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Adaptive Network Sustainability and Defense Based on Artificial Bees Colony Optimization Algorithm for Nature Inspired Cyber Security

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Computer Systems Science & Engineering 2024年第3期48卷 739-758页

作者： Chirag Ganguli shishir.kumar.shandilya Michal Gregus Oleh Basystiuk Institute of Technology VIT Bhopal UniversityBhopalIndia School of Data Science and Forecasting Devi Ahilya UniversityIndore452001India Department of Information Systems Comenius University in BratislavaBratislava82005Slovak Republic Department of Artificial Intelligence Lviv Polytechnic National UniversityLviv79013Ukraine

Cyber Defense is becoming a major issue for every organization to keep business continuity *** presented paper explores the effectiveness of a meta-heuristic optimization algorithm-Artificial Bees Colony Algorithm(ABC)as an Nature Inspired Cyber Security mechanism to achieve adaptive *** experiments on the Denial-Of-Service attack scenarios which involves limiting the traffic flow for each *** today have adapted their service distribution models to include the use of the Internet,allowing them to effectively manage and interact with their customer *** shift has created an increased reliance on online services to store vast amounts of confidential customer data,meaning any disruption or outage of these services could be disastrous for the business,leaving them without the knowledge to serve their *** can exploit such an event to gain unauthorized access to the confidential data of the *** proposed algorithm utilizes an Adaptive Defense approach to continuously select nodes that could present characteristics of a probable malicious *** any changes in network parameters,the cluster of nodes is selected in the prepared solution set as a probable malicious node and the traffic rate with the ratio of packet delivery is managed with respect to the properties of normal nodes to deliver a disaster recovery plan for potential businesses.

关键词： Artificial bee colonization adaptive defense cyber attack nature inspired cyber security cyber security cyber physical infrastructure

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Molecular pathology for cholangiocarcinoma:a review of actionable genetic targets and their relevance to adjuvant&neoadjuvant therapy,staging,follow-up,and determination of minimal residual disease

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Hepatobiliary Surgery and Nutrition 2024年第1期13卷 29-38页

作者： Emilie A.K.Warren shishir K.Maithel Division of Surgical Oncology Winship Cancer InstituteEmory UniversityAtlantaGAUSA

Cholangiocarcinoma(CCA)represents a group of epithelial cell tumors classified based on their anatomic location along the biliary *** rare malignancy is often diagnosed at an advanced stage and deemed *** for those patients who are surgical candidates,recurrence rates are high and survival rates *** mainstay of therapy for advanced CCA remains cisplatin plus gemcitabine,with a median overall survival(mOS)under 12 months,although the TOPAZ-1 trial showed a survival benefit with the addition of programmed cell death ligand 1(PD-L1)*** recent years,molecular profiling has revealed a wealth of potentially targetable genetic alterations,including fibroblast growth factor receptor(FGFR)fusions,isocitrate dehydrogenase 1(IDH1)mutations,human epidermal growth factor receptor 2(HER2)amplification and overexpression,and microsatellite instability(MSI).These discoveries have prompted numerous clinical trials employing drugs against these specific genetic *** foundation laid by early clinical studies and the landscape of ongoing trials are both summarized *** the role of adjuvant therapy has yet to be defined in this disease,we emphasize the importance of employing targeted therapies in trials in the adjuvant and neoadjuvant spaces and discuss ways to overcome challenges due to low incidence of targetable *** medicine for this disease promises significant clinical benefit to patients,but further investigation is needed.

关键词： Cholangiocarcinoma(CCA) biliary tract cancer(BTC) targeted therapy molecular profiling

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INFLUENCE OF RIGID BOUNDARY ON THE LOVE WAVE PROPAGATION IN ELASTIC LAYER WITH VOID PORES

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Acta Mechanica Solida Sinica 2013年第5期26卷 551-558页

作者： Sumit kumar Vishwakarma shishir Gupta Dinesh kumar Majhi Department of Applied Mathematics Indian School of Mines Department of Mathematics Birla Institute of Technology and Science

In this paper, a mathematical model for Love wave propagation in a porous elastic layer under a rigid boundary resting over a poro-elastic half-space has been developed. The study shows that such a medium transmits two types of Love waves. The first front depends on the change in volume fraction of the pores whereas the second front depends upon the modulus of rigidity of the elastic matrix of the medium and is the same as the Love wave in an elastic layer over an elastic half-space. It is observed that the first front is many times faster than the shear wave in the medium with void pores due to the change in the volume fraction of the pores and is significant.

关键词： Love waves void pores volume fraction rigid boundary wave front

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Ethanol mediated As(Ⅲ) adsorption onto Zn-loaded pinecone biochar：Experimental investigation,modeling,and optimization using hybrid artificial neural network-genetic algorithm approach

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Journal of Environmental Sciences 2017年第4期29卷 114-125页

作者： Mohd.Zafar N.Van Vinh shishir kumar Behera Hung-Suck Park Center for Clean Technology and Resource Recycling University of Ulsan Ulsan 680749 South Korea Department of Applied Biotechnology Sur College of Applied Sciences Sur 411 Al Shariya Sultanate of Oman Department of Civil and Environmental Engineering University of Ulsan Ulsan 680749 South Korea Chemical Engineering Department GMR Institute of Technology Rajam 532127 Srikakulam Dist. India

Organic matters（OMs） and their oxidization products often influence the fate and transport of heavy metals in the subsurface aqueous systems through interaction with the mineral surfaces. This study investigates the ethanol（EtO H）-mediated As（Ⅲ） adsorption onto Zn-loaded pinecone（PC） biochar through batch experiments conducted under Box–Behnken design. The effect of EtO H on As（Ⅲ） adsorption mechanism was quantitatively elucidated by fitting the experimental data using artificial neural network and quadratic modeling approaches. The quadratic model could describe the limiting nature of EtO H and pH on As（Ⅲ） adsorption,whereas neural network revealed the stronger influence of Et OH（64.5%） followed by pH（20.75%）and As（Ⅲ） concentration（14.75%） on the adsorption phenomena. Besides, the interaction among process variables indicated that Et OH enhances As（Ⅲ） adsorption over a pH range of2 to 7, possibly due to facilitation of ligand–metal（Zn） binding complexation ***, hybrid response surface model–genetic algorithm（RSM–GA） approach predicted a better optimal solution than RSM, i.e., the adsorptive removal of As（Ⅲ）（10.47 μg/g） is facilitated at 30.22 mg C/L of Et OH with initial As（Ⅲ） concentration of 196.77 μg/L at pH 5.8. The implication of this investigation might help in understanding the application of biochar for removal of various As（Ⅲ） species in the presence of OM.

关键词： As(Ⅲ) removal Competitive adsorption Ethanol Box–Behnken design Artificial neural network Hybrid RSM–GA optimization

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Pre-operative visceral adipose tissue radiodensity is a potentially novel prognostic biomarker for early endoscopic post-operative recurrence in Crohn’s disease

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 740-750页

作者： Phillip Gu shishir Dube Norman Gellada So Yung Choi Susan Win Yoo Jin Lee Shaohong Yang Talin Haritunians Gil Y Melmed Eric A Vasiliauskas Niru Bonthala Gaurav Syal Andres J Yarur David Ziring Shervin Rabizadeh Phillip Fleshner Cindy Kallman Suzanne Devkota Stephan R Targan Dalin Li Dermot PB McGovern Department of Medicine Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Imaging Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Biostatistics Shared Resource Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Internal Medicine Keimyung University School of MedicineDaegu 42601South Korea Department of Medicine University of California at Los AngelesLos AngelesCA 90095United States Department of Medicine University of California at San DiegoSan DiegoCA 92093United States Department of Pediatrics Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Surgery Cedars-Sinai Medical CenterLos AngelesCA 90048United States

BACKGROUND Evidence suggests inflammatory mesenteric fat is involved in post-operative recurrence(POR)of Crohn’s disease(CD).However,its prognostic value is INTRODUCTION Crohn’s disease(CD)is a debilitating chronic immune-mediated inflammatory disease(IMID)of the gastrointestinal tract that is increasing in incidence and prevalence globally[1].CD patients often undergo surgery for disease-related complic-ations and/or medically refractory ***,surgery is not curative,and many patients develop post-operative recurrence(POR)of CD with a significant proportion eventually requiring additional *** advances in early detection and therapeutics,the contemporary 10-year risk of surgery has improved from 50%to 26%,but the risk of recurrent surgery has remained unchanged at 30%,suggesting a need to improve post-operative management strategies[2].Presently,there are two accepted strategies to mitigate POR,but each have potential ***,patients start early post-operative pharmacologic prophylaxis within 4-6 wk after *** strategy can potentially overtreat a subset of patient who may not develop long-term disease recurrence off ***,these patients are at risk of medication-related adverse events and the direct and indirect costs associated with therapy with little or no benefit[3].The second strategy is performing early colonoscopy within 6-12 months after surgery and escalating therapy based on FOOTNOTES Author contributions:Gu P is the guarantor of the article and was involved in concept and design,data collection,statistical analysis,drafting of manuscript,and final approval of manuscript;Dube S and Choi SY were involved in statistical analysis,drafting of the manuscript,and final approval of manuscript;Gellada N,Win S,Lee YJ and Yang S were involved in the data collection,drafting of the manuscript,and final approval of manuscript;Haritunians T and Li D were involved in data analysis and interpretation,drafting

关键词： Crohn’s disease Surgery Visceral adipose tissue Mesenteric adipose tissue Creeping fat Computed tomography

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Wind energy as a source of green hydrogen production in the USA

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Clean Energy 2023年第1期7卷 8-22页

作者： Ashish Sedai Rabin Dhakal shishir Gautam Bijaya kumar Sedhain Biraj Singh Thapa Hanna Moussa Suhas Pol National Wind Institute Texas Tech UniversityLubbockTX 79401USA Department of Mechanical Engineering Texas Tech UniversityLubbockTX 79401USA Department of Mechanical Engineering Tribhuvan UniversityPurbanchal CampusDharanNepal Green Hydrogen Lab Department of Mechanical EngineeringKathmandu UniversityDhulikhelNepal Wind Energy Program Texas Tech UniversityLubbockTX 79401USA

The study incorporates an overview of the green hydrogen-production potential from wind energy in the USA,its application in power generation and the scope of substituting grey and blue hydrogen for industrial *** 10 million metric tons of grey and blue hydrogen is produced in the USA annually to fulfil the industrial demand,whereas,for 1 million metric tons of hydrogen generated,13 million metric tons of CO_(2) are released into the *** research aims to provide a state-of-the-art review of the green hydrogen technology value chain and a case study on the production of green hydrogen from an 8-MW wind turbine installed in the southern plain region of *** research estimates that the wind-farm capacity of 130 gigawatt-hours is required to substitute grey and blue hydrogen for fulfilling the current US annual industrial hydrogen demand of 10 million metric *** study investi-gates hydrogen-storage methods and the scope of green hydrogen-based storage facilities for energy produced from a wind *** research focuses on the USA’s potential to meet all its industrial and other hydrogen application requirements through green hydrogen.

关键词： green hydrogen wind energy electrolysis greenhouse gases

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An empirical L-band scintillation model for a mid-latitude station,Weihai, China during the low solar activity period

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Science China(Technological Sciences) 2019年第7期62卷 1182-1190页

作者： PRIYADARSHI shishir ZHANG Qing-He WANG Yong Shandong Provincial Key laboratory of Optical Astronomy and Solar-Terrestrial Environment Institute of Space SciencesShandong University

Mid-latitude ionospheric scintillation has been studied in very poor proportion as compared to the equatorial and high latitude ionospheric scintillation. Mid-latitude ionospheric scintillations are often associated with either day time photo-ionization or due to the storm enhanced density. Using the phase screen model and the wave propagation theory in random media, we have identified the orientation of the ionospheric irregularities over Weihai with the local geomagnetic field. Amplitude and phase scintillation data observed using global positioning system(GPS) scintillation receiver deployed at the mid-latitude observation station Weihai, have been used along with K-index derived from the horizontal magnetic field component of the local magnetometer. The proposed model uses the scintillation indices relationship with the local K-index. We identified the scintillation dependence over local K-index during geomagnetic quiet and disturbed condition. This dependence coefficient is used on the real scintillation data for modeling. The presented scintillation model has been validated by comparing it to the real observations. The co-relation coefficient is more than 90% during the disturbed as well as quiet geomagnetic conditions.

关键词： mid-latitude ionosphere scintillation GPS global navigation satellite systems (GNSS)

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Effects of Topography and Land use on Woody Plant Species Composition and Beta Diversity in an Arid Trans-Himalayan Landscape, Nepal

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Journal of Mountain Science 2014年第5期11卷 1112-1122页

作者： shishir PAUDEL Ole R VETAAS Natural Resources Ecology and Management Oklahoma State UniversityStillwater OK 74078 USA Department of Geography University of BergenPost Box 7800 N-5020 Bergen Norway

Distribution patterns of plant species are believed to be impacted by small-scale habitat heterogeneity. However, there have been few comparative studies examining how woody vegetation composition and diversity varies with aspects of different orientations in the Trans-Himalayan region at a local scale. Here, we examined the effects of incoming solar radiation on variation in woody species composition and compared the diversity between the northeast- and southwest-facing slopes in a Trans-Himalayan valley of Nepal. We also examined the implicit interactions between slope orientation and land use in determining the compositional variations between the slopes. We selected two pairs of northeast- and southwest-facing slopes where the first pair has a similar land use and differs in exposure only(Pisang site) while the other pair has clear differences in land use in addition to slope exposure(Braka site). In each site, we sampled 72 plots(36 on each slope) in which the presence and absence of woody species, environmental variables, and disturbance were recorded. Correspondence Analysis(CA) results suggested that the woody species composition significantly varied between northeast- and southwest-facing slopes at both sites, and was significantly correlated with measured environmental variables such as radiation index, altitude, and canopy openness. In the Braka site,mean alpha diversity was significantly higher on southwest-facing slopes. In contrast, beta diversity and gamma diversity were greater on northeast-facing slopes at both sites. Our results suggest that topographic variables(e.g., radiation index) affect species composition between the slopes, likely due to their influence on small scale abiotic environmental variables. However, the effects of land use, such as livestock browsing/grazing may interact with the effects of slope exposure, effectively reducing differences in species composition within slopes but enhancing the differences in beta diversity between

关键词： Correspondence analysis Diversity Environmental gradients Himalaya Land use Topographic aspect Woody vegetation

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Memory response in a nonlocal micropolar double porous thermoelastic medium with variable conductivity under Moore-Gibson-Thompson thermoelasticity theory

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Journal of Ocean Engineering and Science 2023年第3期8卷 263-277页

作者： shishir Gupta Rachaita Dutta Soumik Das Department of Mathematics and Computing Indian Institute of Technology(ISM)DhanbadJharkhand 826004India

The present study enlightens the two-dimensional analysis of the thermo-mechanical response for a mi-cropolar double porous thermoelastic material with voids(MDPTMWV)by virtue of Eringen’s theory of nonlocal ***-Gibson-Thompson(MGT)heat equation is introduced to the considered model in the context of memory-dependent derivative and variable *** employing the normal mode technique,the non-dimensional coupled governing equations of motion are solved to determine the an-alytical expressions of the displacements,temperature,void volume fractions,microrotation vector,force stress tensors,and equilibrated stress *** two-dimensional graphs are presented to demon-strate the influence of various parameters,such as kernel functions,thermal conductivity,and ***,different generalized thermoelasticity theories with variable conductivity are compared to visualize the variations in the distributions associated with the prior mentioned *** particu-lar cases are also discussed in the presence and absence of different parameters.

关键词： Memory-dependent derivative Eringen’s nonlocal elasticity theory Micropolar double porous thermoelastic material with voids Moore-Gibson-Thompson thermoelasicity Variable conductivity

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Screening of the whole human cytochrome P450 complement(CYPome)with enzyme bag cocktails

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Journal of Pharmaceutical Analysis 2020年第3期10卷 271-276页

作者： Sangeeta Shrestha Sharma shishir Sharma Matthias Bureik School of Pharmaceutical Science and Technology Health Sciences PlatformTianjin UniversityTianjin300072China

We have previously introduced the use of permeabilized fission yeast cells(enzyme bags)that recombinantly express full-length CYPs for drug metabolism *** enzyme bags are cells with pores that function as enzymes in *** can easily be prepared without a need for ultracentrifugation and may be used in similar protocols as *** this study we report the preparation of enzyme bag cocktails that permit the testing of multiple CYPs in a single enzyme bag ***,we established a convenient testing scheme that permits a rapid screen of all human CYPs for activity towards any given candidate *** important aspect of this approach is the reduction of individual CYP test *** a cocktail containing many CYPs tests negative,it follows that all CYPs included in that cocktail need not be tested individually,thus saving time and *** new protocol was validated using two probe substrates.

关键词： Cytochrome P450 Drug metabolism Fission yeast Luminescence Proluciferin

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