Remodeling the tumor immune microenvironment via siRNA therapy for precision cancer treatment

作     者：Lingxi Jiang Yao Qi Lei Yang Yangbao Miao Weiming Ren Hongmei Liu Yi Huang Shan Huang Shiyin Chen Yi Shi Lulu Cai Lingxi Jiang;Yao Qi;Lei Yang;Yangbao Miao;Weiming Ren;Hongmei Liu;Yi Huang;Shan Huang;Shiyin Chen;Yi Shi;Lulu Cai

作者机构：Department of PharmacyPersonalized Drug Therapy Key Laboratory of Sichuan ProvinceSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610072China Sichuan Provincial Key Laboratory for Human Disease Gene Study and Department of Laboratory MedicineSichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Health Management CenterSichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences(2019RU026)Sichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalChengdu 610072China Department of PharmacyJianyang People’s Hospital of Sichuan ProvinceJianyang 641400China 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2023年第18卷第5期

页      面：51-76页

核心收录：

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the Natural Science Foundation of China(U2230123,81870683,82121003 and 82201234) CAMS Innovation Fund for Medical Sciences(2019-I2M-5-032) the Department of Science and Technology of Sichuan Province,China(22ZYZYTS0159,2022YFS0606,2023YFS0125,2023YFS0131,2023NSFSC0033,and 22ZYZYTS0151) 

主　　题：Small interfering RNA Tumor microenvironment siRNA delivery Cancer therapy Co-delivery 

摘      要：How to effectively transform the pro-oncogenic tumor microenvironments(TME)surrounding a tumor into an anti-tumoral never fails to attract people to *** interfering RNA(siRNA)is considered one of the most noteworthy research directions that can regulate gene expression following a process known as RNA interference(RNAi).The research about siRNA delivery targeting tumor cells and TME has been on the rise in recent *** siRNA drugs to silence critical proteins in TME was one of the most efficient ***,the manufacture of a siRNA delivery system faces three major obstacles,i.e.,appropriate cargo protection,accurately targeted delivery,and site-specific cargo *** the following review,we summarized the pharmacological actions of siRNA drugs in remolding *** addition,the delivery strategies of siRNA drugs and combination therapy with siRNA drugs to remodel TME are thoroughly *** the meanwhile,the most recent advancements in the development of all clinically investigated and commercialized siRNA delivery technologies are also ***,we propose that nanoparticle drug delivery siRNA may be the future research focus of oncogene *** summary offers a thorough analysis and roadmap for general readers working in the field.