检索结果-南通市图书馆

Exosomes loaded a smart bilayer-hydrogel scaffold with ROS-scavenging and macrophage-reprogramming properties for repairing cartilage defect

引用

Bioactive Materials 2024年第8期38卷 137-153页

作者： Xiaoqing Lu Shimin Dai Benzhao Huang shishuo li Peng Wang Zhibo Zhao Xiao li Ningbo li Jie Wen Yunhan Sun Zhentao Man Bing liu Wei li Department of Joint Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandong250021PR China School of Stomatology Shandong First Medical University&Shandong Academy of Medical SciencesJinanShandong250117PR China College of Sports Medicine and Rehabilitation Shandong First Medical University&Shandong Academy of Medical SciencesTaianShandong271016PR China Medical Science and Technology Innovation Center Shandong First Medical University&Shandong Academy of Medical SciencesJinanShandong250117PR China Endocrine and Metabolic Diseases Hospital of Shandong First Medical University Shandong Institute of Endocrine and Metabolic DiseasesJinanShandong250062PR China

Enhancing the regeneration of cartilage defects remains challenging owing to limited innate self-healing as well as acute inflammation arising from the overexpression of reactive oxygen species(ROS)in post-traumatic ***,stem cell-derived exosomes(Exos)have been developed as potential cell-free therapy for cartilage *** this approach promotes chondrogenesis,it neglects the emerging inflammatory *** this study,a smart bilayer-hydrogel dual-loaded with sodium diclofenac(DC),an anti-inflammatory drug,and Exos from bone marrow-derived mesenchymal stem cells was developed to mitigate initial-stage inflammation and promote late-stage stem-cell recruitment and chondrogenic ***,the upper-hydrogel composed of phenylboronic-acid-crosslinked polyvinyl alcohol degrades in response to elevated levels of ROS to release DC,which mitigates oxidative stress,thus reprogramming macrophages to the pro-healing ***,Exos are slowly released from the lower-hydrogel composed of hyaluronic acid into an optimal microenvironment for the stimulation of *** in vitro and in vivo assays confirmed that the dual-loaded bilayer-hydrogel reduced post-traumatic inflammation and enhanced cartilage regeneration by effectively scavenging ROS and reprogramming *** proposed platform provides multi-staged therapy,which allows for the optimal harnessing of Exos as a therapeutic for cartilage regeneration.

关键词： Exosomes Hydrogels Cartilage Reactive oxygen species Macrophage Inflammation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

冷却条件对等离子弧送粉增材316L不锈钢组织性能影响研究

引用

稀有金属 2021年第9期45卷 1062-1069页

作者：赵宇辉王志国赵吉宾何振丰李世硕张宏伟中国科学院沈阳自动化研究所辽宁沈阳110016 中国科学院机器人与智能制造创新研究院辽宁沈阳110169 中国科学院大学北京100049 沈阳航空航天大学机电工程学院辽宁沈阳110135 中国科学院金属研究所辽宁沈阳110016 泰州鑫玛科技产业发展有限公司江苏泰州225327

分别在气体强制冷却和自然冷却条件下,采用等离子弧送粉增材设备成形316L不锈钢薄壁试样,基于光学显微镜(OM)、扫描电镜(SEM)、显微硬度仪、万能材料试验机等对比分析了其宏观形貌、组织形态、枝晶尺度、显微硬度及室温拉伸性能差异性,... 详细信息

分别在气体强制冷却和自然冷却条件下,采用等离子弧送粉增材设备成形316L不锈钢薄壁试样,基于光学显微镜(OM)、扫描电镜(SEM)、显微硬度仪、万能材料试验机等对比分析了其宏观形貌、组织形态、枝晶尺度、显微硬度及室温拉伸性能差异性,以获得冷却条件差异对离子弧增材试样组织及性能的影响机制。结果分析表明:在外加气体强制冷却条件下,沉积层组织生长方向性更明显,沉积层内等轴晶与柱状晶比例明显少于自然冷却条件;不同冷却条件下组织均呈现树枝晶形态,而气体强制冷却条件下二次枝晶间距更小,且随着沉积层增加差异性更加明显,这导致气体强制冷却条件下沉积试样整体硬度分布更加均匀;通过应力应变曲线及断口形貌分析可以得出,气体强制冷却条件下沉积试样的抗拉强度和屈服强度得到提升,其中抗拉强度从489 MPa提升到了523 MPa,强度的提升与沉积层组织中枝晶尺度细化相对应。

关键词：冷却条件离子弧增材 316L不锈钢组织

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Review on Thermal Management of li-ion Battery:from Small-Scale Battery Module to Large-Scale Electrochemical Energy Storage Power Station

引用

Journal of Thermal Science 2025年第1期34卷 1-23页

作者： CHEN Zhifeng JIA li YIN liaofei DANG Chao REN Honglei ZHANG Zhiqiang Beijing Key Laboratory of Flow and Heat Transfer of Phase Changing in Micro and Small Scale School of MechanicalElectronic and Control EngineeringBeijing Jiaotong University

li-ion battery is an essential component and energy storage unit for the evolution of electric vehicles and energy storage technology in the ***,in order to cope with the temperature sensitivity of li-ion battery and maintain li-ion battery safe operation,it is of great necessary to adopt an appropriate battery thermal management system(BTMS).In this paper,the current main BTM strategies and research hotspots were discussed from two aspects:small-scale battery module and large-scale electrochemical energy storage power station(EESPS).The practical application situation,advantages and disadvantages,and the future development trend of each heat dissipation method(air,liquid,PCM,heat pipe,hybrid cooling) were described in *** them,the air cooling and liquid cooling were reviewed in-depth based on the engineering *** PCM,heat pipe and hybrid cooling were reviewed extensively based on the latest *** research provides a comprehensive understanding for the BTMS in all scales.

关键词： battery thermal management cooling methods large-scale electrochemical energy storage power station small-scale battery module

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Interpretable Machine Learning Method for Compressive Strength Prediction and Analysis of Pure Fly Ash-based Geopolymer Concrete

引用

Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 65-78页

作者： SHI Yuqiong li Jingyi ZHANG Yang li li Key Laboratory of Agricultural Soil and Water Engineering in Arid and Semiarid Areas of Ministry of Education Northwest A&F Uni-versityYangling 712100China College of Water Resources and Architectural Engineering Northwest A&F UniversityYangling 712100China Chongqing Key Laboratory of Public Big Data Security Technology Chongqing 401420China Chongqing College of Mobile Communication Chongqing 401520China Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina National Rail Transit Electrification and Automation Engineering Technology Research Center(Hong Kong Branch) The Hong Kong Polytechnic UniversityKowloonHung HomHong KongChina

In order to study the characteristics of pure fly ash-based geopolymer concrete(PFGC)conveniently,we used a machine learning method that can quantify the perception of characteristics to predict its compressive *** this study,505 groups of data were collected,and a new database of compressive strength of PFGC was *** order to establish an accurate prediction model of compressive strength,five different types of machine learning networks were used for comparative *** five machine learning models all showed good compressive strength prediction performance on *** them,R2,MSE,RMSE and MAE of decision tree model(DT)are 0.99,1.58,1.25,and 0.25,*** R2,MSE,RMSE and MAE of random forest model(RF)are 0.97,5.17,2.27 and 1.38,*** two models have high prediction accuracy and outstanding generalization *** order to enhance the interpretability of model decision-making,we used importance ranking to obtain the perception of machine learning model to 13 *** 13 variables include chemical composition of fly ash(SiO_(2)/Al_(2)O_(3),Si/Al),the ratio of alkaline liquid to the binder,curing temperature,curing durations inside oven,fly ash dosage,fine aggregate dosage,coarse aggregate dosage,extra water dosage and sodium hydroxide *** temperature,specimen ages and curing durations inside oven have the greatest influence on the prediction results,indicating that curing conditions have more prominent influence on the compressive strength of PFGC than ordinary Portland cement *** importance of curing conditions of PFGC even exceeds that of the concrete mix proportion,due to the low reactivity of pure fly ash.

关键词： machine learning pure fly ash geopolymer compressive strength feature perception

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Manufacture the conducting polymer with light

引用

Science China Chemistry 2025年第1期68卷 8-9页

作者： Yang li Tianyu li Yan Ji Baoguang liu College of Electronic and Optical Engineering & College of Flexible Electronics (Future Technology) Nanjing University of Posts & Telecommunications

Poly(3,4-ethylenedioxythiophene) (PEDOT), heralded as the “king” of conducting polymers, is esteemed in bioelectronics for its mixed electronic and ionic conductivity, mechanical properties compatible with biological tissues, tunable healing ability and stability in diverse environments [1]. Based on additive manufacturing of three-dimensional structures,PEDOT realizes the implementation in the efficient production of flexible bioelectronics, the construction of intricate electrode-neural implantations, and the development of smart brain-computer-interfaces [2].

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

A Wind Tunnel Experimental Study on the Wake Characteristics of a Horizontal Axis Wind Turbine

引用

Journal of Thermal Science 2025年第1期34卷 145-158页

作者： GUO Xingduo li Yinran li Rennian MA Yulong WEI Kui College of Energy and Power Engineering Lanzhou University of Technology Key Laboratory of Fluid Machinery and Systems Gansu Provincial Technology Centre for Wind Turbines

The characteristics of wind turbine wakes are influenced by multiple factors,including the atmospheric boundary layer(ABL) wind and wind turbine operating conditions(e.g.,tip speed ratio and yaw angle).In this study,two types of ABL winds with different velocity gradients and turbulence intensities are generated in a wind tunnel through configurations of spires,baffles,and various numbers of roughness elements.A wind turbine with a rotor diameter of 0.8 m and a hub height of 0.6 m is tested under varying tip speed ratios,yaw angles,and ABL wind *** results indicate that the streamwise velocity deficit in the near-wake region becomes more pronounced with an increase in the tip speed ratio,while the far-wake velocity deficit remains largely unaffected by changes in the tip speed *** the yaw angle increases,the wake deflection becomes more prominent and the wake narrows;the offset of the wake center at various downstream positions grows linearly,reaching a maximum value of approximately half the rotor ***,the turbulence level and influence range in the wake region are reduced when the turbine is *** ABL wind conditions,high turbulence intensity in the incoming flow accelerates wake recovery,and the Reynolds stress at different lateral positions tends to become consistent with increasing longitudinal ***,turbulence has a significant impact on the meandering characteristics of the wind turbine wake,with greater fluctuations in the wake center observed under higher turbulence ***,this study provides insights that could inform the optimal operation of wind farms.

关键词： horizontal axis wind turbine turbulence wind tunnel experiment wind turbine wake

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Exploring spatiotemporal patterns of geosocial media data for urban functional zone identification

引用

International Journal of Digital Earth 2022年第1期15卷 1305-1325页

作者： Aleta Mawuenyegah Songnian li shishuo Xu Department of Civil Engineering Toronto Metropolitan UniversityTorontoCanada School of Geomatics and Urban Spatial Informatics Beijing University of Civil Engineering and ArchitectureBeijingPeople’s Republic of China Key Laboratory of Urban Spatial Informatics Ministry of Natural Resources of the People’s Republic of ChinaBeijingPeople’s Republic of China

Urban Functional Zones(UFZs)can be identified by measuring the spatiotemporal patterns of activities that occur within *** media data possesses abundant spatial and temporal information for activity *** UFZs from geosocial media data aids urban planning,infrastructure,resource allocation,and transportation modernization in the complex urban *** this work,we proposed an integrated approach by combining the spatiotemporal clustering method with a machine learning *** spatiotemporal clustering method was used to mine the spatiotemporal patterns of activities,of which the distinctive features were extracted as inputs into a machine learning classifier for UFZ *** results show that more than 80%of the UFZs can be correctly identified by our proposed *** reveals that this work serves as a functional groundwork for future studies,facilitating the understanding of urban systems as well as promoting sustainable urban development.

关键词： Urban functional zones geosocial media twitter spatiotemporal clustering random forest

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Photo‑Energized MoS_(2)/CNT Cathode for High‑Performance li–CO_(2)Batteries in a Wide‑Temperature Range

引用

Nano-Micro Letters 2025年第1期17卷 160-175页

作者： Tingsong Hu Wenyi lian Kang Hu Qiuju li Xueliang Cui Tengyu Yao Laifa Shen Jiangsu Key Laboratory of Materials and Technologies for Energy Storage College of Materials Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

li–CO_(2) batteries are considered promising energy storage systems in extreme environments such as Mars;however,severe performance degradation will occur at a subzero temperature owning to the sluggish reaction ***,a photo-energized strategy adopting sustainable solar energy in wide working temperature range li–CO_(2) battery was achieved with a binder-free MoS_(2)/carbon nanotube(CNT)photo-electrode as *** unique layered structure and excellent photoelectric properties of MoS_(2) facilitate the abundant generation and rapid transfer of photo-excited carriers,which accelerate the CO_(2) reduction and li_(2)CO_(3) decomposition upon *** illuminated battery at room temperature exhibited high discharge voltage of 2.95 V and mitigated charge voltage of 3.27 V,attaining superior energy efficiency of 90.2%and excellent cycling stability of over 120 *** at an extremely low temperature of−30℃,the battery with same electrolyte can still deliver a small polarization of 0.45 V by the photoelectric and photothermal synergistic mechanism of MoS_(2)/CNT *** work demonstrates the promising potential of the photo-energized wide working temperature range li–CO_(2) battery in addressing the obstacle of charge overpotential and energy efficiency.

关键词： li-CO_(2)batteries Photo-energized Wide operation-temperature Kinetics MoS_(2)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Constraints on holographic QCD phase transitions from PTA observations

引用

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He li li Sai Wang Shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Deciphering the role of mtH2O2 in hepatic ischemia-reperfusion injury mechanisms with low-background super-resolution fluorogenic probe

引用

Science China Chemistry 2025年第1期68卷 297-307页

作者： Bin Fang limin Wang Haoqin li Jiaxin Zhang Yang Ding Pan Pan li Bo Peng Hua Bai lin li Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials &Engineering Northwestern Polytechnical University Institute of Flexible Electronics (IFE Future Technologies) Xiamen University

Hepatic ischemia-reperfusion injury（HIRI） is characterized by mitochondrial dysfunction and oxidative stress. Monitoring mitochondrial hydrogen peroxide（mtH2O2） levels in real-time through super-resolution imaging is crucial for elucidating its distribution in live cells and its mechanism of action during HIRI. However, low-background fluorogenic probes have been overlooked in the context of super-resolution imaging. In this study, we developed a low-background fluorogenic probe（MitoWG） with the potential for super-resolution morphology-correlated mitochondrial identification to track the fluctuates of mtH2O2in HIRI. Activation of the desirable fluorescence properties of the probe by mtH2O2was confirmed using structural illumination microscopy（SIM）, enabling high-quality mitochondrial imaging with exceptional specificity and *** in mtH2O2levels were successfully observed in both cellular and rat models of HIRI. Furthermore, we associated the decline in mitochondrial redox homeostasis with accelerated mtH2O2production during HIRI, which triggered mitophagy deficiency and led to cell death. In conclusion, Mito-WG possesses excellent photophysical and low-background properties for SIM imaging, making it a promising tool for mtH2O2tracking in HIRI research and clinical diagnosis.

关键词： hepatic ischemia-reperfusion injury low-background mtH2O2-activatable super-resolution imaging fluorogenic probe

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：