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甘油三酯/胱抑素C比值对2型糖尿病患者并发症的诊断效果

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社区医学杂志 2024年第11期22卷 394-398页

作者：康曼琳袁世琪王旭昕郑州市第一人民医院检验科河南郑州450000

目的分析甘油三酯/胱抑素C(TG/Cys-C)比值对2型糖尿病患者并发症的诊断效果。方法回顾性分析2021-01-01-2022-01-01郑州市第一人民医院收治的167例2型糖尿病(T_(2)DM)患者的临床资料,依据其是否发生并发症分为并发症组(n=126)和对照组(n... 详细信息

目的分析甘油三酯/胱抑素C(TG/Cys-C)比值对2型糖尿病患者并发症的诊断效果。方法回顾性分析2021-01-01-2022-01-01郑州市第一人民医院收治的167例2型糖尿病(T_(2)DM)患者的临床资料,依据其是否发生并发症分为并发症组(n=126)和对照组(n=41),比较2组的各项资料,对差异统计学有意义的因素进一步行logistic多因素分析,明确T_(2)DM患者发生并发症的危险因素,并分析各危险因素对T_(2)DM患者并发症的诊断效果。结果并发症组患者收缩压(160.23±14.20)mmHg、舒张压(91.12±10.36)mmHg、糖尿病病程(84.52±19.65)月、空腹血糖(7.65±1.02)mmol/L、胱抑素C(1.47±0.26)mg/L、肌酐(110.56±16.37)μmol/L水平均高于对照组的收缩压(134.65±20.62)mmHg、舒张压(81.14±9.56)mmHg、糖尿病病程(13.16±3.42)月、空腹血糖(7.10±1.17)mmol/L、胱抑素C(0.85±0.19)mg/L、肌酐(69.56±17.84)μmol/L水平,高血压占比(84.13%)高于对照组(60.98%),血红蛋白(113.52±23.36)g/L、尿酸(328.56±74.51)μmol/L、TG/Cys-C比值(1.23±0.32)水平均低于对照组的血红蛋白(136.56±20.74)g/L、尿酸(368.65±59.45)μmol/L、TG/Cys-C比值(2.82±0.44)水平,差异统计学有意义,均P<0.05。高血压、糖尿病病程、TG/Cys-C比值为T_(2)DM患者发生并发症的危险因素,P<0.05。收缩压(95%CI为1.064~3.780)、糖尿病病程(95%CI为1.054~1.196)、TG/Cys-C比值(95%CI为0.271~0.670)单项检测对于T_(2)DM患者并发症均有一定诊断价值,但三者联合应用诊断效果更佳。结论高血压、糖尿病病程、TG/Cys-C比值为T_(2)DM患者发生并发症的危险因素,三者单项检测对于T_(2)DM患者并发症均有一定诊断价值,但三者联合应用诊断效果更佳。

关键词： 2型糖尿病并发症危险因素甘油三酯/胱抑素C比值诊断

Off-design condition optimization of organic Rankine cycle based on genetic algorithm

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Energy and Built Environment 2024年第5期5卷 665-682页

作者： shiqi Wang Zhongyuan yuan Nanyang Yu School of Mechanical Engineering Southwest Jiaotong UniversityNo.111North Section 12nd Ring RoadChengdu610031China

Organic Rankine cycle(ORC)has been considered as one of the most promising technologies in industrial waste heat utilization and power *** the actual operation of ORC system,due to the fluctuation of cooling and heat sources,the system operates under off-design conditions in most *** this paper,thermodynamic model,heat transfer process description and power equipment model are established to evaluate the operating parameters of ORC for the off-design *** temperature and condensation temperature are taken as independent parameters for the operation of ORC *** algorithm is adopted to optimize the independent parameters under the maximum net output *** results show that the effect of optimizing independent parameters is to make the working fluid at the outlet of the preheater as close as possible to a saturated liquid state,and the working fluid at the inlet of the screw expander should be in a saturated gas *** the optimal power output increasing by 19.1%for every 5°C increase in hot water inlet temperature,9.2%for every 20 kg/s increase in hot water mass flow rate,and 3.9%for every 1°C decrease in cooling water *** optimization method of off-design operating conditions has good system performance and good engineering application prospects.

关键词： Organic rankine cycle Optimize operation Genetic algorithm Net output power

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锂电铜箔表面防氧化工艺研究

有色金属工程 2024年第8期14卷 31-38页

作者：马秀玲陈明彪潘美君他得保袁世祺李永贞彭丽军青海交通职业技术学院西宁810000 青海电子材料产业发展有限公司西宁810000 有研工程技术研究院有限公司北京101407

锂电铜箔在生产、储存、运输和使用时,很容易使铜箔表面发生氧化变色,会直接影响锂电池的产品良率、可靠性、使用寿命、粘接性等,要求铜箔有良好的防氧化性能。采用SEM、EDAX等表征手段,研究了不同浸泡工艺和微量电镀工艺条件下铜箔表... 详细信息

锂电铜箔在生产、储存、运输和使用时,很容易使铜箔表面发生氧化变色,会直接影响锂电池的产品良率、可靠性、使用寿命、粘接性等,要求铜箔有良好的防氧化性能。采用SEM、EDAX等表征手段,研究了不同浸泡工艺和微量电镀工艺条件下铜箔表面形貌和氧含量的变化,得到浸泡工艺和微量电镀工艺对铜箔表面防氧化性能的影响。结果表明:在电流密度为5 A/dm^(2),电镀时间为10 s,铬酐浓度为0.5 g/L,葡萄糖浓度为1.5 g/L时,铜箔经高温烘烤后表面无变色,防氧化性能较优。

关键词：锂电铜箔浸泡微量电镀防氧化性能

Associations of HDL-C/LDL-C with myocardial infarction,all-cause mortality,haemorrhagic stroke and ischaemic stroke:a longitudinal study based on 384093 participants from the UK Biobank

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Stroke & Vascular Neurology 2023年第2期8卷 119-126页

作者： shiqi yuan Xiaxuan Huang Wen Ma Rui Yang Fengshuo Xu Didi Han Tao Huang MIn Peng Anding Xu Jun Lyu Department of Neurology Jinan University First Affiliated HospitalGuangzhouGuangdongChina School of Public Health Xi'an Jiaotong UniversityXi'anShaanxiChina Department of Clinical Research Jinan University First Affiliated HospitalGuangzhouGuangdongChina Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Informatization GuangzhouGuangdongChina

Objective To explore the correlations of high-density lipoprotein cholesterol(HDL-C)/low-density lipoprotein cholesterol(LDL-C)with myocardial infarction(MI),all-cause mortality,haemorrhagic stroke and ischaemic stroke,as well as the joint association of genetic susceptibility and HDL-C/LDL-C with the MI *** and results This study selected 384093 participants from the UK Biobank(UKB)***,restricted cubic splines indicated non-linear associations of HDL-C/LDL-C with MI,ischaemic stroke and all-cause ***,a Cox proportional-hazards model indicated that compared with HDL-C/LDL-C=0.4-0.6,HDL-C/LDL-C0.6 were correlated with all-cause mortality(HR=0.97 for HDL-C/LDL-C0.6,95%CI=1.16 to 1.26,p0.6 was associated with higher risk haemorrhagic stroke risk after full multivariable adjustment(HR=1.25,95%CI=1.03 to 1.52,p<0.05).Third,after calculating the coronary heart disease Genetic Risk Score(CHD-GRS)of each participant,the Cox proportional-hazards model indicated that compared with low CHD-GRS and HDL-C/LDL-C=0.4-0.6,participants with a combination of high CHD-GRS and HDL-C/LDL-C<0.4 were associated with the highest MI risk(HR=2.45,95%CI=2.15 to 2.8,p<0.001).Participants with HDL-C/LDL-C<0.4 were correlated with a higher MI risk regardless of whether they had a high,intermediate or low *** In UKB participants,HDL-C/LDL-C ratio of 0.4-0.6 was correlated with lower MI risk,all-cause mortality,haemorrhagic stroke and ischaemic *** with HDL-C/LDL-C<0.4 were correlated with a higher MI risk regardless of whether they had a high,intermediate or low *** clinical significance and impact of HDL-C/LDL-C need to be further

关键词： infarction haemorrhagic restricted

Effect of red clover isoflavones on hormone, immune, inflammatory,and plasma biochemistry in lactating dairy cows

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Animal Nutrition 2024年第1期16卷 306-312页

作者： shiqi Zhang Xiaoyin Zhang Zhanbo Xiong Kexin Li yuan Gao Ying Bu Nan Zheng Shengguo Zhao Jiaqi Wang State Key Laboratory of Animal Nutrition Institute of Animal Sciences Chinese Academy of Agricultural Sciences

This study was to conducted to investigate the effect of red clover isoflavones on the health indicated by immune status and blood biochemistry in dairy cows. Sixty-eight healthy Holstein lactating cows were randomly divided into four treatments(n = 17 per treatment) from 5 blocks according to milk yield using a randomized complete block design. No initial differences in parity(2.13 ± 1.21), days in milk(165 ± 21 d), and milk yield(33.93 ± 3.81 kg/d) between groups. Cows were fed the basal diet supplemented with 0, 2, 4, or 8 g/kg red clover extract(RCE) in diet(dry matter based). Feeding, refusal feed weights, and milk yield were recorded three consecutive days in weeks 0, 4, 8, and 12. Blood was collected from the tail vein of the cows on the last day of weeks 4, 8 and 12, 1 h after the morning feeding,and analyzed for hormones, immunoglobulins, inflammatory markers, and markers of liver and kidney activities. The dry matter intake was significantly decreased by 3.7% in the 8 g/kg group(P 0.05). These results recommend the supplementation of RCE at a level from 2 to4 g/kg DM.

关键词： Dairy cow Red clover isoflavone Immunity Anti-inflammatory

ST6Gal-I Modulates Docetaxel Sensitivity in Human Hepatocarcinoma Cells via the p38 MAPK/caspase Pathway

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ST6Gal-I Modulates Docetaxel Sensitivity in Human Hepatocarc...

Efficient genome editing in rice with miniature Cas12f variants

第六届泛环渤海生物化学与分子生物学会学术交流会

作者： Xixi Chen Liping Wang Yujie Zhao shiqi yuan Qiang Wu Xiaoling Zhu Bachir Niang Shujing Wang Jianing Zhang School of Life Science and Medicine Dalian University of Technology Department of Biochemistry Institute of GlycobiologyDalian Medical University

The β-galactoside α2-6-sialyltransferase 1(ST6 Gal-I) is the principal siaiyltransferase responsible for the addition of α2-6-sialic acid to the termini N-glycans on cell *** ST6 Gal-I in cancer cell resistance to chemotherapeutics agents has been previously reported,the role of ST6 Gal-I in clinical drug resistance of hepatocellular carcinoma(HCC) is not fully *** this study,we found that knockdown of ST6 Gal-I increased the sensitivity of hepatocarcinoma MHCC97-H cells to docetaxel treatment by instigating the process of *** ST6 Gal-I expression decreased the survival rate of MHCC97-H cells after docetaxel ***,ST6 Gal-I silencing resulted in an increasing of phospho-p38,Bax,Bad,cytochrome c and the cleaved caspase-9,3 and PARP,while a decreasing of the anti-apoptotic protein *** addition,we found that p38 MAPK and caspase-3 inhibitors can reduce the enhanced apoptosis levels of MHCC97-H cells resulted by either ST6 Gal-I silencing or docetaxel ***,exogenous expression of ST6 Gal-I in hepatocarcinoma Huh7 cells inhibited apoptotic cell death and prevented docetaxel-induced apoptosis by inhibiting p38 MAPK mediated mitochondrial-dependent *** together,these results indicate that ST6 Gal-I might play a positive role in mediating the survival of human hepatocarcinoma cells and could be a potential target for gene and antitumor drugs therapy.

关键词： HCC ST6Gal-I Docetaxel Apoptosis p38 MAPK

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aBIOTECH 2024年第2期5卷 184-188页

作者： Zhengyan Ye yuanyan Zhang shiqi He Shaokang Li Longjiong Luo Yanbiao Zhou Junjie Tan Jianmin Wan Sanya Institute of Nanjing Agricultural University State Key Laboratory of Crop Genetics&Germplasm Enhancement and UtilizationProvince and Ministry Co-sponsored Collaborative Innovation Center for Modern Crop ProductionNanjing Agricultural UniversityNanjing 210095China Zhongshan Biological Breeding Laboratory No.50 Zhongling StreetNanjing 210014China Key Laboratory of Southern Rice Innovation&Improvement Ministry of Agriculture and Rural Affairs/Hunan Engineering Laboratory of Disease and Pest Resistant Rice BreedingYuan Longping High-Tech Agriculture Co.LtdChangsha 410001China

Genome editing,particularly using the CRISPR/Cas system,has revolutionized biological research and crop *** the widespread use of CRISPR/Cas9,it faces limitations such as PAM sequence requirements and challenges in delivering its large protein into plant *** hypercompact Cas12f,derived from Acidibacillus sulfuroxidans(AsCas12f),stands out due to its small size of only 422 amino acids and its preference for a T-rich motif,presenting advantageous features over ***,its editing efficiency is extremely low in *** studies have generated two AsCas12f variants,AsCas12f-YHAM and AsCas12f-HKRA,demonstrating higher editing efficiencies in mammalian cells,yet their performance in plants remains *** this study,through a systematic investigation of genome cleavage activity in rice,we unveiled a substantial enhancement in editing efficiency for both AsCas12f variants,particularly for AsCas12f-HKRA,which achieved an editing efficiency of up to 53%.Furthermore,our analysis revealed that AsCas12f predominantly induces deletion in the target DNA,displaying a unique deletion pattern primarily concentrated at positions 12,13,23,and 24,resulting in deletion size mainly of 10 and 11 bp,suggesting significant potential for targeted DNA deletion using *** findings expand the toolbox for efficient genome editing in plants,offering promising prospects for precise genetic modifications in agriculture.

关键词： CRISPR/Cas Cas12 AsCas12f Rice Genome editing

ST6Gal-I Modulates Docetaxel Sensitivity in Human Hepatocarcinoma Cells via the p38 MAPK/caspase Pathway

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ST6Gal-I Modulates Docetaxel Sensitivity in Human Hepatocarc...

中国生物化学与分子生物学会2016年全国学术会议

The The β-galactosideα2-6-sialyltransferase 1(ST6Gal-I)is the principal sialyltransferase responsible for the addition ofα2-6-sialic acid to the termini N-glycans on cell *** ST6Gal-I in cancer cell resistance to chemotherapeutics agents has been previously reported,the role of ST6Gal-I in clinical drug resistance of hepatocellular carcinoma(HCC)is not fully *** this study,we found that knockdown of ST6Gal-I increased the sensitivity of hepatocarcinoma MHCC97-H

关键词： HCC ST6Gal-I Docetaxel Apoptosis p38 MAPK

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针对抗老化门替换技术的关键门识别算法

东南大学学报（自然科学版） 2018年第3期48卷 411-416页

作者：易茂祥吴清焐袁诗琪张姚丁力梁华国合肥工业大学电子科学与应用物理学院合肥230009

为解决现有门替换技术应用中存在的时延仿真不精确和关键门选取冗余问题,对时序分析方法进行改进,通过引入电路内部节点信息,准确预测电路NBTI老化.然后,提出了一种门替换技术应用下的关键门识别算法,定义了表征门电路抗NBTI老化能力的... 详细信息

为解决现有门替换技术应用中存在的时延仿真不精确和关键门选取冗余问题,对时序分析方法进行改进,通过引入电路内部节点信息,准确预测电路NBTI老化.然后,提出了一种门替换技术应用下的关键门识别算法,定义了表征门电路抗NBTI老化能力的度量公式,将其作为电路老化关键门的识别依据,用于提高关键门识别精度和效率.基于45 nm PTM工艺库和ISCAS85基准电路的仿真结果表明,应用改进门替换技术进行电路抗NBTI老化设计得到的电路时延退化改善率平均值为25.11%,较现有方案提高13.24%,而反映硬件开销的平均门替换率仅为5.82%,明显低于现有方案的11.95%.因此,所提方案仅以较低的硬件开销便可获得较好的门替换技术抗老化效果.

关键词：负偏置温度不稳定性门替换技术时序分析电路老化关键门