A novel technique using hydrophilic polymers to promote axonal fusion

作     者：Ravinder Bamba D.Colton Riley Nathaniel D.Kelm Mark D.Does Richard D.Dortch Wesley P.Thayer 

作者机构：Department of Plastic Surgery Vanderbilt University Medical Center Nashville TN USA Department of Surgery Georgetown University Washington DC USA Georgetown University School of Medicine Washington DC USA Vanderbilt University Institute of Imaging Science Nashville TN USA Department of Radiology and Radiological Sciences Vanderbilt University Nashville TN USA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2016年第11卷第4期

页      面：525-528页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by the Department of Defense:Grant Number OR120216--Development of Class Ⅱ Medical Device for Clinical Translation of a Novel PEG Fusion Method for Immediate Physiological Recovery after Peripheral Nerve Injury 

主　　题：peripheral nerve injury polyethylene glycol axonal fusion nerve transection traumatic neuropathy 

摘      要：The management of traumatic peripheral nerve injury remains a considerable concern for *** minimal innovations in surgical technique and a limited number of specialists trained to treat peripheral nerve injury,outcomes of surgical intervention have been *** inability to manipulate the pathophysiology of nerve injury（i.e.,Wallerian degeneration） has left scientists and clinicians depending on the slow and lengthy process of axonal regeneration（-1 mm/day）.When axons are severed,the endings undergo calcium-mediated plasmalemmal sealing,which limits the ability of the axon to be primarily *** glycol（PEG） in combination with a bioengineered process overcomes the inability to fuse *** mechanism for PEG axonal fusion is not clearly understood,but multiple studies have shown that a providing a calcium-free environment is essential to the process known as PEG *** proposed mechanism is PEG-induced lipid bilayer fusion by removing the hydration barrier surrounding the axolemma and reducing the activation energy required for membrane fusion to *** review highlights PEG fusion,its past and current studies,and future directions in PEG fusion.