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Adiponectin deficiency exacerbates lipopolysaccharide/ D-galactosamine-induced liver injury in mice

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World Journal of Gastroenterology 2006年第21期12卷 3352-3358页

作者： Hitoshi Matsumoto shinji tamura Yoshihiro Kamada Shinichi Kiso Juichi Fukushima Akira Wada Norikazu Maeda shinji Kihara Tohru Funahashi Yuji Matsuzawa Iichiro Shimomura Norio Hayashi Department of Gastroenterology and Hepatology Osaka University Graduate School of Medicine2-2K1Yamada-okaSuitaOsaka 565-0871Japan Department of Metabolic Medicine Osaka University Graduate School of Medicine2-2B5Yamada-okaSuitaOsaka 565-0871Japan Sumitomo Hospital 5-3-20 Kita-Ku nakanoshimaOsaka530-0005Japan

瞄准：在 Kupffer 房间的功能上检验 adiponectin 的效果，脂肪的多糖(LPS ) 的关键调节的人导致了肝损伤。方法：D-galactosamine (GalN ) 和 LPS intraperitoneally 被注入 adiponectin-/- 老鼠和野类型老鼠。Kupffer 房间，从 Spragu... 详细信息

瞄准：在 Kupffer 房间的功能上检验 adiponectin 的效果，脂肪的多糖(LPS ) 的关键调节的人导致了肝损伤。方法：D-galactosamine (GalN ) 和 LPS intraperitoneally 被注入 adiponectin-/- 老鼠和野类型老鼠。Kupffer 房间，从 Sprague-Dawley 孤立老鼠，是 preincubated 与或没有 adiponectin，然后与 LPS 对待。结果：在猛烈老鼠， GalN/LPS 注射显著地降低了幸存率，显著地提起了丙氨酸转氨酶和肿瘤坏死 factor-alpha (TNF-alpha ) 的血浆层次并且显著地减少了与野类型老鼠相比的 IL-10 层次。在肝的 TNF-alpha 基因表示是哪个更高并且 IL-10 的那些比在野类型老鼠在猛烈老鼠是更低的。在有教养的 adiponectin-pre-treated Kupffer 房间， LPS 显著地降低了 TNF-alpha 层次并且在培养基和他们的各自的基因表示层次提起了 IL-10 层次，与没有 adiponectin-pre-treatment 的 Kupffer 房间相比。结论：Adiponectin supresses TNF-alpha 生产并且响应 LPS 刺激由 Kupffer 房间导致 IL-10 生产，并且 adiponectin 的缺乏提高导致 LPS 的肝损伤。

关键词：脂多糖半乳糖胺肝损伤病理机制

Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by azoxymethane in mice

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World Journal of Gastroenterology 2008年第42期14卷 6473-6480页

作者： Tamao Nishihara Miyako Baba Morihiro Matsuda Masahiro Inoue Yasuko Nishizawa Atsunori Fukuhara Hiroshi Araki shinji Kihara Tohru Funahashi shinji tamura Norio Hayashi Hiroyasu Iishi Iichiro Shimomura Department of Gastroenterology and Hepatology Graduate School of Medicine Osaka University 2-2 Yamada-oka Suita Osaka 565-0871 Japan Department of Pathology Osaka Medical Center for Cancer and Cardiovascular Diseases Research Institute 1-3-2 Nakamichi Higashinari-ku Osaka 537-8511 Japan Department of Metabolic Medicine Graduate School of Medicine Osaka University 2-2 Yamada-oka Suita Osaka 565-0871 Japan Department of Biochemistry Osaka MedicaCenter for Cancer and Cardiovascular Diseases ResearchInstitute 1-3-2 Nakamichi Higashinari-ku Osaka 537-8511Japan Department of Gastrointestinal Oncology Osaka Medical Center for Cancer and Cardiovascular Diseases 1-3-3 Nakamichi Higashinari-ku Osaka 537-8511 Japan

AIM:To investigate the causal relationship between hypoadiponectinemia and colorectal carcinogenesis in in vivo experimental model,and to determine the con-tribution of adiponectin defi ciency to colorectal cancer development and ***:We examined the influence of adiponectin defi ciency on colorectal carcinogenesis induced by the administration of azoxymethane(AOM)(7.5 mg/kg,in-traperitoneal injection once a week for 8 wk),by using adiponectin-knockout(KO) ***:At 53 wk after the fi rst AOM treatment,KOmice developed larger and histologically more progres-sive colorectal tumors with greater frequency com-pared with wild-type(WT) mice,although the tumor incidence was not different between WT and KO *** mice showed increased cell proliferation of colorec-tal tumor cells,which correlated with the expression levels of cyclooxygenase-2(COX-2) in the colorectal *** addition,KO mice showed higher incidence and frequency of liver tumors after AOM *** percent of WT mice developed liver tumors,and these WT mice had only a single *** contrast,50% of KO mice developed liver tumors,and 58% of these KO mice had multiple ***:Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by AOM in *** study strongly suggests that hypoadiponectinemia could be involved in the pathogenesis for colorectal cancer and liver tumor in human subjects.

关键词：结肠直肠癌细胞增殖致癌作用肝癌

Peripheral Nerve Block Combined with Epidural Anesthesia for Incarcerated Inguinal Hernia Repair in a Patient with Severe Chronic Obstructive Pulmonary Disease: A Case Report

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Open Journal of Anesthesiology 2022年第3期12卷 105-112页

作者： Yui Ikuta Hideya Kato Yuko YNishiwaki Junko tamura Ryuhei Araki shinji Nozuchi Department of Anesthesiology Saiseikai Shiga Hospital Ritto Japan

Background: Invasive mechanical ventilation worsens prognosis in patients with severe chronic obstructive pulmonary disease (COPD). To avoid complications in these patients, anesthesia should be carefully considered. Case presentation: A 78-year-old man with COPD presented with dyspnea and pain from the epigastric to the umbilical regions. He was diagnosed with left incarcerated inguinal hernia and underwent radical inguinal hernia repair and surgical ileus treatment. To avoid general anesthesia with tracheal intubation, epidural anesthesia was combined with peripheral nerve blocks. An epidural catheter was inserted from T12/L1, and ilioinguinal-iliohypogastric and genitofemoral nerve blocks were performed under ultrasound guidance. No post-surgery complications or pain symptoms were noted. Conclusions: General anesthesia would likely have been challenging due to the patient’s COPD;however, management of peritoneal traction pain is difficult using peripheral nerve block alone. By combining epidural anesthesia with peripheral nerve blocks, we safely performed a procedure in a patient with severe COPD while avoiding invasive positive pressure ventilation.

关键词： COPD Hernia Repair Peripheral Nerve Block Epidural Anesthesia

Airway Scope、Airtraq、Macintosh喉镜用于困难气道的气管插管：一项关于无操作经验人员在人体模型上操作的对照研究

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麻醉与镇痛 2012年第4期8卷 46-54页

作者： Liangji Liu Koichi Tanigawa shinji Kusunoki Tomoko tamura Kohei Ota Satoshi Yamaga Yoshiko Kida Tadatsugu Otani Takuma Sadamori Taku Takeda Yasumasa Iwasaki Nobuyuki Hirohashi 毛祖旻(译) 李士通(校) Department of Emergency and Critical Care Medicine Hiroshima University Hiroshima Japan 不详

背景AirwayScope（AWS）和Airtraq（ATQ）喉镜的镜片结构相似，在本次研究中，我们评估了无操作经验的人员在模拟人困难气道模型上分别应用AWS、ATQ和Macintoshlamgoscope（ML）喉镜所完成气管插管的难易性。方法24名无气管插管经验的5... 详细信息

背景AirwayScope（AWS）和Airtraq（ATQ）喉镜的镜片结构相似，在本次研究中，我们评估了无操作经验的人员在模拟人困难气道模型上分别应用AWS、ATQ和Macintoshlamgoscope（ML）喉镜所完成气管插管的难易性。方法24名无气管插管经验的5年级医学生参加了此项研究，采用人体模型（SimMan）来模拟各种不同的困难气道，包括颈椎强直、张口受限、咽部阻塞3种场景。气管插管装置及困难气道类型的顺序是随机的。我们分析了气管插管的成功率，声门暴露、气管插管、张肺所需的时间，调整手法使用次数和摩擦牙齿的喀声次数。24名学生用3种不同的插管装置在4种不同的气道条件下进行操作。结果与ML组相比，AWS组、ATQ组均有较高的气管插管成功率（AWS组为100％，ATQ组为98％，ML组为89％，AWS组、ATQ组与ML组相比P〈0．05），AWS组所需的插管时间显著少于ATQ组和ML组（AWS组为11±6秒，ATQ组为16±12秒，ML组为16±11秒），与ATQ组和ML组相比，AWS组需要优化调整的次数显著减少（P〈0．05），ML组插管过程中可闻及的牙齿喀声比AWS组和ATQ组显著增多。结论对于在模拟困难气道下进行气管插管的无插管经验的人员，AWS和ATQ可能是更适合的插管装置，有必要在今后的临床实践中进一步证实此项发现。

关键词： Macintosh喉镜气管插管困难气道操作经验人体模型插管成功率插管装置 AWS