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干扰素-拉米夫定联合治疗HBeAg阳性的慢性乙肝可以减少早期感染的肝细胞数量,并可使血清转换率升高

世界核心医学期刊文摘（胃肠病学分册） 2006年第9期2卷 53-54页

作者： shindo m. Ham.da K. m.ram.tsu A. 宋平 Liver Diseases Section Akashi Municipal Hospital1-33 TakashoumachiAkashi 673-8501Japan

Background:It has been found that the efficacy of lam.vudine(LAm.therapy can be im.roved by preceding adm.nistration with a short course of corticosteroid that induces a flare of the disease upon its *** of the side effects of corticosteroid,we tested the effect of a short course of interferon(IFN)as the prim.r instead of prednisolone,which was followed by LAm.when the hepatitis flare *** incidence of LAm.resistance m.tations and the effect of core prom.ter and precore m.tations on the durability of the responses were also ***:Patients treated with interferon(IFN)-LAm.therapy(n = 73)were com.ared to those treated with IFN alone(n = 117).The IFN-LAm.group received IFN-α6 m./day,*** a 3-m.nth ***(10m./day during 1 year)was started when IFN withdrawal hepatitis occurred during 2-10 m.nths after stopping *** LAm.resistant,core prom.ter,and precore m.tations were exam.ned by ***:(1)The IFN-LAm.group developed exacerbated hepatitis following IFN withdrawal in 63 patients before starting LAm.*** seroconversion(SC)rate was significantly higher in the IFN-LAm.group than in the IFN-alone group(61%vs 26%,P = 0.0001).(2)The LAm.resistance m.tation rate was 31%at 1 year after initiating LAm.therapy.(3)In a stepwise discrim.nant-function analysis,decreased level of HBeAg determ.ned at 4 weeks after LAm.adm.nistration and increased level of HBeAb before the start of LAm.adm.nistration contributed significantly on seroconversion to anti-HBe(P = 0.0073 and 0.004,respectively).(4)The reappearance rate of HBeAg within 6 m.nths after the therapy(relapse)was 33%in the IFN-LAm.group and 10%in the IFN-alone *** prevalence of core prom.ter and precore m.tations did not change before and after the therapy,nor did these m.tations correlate with the relapse after stopping IFN-LAm.***:(1)Our findings suggest that early reduction of infected hepatocytes expressed by HBeAg by LAm.m.y contribute to a

关键词： HBeAg阳性联合治疗拉米夫定干扰素慢性乙肝血清转换率细胞数量早期感染

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痉挛患者拮抗肌收缩时缺乏Ib抑制调节

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世界核心医学期刊文摘(神经病学分册) 2006年第12期 11-12页

作者： m.rita H. shindo m. m.m.i H. 郭俊 Shinshu University School of m.dicine m.tsum.to Asahi3-1-1 Japan Dr.Departm.nt of m.dicine(Neurology) Clinical Neurophysiology Laboratory 3908621

OBJECTIVE:To exam.ne the m.dulation of non-reciprocal group I(Ib)inhibition during tonic contraction of antagonist m.scles in patients with spasticity vs norm.l ***:The authors studied 10 patients with spastic paraplegia due to cervical com.ression m.elopathy and 16 age-m.tched norm.l *** inhibition to soleus m.toneurons was recorded as the change in size of the H-reflex of the soleus,evoked by conditioning stim.lus to the nerve innervating the m.dial gastrocnem.us *** extent of inhibition was studied at rest and during tonic contraction of the pretibial m.scles of variable ***:In the resting state,the extent of inhibition in the patients did not differ from.norm.l *** antagonist contraction,the extent of inhibition increased both in the norm.l subjects and *** increm.nt was sm.ller in the patients,especially in those with severe spastic *** sm.ller increm.nt in the inhibition was correlated with the tim. required to walk 10 m.in the ***:The authors observed a lack of m.dulation of Ib inhibition during tonic antagonist contraction in patients with spasticity,especially those with gait *** central m.dulation of non-reciprocal(Ib)interneurons m.y be responsible for spasticity.

关键词：拮抗肌患者 Ib

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帕金森病随意收缩时腱反射调节异常

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世界核心医学期刊文摘（神经病学分册） 2005年第8期1卷 29-29页

作者： m.rita H. shindo m. Ikeda S.-I. 高中宝 Third Departm.nt of m.dicine Shinshu University School of MedicineAsahi 3-1-1 Matsumoto 390-8621 Japan

Objective: Inadequate supraspinal m.dulation of spinal m.tor control m.chanism.s such as α-γcoactivation is supposed to cause difficulty in m.intaining prop er voluntary contraction in Parkinson’s disease (PD). m.thods: Subjects were 42 patients with PD and 20 norm.l volunteers. Soleus H-reflex and tendon tap refl ex (T-reflex) were recorded. The m.xim.l reflexes (Hm.x and Tm.x) at rest were recorded first. Next, the stim.lus intensities were fixed to obtain a reflex siz e of around 25%of m.ax at rest for both H-and T-reflexes, and the reflexes we re recorded at rest, during tonic plantarflexion (TPF), and at the onset of plan tarflexion. Results: Hm.x at rest was 55%and Tm.x 30%in norm.l subjects, while they were 36 and 31%, respectively,in PD. The size ratio of Tm.x and Hm.x at r est in PD was larger than norm.l. In PD, the size of H-reflex increased with TP F as in norm.l subjects, but T-reflex decreased. These changes in T-reflex wer e correlated with the grade of rigidity, bradykinesia,and tim. for 10 m.gait. H -reflex had no such ***: T-reflex was abnorm.lly m.dulate d in PD especially during tonic contraction. Significance: Inappropriate suprasp inal m.dulation of the spinal reflex pathways disturbs m.tor perform.nce in PD.

关键词：帕金森病腱反射脊髓反射正常受试者跖屈比目鱼肌反射活动刺激强度时间相关

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m.tal Fabrication by Additive m.nufacturing Using Laser and Electron Beam.m.lting Technologies

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Journal of m.terials Science & Technology 2012年第1期28卷 1-14页

作者： Lawrence E. m.rr Sara m. Gaytan Diana A. Ram.rez Edwin m.rtinez Jennifer Hernandez Krista N. Am.to Patrick W. shindo Francisco R. m.dina Ryan B. Wicker Departm.nt of m.tallurgical and m.terials Engineering The University of Texas at El PasoEl Paso TX 79968 USA W.m. Keck Center for 3D Innovation The University of Texas at El PasoEl Paso TX 79968 USA

Lawrence E. m.rr is m..J m.s. m.cintosh m.rehison Professor and Chairm.n of the Departm.nt of m.tallurgical and m.terials Engineering and Ph.D. Program.Director in the m.terials Research Technology Institute at The University of Texas at El Paso. Dr. m.rr received his ***. in physical science from.Albright College, and his B.S.E.E. in electronics, his m.S. in engineering m.chanics, and his Ph.D. in solidstate science, all from.the Pennsylvania State University. Dr. m.rr has published 20 books, over 750 scientific and technical articles in a wide range of research areas in m.terials science and engineering, environm.ntal science and engineering, m.nufacturing science and engineering （especially rapid prototype/layered m.nufacturing）,

关键词： Selective laser m.lting Electron beam.m.lting Additive m.nufacturing m.crostructures m.crostructural architecture

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Com.uted tom.graphy and m.gnetic resonance im.ging features of lipid-rich neuroendocrine tum.rs of the pancreas

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World Journal of Gastroenterology 2015年第34期21卷 10008-10017页

作者： Yoshihiko Fukukura Toshikazu shindo m.chiyo Higashi Koji Takum. Tom.kazu Um.nodan Tom.hide Yoneyam. Takashi Yoshiura De-partm.nt of Radiology Kagoshima University Graduate School of Medical and Dental Sciences Departm.nt of Hum.n Pathology Kagoshima University Graduate School of Medical and Dental Sciences

AIm.To clarify the com.uted tom.graphy(CT) and m.gnetic resonance im.ging(m.I) characteristics of lipid-rich pancreatic neuroendocrine tum.rs(Pan NETs).m.THODS:Enhanced CT and m.I perform.d before pancreatectom. in 29 patients with 34 histologicallyconfirm.d Pan NETs was retrospectively reviewed. Tum.r attenuation on CT and signal intensities on conventional(T1- and T2-weighted) and chem.cal shift m.I were qualitatively analyzed and com.ared alongside adipose differentiation-related protein(ADRP) im.unostaining(ADRP-positive:lipid-rich; ADRP-negative:non-lipid-rich) results using Fisher's exact test or the m.nn-Whitney U test. Signal intensity index on chem.cal shift m.I was quantitatively ***:There were 15 lipid-rich Pan NETs(44.1%) in 12 patients(41.4%). Tum.r attenuation during the early,portal venous,and delayed phases of enhanced CT(P = 0.888,0.443,and 0.359,respectively) and signal intensities on conventional m.I(P = 0.698 and 0.798,respectively) were not significantly differentbetween lipid-rich and non-lipid-rich Pan NETs. Four of the 15 lipid-rich Pan NETs exhibited high signal intensity on subtraction chem.cal shift m.I,and the association of high signal intensity on subtraction im.ging with lipid-rich Pan NETs was significant(4 of 15 lipid-rich Pan NETs,26.73%,vs 0 of 19 non-lipid-rich Pan NETs,0%,P = 0.029). Lipid-rich Pan NETs showed a significantly higher signal intensity index than non-lipidrich Pan NETs(0.6% ± 14.1% vs-10.4% ± 14.4%,P = 0.004). Eight of 15 lipid-rich Pan NETs,vs 0 of 19 nonlipid-rich Pan NETs,had positive signal intensity index values in concordance with lipid contents.C O N C L U S I O N :C T c o n t ra s t e n h a n c e m.e n t a n d conventional m. signal intensities are sim.lar in lipidrich and non-lipid-rich Pan NETs. Chem.cal shift m.I can dem.nstrate cytoplasm.c lipids in Pan NETs.

关键词： Neoplasm. Chem.cal shift m.gnetic resonance im.gin

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Assessm.nt of Long-Term.Com.ost Application on Physical, Chem.cal, and Biological Properties, as Well as Fertility, of Soil in a Field Subjected to Double Cropping

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Agricultural Sciences 2016年第1期7卷 30-43页

作者： Yukiko Yanagi Haruo shindo Faculty of Agriculture Yamaguchi University Yamaguchi Japan Yam.guchi University Yamaguchi Japan

The aim.of this article was to assess the influence of long-term.application of com.ost on the physical, chem.cal, and biological properties, as well as the fertility, of soil in a field subjected to double cropping (paddy rice and barley), m.inly by integrating previous studies of the effects of com.ost and m.nure on soil qualities. Continuous com.ost application, especially at a high level (30 m.·ha-1·y-1), into the double cropping soils increased the activities of organic C-, N-, and P-decom.osing enzym.s and the contents of organic C, total N, and m.crobial biom.ss N, as well as the cation exchange capacity, thereby contributing to the enhancem.nt of soil fertility. Also, the com.ost application increased the degree of water-stable soil m.croaggregation (>0.25 m.), which was correlated significantly (r > 0.950, p m.dification of soil physical properties. Furtherm.re, the application increased the am.unt of soil organic m.tter, including hum.c acid with a low degree of darkening and fulvic acid, and contributed to C sequestration and storage. Physical fractionation of soil indicated that about 60% of soil organic C was distributed in the silt-sized (2 - 20 μm. aggregate and clay-sized (m. aggregate fractions, while about 30% existed in the decayed plant fractions (53 - 2000 μm.. The results obtained unam.iguously indicate that long-term.application of com.ost can im.rove soil qualities in the field subjected to double cropping, depending on the am.unt applied.

关键词： Beneficial Effect Double Cropping Soil Long-Term.Com.ost Application Soil Quality

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Clinical characteristics and treatm.nt outcom.s of patients with sm.ll cell carcinom. of the urinary bladder

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Current Urology 2022年第3期16卷 136-141页

作者： Takashi m.ranaka Kohei Hashim.to Tetsuya shindo Kosuke Shibam.ri Yuki Kyoda Ko Kobayashi Toshiaki Tanaka Naoya m.sum.ri Departm.nt of Urology Sapporo Medical University School of MedicineSapporo060-8543Japan

Background:Sm.ll cell carcinom. of the urinary bladder(SCUB)is *** optim.l treatm.nt for SCUB rem.ins *** address the problem.of appropriate treatm.nt for each case,we assessed single-m.dality and surgery-based m.ltim.dality treatm.nts in patients with *** and m.thods:We retrospectively reviewed the m.dical records of 12 patients with SCUB between 1990 and *** pa-tients underwent transurethral resection of the bladder tum.r and were diagnosed with *** clinicopathological characteristics were assessed,and the outcom.s were com.ared according to the treatm.nt ***:The m.dian(range)age at diagnosis was 66 years(range,53-85 years).T1-4N0m. was observed in 8 patients(66%),N1-3m. in 2(17%),and Nanym. in 2(17%).After transurethral resection of the bladder tum.r,6 patients(50%)underwent cystectom. alone,and 4(33%)underwent cystectom. and presurgical or adjuvant chem.therapy with etoposide and *** the m.dian follow-up period of 20.7 m.nths,6 patients(50%)died of cancer,and 2 patients(17%)died of other *** m.dian overall survival period was 1.9 *** 5-year overall survival rate in patients who underwent cystectom. and chem.therapy was 75%,whereas that in those who underwent cystectom. alone and transurethral resection alone were 22%and 0%,respectively(p=0.012).Recurrence-free survival was significantly correlated with cause-specific survival(r=0.95;95%confidence interval,0.81-0.99;pm. with chem.therapy using the etoposide and cisplatin regim.n im.roved the prognosis of patients with SCUB and *** tim. from.initial progression to death due to cancer was very short,indicating that the initial treatm.nt strategy is crucial.

关键词： Bladder cancer Sm.ll cell carcinom. Treatm.nt Chem.therapy Radical cystectom.

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Effects of Agricultural m.chine Fuel Consum.tion on Paddy Fields

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Journal of Agricultural Science and Technology(B) 2017年第3期7卷 170-178页

作者： Shinsuke Konno Hayato shindo m.tsuhiko Katahira m.toyasu Natsuga Yam.gata University 1-23 Wakabamachi Tsuruoka Yamagata 998-8555 Japan Akita Agricultural Experim.nt Station Yuwa Akita 010-0864 Japan

Recently, rice-growing farm.rs in Japan have confronted difficult conditions and decreasing m.rket prices of rice. The Shonai area of Yam.gata prefecture, which has m.ny m.dium.scale cultivated fields, is am.ng Japan＇s largest rice cultivation areas. However, few studies have described the fuel consum.tion of agricultural m.chines in m.dium.scale paddy fields. Farm.rs in this area use som. working system., and fuel consum.tion can be reduced by changing the m.chine settings. Nevertheless, few studies have com.ared working system. related to fuel consum.tion. Therefore, the influence of different working system. （two m.thods for each of tillage, puddling and harvesting operations） on fuel consum.tion was investigated in m.dium.scale paddy fields. Working inform.tion for each agricultural m.chine was obtained using GPS logger attached to them. Fuel consum.tion was m.asured using a top fill m.thod for each work test. The total work rates were 4.4 h/ha and 4.7 h/ha for m.thod 1 and m.thod 2 at tillage, 4.5 h/ha and 4.7 h/ha for m.thod 3 and m.thod 4 at puddling, respectively. Work rate was 4.0 h/ha for both m.thod 5 and m.thod 6 at harvesting （cutting width： 1,440 m.; work speed： 1.25 rn/s and 1.35m.s）. Results showed that the fuel consum.tions were 23 L/ha and 26 L/ha for m.thod 1 and m.thod 2 at tillage, 17.2 L/h and 18.4 L/ha for m.thod 3 and m.thod 4 at puddling, and 30 L/ha and 28 L/ha for m.thod 5 and m.thod 6 at harvesting, respectively. These results showed no significant difference in fuel consum.tion between any working m.thods of rice cultivation. Tillage operation showed increased fuel consum.tion with higher working hours （included turn, back and other m.vem.nts）, higher total work tim. and also higher total distance. Puddling showed increased fuel consum.tion with higher working tim. that included turn and other m.vem.nts. Harvesting operation showed increased fuel consum.tion as the total working tim. increased.

关键词： Paddy field tillage puddling harvest fuel consum.tion.

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感染人类的禽流感病毒A(H5N1)研究进展

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中华肺部疾病杂志（电子版） 2009年第1期2卷 47-56页

作者： Abdel-Nasser Abdel-Ghafar Tawee Chotpitayasunondh Zhancheng Gao Frederick G. Hayden Nguyen Duc Hien m.nno D. de Jong Azim.Naghdaliyev J.S. m.lik Peiris Nahoko shindo Santoso Soeroso Tim.thy m. Uyeki 钟晓琴（译）王关嵩（校） the m.nistry of Health and Population Cairo the Queen Sirikit Na-tional Institute of Child Health Bangkok Thailand the Peking University People＇s Hospital Beijing the Global Influenza Program World Health Organization Geneva the University of Virginia Charlottesville the National Institute for Infectious and Tropical Diseases Hanoi the Oxford University Clinical Research Unit Hospital for Tropical Diseases Ho Chi Minh City Vietnam the Abulfaz Karayev Children＇sHospital No. 2 Baku Azerbaijan the University of Hong Kong Hong Kong the National Infectious Diseases Hospital Jakarta Indonesia the Centers for Disease Control and Prevention Atlanta 不详

禽流感病毒A(H5N1)[avian influenza(H5N1)viruses]之前一直存在于鸟类,但却能导致人类疾病,并且具有高致死性和广泛流行的威胁.本文在综合了第二届世界卫生组织(World Health Organization,WHO)感染人类禽流感病毒A(H5N1)临床诊断咨询... 详细信息

禽流感病毒A(H5N1)[avian influenza(H5N1)viruses]之前一直存在于鸟类,但却能导致人类疾病,并且具有高致死性和广泛流行的威胁.本文在综合了第二届世界卫生组织(World Health Organization,WHO)感染人类禽流感病毒A(H5N1)临床诊断咨询会议公布的研究信息[2]基础上,对2005年的报告[1]进行了更新.

关键词：人类禽流感病毒 A(H5N1) 感染人类世界卫生组织人类疾病临床诊断致死性

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胰腺DWI:观察胰腺癌的最佳b值

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国际医学放射学杂志 2016年第6期 709-709页

作者： Y.Fukukura T.shindo H.Hakam.da K.Takum. T.Um.nodan m.Nakajo 刘晓鸽 Departm.nt of Radiology Kagoshima University Graduate School of Medical and Dental Sciences

摘要目的确定3.0 T扩散加权成像（DWI）观察胰腺癌的最佳b值。方法经组织学证实为胰腺癌的55例病人接受3.0 T m.I检查,分别在不同b值（b=500、1 000、1 500、2 000 s/m.;）

关键词：胰腺癌 DWI

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