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Impacts of Nutlin-3a and exercise on murine double minute 2-enriched glioma treatment

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Neural Regeneration Research 2025年第4期20卷 1135-1152页

作者： Yisheng Chen Zhongcheng Fan Zhiwen Luo Xueran Kang Renwen Wan Fangqi Li Weiwei Lin Zhihua han Beijie Qi Jinrong Lin Yaying Sun Jiebin Huang Yuzhen Xu shiyi Chen Department of Sport Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Orthopedic Surgery Hainan Province Clinical Medical CenterHaikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikouHainan ProvinceChina Department of Basic Medicine Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Orthopedics Shanghai General HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina

Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural *** role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of *** used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other *** demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by *** underscores the intricate relationship between natural compounds such as nutlin-3 and immune *** comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma *** also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic ***-3a inhibited glioma cell proliferation and activated the p53 *** efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or *** using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway ***,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing *** results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma *** research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.

关键词： exercise and SUMO-related gene signatures(ESLRS) glioblastoma management low-grade glioma natural bioactives neural regeneration physical exercise

The Fabrication and SERS Performance of Multi-layer Hollow Au-Ag Alloy Nano Urchins Structure-based SERS Fiber Probe

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Journal of Wuhan University of Technology(Materials Science) 2023年第2期38卷 274-279页

作者： HAO Zhenbang TIAN Qihang CAO shiyi han Xiaoyu ZhanG Jihong XIE Jun ZHAO Xiujian State Key Laboratory of Silicate Materials for Architectures(Wuhan University of Technology) Wuhan430070China International School of Materials Science and Engineering Wuhan University of TechnologyWuhan430070China Hainan Research Institute of Wuhan University of Technology Sanya572100China

Novel hollow Au Ag alloy nano urchins were synthesized via Ag seeds growth method,and self-assembly coated on the wall and end-tip of silica fiber for fiber probe *** nano urchins homogeneously distributed on fiber surface because of fiber *** sizes and tip sharpness of the nano-urchins could be controlled by Ag *** elements distribution analysis indicated there was high Ag content in tip-top for better surface enhance Raman scattering *** detectable concentration could be as low as 10-8 M using crystal violet molecules as ***,the fiber probes were stable in air,due to Au in the *** fiber probe could be used for low content single molecular analysis.

关键词： surface enhanced raman spectroscopy hollow Au-Ag alloy nano urchins fiber probe

The Fabrication and Detection Performance of High Sensitivity Au-Ag Alloy Nanostar/Paper Flexible Surface Enhanced Raman Spectroscopy Sensors

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Journal of Wuhan University of Technology(Materials Science) 2024年第2期39卷 436-443页

作者：邓芷盈 WANG Tianyi CAO shiyi ZHAO Yuan han Xiaoyu 张继红谢俊 State Key Laboratory of Silicate Materials for Architectures Department of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China Hainan Institute of Wuhan University of Technology Sanya 572000China International School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China Hepu Research Center for Silicate Materials Industry Technology Beihai 536100China

Au-Ag alloy nanostars based flexible paper surface enhanced Raman spectroscopy sensors were fabricated through simple nanostar coating on regular office paper,and the surface enhanced Raman spectroscopy detection performances were investigated using crystal violet dye ***-Ag nanostars with sharp tips were synthesized via metal ions reduction *** electron microscope images,X-Ray diffraction pattern and energy dispersive spectroscopy elemental mapping confirmed the nanostar geometry and Au/Ag components of the ***-Vis-NIR absorption spectrum shows wide local surface plasmon resonance induced optical *** addition,finite-difference time-domain simulation shows much stronger electromagnetic field from nanostars than from sphere *** effect of coating layer on Raman signal intensities was discussed,and optimized 5-layer coating with best Raman signal was *** Au-Ag nanostatrs homogeneously distribute on paper fiber *** detection limit is 10-10 M,and the relationship between analyte concentrations and Raman signal intensities shows well linear,for potential quantitative *** calculated enhancement factor is 4.795×10^(6).The flexible paper surface enhanced Raman spectroscopy sensors could be applied for trace chemical and biology molecule detection.

关键词： surface-enhanced raman gold-silver alloy nanostars paper-based SERS sensor flexibility

Understanding the dehydrogenation properties of Mg(0001)/MgH_(2)(110)interface from first principles

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Materials Reports(Energy) 2024年第1期4卷 89-94页

作者： Jianchuan Wang Bo han Zhiquan Zeng shiyi Wen Fen Xu Yong Du State Key Laboratory of Powder Metallurgy Central South UniversityChangsha410083PR China Powder Metallurgy Research Institute Central South UniversityChangsha410083PR China Guangxi Key Laboratory of Information Materials Guilin University of Electronic TechnologyGuilin541004PR China

Magnesium hydride is one of the most promising solid-state hydrogen storage materials for on-board *** desorption from MgH_(2) is accompanied by the formation of the Mg/MgH_(2) interfaces,which may play a key role in the further dehydrogenation *** this work,first-principles calculations have been used to understand the dehydrogenation properties of the Mg(0001)/MgH_(2)(110) *** is found that the Mg(0001)/MgH_(2)(110) interface can weaken the Mg-H *** removal energies for hydrogen atoms in the interface zone are significantly lower compared to those of bulk MgH_(2).In terms of H mobility,hydrogen diffusion within the interface as well as into the Mg matrix is *** calculated energy barriers reveal that the migration of hydrogen atoms in the interface zone is easier than that in the bulk MgH_(2).Based on the hydrogen removal energies and diffusion barriers,we conclude that the formation of the Mg(0001)/MgH_(2)(110) interface facilitates the dehydrogenation process of magnesium hydride.

关键词： Magnesium hydrides First-principles calculation Hydrogen storage materials Interface Hydrogen desorption

Na_(2)O/Li_(2)O Ratio Dependency on the Thermal,Mechanical,Dielectric Properties and Chemical Stabilities of Li_(2)O-Al_(2)O_(3)-SiO_(2) Glass

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Journal of Wuhan University of Technology(Materials Science) 2022年第6期37卷 1129-1136页

作者： CHEN Lina XIE Jun WANG Mingzhong CAO shiyi CUI Xiuzhen LIANG Xinhui ZhanG Jihong han Jianjun HU Kaiwen State Key Laboratory of Silicate Materials for Architectures Wuhan University of TechnologyWuhan 430070China Shenzhen Research Institute of Wuhan University of Technology Shenzhen 518000China Xianning Nanbo Photoelectric Glass Co.Ltd. Xianning 437100China International School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China

Li_(2)O-Al_(2)O_(3)-SiO_(2) based glasses were investigated as potential protection glass for electronic devices due to their excellent mechanical properties,such as high hardness,toughness,and scratch *** this paper,Li_(2)O-Na_(2)O-Al_(2)O_(3)-SiO_(2) glass with different Li_(2)O/Na_(2)O ratio components were prepared by meltquenching method,and the effects of Na_(2)O/Li_(2)O ratio on the glass densities,structure,thermal,mechanical properties,and chemical stabilities were *** experimental results indicate that the glass transition temperature increases with the increases in Na_(2)O/Li_(2)O ratios,due to larger ion *** the thermal expansion coefficient slightly decreases from 11.4×10^(-6) to 11.09×10^(-6)/℃.The elastic modulus increases from 57 to 72 *** bending strength reaches maximum 80.90 MPa when the Na_(2)O/Li_(2)O ratio is 1.7,then decreases as the ratio further *** addition,the Vicker’s hardness gets to 7.37 GPa with largest Na_(2)O/Li_(2)O ***,the dielectric loss and dielectric constant increases as the ratio *** Raman structure analysis shows the Q4[Si-O-Si]decreases as Na_(2)O/Li_(2)O ratio increases,which is responsible for the characteristic properties ***,the glass shows lowest mass loss in 10vol%HF solutions when the ratio is 1.4,while 1.7 in 5wt%NaOH solution.

关键词： glass composition dielectric constant coefficient of thermal expansion elastic modulus

A novel low-loss four-bit bandpass filter using RF MEMS switches

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Chinese Physics B 2022年第1期31卷 680-685页

作者： Lulu han Yu Wang Qiannan Wu shiyi Zhang Shanshan Wang Mengwei Li School of Instrument and Electronics North University of ChinaTaiyuan 030051China Nantong Institute of Intelligent Opto-Mechatronics North University of ChinaNantong 226000China Center for Microsystem Integration North University of ChinaTaiyuan 030051China Academy for Advanced Interdisciplinary Research North University of ChinaTaiyuan 030051China School of Science North University of ChinaTaiyuan 030051China

This paper details the design and simulation of a novel low-loss four-bit reconfigurable bandpass filter that integrates microelectromechanical system(MEMS)switches and comb resonators.A T-shaped reconfigurable resonator is reconfigured in a'one resonator,multiple MEMS switches'configuration and used to gate the load capacitances of comb resonators so that a multiple-frequency filtering function is realized within the 7-16 GHz frequency *** addition,the insertion loss of the filter is less than 1.99 dB,the out-of-band rejection is more than 18.30 dB,and the group delay is less than 0.25 *** the other hand,the size of this novel filter is only 4.4 mm×2.5 mm×0.4 *** results indicate that this MEMS reconfigurable filter,which can switch 16 central frequency bands through eight switches,achieves a low insertion loss compared to those of traditional MEMS *** addition,the advantages of small size are obtained while achieving high integration.

关键词： four-bit RF microelectromechanical system(MEMS)switch reconfigurable filter comb resonator

Early life administration of milk fat globule membrane promoted SCFA-producing bacteria colonization,intestinal barriers and growth performance of neonatal piglets

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Animal Nutrition 2021年第2期7卷 346-355页

作者： Yujun Wu Xiangyu Zhang Dandan han Yu Pi Shiyu Tao shiyi Zhang Shilan Wang Junying Zhao Lijun Chen Junjun Wang State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing100193China National Engineering Center of Dairy for Early Life Health Beijing Sanyuan Foods Co.LtdBeijing100163China

Milk fat globule membrane(MFGM)possesses various nutritional and biological benefits for mammals,whereas its effects on neonatal gut microbiota and barrier integrity remained *** study investigated the effects of MFGM administration on microbial compositions and intestinal barrier functions of neonatal *** newborn piglets were randomly allocated into a CON group or MFGM group,orally administered with saline or MFGM solution(1 g/kg body weight)respectively during the first postnatal week,and all piglets were breastfed during the whole neonatal *** present study found that the MFGM oral administration during the first postnatal week increased the plasma immunoglobulin(lg)G level,body weight and average daily gain of piglets(Phanced intes-tinal barrier functions and consequently improved growth performance of neonatal piglets on 21 *** findings will provide new insights about MFGM intervention for microbial colonization and intestinal development of neonates during their early life.

关键词： Milk fat globule membrane Gut microbiota SCFA Intestinal barrier Piglet

WALK-ASSISTING BALANCE SYSTEM OF THE EXOSKELETON ROBOT FOR DISABLED PEOPLE

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Chinese Journal of Mechanical Engineering 2004年第2期17卷 263-267页

作者： Yin Yuehong Zhou Chunlin Song Jiaren Chen shiyi han Tianpu Zhou Chen Research Institute of Robotics,Shanghai Jiaotong University,Shanghai 200030, China Research Institute of Robotics Shanghai Jiaotong University 上海 200030

A novel methodology for a walk-assisting balance system of the exoskeleton robot for dis-abled people is presented. The experiment on the walk-assisting balance system is implemented using amini-type ropewalker robot. The mechanism of the ropewalker robot is designed, its dynamic model isbuilt, and its control system based on PWM is developed. The emulations in Matlab and the results ofexperiments prove that this methodology is effective.

关键词： Balance system Ropewalker robot Exoskeleton robot

Dynamic Variations in Brain Glycogen are Involved in Modulating Isoflurane Anesthesia in Mice

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Neuroscience Bulletin 2020年第12期36卷 1513-1523页

作者： Ze Fan Zhihao Zhang shiyi Zhao Yuanyuan Zhu Dong Guo Bo Yang Lixia Zhuo Jiao han Rui Wang Zongping Fang Hailong Dong Yan Li Lize Xiong Department of Anesthesiology and Perioperative Medicine Xijing HospitalFourth Military Medical UniversityXi'an 710032ShaanxiChina College of Basic Medicine Fourth Military Medical UniversityXi'an 710032ShaanxiChina Department of Neurobiology Fourth Military Medical UniversityXi'an 710032ShaanxiChina Center for Brain Science and Department of Anesthesiology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi*an 710061ShaanxiChina Translational Research Institute of Brain and Brain-Like Intelligence Department of Anesthesiology and Perioperative MedicineShanghai Fourth People's Hospital Affiliated to Tongji University School of MedicineShanghai 200081China

General anesthesia severely affects the metabolites in the ***,principally stored in astrocytes and providing the short-term delivery of substrates to neurons,has been implicated as an affected ***,whether glycogen plays a pivotal role in modulating anesthesia-arousal remains ***,we demonstrated that isoflurane-anesthetized mice exhibited dynamic changes in the glycogen levels in various brain *** synthase(GS)and glycogen phosphorylase(GP),key enzymes of glycogen metabolism,showed increased activity after isoflurane *** blocking glycogenolysis with 1,4-dideoxy-1,4-imino-Darabinitol(DAB),a GP antagonist,we found a prolonged time of emergence from anesthesia and an enhancedδfrequency in the EEG(electroencephalogram).In addition,augmented expression of glycogenolysis genes in glycogen phosphorylase,brain(Pygb)knock-in(PygbH11/H11)mice resulted in delayed induction of anesthesia,a shortened emergence time,and a lower ratio of EEG-δ.Our findings revealed a role of brain glycogen in regulating anesthesiaarousal,providing a potential target for modulating anesthesia.

关键词： Anesthesia-arousal Brain glycogen General anesthesia Glycogen phosphorylase Glycogen synthetase Isoflurane