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Acute perimyocarditis following heterologous vaccination of CoronaVac and BNT162b2 SARS-CoV-2 vaccine in an elderly woman

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Journal of Geriatric Cardiology 2022年第10期19卷 785-787页

作者： shing ching Chiu Sun Yue Division of Cardiology Department of Medicine and GeriatricsUnited Christian HospitalHong KongChina

Inactivated and mRNA SARS-CoV-2 vaccines are highly efficacious in preventing severe disease and *** the antibody level wanes over time,^([1])booster vaccination is recommended by the World Health Organization after completion of basic vaccination sequence.^([2])Heterologous compared to homologous boosting is found to be more immunogenic,generate higher antibody levels and may reduce the risk of breakthrough infections.

关键词： vaccination mortality Acute

3D vena contracta area in degenerative mitral regurgitation:cross-platform comparison in a single patient

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Journal of Geriatric Cardiology 2022年第4期19卷 322-324页

作者： shing ching Chiu Sun Yue Division of Cardiology Department of Medicine and GeriatricsUnited Christian HospitalHong KongChina

Quantification of degenerative mitral reg-urgitation(MR)by two-dimensional(2D)transthoracic echocardiography(TTE)and transesophageal echocardiography(TEE)is ***,obliquely oriented regurgitant jets limit inter-observer and intra-observer *** recent years,with increasingly sophisticated three-dimensional(3D)TTE and TEE systems that enable single-beat 3D color acquisition,3D vena contracta area(VCA)has emerged as an attractive indicator of MR *** overcomes geometric assumptions in 2D techniques and can be acquired in a single car-diac cycle,which is a major benefit in atrial ***,most studies of 3D VCA were perfo-rmed on the Philips TEE platform.[1-3]The perform-ance of the technique on GE systems and on 3D TTE is *** report 3D VCA measurements in a case of severe degenerative MR on 3D TTE(4V-D transducer,Vivid E95,GE Vingmed Ultrasound,Horten,Norway),and 3D TEE performed on GE(6VT-D transducer,Vivid E95,GE Vingmed Ultraso-und,Horten,Norway)and Philips(X7-2t transdu-cer,EPIC 7C,Philips Medical Systems,Andover,MA,USA).

关键词： degenerative overcome attractive

An unusual cause of myocardial infarction in an elderly man

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Journal of Geriatric Cardiology 2024年第8期21卷 826-827页

作者： shing ching Chiu Sun Yue Division of Cardiology Department of Medicine and GeriatricsUnited Christian HospitalHong KongChina

Cardiac involvement in eosinophilic granulomatosis with polyangiitis (EPGA) is increasingly recognized,but it is unusual to be the initial *** report a case of vasculitic myocardial infarction (MI) and cardiogenic shock in an elderly man caused by EPGA.A 73-year-old man presented with acute chest pain radiating to back for two *** has a history of asthma and allergic rhinitis for more than ten years well controlled by inhaled *** electrocardiogram showed sinus rhythm,right bundle-branch block and anterolateral ST-segment *** had elevated troponin T of 548 ng/L (reference:<14 ng/L),creatine kinase of 454 IU/L (reference:39–308 IU/L)。

关键词： infarction involvement elevated

Ventricular tachycardia induced by functional ventricular undersensing and AutoCapture®

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Journal of Geriatric Cardiology 2022年第5期19卷 393-397页

作者： shing ching Chiu Sun Yue Division of Cardiology Department of Medicine and GeriatricsUnited Christian HospitalHong KongChina

The implantable cardioverter-defibrillator(ICD)is a key component in the primary pre-vention of sudden cardiac death in patients with ischemic *** device programming is pivotal in maximizing the benefit as well as minimizing any proarrhythmic effect of dev-ice *** is even more so for patients who require pacing for bradycardia,in which interaction of the de-vice with intrinsic rhythm may generate unexpected *** report a case of pacing induced ven-tricular tachycardia as a result of complex interplay of competitive atrial pacing,atrial and ventricular func-tional undersensing,ventricular functional loss of capture,and the AutoCapture®algorithm specific to Abbott devices.

关键词： ventricular tachycardia functional

Porphyrins and Phthalocyanines Catalyzed Direct C--H Arylation

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Chinese Journal of Chemistry 2016年第10期34卷 955-961页

作者： ching Tat To Wu Yang Kin shing Chan Department of Chemistry The Chinese University of Hong Kong Shatin New Territories Hong Kong China

Catalytic direct functionalization of unreactive C--H bonds represents a sustainable and more atom economical transformation process. Porphyrin and pbthalocyanine derivatives show promising catalytic activities in direct C-- H arylation reactions. These reactions share a common C--C bond formation process via homolytic radical substi- tution. This review summarizes the catalytic direct C--H arylation reactions catalyzed by metalloporphyrins, free base porphyrins and free base phthalocyanines.

关键词： porphyrin phthalocyanine C--H arylation C--C coupling radical reaction

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LaNi5的硫化物中毒及其再生的表面研究

物理学报 1983年第3期 360-365页

作者：虞心南张青哲谢侃康瑾林彰达中国科学院物理研究所

本文概括了氢气中的硫化物（如H2S,SO2和CS2）对LaNi5的表面中毒和再生。 AES,XPS的分析表明,三种硫化物的中毒性质不同:H2S中毒产生La2S3和NiS这样的表面化合物;SO2和CS2中毒分别发生化学吸附和物理吸附。此外,从Ni(2P3/2)谱峰强度变化... 详细信息

本文概括了氢气中的硫化物（如H2S,SO2和CS2）对LaNi5的表面中毒和再生。 AES,XPS的分析表明,三种硫化物的中毒性质不同:H2S中毒产生La2S3和NiS这样的表面化合物;SO2和CS2中毒分别发生化学吸附和物理吸附。此外,从Ni(2P3/2)谱峰强度变化,表明了在LaNi5表面上活性镍的表面催化性质。纯氢循环法再生CS2和SO2中毒是有效的,但对H2S中毒无效。试验结果对解释稀土金属间氢化物的表面中毒机理和再生机理非常有用。

关键词：贮氢量 LaNi5 物理吸附化学吸附氢气循环再生纯氢工业气体表面化合物贮氢材料硫化合物硫化物表面研究

Prediction of hepatocellular carcinoma development by aminotransferase to platelet ratio index in primary biliary cholangitis

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World Journal of Gastroenterology 2017年第44期23卷 7863-7874页

作者： Ka-shing Cheung Wai-Kay Seto James Fung Lung-Yi Mak ching-Lung Lai Man-Fung Yuen Department of Medicine The University of Hong Kong Queen Mary Hospital State Key Laboratory for Liver Research The University of Hong Kong

AIM To investigate the usefulness of aspartate aminotransferase to platelet ratio index(APRI) in predicting hepatocellular carcinoma(HCC) risk in primary biliary cholangitis(PBC).METHODS We identified PBC patients between 2000 and 2015 by searching the electronic medical database of a tertiary center. The hazard ratio(HR) of HCC with different risk factors was determined by Cox proportional hazards model. RESULTS One hundred and forty-four PBC patients were recru-ited. Patients were diagnosed at a median age of 57.8 years [interquartile range(IQR): 48.7-71.5 years), and 41(28.5%) patients had cirrhosis at baseline. The median follow-up duration was 6.9 years(range: 1.0-26.3 years). Twelve patients developed HCC, with an incidence rate of 10.6 cases per 1000 patient-years. The overall 5-, 10-and 15-year cumulative incidences of HCC were 2.3% 95%CI: 0%-4.8%), 8.4%(95%CI: 1.8%-14.5%) and 21.6%(6.8%-34.1%), respectively. Older age(HR = 1.07), cirrhosis(HR = 4.38) and APRI at 1 year after treatment(APRI-r1) > 0.54(HR = 3.94) were independent factors for HCC development. APRI-r1, when combined with treatment response, further stratified HCC risk(log rank P < 0.05). The area under receiver operating curve of APRI-r1 in predicting HCC was 0.77(95%CI: 0.64-0.88).CONCLUSION APRI-r1 can be used to predict the development of HCC in PBC patients. Combination of APRI-r1 with treatment response can further stratify the HCC risk.

关键词： Aspartate aminotransferase Platelet ratio index Hepatocellular carcinoma Primary biliary cholangitis Ursodeoxycholic acid Cirrhosis

Epidemiology and natural history of Wilson's disease in the Chinese: A territory-based study in Hong Kong between 2000 and 2016

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World Journal of Gastroenterology 2017年第43期23卷 7716-7726页

作者： Ka-shing Cheung Wai-Kay Seto James Fung Lung-Yi Mak ching-Lung Lai Man-Fung Yuen Department of Medicine The University of Hong KongQueen Mary Hospital State Key Laboratory for Liver Research The University of Hong Kong

AIM To investigate the epidemiology and natural history of Wilson's disease in the *** Data were retrieved via electronic search of hospital medical registry of the Hong Kong Hospital Authority,which covers all the public healthcare services. We identified cases of Wilson's disease between 2000 and 2016 by the International Classification of Diseases(ICD)-9 code. We analyzed the incidence rate,prevalence and adverse outcomes of Wilson's *** We identified 211 patients(male cases 104; female cases 107; median age 27.2 years,IQR: 17.1-38.6 years; duration of follow-up 8.0 years,IQR: 5.0-14.0 years). The average annual incidence rate was 1.44 per million person-years while the prevalence was 17.93 per million. Between 2000 and 2016,there was a decrease in the annual incidence rate from 1.65 to 1.23 per million person-years(P = 0.010),whereas there was an increase in the annual prevalence from 7.80 to 25.20 per million(P < 0.001). Among the 176 cases with hepatic involvement,38(21.6%) had cirrhosis,three(1.7%) developed hepatocellular carcinoma,24(13.6%) underwent liver transplantations,and 26(14.8%) died. Seven patients had concomitant chronic viral hepatitis B or C. The 5-year and 10-years rates of overall survival were 92.6% and 89.5%,and for transplant-free survival rates 91.8% and 87.4%,respectively. Cirrhosis and possibly chronic viral hepatitis were associated with poorer overall survival. CONCLUSION There was a significant increase in the prevalence of Wilson's disease in Hong Kong. The prognosis was favorable except for those with cirrhosis or concomitant viral hepatitis.

关键词： Hepaticolenticular degeneration Cirrhosis Hepatocellular carcinoma Transplantation

Identification of Ca2+ signaling components in neural stem/progenitor cells during differentiation into neurons and glia in intact and dissociated zebrafish neurospheres

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Science China(Life Sciences) 2018年第11期61卷 1352-1368页

作者： Man Kit Tse Ting shing Hung ching Man Chan Tiffany Wong Mike Dorothea Catherine Leclerc Marc Moreau Andrew L.Miller Sarah E.Webb Division of Life Science & State Key Laboratory of Molecular Neuroscience HKUSTClear Water BayHongKongChina Centre de Biologie du Developpement(CBD) Centre de Biologie Integrative(CBI)Universite de ToulouseCNRSUPSToulouse F-31062France

The development of the CNS in vertebrate embryos involves the generation of different sub-types of neurons and glia in a complex but highly-ordered spatio-temporal manner. Zebrafish are commonly used for exploring the development, plasticity and regeneration of the CNS, and the recent development of reliable protocols for isolating and culturing neural stem/progenitor cells(NSCs/NPCs) from the brain of adult fish now enables the exploration of mechanisms underlying the induction/specification/differentiation of these cells. Here, we refined a protocol to generate proliferating and differentiating neurospheres from the entire brain of adult zebrafish. We demonstrated via RT-qPCR that some isoforms of ip3 r, ryr and stim are upregulated/downregulated significantly in differentiating neurospheres, and via immunolabelling that 1,4,5-inositol trisphosphate receptor(IP3 R) type-1 and ryanodine receptor(RyR) type-2 are differentially expressed in cells with neuron-or radial glial-like properties. Furthermore, ATP but not caffeine(IP3 R and RyR agonists, respectively), induced the generation of Ca^(2+) transients in cells exhibiting neuron-or glial-like morphology. These results indicate the differential expression of components of the Ca^(2+) -signaling toolkit in proliferating and differentiating cells. Thus, given the complexity of the intact vertebrate brain, neurospheres might be a useful system for exploring neurodegenerative disease diagnosis protocols and drug development using Ca^(2+) signaling as a read-out.

关键词： Ca^2+ signaling neurospheres zebrafish neural stem/progenitor cells differentiation IP3receptors ryanodine receptors STIM and Orai