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Chinese Journal of Chemical Engineering 2023年第10期62卷 159-167页

作者： Yi Wu Hongzhou Shang shisheng lai Yali Di Xiaoran Sun Ning Qiao Lihua Han Zheng Zhao Yujin Lu College of Chemical Engineering North China University of Science and TechnologyTangshan 063210China College of Materials Science and Engineering North China University of Science and TechnologyTangshan 063210China College of Pharmacy North China University of Science and TechnologyTangshan 063210China Department of Cardiology Tangshan Central HospitalTangshan 063000China

A novel light responsive nanosphere was constructed,and it was used as a drug carrier to investigate the loading and release properties of the Quercetin(QU).In this paper,mesoporous silica nanoparticles(MSN)were used as a substrate,and 3-aminopropyl triethyoxysilane was used as a surface modification agent to introduce—NH_(2),and the azobenzene-4,4’-dicarboxylic acid(AZO)was used as light responsive agent to introduce the group of—N=N—,and thenβ-cyclodextrin(β-CD)was combined with AZO through host-guest interaction to construct light responsive nanoparticles(MSN@β-CD).The structure and properties of the carrier were analyzed by FTIR,BET,XPS,TGA,XRD,SEM and *** vitro drug release studies showed the release rate of QU@MSN@β-CD(dark)was 12.19%within 72 h,but the release rate of QU@MSN@β-CD(light 10 min)was 26.09%,exhibiting a light-responsive *** CCK8 tests demonstrated that MSN@β-CD could significantly decrease the toxicity of ***,the controllable light-responsive drug delivery system has great application prospects.

关键词： Silica Drug delivery system Light-responsive b-CD Nanomaterials Support

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L-多巴脱羧酶在喉癌中的表达

临床耳鼻咽喉头颈外科杂志 2014年第24期28卷 1964-1967,1971页

作者：赖史胜万志荔赣南医学院第一附属医院耳鼻咽喉科江西赣州3410002 赣南医学院第一附属医院眼科

目的:分析L-多巴脱羧酶(DDC)mRNA和蛋白在喉癌组织中的表达,以评估其在喉癌诊断和预后中的临床意义。方法:从53例喉癌患者的肿瘤切除手术中获取106份组织样品,并从这些组织样品中分别分离出总RNA。采用RT-PCR法对DDC mRNA的表达水平进... 详细信息

目的:分析L-多巴脱羧酶(DDC)mRNA和蛋白在喉癌组织中的表达,以评估其在喉癌诊断和预后中的临床意义。方法:从53例喉癌患者的肿瘤切除手术中获取106份组织样品,并从这些组织样品中分别分离出总RNA。采用RT-PCR法对DDC mRNA的表达水平进行量化,同时采用Western Blot蛋白质印迹法对DDC蛋白的表达水平进行检测。结果:与正常喉黏膜组织相比,原发性喉癌(P=0.000)和复发性喉癌(P=0.033)样品中的DDC mRNA表达水平都出现了显著下调。且DDC mRNA表达水平与患者年龄和组织学分级无关,但与TNM分期之间存在显著的负相关性(P=0.021)。同时,我们在肿瘤和正常喉组织中都检测到了DDC蛋白的表达。结论:DDC的表达状态可能在喉癌的发展中发挥重要的作用,在未来的喉癌患者临床管理中具有重要的意义。

关键词：喉肿瘤 L-多巴脱羧酶相对定量RT-PCR 印迹法,蛋白质

S100A7蛋白在头颈鳞状细胞癌中的表达与意义

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临床耳鼻咽喉头颈外科杂志 2014年第18期28卷 1376-1379页

作者：赖史胜万志荔赣南医学院第一附属医院耳鼻咽喉科江西赣州341000 赣南医学院第一附属医院眼科

目的:检测S100A7蛋白在头颈鳞状细胞癌组织中的表达,分析其与头颈鳞状细胞癌临床病理学参数的关系,从而确定其在头颈鳞状细胞癌诊断和预后中的临床意义。方法:采用免疫组织化学SP法分别检测44例正常口腔黏膜组织和44例头颈鳞状细胞癌组... 详细信息

目的:检测S100A7蛋白在头颈鳞状细胞癌组织中的表达,分析其与头颈鳞状细胞癌临床病理学参数的关系,从而确定其在头颈鳞状细胞癌诊断和预后中的临床意义。方法:采用免疫组织化学SP法分别检测44例正常口腔黏膜组织和44例头颈鳞状细胞癌组织中S100A7蛋白。结果:头颈鳞状细胞癌组织中S100A7蛋白的高表达,其阳性率(72.72%)显著高于正常口腔黏膜组织(13.64%),且S100A7蛋白的表达与头颈鳞状细胞癌患者性别无关(P>0.05),但与患者年龄、分化程度、浸润深度、TNM分期和淋巴结转移密切相关。结论:S100A7的高表达可能在头颈鳞状细胞癌的发展中发挥十分重要作用,其高表达可能作为头颈鳞状细胞癌诊断和预后的分子指标。

关键词：头颈鳞状细胞癌 S100A7 免疫组织化学临床病理学参数

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油-稻-稻三熟制下双季稻高产品种特征研究

中国农业科学 2018年第1期51卷 37-48页

作者：吕伟生肖国滨叶川李亚贞陈明肖小军赖诗盛郑伟吴艳黄天宝江西省红壤研究所/江西省红壤耕地保育重点实验室/农业部江西耕地保育科学观测实验站章贡区粮食流通服务中心

【目的】在早稻-晚稻-套播早熟油菜(油-稻-稻)三熟制下,筛选生育期适宜的高产水稻品种,系统研究早、晚稻高产品种特征,以期为油稻稻三熟制下水稻高产品种的选育与栽培提供理论参考。【方法】以9个早稻品种和10个晚稻品种为材料,通过系... 详细信息

【目的】在早稻-晚稻-套播早熟油菜(油-稻-稻)三熟制下,筛选生育期适宜的高产水稻品种,系统研究早、晚稻高产品种特征,以期为油稻稻三熟制下水稻高产品种的选育与栽培提供理论参考。【方法】以9个早稻品种和10个晚稻品种为材料,通过系统聚类分析和方差分析等方法对油稻稻三熟制下双季稻高产品种特征进行研究。【结果】(1)与低产和中产类型双季稻相比,高产类型双季稻有效穗数、结实率、千粒重、生育期差异不显著,但每穗粒数、总颖花量、产量及日均产量显著高于低产类型。(2)高产类型与低产及中产类型双季稻的分蘖增长率、分蘖下降率及高峰苗数差异不显著,但成穗率显著高于低产类型,高产类型分蘖呈稳增缓降的发展态势。(3)早稻抽穗期干物质量及各生育时期平均单茎干物质量不同类型间无显著差异,结实期与全生育期干物质量随产量水平的提高呈增加趋势,高产类型显著高于低产类型;晚稻各生育时期干物质量及平均单茎干物质量不同类型间差异较大,高产类型均显著高于低产类型,但与中产类型差异不显著;各产量类型品种收获指数差异不显著。(4)随产量水平的提高,双季稻抽穗期和成熟期群体叶面积(lai)和单茎叶面积呈增加趋势,灌浆结实期叶面积下降率则呈降低趋势,高产类型与低产类型均存在显著差异;粒叶比随产量水平的提高而增大,其中早稻高产类型与低产类型差异显著,而晚稻差异不明显。【结论】在油稻稻三熟制条件下,高产类型双季稻具有分蘖力中等、成穗率较高、全生育期特别是花后干物质生产量及单茎干物质量大、中后期lai及单茎叶面积较高、每穗粒数较多、总颖花量大、粒叶比协调和日产量高等基本特征。高产类型早稻品种生育期为105—110 d,日产量75—78 kg·hm-2·d-1,每穗粒数125—140粒,千粒重26—28 g;高产类型晚稻品种生育期约115 d,日产量77—81 kg·hm-2·d-1,每穗粒数140—160粒,千粒重24—28 g。

关键词：水稻油菜三熟制产量品种特征

介孔二氧化硅基纳米粒作为药物载体的最新研究进展

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化工新型材料 2021年第9期49卷 240-243,249页

作者：江悦尚宏周孙晓然韩利华杨梦然来士胜华北理工大学化学工程学院唐山063210 华北理工大学材料科学与工程学院唐山063210 华北理工大学药学院唐山063210

介孔SiO_(2)纳米粒具有较大的比表面积、均匀可控的粒径、良好的生物相容性和生物降解性,被广泛用于药物载体。通过对介孔SiO_(2)纳米粒进行刺激响应性修饰作为药物载体方面的研究进行了归纳总结,并对其未来发展趋势进行了展望。

关键词：介孔二氧化硅表面修饰刺激响应性药物载体

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao lai Xu Zhen Gu Hua Yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

DEVELOPMENT OF EXPERIMENTAL METHODS FOR IMPACT TESTING BY COMBINING HOPKINSON PRESSURE BAR WITH OTHER TECHNIQUES

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Acta Mechanica Solida Sinica 2014年第4期27卷 331-344页

作者： Lili Wang shisheng Hu Liming Yang Zijian Sun Jue Zhu Huawei lai Yuanyuan Ding Mechanics and Material Science Research Center Ningbo University Department of Modern Mechanics University of Science & Technology of China Huafeng Faculty Ningbo Polytechnic Department of Municipal Engineering Zhejiang University of Water Resources and Electric Power

The split Hopkinson pressure bar（SHPB） technique and the wave propagation inverse analysis（WPIA） technique are both extensively used to experimentally investigate the impact behavior of materials, although neither of them alone provides a fully satisfactory analysis. In the present paper, attention is given to new experimental techniques by incorporating a damagemodified constitutive model into the SHPB technique and combining the Hopkinson pressure bar（HPB） technique with WPIA. First, to distinguish the response due to dynamic constitutive behavior and the response due to dynamic damage evolution, the SHPB method incorporating a damage-modified constitutive model is developed, including an explicit damage-modified Zhu–Wang–Tang model and an implicit damage-modified constitutive model. Second, when the SHPB results become invalid, a method of combining new Lagrange inverse analyses with the HPB technique is developed, including cases of the HPB arranged in front of a long specimen and behind the specimen. As examples of these new methods, typical results are given for nonlinear viscoelastic polymers and concretes considering damage evolution, a super-elastic Ti–Ni alloy with phase transformation and an aluminum foam with shock waves propagating within it.

关键词： Hopkinson pressure bar SHPB Lagrangian analysis high strain rate rate-dependent constitutive relation damage evolution

Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang Gao Xinyue Wang Shijie Su Weicheng Feng Yaona lai Kongli Huang Dandan Cao Qi Wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease

Structural Modal Parameter Recognition and Related Damage Identification Methods under Environmental Excitations: A Review

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Structural Durability & Health Monitoring 2025年第1期19卷 25-54页

作者： Chao Zhang Shang-Xi lai Hua-Ping Wang School of Civil Engineering and Mechanics Lanzhou UniversityLanzhou730000China Key Laboratory of Special Functional Materials and Structural Design Ministry of EducationLanzhou UniversityLanzhou730000China

Modal parameters can accurately characterize the structural dynamic properties and assess the physical state of the ***,it is particularly signiﬁcant to identify the structural modal parameters according to the monitoring data information in the structural health monitoring(SHM)system,so as to provide a scientiﬁc basis for structural damage identiﬁcation and dynamic model modiﬁ*** view of this,this paper reviews methods for identifying structural modal parameters under environmental excitation and brieﬂy describes how to identify structural damages based on the derived modal *** paper primarily introduces data-driven modal parameter recognition methods(e.g.,time-domain,frequency-domain,and time-frequency-domain methods,etc.),brieﬂy describes damage identiﬁcation methods based on the variations of modal parameters(e.g.,natural frequency,modal shapes,and curvature modal shapes,etc.)and modal validation methods(e.g.,Stability Diagram and Modal Assurance Criterion,etc.).The current status of the application of artiﬁcial intelligence(AI)methods in the direction of modal parameter recognition and damage identiﬁcation is further *** on the pre-vious analysis,the main development trends of structural modal parameter recognition and damage identiﬁcation methods are given to provide scientiﬁc references for the optimized design and functional upgrading of SHM systems.

关键词： Structural health monitoring data information modal parameters damage identiﬁcation AI method

Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins

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Neural Regeneration Research 2025年第1期20卷 242-252页

作者： Daiyu Hu Yuanqing Cao Chenglin Cai Guangming Wang Min Zhou Luying Peng Yantao Fan Qiong lai Zhengliang Gao Fundamental Research Center Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)School of MedicineTongji UniversityShanghaiChina Institute of Geriatrics(Shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)Shanghai University School of MedicineNantongJiangsu ProvinceChina Shanghai Engineering Research Center of Organ Repair Shanghai University School of MedicineShanghaiChina Key Laboratory of Arrhythmias Ministry of EducationShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Human brain development is a complex process,and animal models often have significant *** address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and *** enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid *** involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid *** cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology *** a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental *** organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature *** exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic *** convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.

关键词： cadmium cell death cell proliferation cortical development environmental toxins neural progenitor cells neurogenesis neurotoxicology organoids stem cells