检索结果-南通市图书馆

A novel technique using hydrophilic polymers to promote axonal fusion

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2016年第4期11卷 525-528页

作者： Ravinder Bamba D.Colton Riley nathaniel D.Kelm Mark D.Does Richard D.Dortch Wesley P.Thayer Department of Plastic Surgery Vanderbilt University Medical Center Nashville TN USA Department of Surgery Georgetown University Washington DC USA Georgetown University School of Medicine Washington DC USA Vanderbilt University Institute of Imaging Science Nashville TN USA Department of Radiology and Radiological Sciences Vanderbilt University Nashville TN USA

The management of traumatic peripheral nerve injury remains a considerable concern for *** minimal innovations in surgical technique and a limited number of specialists trained to treat peripheral nerve injury,outcomes of surgical intervention have been *** inability to manipulate the pathophysiology of nerve injury（i.e.,Wallerian degeneration） has left scientists and clinicians depending on the slow and lengthy process of axonal regeneration（-1 mm/day）.When axons are severed,the endings undergo calcium-mediated plasmalemmal sealing,which limits the ability of the axon to be primarily *** glycol（PEG） in combination with a bioengineered process overcomes the inability to fuse *** mechanism for PEG axonal fusion is not clearly understood,but multiple studies have shown that a providing a calcium-free environment is essential to the process known as PEG *** proposed mechanism is PEG-induced lipid bilayer fusion by removing the hydration barrier surrounding the axolemma and reducing the activation energy required for membrane fusion to *** review highlights PEG fusion,its past and current studies,and future directions in PEG fusion.

关键词： peripheral nerve injury polyethylene glycol axonal fusion nerve transection traumatic neuropathy

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

亚洲城市进一步发展和扩张的规划和管理

建筑学报 2006年第9期 13-16页

作者： nathaniel von Einsiedel 城市合作基金会

引言亚太地区的城市化是当今世界面临的一个主要问题.如何应对这一城市化浪潮,不仅仅会对该地区,而且将对全世界的未来发展产生重大影响.我们在未来几年采取的措施,将会对未来的发展产生重大的杠杆效应和深远的影响.因此,现在就应该制... 详细信息

引言亚太地区的城市化是当今世界面临的一个主要问题.如何应对这一城市化浪潮,不仅仅会对该地区,而且将对全世界的未来发展产生重大影响.我们在未来几年采取的措施,将会对未来的发展产生重大的杠杆效应和深远的影响.因此,现在就应该制定适当的政策和方法,同时随着环境的改变不断作出更正,以引导那些关键参与者共同塑造亚洲的都市区域,这一点很重要.本文考察了亚太地区在城市化进程中遇到的一些关键挑战和问题,并为一些关键问题,特别是未来城市发展和扩张以及市内老城区的重注生机给出了一些政策提示.此外,本文还就这些问题的解决,提出了一些工具和方法建议.

关键词：城市化亚洲管理规划扩张亚太地区杠杆效应都市区

Can bedside needle arthroscopy of the ankle be an accurate option for intra-articular delivery of injectable agents?

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2022年第1期13卷 78-86页

作者： Tobias Stornebrink Sjoerd A S Stufkens nathaniel P Mercer John G Kennedy Gino M M J Kerkhoffs Department of Orthopedic Surgery Amsterdam UMCUniversity of AmsterdamAmsterdam Movement SciencesAmsterdam 1105AZNetherlands Academic Center for Evidence based Sports Medicine Amsterdam 1105AZNetherlands Amsterdam Collaboration for Health and Safety in Sports International Olympic Committee Research Center Amsterdam UMCAmsterdam 1105AZNetherlands Department of Orthopedic Surgery NYU Langone HealthNew YorkNY 10010United States

BACKGROUND Bedside needle arthroscopy of the ankle under local anesthesia has been proposed for intra-articular delivery of injectable *** and tolerability of this approach in the clinical setting–including patients with end-stage ankle pathology and/or a history of prior surgery–is not *** To assess clinical accuracy and tolerability of bedside needle arthroscopy as a delivery system for injectable agents into the tibiotalar *** This was a prospective study that included adult patients who were scheduled for an injection with hyaluronic acid to the tibiotalar *** our center,these injections are used as a last resort prior to extensive *** primary outcome was injection accuracy,which was defined as injecting through the arthroscopic cannula with intra-articular positioning confirmed by a clear arthroscopic view of the joint *** outcome measures included a patientreported numeric rating scale(NRS,0-10)of pain during the procedure and willingness of patients to return for the same *** of ankle pain at rest and during walking was collected at baseline and at 2-wk *** were monitored from inclusion up to a 2-wk control *** We performed 24 ***(46%)participants were male,and mean age was 46.8±14.5 *** was the indication for injection in 20(83%)cases,of which 8(33%)patients suffered from osteoarthritis Kellgren-Lawrence grade IV,and 10(42%)patients from Kellgren-Lawrence grade *** osteochondral defect was the indication for injection in 4(17%)cases.A history of ankle surgery was present in 14(58%)participants and a history of multiple ankle surgeries in 11(46%)*** was possible to confirm accuracy in 21(88%)*** 3(12%)participants where needle arthroscopy did not reach a clear view of the joint space all suffered from Kellgren-Lawrence grade IV *** during the procedure was reported with a median of 1[i

关键词： Ankle arthroscopy NanoScope Needle arthroscopy Injections Proof of concept Patient experience

Albumin-linked prostate-specific antigen-activated thapsigargin- and niclosamide-based molecular grenades targeting the microenvironment in metastatic castration-resistant prostate cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Urology 2019年第1期6卷 99-108页

作者： Emmanuel S.Akinboye W.nathaniel Brennen Samuel R.Denmeade John T.Isaacs Department of Oncology Prostate Cancer ProgramThe Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsThe Johns Hopkins University School of MedicineBaltimoreMDUSA

Localized prostate cancer is curable via annihilation of the entire cancer neighborhood by surgery or local ***,once metastatic,no available therapy is *** vast majority will die despite aggressive systemic combinational androgenablation ***,there is an urgent need for effective systemic therapeutics that sterilize the entire microenvironment in metastatic castration-resistant prostate cancer(mCRPC).To accomplish this goal,advantage can be taken of the unique biology of mCRPC *** their normal cell of origin,mCRPCs retain expression of the prostate-specific differentiation protein,prostate-specific antigen(PSA),which they abundantly secrete into their extracellular fluid(ECF).This unique,and essentially universal,secretion of enzymatically active PSA into the ECF by mCRPCs creates an exploitable therapeutic index for activation of systemically delivered highly lipophilic toxins as“molecular grenades”covalently linked to cysteine-34 of human serum albumin(HSA)via a stable maleimide containing PSA cleavable peptide such that PSA-dependent hydrolysis(i.e.,“detonation”)releases the grenades restrictively within the ECF of *** approach decreases dose-limiting host toxicity while enhancing plasma half-life from minutes to days(i.e.,pharmacokinetic effect)and increasing the tissue concentration of the maleimide coupled albumin delivery(MAD)in the ECF at sites of cancer due to the enhanced permeability of albumin at these sites(i.e.,enhanced permeability and retention effect).This allows the MAD-PSA detonated grenades to circulate throughout the body in a non-toxic *** within sites of mCRPC is there a sufficiently high level of enzymatically active PSA to efficiently“pull the pin”on the grenades releasing their lipophilic cellpenetrant toxins from ***,if a sufficient level of“detonation”occurs,this will kill mCRPC cells,and sterilize the entire PSA-rich metastatic sites via a bystander *** this review,two

关键词： Albumin-linked prodrug Maleimide coupled albumin delivery Thapsigargin Niclosamide

Five years of fecal microbiota transplantation-an update of the Israeli experience

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2018年第47期24卷 5403-5414页

作者： Sharon A Greenberg Ilan Youngster nathaniel A Cohen Dan M Livovsky Jacob Strahilevitz Eran Israeli Ehud Melzer Kalman Paz Naomi Fliss-Isakov Nitsan Maharshak Department of Gastroenterology and Liver Diseases Tel Aviv Sourasky Medical Centeraffiliated with the Sackler Faculty of MedicineTel Aviv UniversityTel Aviv 6423906Israel Bacteriotherapy Clinic Tel Aviv Sourasky Medical Centeraffiliated with the Sackler Faculty of MedicineTel Aviv UniversityTel Aviv 6423906Israel Assaf Harofe Medical Center Zerifin 70300Israel Digestive Diseases Institute Shaare Zedek Medical CenterJerusalem 91031Israel Department of Clinical Microbiology and Infectious Diseases Hadassah-Hebrew UniversityJerusalem 91120Israel Department of Gastroenterology and Liver Diseases Hadassah-Hebrew UniversityJerusalem 91120Israel Gastrointestinal and Liver Diseases Institute Kaplan Medical CenterRehovot 76100Israel

AIM To evaluate and describe the efficacy of fecal microbiota transplantation(FMT) for Clostridium difficile infection(CDI) in a national Israeli *** All patients who received FMT for recurrent(recurrence within 8 wk of the previous treatment) or refractory CDI from 2013 through 2017 in all the five medical centers in Israel currently performing FMT were included. Stool donors were screened according to the Israeli Ministry of Health guidelines. Clinical and laboratory data of patients were collected from patients' medical files, and they included indications for FMT, risk factors for CDI and disease severity. Primary outcome was FMT success(at least 2 mo free of CDI-related diarrhea post-FMT). Secondary outcomes included initial response to FMT(cessation of diarrhea within 7 d) and recurrence at 6 *** There were 111 FMTs for CDI, with a median age of 70 years [interquartile range(IQR): 53-82], and 42%(47) males. Fifty patients(45%) were treated via the lower gastrointestinal(LGI, represented only by colonoscopy) route, 37(33%) via capsules, and 24(22%) via the upper gastrointestinal(UGI) route. The overall success rate was 87.4%(97 patients), with no significant difference between routes of administration(P = 0.338). In the univariant analysis, FMT success correlated with milder disease(P = 0.01), ambulatory setting(P < 0.05) and lower Charlson comorbidity score(P < 0.05). In the multivariant analysis, only severe CDI [odd ratio(OR) = 0.14, P < 0.05] and inpatient FMT(OR = 0.19, P < 0.05) were each independently inversely related to FMT success. There were 35(32%) patients younger than 60 years of age, and 14(40%) of them had a background of inflammatory bowel *** FMT is a safe and effective treatment for CDI, with capsules emerging as a successful and well-tolerated route. Severe CDI is less likely to respond to FMT.

关键词： Clostridium difficile infection Capsules Israel Fecal microbiota transplantation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

红字 5

丛书名：书虫·牛津英汉双语读物

2014年

作者： (美) nathaniel Hawthorne

本书讲述的是一出发生在北美殖民时期的恋爱悲剧。通过女人公海丝特·白兰的悲惨遭遇，反映了清教徒殖民统治的黑暗、残酷和教会的虚伪、凶恶。

ISBN: (纸本)9787513544726

本书讲述的是一出发生在北美殖民时期的恋爱悲剧。通过女人公海丝特·白兰的悲惨遭遇，反映了清教徒殖民统治的黑暗、残酷和教会的虚伪、凶恶。

关键词：长篇小说汉语英语

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

美国霸权战略视角下的对华政策

美国霸权战略视角下的对华政策

作者： Johns nathaniel Paul 华东师范大学

学位级别：硕士

本文考察了冷战结束后美国对中国的大战略前景,解释了在克林顿、小布什、奥巴马和特朗普执政的30年间,美国的大战略是如何实现从优先考虑遏制前苏联到成为全球主导地位之一的转变的。此外,本文认为美国政府行政部门在外交决策中的作用... 详细信息

本文考察了冷战结束后美国对中国的大战略前景,解释了在克林顿、小布什、奥巴马和特朗普执政的30年间,美国的大战略是如何实现从优先考虑遏制前苏联到成为全球主导地位之一的转变的。此外,本文认为美国政府行政部门在外交决策中的作用往往被过分强调,尤其是在特朗普执政时期。为了解释美国对华大战略变化的方式和原因,本论文将使用美国国防部2002年—2020年发布的年度中国军事报告的数据,以及华盛顿内部人士制定的非保密的外交政策制定程序进行文本分析。本文研究认为,美国对华大战略的前景已经转变为将中国视为战略竞争对手,但因受到一系列复杂因素的制约,两者的冲突更可能发生在非传统领域和非军事领域。

关键词：主导大战略中美关系中国美国战略竞争国防外交政策文本分析

Geological Exploration of Marble Deposits in Toto Area, Nasarawa State, Nigeria

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

Natural Resources 2016年第2期7卷 83-92页

作者： Ali Moumouni nathaniel Goeter Goki Mohammed Suleiman Chaanda Université Dandicko Dankoulodo de Maradi Maradi Niger Nasarawa State University Keffi Nigeria School of Geography Earth and Environmental Sciences University of Plymouth Plymouth UK

Geological mapping as well as chemical analysis for marble deposit in the Muro-Obugu-Panda area of Toto Local Government, Nasarawa State, Nigeria, was carried out. The objectives of the study are to first map out the extent of the deposit and then evaluate its chemical characteristics. The geology of the area forms part of the Upper Proterozoic low-grade (green schist facies) schist belts of Central Nigeria, and consists of schists, banded iron, quartzite, and marble. Geological mapping revealed that the marble deposit stretches in a NE-SW direction, from Muro in the north to Kolo in the south, covering about 28 km2. This deposit consists mainly of silicified gray and white varieties of marble. The mapping also identified three (3) exploration targets A—Panda, B—Obugu, and C— Soka. Chemical analysis of eight (8) selected samples shows that CaO content varies from 3.72 to 53.12 wt%. Other impurities are Fe2O3, Al2O3, MgO and SiO2. Plot of Na2O + K2O vs. SiO2 shows a positive correlation while that of CaO and MgO exhibits a well defined negative correlation with SiO2 and this reflects the introduction of chert during the deposition of the parent limestone of the marble body. The variation plot of CaO vs. MgO shows an inverse relationship. This is reflected in the inverse relationship in the proportion of calcite to dolomite in the marble. All these results correlate with those found in the adjacent area by previous workers and this indicates the same extension of marble in these areas. The Muro marble can be used economically as raw materials for a variety of products such as fillers, glass, papers, lime, pesticide and sewage treatment, decorative construction, monuments, paint making and most of all very suitable for cement production.

关键词： Marble Muro Obugu Panda-Toto Geochemistry

Environmental and Cost Advantages of Using Polyethylene Terephthalate Fibre Reinforced Concrete with Fly Ash as a Partial Cement Replacement

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Civil Engineering 2019年第4期9卷 281-290页

作者： Rebecca Belay Kassa Christopher Kanali nathaniel Ambassah Department of Civil Engineering Pan African University Institute for Basic Sciences Technology and Innovation (PAUSTI) Nairobi Kenya Department of Agricultural and Biosystems Engineering Jomo Kenyatta University of Agriculture & Technology (JKUAT) Nairobi Kenya Department of Civil Engineering Jomo Kenyatta University of Agriculture & Technology (JKUAT) Nairobi Kenya

Solid waste disposal is an alarming problem in most African countries. Plastic wastes like Polyethylene Terephthalate (PET) bottles and powdered wastes like fly ash are severely persisting environmental hazards. They are brutally polluting the water bodies, landfills, as well as the atmosphere. The construction industry has been working towards improving concrete quality by developing alternative methods like partial cement replacement with different pozzolanic elements as well as using waste fibrous materials. Fly ash and PET bottle fibres are two common waste materials that can be used. This article is a part of a research that studied the combined effects of the addition of PET bottle fibres and fly ash (as a partial cement replacement) on the structural performance of concrete. From a purely engineering point of view, the research results indicate that the utilization and incorporation of PET and fly ash wastes in the construction industry are a viable solution to make concrete quality better. This article presents, beyond the engineering properties and experimental works, the economic and environmental advantages of the addition of these waste materials to the conventional concrete mixture. The addition of PET bottle fibres and fly ash resulted in positive cost implications providing a production cost reduction of 19% over the conventional concrete mixture. The removal of these materials from the environment also showed reduction of the emission of toxic elements to landfills and water bodies that put human, animal and plant lives in danger.

关键词： Concrete PET Fly Ash Cost Environment Pollution Landfill