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Repeated pregnancy losses with multiple aneuploidies and major genomic imbalance:A case report

Asian pacific Journal of Reproduction 2024年第3期13卷 143-146页

作者： Shailesh Pande shiny babu Harshavardhan Gawde Neha Minde Genetic Research Center ICMR-National Institute for Research in Reproductive and Child HealthJehangir Merwanji StreetParelMumbai-400012India

Rationale:If one of the partners is having balanced autosomal translocation,it is usually observed that the offspring inherit either normal chromosomes,balanced translocation identical to one of the parent or unbalanced chromosomal rearrangements of the same parental chromosome having ***:A unique case presented with history of 8 miscarriages for genetic *** last abortus material evaluation showed monosomy of chromosome X(Turner syndrome)in all the analyzed *** was a history of infertility and also repeated second trimester abortions on the paternal *** the maternal side,there was a history of intellectual ***:History of repeated abnormal pregnancy ***’s karyotype is normal;however,husband shows translocation between chromosome 4 and ***:Peripheral blood sample around 3 mL was collected for *** biopsy was done and DNA was extracted and processed for whole exome ***:Wife’s karyotype is normal and husband has translocation between chromosome 4 and ***,the entire pregnancy outcome including embryo screening has different,complete or partial aneuploidies of chromosomes other than chromosome 4 and *** lesson:Though the translocation in one of the parent is balanced,we have to think beyond traditional ways for evaluating a couple with repeated pregnancy loss as we cannot predict the errors at cell *** of in vitro fertilization and preimplantation genetic diagnosis in couples having balanced translocations should be discussed so that early intervention can prevent the agony of pregnancy loss.

关键词： In vitro fertilization Karyotype Products of conception Preimplantation genetic testing PGT Recurrent pregnancy loss

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Performance and Emission Characteristics of a CRDI Diesel Engine Fuelled by SiO_(2) Nanoparticle-Waste Fat Biodiesel Blends

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China Petroleum Processing & Petrochemical Technology 2024年第1期26卷 56-66页

作者： babu Aurtherson P Dinesh babu Munuswamy Ravikumar Jayabal Yuvarajan Devarajan Department of Mechanical Engineering Mahat Amma Institute of Engineering and TechnologyPudukkottaiTamil NaduIndia Department of Mechanical Engineering Rajalakshmi Institute of TechnologyChennaiTamil NaduIndia Department of Thermal Engineering Saveetha School of EngineeringSaveetha Institute of Medical and Technical SciencesChennaiTamil NaduIndia

This study investigates the use of waste fat biodiesel(WFB)from the leather industry as a substitute for diesel ***,it examines the diesel engine performance of WFB,a blend of WFB and diesel(B50),and different blends of WFB and silicon dioxide(SiO_(2))nanoparticles(B50SiO_(2)40,B50SiO_(2)80,and B50SiO_(2)120μg/g).The results indicate that the B50SiO_(2)120 blend increases brake thermal efficiency by 10.03%compared to pure biodiesel but falls 1.93%short of neat ***,the B50SiO_(2)120 mixture reduces smoke,hydrocarbon,and carbon monoxide emissions by 31.87%,34.14%,and 43.97%respectively,compared to ***,the B50SiO_(2)120 blend shows a 4.91%increase in nitrogen oxide emissions compared to diesel.

关键词： waste fat transesterification biodiesel silicon dioxide emission

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Impacts of road on plant invasions in the Middle Mountain region of central Nepal

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Journal of Mountain Science 2024年第2期21卷 619-632页

作者： Ananda ADHIKARI Adarsha SUBEDI Achyut TIWARI Bharat babu SHRESTHA Central Department of Botany Tribhuvan UniversityKirtipur 44618Nepal

Biological invasion is triggered by human development activities such as the construction and expansion of road *** verges serve as important habitats and corridors for the distribution of invasive alien plant species(IAPS)between geographically distant ***,the trajectory of plant invasion and the data regarding the impact of roads on IAPS distribution are relatively poor in ***,we surveyed two road types(main roads and feeder road)in the Middle Mountain region of central Nepal in order to investigate how different road types are driving the dispersal of IAPS along road verges and the adjacent natural *** sampling was conducted at ca 2.5 km intervals along the *** each sampling site,paired plots(25 m×4 m)were sampled:one adjacent to and along the road,and another 20 m away and parallel to it in the interior *** results revealed that the main road verges had a higher cover(33%)and a larger number of IAPS(14 species)than the feeder road(25%;10 species).The IAPS cover and richness were significantly higher along verges than in the adjacent interior habitats for both road types,indicating that roads are contributing as corridors for the dispersal of IAPS in the Middle Mountain areas of central ***,elevation,tree canopy,and disturbances(grazing/mowing/trampling)were found to be the key factors that determine spatial distribution of IAPS along road *** emphasize that regular monitoring of vegetation along the road verges can help with the early detection and control of potential IAPS in the region before they become problematic.

关键词： Biological invasions Dispersal corridor Invasive alien plants Transport infrastructure Himalayan mountains

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Magnesium-incorporated biocomposite scaffolds:A novel frontier in bone tissue engineering

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Journal of Magnesium and Alloys 2024年第6期12卷 2231-2248页

作者： Abinaya Shanmugavadivu Sundaravadhanan Lekhavadhani Sushma babu Nivetha Suresh Nagarajan Selvamurugan Department of Biotechnology School of BioengineeringCollege of Engineering and TechnologySRM Institute of Science and TechnologyKattankulathur603203Tamil NaduIndia

Nonunion represents a crucial challenge in orthopedic medicine,demanding innovative solutions beyond the scope of traditional bone grafting *** the various strategies available,magnesium(Mg)implants have been recognized for their biocompatibility and ***,their susceptibility to rapid corrosion and degradation has garnered notable research interest in bone tissue engineering(BTE),particularly in the development of Mg-incorporated biocomposite *** scaffolds gradually release Mg2+,which enhances immunomodulation,osteogenesis,and angiogenesis,thus facilitating effective bone *** review presents myriad fabrication techniques used to create Mg-incorporated biocomposite scaffolds,including electrospinning,three-dimensional printing,and sol-gel *** these advancements,the application of Mg-incorporated biocomposite scaffolds faces challenges such as controlling the degradation rate of Mg and ensuring mechanical *** limitations highlight the necessity for ongoing research aimed at refining fabrication techniques to better regulate the physicochemical and osteogenic properties of *** review provides insights into the potential of Mg-incorporated biocomposite scaffolds for BTE and the challenges that need to be addressed for their successful translation into clinical applications.

关键词： Magnesium Bone tissue engineering Immunomodulation Osteogenesis Angiogenesis

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Applications of silk-based biomaterials in biomedicine and biotechnology

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Engineered Regeneration 2024年第1期5卷 56-69页

作者： Punuri Jayasekhar babu Laldinthari Suamte Biomaterials and Bioengineering Research Laboratory Department of BiotechnologyMizoram UniversityPachhunga University CollegeAizawl-796001MizoramIndia Department of Life Sciences Mizoram UniversityPachhunga University CollegeAizawl-796001MizoramIndia

Silk-based biomaterials have gained significant importance making them a promising choice for the future of med-ical technology due to their versatility and *** can be fabricated and tailored through various processing methods such as electrospinning,freeze-drying,and 3D printing,to achieve specific properties and structures namely sponges,hydrogels,films,and scaffolds that can be utilized for different biomedical ***,a unique property of silk-based biomaterials,has been demonstrated through both in vivo and in vitro studies and to date many studies have reported the successful use of these silk-based biomaterials in different fields of *** this review,we have elaborately discussed different types of silk,their structural composition,and biophysical ***,the current review focuses on highlighting various biomedical ap-plications of engineered and fabricated silk-based biomaterials which aid in the treatment of certain infections and diseases related to skin,eyes,teeth,bone,heart,nerves,and ***,we have consolidated the advancements of silk-based biomaterials in the different fields of biotechnology such as sensors,food coating and packaging,textiles,drug delivery,and ***,the research in this field continues to expand and more significant observations must be generated with feasible results for their reliable use in different biomedical applications.

关键词： Fabrication of silk Biomaterials Biomedicine Tissue engineering Scaffolds

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Integrating Transformer and Bidirectional Long Short-Term Memory for Intelligent Breast Cancer Detection from Histopathology Biopsy Images

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 443-458页

作者： Prasanalakshmi Balaji Omar Alqahtani Sangita babu Mousmi Ajay Chaurasia Shanmugapriya Prakasam Department of Computer Science College of Computer ScienceKing Khalid UniversityAbha61451Saudi Arabia College of Science and Arts in Rijal Alma King Khalid UniversityAbha61451Saudi Arabia Department of Information Technology Muffakham Jah College of Engineering and TechnologyHyderabad500034India Department of Computer Science and Business Systems Rajalakshmi Engineering CollegeThandalam602105India

Breast cancer is a significant threat to the global population,affecting not only women but also a threat to the entire *** recent advancements in digital pathology,Eosin and hematoxylin images provide enhanced clarity in examiningmicroscopic features of breast tissues based on their staining *** cancer detection facilitates the quickening of the therapeutic process,thereby increasing survival *** analysis made by medical professionals,especially pathologists,is time-consuming and challenging,and there arises a need for automated breast cancer detection *** upcoming artificial intelligence platforms,especially deep learning models,play an important role in image diagnosis and ***,the histopathology biopsy images are taken from standard data ***,the gathered images are given as input to the Multi-Scale Dilated Vision Transformer,where the essential features are ***,the features are subjected to the Bidirectional Long Short-Term Memory(Bi-LSTM)for classifying the breast cancer *** efficacy of the model is evaluated using divergent *** compared with other methods,the proposed work reveals that it offers impressive results for detection.

关键词： Bidirectional long short-term memory breast cancer detection feature extraction histopathology biopsy images multi-scale dilated vision transformer

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A systematic review of climate change impacts,adaptation strategies,and policy development in West Africa

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Regional Sustainability 2024年第2期5卷 13-25页

作者： Camillus Abawiera WONGNAA Alex Amoah SEYRAM Suresh babu Department of Agricultural Economics Agribusiness and ExtensionKwame Nkrumah University of Science and TechnologyKumasi00233Ghana International Food Policy Research Institute Washington20005USA

Climate change studies are diverse with no single study giving a comprehensive review of climate change impacts,adaptation strategies,and policy development in West *** unavailability of an all-inclusive study to serve as a guide for practitioners affects the effectiveness of climate change adaptation strategies proposed and adopted in the West African *** purpose of this study was to review the impacts of climate change risks on the crop,fishery,and livestock sectors,as well as the climate change adaptation strategies and climate-related policies aimed at helping to build resilient agricultural production systems in West *** review process followed a series of rigorous stages until the final selection of 56 articles published from 2009 to ***,the results highlighted the adverse effects of climate change risks on food *** found a continuous decline in food crop ***,the livestock sector experienced morbidity and mortality,as well as reduction in meat and milk *** fishery sector recorded loss of fingerlings,reduction in fish stocks,and destruction of mariculture and *** West Africa,climate-smart agriculture technologies,physical protection of fishing,and inclusion of gender perspectives in programs appear to be the major adaptation *** study therefore recommends the inclusion of ecosystem and biodiversity restoration,weather insurance,replacement of unsafe vessels,and strengthening gender equality in all climate change mitigation programs,as these will help to secure enough food for present and future generations.

关键词： Climate change Climate extreme events Food security Adaptation strategies Climate-smart agriculture West Africa

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Mesenchymal stem cell-based TRAIL delivery inhibits the metastatic state of clinical therapy-resistant progressive neuroblastoma

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World Journal of Pediatrics 2024年第3期20卷 287-293页

作者： Dinesh babu Somasundaram Andrew Maher Sheeja Aravindan Zhongxin Yu Brian MBesch Natarajan Aravindan Department of Radiation Oncology University of Oklahoma Health Sciences CenterOklahoma CityOKUSA Stephenson Cancer Center Oklahoma CityOKUSA Department of Pathology University of Oklahoma Health Sciences CenterOklahoma CityOKUSA Radiation Biology Laboratory University of Oklahoma Health Sciences CenterBSEB 302F941 Stanton L.Young BoulevardOklahoma CityOK 73104USA

Progressive neuroblastomas(pNBs)that defy current intensive multimodal clinical therapy(IMCT)are a significant contributor to overall childhood cancer deaths[l].Neuroblastomas(NBs)that survive first-line IMCT actively evolve to acquire genetic and molecular rearrangements and display unparalleled plasticity and evolution,which causes frequent relapses in a rapidly accelerating timeline[2-4].

关键词： neuroblastoma clinical evolve

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The function of doping nitrogen on removing fluoride with decomposing La-MOF-NH_2:Density functional theory calculation and experiments

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Journal of Environmental Sciences 2024年第1期135卷 118-129页

作者： Hongguo Zhang KuilinWan Jia Yan Qian Li Yufang Guo Lei Huang Samuel Raj babu Arulmani Jian Luo School of Environmental Science and Engineering Guangzhou UniversityGuangzhou 510006China Guangzhou University-Linkoping University Research Center on Urban Sustainable Development Guangzhou UniversityGuangzhou 510006China School of Civil and Environmental Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

Fluoride is an important pollutant in wastewater,and adsorption is an effective way to remove *** nitrogen plays an important role in adsorbent materials,computational models were developed to understand the changes in work function resulting from nitrogen ***-N-C-800℃,was prepared by pyrolyzing La-MOF-NH_(2)to verify the influence on the performance of removing fluoride by *** and electrochemical performance tests were performed to characterize La-N-C-800℃.Adsorption kinetics,adsorption thermodynamics,initial concentrations,pH,and ions competition were investigated using La-N-C-800℃for fluoride *** addition,density functional theory was applied to evaluate the function of *** nitrogen atoms were added,the density of states,partial density of states,populations,and different orbits of charge were calculated to discover deep *** strengthened the carbon structure and La_(2)O_(3)structure to remove *** addition,nitrogen can also act as an adsorption site in the carbon *** results provide design ideas for improving the performance of adsorbent materials by doping elements.

关键词： Capacitive deionization Fluoride La-MOFs Doping nitrogen

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The role of Piezo1 and Piezo2 proteins in tissue engineering:A Comprehensive review

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Engineered Regeneration 2024年第2期5卷 170-185页

作者： Tejaswini Tadge Ashwini Pattewar Namdev More Srivalliputtur Sarath babu Ravichandiran Velyutham Govinda Kapusetti National Institute of Pharmaceutical Education and Research KolkataWest Bengal 700054India National Institute of Pharmaceutical Education and Research AhmedabadGujarat 382355India

Almost every life form,from the tiniest bacterium to humans,is mechanosensitive,implying it can use mechani-cal stresses to trigger certain physiological responses in the form of electric *** largely relies on ion channels that respond to mechanical forces,such as the epithelial sodium channels/degenerins,tran-sient receptor potential channel,and the two-pore domain potassium ***1 and Piezo2 proteins were discovered to be the biggest non-selective mechanosensitive cation channels in the cell membrane.A substantial amount of research has previously been published on the Piezo channel’s function in touch sensation,balance,and cardiovascular ***,the mechanistic perspective must be refined to fully understand the role of Piezo proteins in tissue *** review centers on the latest insights into the structure of Piezo chan-nels,activation mechanisms,and its interactions with cytoskeletal components,by emphasizing the physiological activities of Piezo channels in different *** study also places focus on the possibilities of targeting this cation channel family as a tissue regeneration aid.

关键词： Piezo1 Piezo2 Mechanotransduction Tissue regeneration Mechanoreceptors

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