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Constrained Large-Eddy Simulation of Compressible Flow Past a Circular Cylinder

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Communications in Computational Physics 2014年第2期15卷 388-421页

作者： Renkai hong Zhenhua Xia Yipeng Shi Zuoli Xiao shiyi Chen State Key Laboratory for Turbulence and Complex Systems College of EngineeringPeking UniversityBeijing 100871P.R.China. Center for Applied Physics and Technology College of EngineeringPeking UniversityBeijing 100871P.R.China

Compressible flow past a circular cylinder at an inflow Reynolds number of 2×105 is numerically investigated by using a constrained large-eddy simulation(CLES)*** simulation with adiabatic wall boundary condition and at a free-stream Mach number of 0.75 is conducted to validate and verify the performance of the present CLES method in predicting separated *** typical and characteristic physical quantities,such as the drag coefficient,the root-mean-square lift fluctuations,the Strouhal number,the pressure and skin friction distributions around the cylinder,*** calculated and compared with previously reported experimental data,finer-grid large-eddy simulation(LES)data and those obtained in the present LES and detached-eddy simulation(DES)on coarse *** turns out that CLES is superior to DES in predicting such separated flow and that CLES can mimic the intricate shock wave dynamics quite ***,the effects of Mach number on the flow patterns and parameters such as the pressure,skin friction and drag coefficients,and the cylinder surface temperature are studied,with Mach number varying from 0.1 to *** behaviors of the pressure and skin friction distributions are observed with increasing Mach number and the minimum mean separation angle occurs at a subcritical Mach number of between 0.3 and ***,the wall temperature effects on the thermodynamic and aerodynamic quantities are explored in a series of simulations using isothermal wall boundary conditions at three different wall *** is found that the flow separates earlier from the cylinder surface with a longer recirculation length in the wake and a higher pressure coefficient at the rear stagnation point for higher wall ***,the influences of different thermal wall boundary conditions on the flow field are gradually magnified from the front stagnation point to the rear stagnation *** is inferred that the CLES approach in its current

关键词： Compressible flow constrained large-eddy simulation circular cylinder separated flow.

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伤口症状自评量表的汉化及信效度检验

中华现代护理杂志 2024年第22期30卷 3000-3006页

作者：张世翼杨红尤渺宁陆宇晗北京大学肿瘤医院暨北京市肿瘤防治研究所护理部恶性肿瘤发病机制及转化研究教育部重点实验室北京100142 北京大学肿瘤医院暨北京市肿瘤防治研究所乳腺肿瘤内科恶性肿瘤发病机制及转化研究教育部重点实验室北京100142

目的对伤口症状自评量表(WoSSAC)进行汉化,并在我国恶性伤口患者中进行信效度检验。方法获得原量表作者授权后,按照Brislin双向翻译原则对WoSSAC进行汉化,形成中文版WoSSAC。采用便利抽样法,选取2022年6—12月在北京大学肿瘤医院住院的... 详细信息

目的对伤口症状自评量表(WoSSAC)进行汉化,并在我国恶性伤口患者中进行信效度检验。方法获得原量表作者授权后,按照Brislin双向翻译原则对WoSSAC进行汉化,形成中文版WoSSAC。采用便利抽样法,选取2022年6—12月在北京大学肿瘤医院住院的有恶性伤口的115例肿瘤患者进行调查,对中文版WoSSAC进行验证。采用项目分析法进行条目筛选;采用内容效度指数和结构效度检验量表的效度;采用Cronbach'sα系数、折半信度系数、重测信度系数检验量表的信度。结果本研究共发放问卷115份,回收有效问卷115份,问卷的有效回收率为100.0%(115/115)。中文版WoSSAC包括伤口相关问题严重程度和对日常生活的影响程度2个部分,共21个条目。探索性因子分析显示,伤口相关问题严重程度部分提取出2个公因子,累计方差贡献率为83.583%;对日常生活的影响程度部分提取出2个公因子,累计方差贡献率为81.422%。量表水平的内容效度指数为0.98,条目水平的内容效度指数为0.80~1.00。伤口相关问题严重程度部分的Cronbach'sα系数为0.979,折半信度系数为0.924;对日常生活的影响程度部分的Cronbach'sα系数为0.975,折半信度系数为0.937。伤口相关问题严重程度部分的重测信度系数为0.842,日常生活的影响程度部分的重测信度系数为0.903。结论中文版WoSSAC具有良好的信度和效度,可用于患者自我评估恶性伤口相关症状的严重程度及对日常生活的影响程度。

关键词：肿瘤恶性伤口评估效度信度

Cloning and characterization of a novel CIPK gene from wheat(Triticum aestivum L.)

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Cloning and characterization of a novel CIPK gene from wheat...

结合对象单元和Transformer网络的城市功能区分类

2010中国作物学会学术年会

作者： Xiaomin Deng~1,Wei Hu~1,shiyi Zhou~1,hong Zhang~1,Guodong Huang~1,Mingjie Chen, Guangyuan He~(1*),Guangxiao Yang~(1*) (1China-UK HUST-RRes Genetic Engineering and Genomics Joint Laboratory International Science & Technology Cooperation Base(Genetic Engineering) of Chinese Ministry of Science and Technology The Key Laboratory of Molecular Biophysics of Chinese Ministry of Education College of Life Science and Technology,Huazhong University of Science & Technology(HUST),Luoyu Road 1037,Wuhan 430074,China)

Ca signals mediate a multitude of plant responses to external stimuli and regulate a wide range of physiological *** is believed that cellular Ca changes are perceived by special sensor molecules,including calcium binding *** calcineurin B-Like(CBL) protein family represents a unique group of Ca sensors in ***-interacting protein kinases(CIPKs) is a new kind of protein kinases that can bind with their target proteins,CBL proteins,and form a complex network,which represent important relays in plant.A novel CIPK gene was isolated from wheat(*** Spring) by RT-PCR,which encoded a polypeptide of 436 amino acid residues with an estimated molecular mass

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来源： cnki会议评论

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遥感学报 2024年第8期28卷 1927-1939页

作者：鲁伟鹏贺清康李佳铃李诗逸陶超中南大学地球科学与信息物理学院长沙410012 香港理工大学土地测量及地理资讯学系中国香港999077

准确识别各类城市功能区并全面掌握其分布情况,对合理规划和科学管理城市至关重要。针对该问题,本文提出一种结合对象单元和Transformer网络的城市功能区分类方法。该方法首先以多尺度分割所获得的过分割对象作为最小分析单元,以避免出... 详细信息

准确识别各类城市功能区并全面掌握其分布情况,对合理规划和科学管理城市至关重要。针对该问题,本文提出一种结合对象单元和Transformer网络的城市功能区分类方法。该方法首先以多尺度分割所获得的过分割对象作为最小分析单元,以避免出现同一分析单元包含多种城市功能区的情况。在此基础上,针对现有方法着重于对分析单元内部特征提取而忽略了分析单元之间的空间关系问题,提出利用Transformer框架和对象地理属性作为位置编码对不同分析单元之间的空间关系进行建模,从而实现兼顾分析单元内部特征和不同分析单元之间空间关系的城市功能区分类。结果表明,使用过分割对象作为最小分析单元能够更加准确地获取城市功能区地边界,从而避免基于规则格网单元所导致的锯齿状边缘及基于路网单元所导致地无法区分路网内不同功能区的问题;与仅考虑分析单元内部特征的传统方法相比,通过对不同分析单元之间的分析单元进行建模可有效提升城市功能区分类精度。

关键词：城市功能区遥感深度学习空间关系建模 Transformer网络

One Stone Four Birds:A Novel Liposomal Delivery System Multi-functionalized with Ginsenoside Rh2 for Tumor Targeting Therapy

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Nano-Micro Letters 2020年第10期12卷 69-86页

作者： Chao hong Jianming Liang Jiaxuan Xia Ying Zhu Yizhen Guo Anni Wang Chunyi Lu hongwei Ren Chen Chen shiyi Li Dan Wang Huaxing Zhan Jianxin Wang Department of Pharmaceutics School of PharmacyFudan University&Key Laboratory of Smart Drug DeliveryMinistry of EducationShanghai 201203People’s Republic of China Institute of Tropical Medicine Guangzhou University of Chinese MedicineGuangzhou 510006People’s Republic of China Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhou 510006People’s Republic of China School of Pharmacy Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Shanghai Ginposome Pharmatech Co. LtdShanghai 201600People’s Republic of China Institute of Integrated Chinese and Western Medicine Fudan UniversityShanghai 200040People’s Republic of China

Liposomes hold great potential in anti-cancer drug delivery and the targeting treatment of ***,the clinical therapeutic efficacy of liposomes is still limited by the complexity of tumor microenvironment(TME)and the insufficient accumulation in tumor ***,the application of cholesterol and polyethylene glycol(PEG),which are usually used to prolong the blood circulation and stabilize the structure of liposomes respectively,has been questioned due to various ***,we developed a ginsenoside Rh2-based multifunctional liposome system(Rh2-lipo)to effectively address these challenges once for *** with the conventional’wooden’liposomes,Rh2-lipo is a much more brilliant carrier with multiple *** Rh2-lipo,both cholesterol and PEG were substituted by Rh2,which works as membrane stabilizer,long-circulating stealther,active targeting ligand,and chemotherapy adjuvant at the same ***,Rh2 could keep the stability of liposomes and avoid the shortcomings caused by ***,Rh2-lipo showed a specifically prolonged circulation behavior in the ***,the accumulation of the liposomes in the tumor was significantly enhanced by the interaction of glucose transporter of tumor cells with ***,Rh2-lipo could remodel the structure and reverse the immunosuppressive environment in *** tested in a 4T1 breast carcinoma xenograft model,the paclitaxel-loaded Rh2-lipo realized high efficient tumor growth ***,Rh2-lipo not only innovatively challenges the position of cholesterol as a liposome component,but also provides another innovative potential system with multiple functions for anti-cancer drug delivery.

关键词： Ginsenoside Rh2 Liposomes Cholesterol Multifunction Tumor targeting

Constrained large-eddy simulation of laminar-turbulent transition in compressible channel flows

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Advances in Aerodynamics 2023年第1期5卷 229-246页

作者： Sanmu Chen Zhou Jiang Minping Wan shiyi Chen Guangdong Provincial Key Laboratory of Turbulence Research and Applications Department of Mechanics and Aerospace EngineeringSouthern University of Science and TechnologyShenzhen 518055China Guangdong-hong Kong-Macao Joint Laboratory for Data-Driven Fluid Mechanics and Engineering Applications Southern University of Science and TechnologyShenzhen 518055China College of Aerospace Engineering Chongqing UniversityChongqing 400044China

An improved approach for constrained large-eddy simulations(CLES)of wall-bounded compressible transitional flows is proposed by introducing an intermittency *** improved model is tested and validated with compressible channel flows at various Mach numbers and Reynolds numbers that are transitioning from laminar to turbulent *** improved model is compared against traditional dynamic Smagorinsky model(DSM)and Direct Numerical Simulations(DNS),where the improved model is in better agreement with DNS results than traditional DSM model,in terms of mean velocity profiles,total Reynolds stress and total heat ***,the proposed method can be used to accurately predict the temporal laminar-turbulent transition process of compressible wall-bounded flows.

关键词： Constrained LES Transition prediction Compressible channel flow

氨基酸复配同步抑制曲奇中多种有害物形成及其对感官品质的影响

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食品与发酵工业 2024年第12期50卷 74-83页

作者：田媛罗紫明隋凤娇陈鳞让杨楠黄才欢欧隽滢欧仕益郑洁暨南大学食品科学与工程系广东广州510632 中山市日威食品有限公司广东中山528415 焙烤食品安全粤港联合创新平台广东广州510632

氨基酸可有效抑制热加工食品中有害物质的形成,但食品中有多种有害物同时存在的情况,目前对于氨基酸对有害物的同步控制研究缺乏,并且氨基酸单独使用常对感官品质造成不良影响。以曲奇为研究对象,选取对活泼羰基化合物消除效果好的4种... 详细信息

氨基酸可有效抑制热加工食品中有害物质的形成,但食品中有多种有害物同时存在的情况,目前对于氨基酸对有害物的同步控制研究缺乏,并且氨基酸单独使用常对感官品质造成不良影响。以曲奇为研究对象,选取对活泼羰基化合物消除效果好的4种氨基酸进行复配,通过单因素和正交实验,以感官评价、色度、质构、有害物抑制效果为指标,在不影响产品感官品质的基础上,获得可同时抑制多种热加工有害物的氨基酸添加配方。最终确定曲奇中氨基酸的最佳添加配方为半胱氨酸0.15 g/kg、γ-氨基丁酸0.35 g/kg、丙氨酸0.5 g/kg、甘氨酸0.5 g/kg。采用该配方制作的曲奇与空白组相比,5-羟甲基糠醛、丙酮醛、3-脱氧奥苏糖、丙烯酰胺、羧甲基赖氨酸、羧乙基赖氨酸、荧光晚期糖基化终末产物分别降低了92%、28%、47%、38%、50%、71%、62%。同时,曲奇的酥脆性显著提高,感官品质有所改善。该研究结果为曲奇等热加工食品中有害物的控制与品质改良提供参考与指导。

关键词：氨基酸曲奇羰基化合物丙烯酰胺晚期糖基化终末产物

A Continuum-Atomistic Multi-Timescale Algorithm for Micro/Nano Flows

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Communications in Computational Physics 2008年第10期4卷 1279-1291页

作者： Jin Liu shiyi Chen Xiaobo Nie Mark O.Robbins Department ofMechanical Engineering Johns Hopkins UniversityBaltimoreMD 21218USA State Key Laboratory for Turbulence and Complex Systems College of Engineering and Center for Computational Science and EngineeringPeking UniversityBeijingChina Department of Physics and Astronomy Johns Hopkins UniversityBaltimoreMD 21218USA Exa Corporation BurlingtonMA 01803USA

Amulti-timescale algorithmis proposed for simulating time-dependent problems in micro-and *** total simulation domain is spatially decomposed into two *** dynamics is employed in the crucial interfacial regions and continuum hydrodynamics is adopted in the remaining bulk *** coupling is through“constrained dynamics”in an overlap *** time scheme is based on the time scale separation between the continuum macro time step and molecular micro time *** allows the molecular dynamics during one macro time step to be treated as in quasi-steady ***,molecular simulation is only performed in two shorter time *** linear extrapolation of macroscopic velocities and re-initialization of particle configurations,we can significantly reduce the total computational *** demonstrate and discuss our time algorithm through hybrid simulation of channel flow driven by a sinusoidally moving top *** results are achieved for cases of large separation of time scale with much less computational cost than with the original hybrid simulation without time extrapolation.

关键词： Multi-scale simulation domain decompositions hybrid simulations micro-/nanofluidics

Analysis of the Harmonic Response of a Modulation Permanent Magnetic Transmission Equipment Based on ANSYS

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Energy and Power Engineering 2015年第3期7卷 63-70页

作者： Zhiping Zeng Jun Li shiyi Zhang Yintao hong Yaohong Wang School of Mechatronics & Automotive Engineering Chongqing Jiaotong University Chongqing China School of Marine Navigation Chongqing Jiaotong University Chongqing China

This paper analyzes the structure and transmission principles of a modulation permanent magnet gear transmission. Its 3D data model is built based on the known optimized parameters from research team. Its structure of the harmonic response is analyzed and discussed under the software ANSYS. The displacement response and the initial 6 order response frequency and phase angle are obtained. The change rule of these responses is known under the forced vibration.

关键词： Magnetic Field Modulation Permanent Magnetic Transmission ANSYS Harmonic Response Analysis