反应主要有皮疹瘙痒、恶心呕吐、胃肠道不适;试验组不良反应主要有恶心呕吐、胃肠道不适,两组不良反应发生情况比较有统计学意义(P<0.05),试验组不良反应明显少于对照组。结论:在丹毒中应用陈氏黑药膏联合五神汤治疗效果显著,可能与其可有效改善CRP、IL-6及TNF-α水平有关。

关键词：陈氏黑药膏五神汤丹毒 C反应蛋白白细胞介素6 肿瘤坏死因子α

陈氏清肝解毒汤治疗肝经郁热型带状疱疹临床观察

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四川中医 2024年第6期42卷 174-177页

作者：王臬蔡惠群陈诗吟张洁上海市中医医院治未病科上海200071 上海市中医医院中医外科上海200071 上海市中医医院中医特色诊疗中心上海200071

目的:观察陈氏清肝解毒汤治疗肝经郁热型带状疱疹的临床效果。方法:选择上海市中医医院治未病科2020年1月~2022年12月带状疱疹患者75例进行研究,随机将其分为两组,其中对照组(n=37)接受盐酸伐昔洛韦片+甲钴胺片+炉甘石洗剂治疗,治疗组(n... 详细信息

目的:观察陈氏清肝解毒汤治疗肝经郁热型带状疱疹的临床效果。方法:选择上海市中医医院治未病科2020年1月~2022年12月带状疱疹患者75例进行研究,随机将其分为两组,其中对照组(n=37)接受盐酸伐昔洛韦片+甲钴胺片+炉甘石洗剂治疗,治疗组(n=38)加用陈氏清肝解毒汤,均实施为期10d治疗。观察两组10d治疗结束后的临床治疗效果;对比治疗前后的症状量化评分;对比治疗前,治疗后3d, 7d, 10d疼痛情况(VAS)评分;对比水疱停止增加时间、病灶结痂时间和脱痂时间;对比治疗前后血清水痘-带状疱疹病毒IgM抗体(VZV-IgM);对比不良反应情况;对比治疗后3个月带状疱疹后遗神经痛(PHN)的发生率。结果:治疗组10d治疗结束后临床疗效总有效率为90.32%,且高于对照组80.00%(P0.05)。治疗组治疗后3个月PHN发生率低于对照组(P<0.05)。结论:陈氏清肝解毒汤加入西药治疗后,不仅能有效改善肝经郁热型带状疱疹患者临床疗效,同时对病程缩短、疼痛减轻及减少PHN发生均有积极作用。

关键词：陈氏清肝解毒汤带状疱疹肝经郁热中医外科

工业地价与制造业FDI的时空演变与影响机制研究--基于广东城市面板数据分析

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自然资源情报 2024年第4期 57-64页

作者：谢巧巧孙伟杰谭春婵陈哲华陈诗茵广东省土地调查规划院广东广州510075 广东中地土地房地产评估与规划设计有限公司广东广州510399

本文运用中国土地市场网供地结果数据,以及广东省、有关城市统计年鉴数据,采用泰尔指数、莫兰指数与计量回归模型等方法,对2008-2020年广东工业地价与制造业FDI的时空演变与影响机制进行探索研究。研究表明,广东省工业地价与制造业FDI... 详细信息

本文运用中国土地市场网供地结果数据,以及广东省、有关城市统计年鉴数据,采用泰尔指数、莫兰指数与计量回归模型等方法,对2008-2020年广东工业地价与制造业FDI的时空演变与影响机制进行探索研究。研究表明,广东省工业地价与制造业FDI的对应关系经历了显著负相关、同步增长正相关、同步下降正相关三个阶段;广东省工业地价整体上涨,城市间差异由小变大,空间聚集程度较低;制造业FDI规模整体减少,城市间差异先增大后缩小,空间分布显著正相关,空间聚集程度相对较高;工业地价的上涨对制造业FDI具有一定负向影响,但这种影响并不普遍。最后,从实施多元化的土地供应政策与差异化的外商引资政策两方面提出了建议。

关键词：工业地价制造业FDI 对外开放高质量发展广东省

Analysis of the Spatio-temporal Differentiation of Cultivated Land Pressure in the Pearl River-Xijiang Economic Zone and Its Influencing Factors

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Journal of Resources and Ecology 2022年第3期13卷 407-416页

作者： chen shiyin WU Xuebiao MA Zhiyu BIN Jinyou Management College of Guangdong Ocean University ZhanjiangGuangdong 524088China Guangdong Coastal Economic Belt Development Research Institute ZhanjiangGuangdong 524088China

Cultivated land pressure is often used to reflect the shortage of cultivated land resources. By using the methods of the Cultivated Land Pressure Index, coefficient of variation and cold-hot spot analysis, this paper analyzes the spatial-temporal differentiation pattern and dynamic change processes of cultivated land pressure in the counties of the Pearl River-Xijiang Economic Zone from 2008 to 2017, and measures the factors which influence cultivated land pressure by using Principal Component Analysis. The results show that the cultivated land pressure in the Pearl River-Xijiang Economic Zone has been in a “high pressure” state, and the Cultivated Land Pressure Index has been rising continuously from 2008 to 2017. The coefficient of variation of the Cultivated Land Pressure Index in the Pearl River-Xijiang Economic Zone and various prefecture-level cities is fluctuating and rising, which indicates that the overall spatial differences in the cultivated land pressure in this region are expanding and polarization is obvious. In addition, the area where the municipal district of the provincial capital city is located is the core area of urban development and also the area with the greatest cultivated land pressure. The spatial pattern of cultivated land pressure cold-hot spots in the Pearl River-Xijiang Economic Zone is obviously heterogeneous, in which the Pearl River Economic Zone is the main hot spot gathering area and the Xijiang Economic Zone is the main cold spot gathering area. Farmers’ income, investment in fixed assets, GDP, population and other socio-economic factors are the main factors driving the changes in the cultivated land pressure in the Pearl River-Xijiang Economic Zone. Furthermore, farming production factors, such as the multiple cropping index and grain yield per unit area,will also have an important impact on the changes in the cultivated land pressure.

关键词： cultivated land pressure spatial-temporal differentiation influencing factors cold-hot spot analysis Pearl River-Xijiang Economic Zone

Super-enhancer receives signals from the extracellular matrix to induce PD-L1-mediated immune evasion via integrin/ BRAF/TAK1/ERK/ETV4 signaling

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Cancer Biology & Medicine 2022年第5期19卷 669-684页

作者： Panpan Ma Xinxin Jin Zhiwei Fan Zhou Wang Suhui Yue Changyue Wu shiyin chen Yuanyuan Wu Miaomiao chen Donghua Gu Siliang Zhang Renfang Mao Yihui Fan Laboratory of Medical Science School of MedicineNantong UniversityNantong 226001China Department of Pathogenic Biology School of MedicineNantong UniversityNantong 226001China Department of Clinical Laboratory Yancheng No.1 People’s HospitalYancheng 224005China School of Life Sciences Nantong UniversityNantong 226001China Department of Dermatology Affiliated Hospital of Nantong UniversityNantong UniversityNantong 226001China The Department of Urology the Second Affiliated Hospital of Nantong UniversityNantong UniversityNantong 226001China The Department of Radiotherapy Oncology Harbin Medical University Cancer HospitalHarbin 150086China Department of Pathophysiology School of MedicineNantong UniversityNantong 226001China

Objective:PD-L1 and PD-L2 expression levels determine immune evasion and the therapeutic efficacy of immune checkpoint *** factors that drive inducible PD-L1 expression have been extensively studied,but mechanisms that result in constitutive PD-L1 expression in cancer cells are largely ***:DNA elements were deleted in cells by CRISPR/Cas9-mediated *** function was inhibited by chemical *** levels were examined by Western blot,mRNA levels were examined by real-time RT-PCR,and surface protein expression was determined by cellular immunofluorescence and flow *** evasion was examined by in vitro T cell-mediated ***:We determined the core regions(chr9:5,496,378–5,499,663)of a previously identified PD-L1L2-super-enhancer(SE).Through systematic analysis,we found that the E26 transformation-specific(ETS)variant transcription factor(ETV4)bound to this core DNA region but not to DNA surrounding *** knockout of ETV4 dramatically reduced the expressions of both PD-L1 and ***4 transcription was dependent on ERK activation,and BRAF/TAK1-induced ERK activation was dependent on extracellular signaling fromαvβ3 integrin,which profoundly affected ETV4 transcription and PD-L1/L2 *** silencing or pharmacological inhibition of components of the PD-L1L2-SE-associated pathway rendered cancer cells susceptible to T cell-mediated ***:We identified a pathway originating from the extracellular matrix that signaled via integrin/BRAF/TAK1/ERK/ETV4 to PD-L1L2-SE to induce PD-L1-mediated immune *** results provided new insights into PD-L1L2-SE activation and pathways associated with immune checkpoint regulation in cancer.

关键词： PD-L1 super-enhancer ETV4 ERK αvβ3 integrin BRAF TAK1

Remodeling the tumor immune microenvironment via siRNA therapy for precision cancer treatment

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Asian Journal of Pharmaceutical Sciences 2023年第5期18卷 51-76页

作者： Lingxi Jiang Yao Qi Lei Yang Yangbao Miao Weiming Ren Hongmei Liu Yi Huang Shan Huang shiyin chen Yi Shi Lulu Cai Department of Pharmacy Personalized Drug Therapy Key Laboratory of Sichuan ProvinceSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610072China Sichuan Provincial Key Laboratory for Human Disease Gene Study and Department of Laboratory Medicine Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Health Management Center Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences(2019RU026) Sichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalChengdu 610072China Department of Pharmacy Jianyang People’s Hospital of Sichuan ProvinceJianyang 641400China

How to effectively transform the pro-oncogenic tumor microenvironments(TME)surrounding a tumor into an anti-tumoral never fails to attract people to *** interfering RNA(siRNA)is considered one of the most noteworthy research directions that can regulate gene expression following a process known as RNA interference(RNAi).The research about siRNA delivery targeting tumor cells and TME has been on the rise in recent *** siRNA drugs to silence critical proteins in TME was one of the most efficient ***,the manufacture of a siRNA delivery system faces three major obstacles,i.e.,appropriate cargo protection,accurately targeted delivery,and site-specific cargo *** the following review,we summarized the pharmacological actions of siRNA drugs in remolding *** addition,the delivery strategies of siRNA drugs and combination therapy with siRNA drugs to remodel TME are thoroughly *** the meanwhile,the most recent advancements in the development of all clinically investigated and commercialized siRNA delivery technologies are also ***,we propose that nanoparticle drug delivery siRNA may be the future research focus of oncogene *** summary offers a thorough analysis and roadmap for general readers working in the field.

关键词： Small interfering RNA Tumor microenvironment siRNA delivery Cancer therapy Co-delivery

明代书信数字化研究的新尝试——以哈佛大学CSA明代书信计划为例

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图书馆论坛 2023年第12期43卷 186-192页

作者：陈士银扬州大学社会发展学院历史系哈佛大学

基于社会关系网络数据众包平台CSA以及中国历代人物传记资料库CBDB的明代书信计划是通过书信作者、收信人、书信名称及其所属文集进行检索的数据平台。自2020年成立以来,该平台已收录1,650位明代人物超过52,399封书信信息,另有约5万封... 详细信息

基于社会关系网络数据众包平台CSA以及中国历代人物传记资料库CBDB的明代书信计划是通过书信作者、收信人、书信名称及其所属文集进行检索的数据平台。自2020年成立以来,该平台已收录1,650位明代人物超过52,399封书信信息,另有约5万封书信信息待收录。通过整理书信往来人物,建立与CBDB数据库的关联,可以批量利用这些书信探索相关人物的身份信息,包括姓名、别名、籍贯、入仕、官名、著述、亲属关系与社交网络等,丰富对明代历史人物及其社会关系的研究。

关键词：明代书信数字化明代书信计划中国历代人物传记资料库

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Temporal and Spatial Characteristics and Optimization of the Intensive Use of Cultivated Land in Maoming City

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Journal of Resources and Ecology 2020年第6期11卷 598-605页

作者： chen shiyin MA Zhiyu Management College of Guangdong Ocean University ZhanjiangGuangdong 524088China

Improving the level of intensive cultivated land use is an important measure to ensure food security and promote the sustainable development of the regional society and *** on data from the statistical yearbook of Maoming City and its counties and districts from 2005 to 2018 and the land use change database of Maoming City for 2018,this study constructed an evaluation index system for four aspects:cultivated land use intensity,cultivated land use degree,cultivated land output benefit and cultivated land sustainable use *** level of intensive use of cultivated land in Maoming City from 2004 to 2017 was evaluated by AHP,the range method and the comprehensive evaluation model,and its temporal and spatial characteristics were *** results revealed three major points.(1)The intensive use of cultivated land in Maoming City in the past 14 years was good,and its level showed an overall upward trend,with the intensive use degree of cultivated land rising from 0.4045 in 2004 to 1.3148 in 2017.(2)The levels of intensive use of cultivated land in each county and district of Maoming City were generally on the rise,with no significant differences between ***,according to the regional distribution,the intensive use level of cultivated land was highest in Maonan District,while it was relatively low in Dianbai *** largest increase in the level of cultivated land intensive use was in Gaozhou,and the smallest was in Dianbai County.(3)According to the existing problems of cultivated land utilization in Maoming City,combined with the current international and domestic measures to effectively improve the level of intensive use of cultivated land,four suggestions are put forward:to improve the efficiency of cultivated land utilization and effectively protect basic farmland;to improve the overall urban planning and rationally adjust the layout of construction land;to raise farmers’awareness of the intensive use of cultivated land;and to increase ag

关键词： cultivated land intensive use temporal and spatial variation characteristics Maoming City