检索结果-南通市图书馆

Science China Chemistry 2025年

作者： Qing Chen Keyu Wang shiyi li Yixing Wang linfeng Lei Minghui Zhu linzhou Zhuang Zhi Xu State Key Laboratory of Chemical Engineering School of Chemical Engineering East China University of Science and Technology Suzhou Laboratory

The oxygen evolution reaction（OER） is crucial for the electrocatalytic water electrolysis into oxygen and hydrogen, but the fourelectron transfer process hinders the OER dynamics. To realize the highly efficient water splitting, the nonprecious metal-based electrodes that can optimize the adsorption energy of intermediates and generate H2with low overpotential and robust stability are essential. Herein, we report a surface modification strategy to grow the trimetallic FeCoNi hydroxide on the amine linkersgrafted carbon cloth（CC-NH2@FeCoNi） by electro-deposition. CC-NH2@FeCoNi possesses a superhydrophilic/superaerophobic surface, which could significantly enhance the mass transfer, and meanwhile promote the in situ generation of MOOH active species. Meanwhile, the superhydrophilic surface could facilitate the adsorption of abundant OH-ions, and repel the Cl-ions via electrostatic repulsive force during seawater oxidation. Consequently, compared with the CC@FeCoNi that grown on the pure CC（320 mV）, the CC-NH2@FeCoNi needs an obviously smaller overpotential of 270 mV to achieve a current density of 100 mA cm-2, and meanwhile it exhibits a superior durability for 100 h at a current density of 200 mA cm-2in both alkaline water and seawater. This strategy could be even applied universally in the preparation of other nonprecious metal hydroxides for efficient OER catalysis.

关键词：

过敏性紫癜患儿合并肺炎支原体感染临床特征分析

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中国病原生物学杂志 2025年第1期20卷 95-99,104页

作者：孙俭李付奎杨乐李世义河南大学附属南阳市第一人民医院河南南阳473000

目的探讨过敏性紫癜(Henoch-Schonlein purpura,HSP)患儿合并肺炎支原体(Mycoplasma pneumoniae,MP)感染的临床表现及实验室检查特点,分析此类患儿的诊治策略及预后情况。方法对本院就诊的112例HSP患儿的临床资料进行回顾性分析,同时选... 详细信息

目的探讨过敏性紫癜(Henoch-Schonlein purpura,HSP)患儿合并肺炎支原体(Mycoplasma pneumoniae,MP)感染的临床表现及实验室检查特点,分析此类患儿的诊治策略及预后情况。方法对本院就诊的112例HSP患儿的临床资料进行回顾性分析,同时选取70例体检健康儿童为对照组。检测各组儿童MP感染情况,对比分析不同分组患儿MP阳性率。采集患儿静脉血,测定Th17细胞和Treg细胞在样本中的百分比,对比不同分组儿童免疫功能的差异。结果在112例HSP患儿中,35例感染MP,感染率31.25%。70例对照组儿童中只有8例感染MP,感染率11.43%,两组的MP感染率差异显著。在HSP患儿中,73例为首次发病,39例为2次或多次发病。首次发病组中MP阳性率为16.44%,而复发组中MP阳性率高达58.97%,两组之间MP阳性率差异显著。在65例男性HSP患儿中,20例为MP阳性,占30.77%;47例女性患儿中,15例为MP阳性,占31.91%。性别间MP阳性率无显著差异。1~5岁患儿MP阳性率为47.37%,5~9岁为32.26%,而>9岁为19.35%,不同年龄间MP阳性率无统计学差异。春季MP阳性率为53.85%,夏季为13.33%,秋季为18.75%,冬季为33.33%,不同季节间MP阳性率差异显著。MP阳性患儿中,皮肤型占14.29%,腹型5.71%,关节型17.14%,肾型14.29%,混合型48.57%。MP阴性患儿中,皮肤型占10.39%,腹型22.08%,关节型23.38%,肾型3.9%,混合型40.26%。腹型和肾型在两组间差异显著(P0.05)。MP阳性患儿首发症状均为皮疹,腹痛47.71%,呕吐28.57%,消化道出血14.29%,关节肿痛57.14%。MP阴性患儿首发症状均为皮疹,腹痛37.66%,呕吐22.08%,消化道出血7.79%,关节肿痛32.47%。关节肿痛在两组间有显著差异(P0.05)。MP阳性患儿31.43%并发紫癜性肾炎,MP阴性患儿15.58%并发紫癜性肾炎,差异无统计学意义(P>0.05)。MP阳性组患儿Th17细胞百分率为(3.64±0.56)%,Treg细胞百分率为(10.57±1.04)%。MP阴性组患儿Th17细胞百分率为(2.63±0.55)%,Treg细胞百分率为(12.45±1.77)%。健康组儿童Th17细胞百分率为(1.79±0.31)%,Treg细胞百分率为(14.88±1.69)%。MP阳性组患儿Th17细胞百分率显著高于MP阴性组患儿及健康组儿童,Treg细胞百分率显著低于MP阴性组患儿及健康组儿童,差异有统计学意义(P<0.05)。结论HSP合并MP感染患儿的免疫功能存在异常,表现为Th17细胞比例升高,Treg细胞比例下降,这可能与疾病的发展和严重程度有关。同时,MP感染在不同季节的阳性率差异提示环境因素可能对感染有一定影响。尽管在紫癜性肾炎的并发率上差异无统计学意义,但MP阳性患儿的腹型和肾型发病率较高,需引起临床重视。

关键词：过敏性紫癜肺炎支原体临床特征

Role of macrophages in aortic dissection pathogenesis:insights from preclinical studies to translational prospective

在线全文

学校读者我要写书评

暂无评论

Science China(life Sciences) 2024年第11期67卷 2354-2367页

作者： shiyi li Weiguo Fu lixin Wang Department of Vascular Surgery Zhongshan HospitalFudan UniversityShanghai 200032China Vascular Surgery Institute of Fudan University Shanghai 200032China National Clinical Research Center for Interventional Medicine Shanghai 200032China Key Laboratory of Panvascular Disease Precision Medicine Zhongshan Hospital XiamenFudan UniversityXiamen 361015China Fudan Zhangjiang Institute Shanghai 201203China

Aortic dissection is a critical vascular disease that is characterized by a high mortality rate and inflammation significantly influences its onset and *** studies highlight the integral role of macrophages,key players in the immune system,in the pathological landscape of aortic *** cells are involved in crucial processes,such as the remodeling of the extracellular matrix,immunocyte infiltration,and phenotypic switching of smooth muscle cells,which are essential for the structural integrity and functional dynamics of the aortic *** these insights,the specific contributions of macrophages to the development and progression of aortic dissection remains *** review explores the pathogenesis of aortic dissection with a focus on macrophages and describes their origins,phenotypic variations,and potential roles based on the most recent research ***,we discuss key molecules related to macrophages during aortic dissection,their interactions with other cellular components within the aorta,and the implications of these interactions for future therapeutic *** comprehensive analysis aimed to improve our understanding of macrophages in aortic dissection and promote the development of targeted interventions.

关键词： aortic dissection macrophages extracellular matrix cytokines

A DFT and TD-DFT study on electronic structures and UV-spectra properties of octaethyl-porphyrin with different central metals(Ni, V, Cu, Co)

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2020年第2期28卷 532-540页

作者： XiaoqinWang shiyi li liang Zhao Chunming Xu Jinsen Gao College of Science China University of Petroleum(Beijing)Beijing 102249China State Key Laboratory of Heavy Oil Processing China University of Petroleum(Beijing)Beijing 102249China

In this work,the octaethyl-porphyrins with different central metals(M-OEP,M=Ni,VO,Cu,Co)were used to investigate the ground-state molecular structure,electron distribution and UV-spectra properties on molecular level by density functional theory(DFT).The results showed that the calculation structure parameters of metalloporphyrins agreed well with the experimental *** to the Natural Bond Orbital(NBO)analysis,the charge distribution of different metalloporphyrins was found that the charge values of the central metal M decreased with the order of VONi>Co>*** the same time,the frontier molecular orbital calculations showed that the SOMO energy of VO(OEP)molecules in the open-shell system was higher than that of Co(OEP)and Cu(OEP),which means that its UV absorption characteristic peak would be *** addition,the IEFPCM model of Time-dependent Density functional theory(TD-DFT)was further utilized to simulate the four substance in toluene solution:Co(OEP),Ni(OEP),Cu(OEP)and VO(OEP),and the Soret band peaks were calculated respectively as:382 nm,383 nm,391 nm and 401 ***,the quantitative simulation analysis of metalloporphyrins was combined with experimental *** could be found that the location rules of the four kinds of metalloporphyrins calculated absorption characteristic peaks were consistent with the experimental ones,and the relative errors of each peak were within 3%.These methods used above provide a theoretical path for analyzing and identifying unknown porphyrin compounds in petroleum.

关键词： Metallic impurity Metalloporphyrin Asphaltenes Quantum chemistry UV–vis spectrum

Plant-derived exosome-like nanoparticles and their therapeutic activities

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2022年第1期17卷 53-69页

作者： Jisu Kim shiyi li Shuya Zhang Jianxin Wang Department of Pharmaceutics School of PharmacyMinistry of EducationFudan University&Key Laboratory of Smart Drug DeliveryShanghai 201203China Institute of Integrated Chinese and Western Medicine Fudan UniversityShanghai 200040China

Nanotechnologies have been successfully applied to the treatment of various ***-derived exosome-like nanoparticles (PENs) are expected to become effective therapeutic modalities for treating disease or in drug-delivery. PENs are minimally cytotoxic to healthy tissues, with which they show excellent biocompatibility, and are biased towards tumors by targeting specific tissues through special endocytosis mechanisms. Thus, the use of these PENs may expand the scope of drug therapies while reducing the off-target *** this review, we summarize the fundamental features and bioactivities of PENs extracted from the grape, grapefruit, ginger, lemon, and broccoli and discuss the applications of these particles as therapeutics and nanocarriers.

关键词： Exosomes Plant-derived exosome-like nanoparticles Drug-delivery systems Nanocarriers

Adipose-derived stem cells inhibit dermal fibroblast growth and induce apoptosis in keloids through the arachidonic acid-derived cyclooxygenase-2/prostaglandin E2 cascade by paracrine

在线全文

学校读者我要写书评

暂无评论

Burns & Trauma 2021年第1期9卷 288-298页

作者： Jinxiu Yang shiyi li Leren He Minliang Chen Department of Burn and Plastic Surgery the Fourth Medical CentreChinese People’s Liberation Army General HospitalNo.51 Fucheng RoadHaidian DistrictBeijing100038China Chinese People’s liberation Army General Hospital No.28 Fuxing RoadHaidian DistrictBeijing100853China 7th Department of Plastic Surgery Plastic Surgery HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeNo.33 Ba Dachu RoadShi Jingshan DistrictBeijing100144China

Background:The clinical features of keloids consist of aberrant proliferation,secretion,differentiation and apoptosis of keloid dermis-derived fibroblasts(KFBs).Notably,the apoptosis rate of KFBs is lower than the proliferation *** the anti-fibrotic effect of adipose-derived stem cells(ADSCs)on keloids has become a hot topic of research,the exact anti-fibrotic mechanism of the paracrine effect remains *** study aimed to find out how the conditioned medium of ADSCs(ADSC-CM)exerts an anti-fibrotic effect in ***:KFBs and ADSCs were extracted and ***,ADSC-CM was *** ADSC-CM could inhibit KFB growth and induce apoptosis was verified by the use of a cell counting kit-8,an 5-Ethynyl-2-deoxyuridine(Edu)kit and flow *** expressions of cyclooxygenase-1(COX-1),COX-2,caspase 3 and B-cell lymphoma-2(Bcl-2)in ADSC-CM-cultured KFBs were tested by real-time PCR and western *** clarify the role of COX-2 in ADSC-CM-induced KFB apoptosis,a specific COX-2 inhibitor,celecoxib,was applied to KFBs cultured in ***,we tested the production of arachidonic acid(AA)and prostaglandin E2(PGE2)by ***,we established a keloid transplantation model in a nude mouse to validate the therapeutic effect in ***:The proliferation ability of KFBs cultured in ADSC-CM was found to be weakened and apoptosis was significantly *** 3 expression was significantly upregulated and Bcl-2 was downregulated in ADSC-CM-cultured ***,ADSC-CM strikingly elevated COX-2 mRNA and protein expressions,but COX-1 expression was ***-2 inhibitors reduced ADSC-CM-induced ***,COX-2 inhibition blocked the elevation of caspase 3 and reversed the decrease in Bcl-2 ***-CM increased PGE2 levels by 1.5-fold and this effect was restrained by COX-2 *** the nude mouse model,expressions of AA,COX-2 and PGE2 were higher in the translated keloid tissues after ADSC-CM injecti

关键词： Keloids Adipose-derived stem cells Fibroblasts Apoptosis Anti-fibrosis cyclooxygenase-2 Arachidonic acid

Crystal Growth and Characterization of Ca3NbGa3Si2O14 Single Crystal

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rare Earths 2006年第Z1期24卷 197-199页

作者： Shi Xuzhong Yuan Duorong Cheng Xiufeng Guo shiyi Yu Guangwei li Zhanfa State Key Laboratory of Crystal Materials Shandong University Jinan 250100 China State Key Laboratory of Crystal Materials Shandong University Jinan 250100 China State Key Laboratory of Crystal Materials Shandong University Jinan 250100 China State Key Laboratory of Crystal Materials Shandong University Jinan 250100 China State Key Laboratory of Crystal Materials Shandong University Jinan 250100 China State Key Laboratory of Crystal Materials Shandong University Jinan 250100 China

Single crystals of Ca3NbGa3Si2O14 (CNGS) with ordered Ca3Ga2Ge4O14 (CGG) structure were successfully grown from stoichiometric melts by conventional Czochralski technique along the a-axis and two large (001) facets and two small (100) facets appear in every crystal. An arrangement of parallel steps and a clear height change were observed in (001) facet by atomic force microscopy (AFM). High-resolution X-ray diffraction (HRXRD) results indicate that CNGS crystals have good quality and free low-angle boundaries. The crystals also exhibit good optical quality and high optical transmittance in c-direction.

关键词： czochralski method gallium compounds atomic force microscopy

Synergic Inhibition of Lung Carcinoma 95-D Cell Proliferation and Invasion by Combination with(—)-Epigallocatechin-3-Gallate and Ascorbic Acid

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Wuhan University Journal of Natural Sciences 2018年第3期23卷 270-276页

作者： MA Yan YANG Jingya li shiyi YU Wenjuan College of Food Science and Technology Shanghai Ocean University Shanghai 201306 China Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation Shanghai Ocean University Shanghai201306 China Laboratory of Quality and Safety Risk Assessment for Aquatic Products on Storage and Preservation (Shanghai) Minis-try of Agriculture Shanghai 201306 China College of Aqua-life Science and Technology Shanghai Ocean University Shanghai 201306 China

In this study, the anti-invasion effects of（-）-epigallocatechin-3-gallate（EGCG） mixed with ascorbic acid（Vc） on human lung carcinoma 95-D cells in vitro were examined and the synergism of the combination of EGCG and Vc was evaluated. Soft agar colony formation assay, cell migration assay, invasion assay, western blot analysis of NF-κB, in situ detection of cellular oxidative stress, and statistical analysis were assessed. The results showed that combining EGCG with Vc could inhibit clone forming rate of 95-D cell by 73.2%, reduce the migration ability of 95-D cell by 65.9%, and decrease the intracellular reactive oxygen species（ROS） level by 76.8%. The results of western blot proved that Vc enhanced the activity of EGCG in inhibiting NF-κB localization. It is speculated that the combination of EGCG and Vc can strongly suppress the proliferation and metastasis of lung carcinoma cells in a synergic manner, possibly with a mechanism associated with the scavenging of reactive oxygen species.

关键词： (-)-epigallocatechin-3-gallate(EGCG) reactive oxygen species(ROS) ascorbic acid(Vc) cancer metastasis

Visualization of cristae and mtDNA interactions via STED nanoscopy using a low saturation power probe

在线全文

学校读者我要写书评

暂无评论

light(Science & Applications) 2024年第9期13卷 1741-1756页

作者： Wei Ren Xichuan Ge Meiqi li Jing Sun shiyi li Shu Gao Chunyan Shan Baoxiang Gao Peng Xi Department of Biomedical Engineering National Biomedical Imaging CenterCollege of Future TechnologyPeking UniversityBeijing 100871China Key Laboratory of Analytical Science and Technology of Hebei Province College of Chemistry and Material ScienceHebei UniversityBaoding 071002China School of life Sciences Peking UniversityBeijing 100871China National Center for Protein Sciences Peking UniversityBeijing 100871China

Mitochondria are crucial organelles closely associated with cellular metabolism and *** DNA(mtDNA)encodes a variety of transcripts and proteins essential for cellular ***,the interaction between the inner membrane(IM)and mtDNA remains elusive due to the limitations in spatiotemporal resolution offered by conventional microscopy and the absence of suitable in vivo probes specifically targeting the ***,we have developed a novel fluorescence probe called HBmito Crimson,characterized by exceptional photostability,fluorogenicity within lipid membranes,and low saturation *** successfully achieved over 500 frames of lowpower stimulated emission depletion microscopy(STED)imaging to visualize the IM dynamics,with a spatial resolution of 40 *** utilizing dual-color imaging of the IM and mtDNA,it has been uncovered that mtDNA tends to habitat at mitochondrial tips or branch points,exhibiting an overall spatially uniform ***,the dynamics of mitochondria are intricately associated with the positioning of mtDNA,and fusion consistently occurs in close proximity to mtDNA to minimize pressure during cristae *** healthy cells,>66%of the mitochondria are Class III(i.e.,mitochondria>5μm or with>12 cristae),while it dropped toling,foster the even distribution of ***,in conditions of apoptosis and ferroptosis where the cristae structure is compromised,mtDNA distribution becomes *** findings,achieved with unprecedented spatiotemporal resolution,reveal the intricate interplay between cristae and mtDNA and provide insights into the driving forces behind mtDNA distribution.

关键词： metabolism saturation utilizing

我国数字媒体技术专业本科教育发展研究———基于235所学校专业招生简章的文本分析

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

湖北师范大学学报(哲学社会科学版) 2025年第1期45卷 129-140页

作者：陈迪樊智康耿辰羽李诗怡王翔华中师范大学人工智能教育学部湖北武汉430079

随着信息技术的发展以及数字文化产业的兴盛,专业人才的需求也在不断上升,我国设立数字媒体技术本科20余年,专业发展备受关注。调查和文本分析研究发现:我国数字媒体专业发展已经进入平稳期,区域分布均衡,且形成了培养单位的塔式结构;... 详细信息

随着信息技术的发展以及数字文化产业的兴盛,专业人才的需求也在不断上升,我国设立数字媒体技术本科20余年,专业发展备受关注。调查和文本分析研究发现:我国数字媒体专业发展已经进入平稳期,区域分布均衡,且形成了培养单位的塔式结构;在人才培养目标上,已经构筑了面向媒体服务全过程的应用型、复合型人才方向设置体系,形成了多元化、市场化的人才去向,打磨了重素质、厚基础的核心能力要求;在人才培养路径上,打造了“艺技双行”且日益趋稳趋深的课程体系,构建了理论引导、实践强化的课程教学理念。基于现状和趋势的思考,研究提出要抓住时代和市场脉搏,结合交叉和创新,联合社会各维度机构,构建学用一体化培养环路,以发展人才核心能力。

关键词：数字媒体技术本科专业人才培养现状