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Production analysis of functionally distributed machines for underground mining

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International Journal of Mining Science and Technology 2016年第3期26卷 477-485页

作者： Fukui Rui Kusaka Kouhei nakao Masayuki Kodama Yuichi Uetake Masaaki Kawai Kazunari Department of Mechanical Engineering The University of Tokyo Komatsu Ltd.

Recent years, underground mining method is becoming popular because of its potentially high productivity and efficiency. In this method, a mining machinery; load haul dump(LHD), is used as both an excavator and a transporter of ore. This paper proposes a distributed system that realizes the excavation and transport functions with separated vehicles, an excavator and a transporter. In addition, this research proposes a mining map and configurations suitable for the proposed distributed system. To evaluate the productivity of the proposed system, a simulation environment has been developed. Analysis using the simulator reveals what performance factors of the excavator and the transporter have large impacts on the productivity. Simulation results also demonstrate the difference of potential between LHD system and the distributed system that can be explained based on their functions allocation.

关键词： Underground mining Mining machinery Autonomous system design Distributed system System configuration

Matrix metalloproteinase-9 in the initial injury after hepatectomy in mice

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World Journal of Gastroenterology 2013年第20期19卷 3027-3042页

作者： Norifumi Ohashi Tomohide Hori Florence Chen Sura Jermanus Akimasa nakao shinji Uemoto Justin H Nguyen Gastroenterological Surgery Nagoya University Graduate School of MedicineNagoyaAichi 466-8550Japan Divisions of Hepato-PancreatoBiliary Transplant and Pediatric SurgeryDepartment of SurgeryKyoto University Graduate School of MedicineKyoto 606-8507Japan Department of Neuroscience Mayo ClinicJacksonvilleFL 32224United States Division of Transplant Surgery Department of TransplantationMayo Clinic in FloridaJacksonvilleFL 32224United States

AIM:To investigate the role of matrix metalloproteinase(MMP)-9 in the pathogenesis of postoperative liver failure(PLF) after extended hepatectomy(EH).METHODS:An insufficient volume of the remnant liver(RL) results in higher morbidity and mortality,and a murine model with 80%-hepatectomy was *** investigations were performed 6 h after *** were first divided into two groups based on the postoperative course(i.e.,the PLF caused or did not),and MMP-9 expression was measured by Western *** source of MMP-9 was then determined by immunohistological *** inhibitor of metalloproteinase(TIMP)-1 is the endogenous inhibitor of MMP-9,and MMP-9 behavior was assessed by the experiments in wild-type,MMP-9(-/-) and TIMP-1(-/-) mice by Western blotting and gelatin *** behavior of neutrophils was also assessed by immunohistological *** anti-MMP-9 monoclonal antibody and a broadspectrum MMP inhibitor were used to examine the role of ***:Symptomatic mice showed more severe PLF(histopathological assessments:2.97 ± 0.92 vs 0.11 ± 0.08,P < 0.05) and a higher expression of MMP-9(71085 ± 18274 vs 192856 ± 22263,P < 0.01).Nonnative leukocytes appeared to be the main source of MMP-9,because MMP-9 expression corresponding with CD11b positive-cell was observed in the findings of immunohistological *** the histopathological findings,the PLF was improved in MMP-9(-/-) mice(1.65% ± 0.23% vs 0.65% ± 0.19%,P < 0.01) and it was worse in TIMP-1(-/-) mice(1.65% ± 0.23% vs 1.78% ± 0.31%,P < 0.01).Moreover,neutrophil migration was disturbed in MMP-9(-/-) mice in the immunohistological *** methods of MMP-9 inhibition revealed reduced PLF,and neutrophil migration was strongly disturbed in MMP-9-blocked mice in the histopathological assessments(9.6 ± 1.9 vs 4.2 ± 1.2,P < 0.05,and 9.9 ± 1.5 vs 5.7 ± 1.1,P < 0.05).CONCLUSION:MMP-9 is important for the process of *** initial injury is associated with MMP-9 derived from neutrophil

关键词： Matrix metalloproteinase Shear stress Sinusoidal injury Hepatectomy Portal hypertension

A patient presenting painful chest wall swelling: Tietze syndrome

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World Journal of Emergency Medicine 2019年第2期10卷 122-124页

作者： Kohei Sawada Hiromi Ihoriya Taihei Yamada Tetsuya Yumoto Kohei Tsukahara Takaaki Osako Hiromichi Naito Atsunori nakao Department of Emergency Critical Care and Disaster Medicine Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Dear editor,Patients frequently visit the emergency room with acute chest *** some potentially life-threatening disorders may cause the pain,in approximately 80%of cases,the chest pain source is benign,and musculoskeletal chest pain accounts for nearly 20%– 50%of those cases.^[1–6]Thus,pain caused by benign and pathological conditions of the chest wall encountered in the emergency department is sometimes incorrectly attributed to angina pectoris or pleuritic and other serious cardiopulmonary diseases.

关键词： Patients frequently emergency room life-threatening

Possibilities of interventional endoscopic ultrasound

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World Journal of Gastrointestinal Endoscopy 2012年第7期4卷 301-305页

作者： Makoto Nishimur Osamu Togawa Miho Matsukawa Takashi Shono Yasutoshi Ochiai Masamitsu nakao Keiko Ishikawa shin Arai Hiroto Kita Department of Gastroenterology Saitama Medical University International Medical Center1397-1 Yamane Hidaka Saitama 350-1298 Japana Department of Gastroenterology Saitama Medical University International Medical Center1397-1 Yamane Hidaka Saitama 350-1298 Japan

Since endoscopic ultrasound (EUS) was developed in the 1990s, EUS has become widely accepted as an imaging tool. EUS is categorized into radial and linear in design. Radial endoscopes provide cross-sectional imaging of the mediastinum, gastrointestinal tract, liver, spleen, kidney, adrenal gland, and pancreas, which has highly accuracy in the T and N staging of esophageal, lung, gastric, rectal, and pancreatic cancer. Tumor staging is common indication of radial-EUS, and EUSstaging is predictive of surgical resectability. In contrast, linear array endoscope uses a side-viewing probe and has advantages in the ability to perform EUSguides fine needle aspiration (EUS-FNA), which has been established for cytologic diagnosis. For example, EUS-FNA arrows accurate nodal staging of esophageal cancer before surgery, which provides more accurate assessment of nodes than radial-EUS imaging alone. EUS-FNA has been also commonly used for diagnose of pancreatic diseases because of the highly accuracy than US or computed tomography. EUS and EUS-FNA has been used not only for TNM staging and cytologic diagnosis of pancreatic cancer, but also for evaluation of chronic pancreatitis, pancreatic cystic lesions, and other pancreatic masses. More recently, EUS-FNA has developed into EUS-guided fine needle injection including EUS-guided celiac plexus neurolysis, celiac plexus block, and other "interventional EUS" procedures. In this review, we have summarized the new possibilities offered by "interventional EUS".

关键词： Endoscopic ultrasound-fine needle aspiration Interventional endoscopic ultrasound

Short term results of endoscopic submucosal dissection in superficial esophageal squamous cell neoplasms

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World Journal of Gastrointestinal Endoscopy 2010年第2期2卷 69-74页

作者： Kouichi Nonaka shin Arai Keiko Ishikawa Masamitsu nakao Yousuke Nakai Osamu Togawa Koji Nagata Michio Shimizu Yutaka Sasaki Hiroto Kita Department of Gastroenterology Saitama Medical University International Medical Center Saitama 350-1298 Japan Department of Pathology Saitama Medical University International Medical Center Saitama 350-1298 Japan Department of Gastroenterology Faculty of Medicine Kumamoto University Kumamoto 860-0856 Japan

AIM: To evaluate the efficacy of endoscopic submucosal dissection for superficial esophageal squamous cell neoplasms. METHODS: Between July 2007 and March 2009, 27 consecutive superficial esophageal squamous cell neoplasms in 25 enrolled patients were treated by endoscopic submucosal dissection. The therapeutic efficacy, complications, and follow-up results were assessed. RESULTS: The mean size of the lesions was 21 ± 13 mm (range 2-55 mm); the mean size of the resection specimens was 32 ± 12 mm (range 10-70 mm). The enblock resection rate was 100% (27/27), and en block resection with tumor-free lateral/basal margins was 88.9% (24/27). Perforation occurred in 1 patient who was managed by conservative medical treatments. None of the patients developed local recurrence or distant metastasis in the follow-up period. CONCLUSION: Endoscopic submucosal dissection is applicable to superficial esophageal squamous cell neoplasms with promising results.

关键词： Endoscopic submucosal dissection Esophageal cancer Squamous cell Neoplasm Endoscopy

Implantation of esophageal cancer onto post-dissection ulcer after gastric endoscopic submucosal dissection

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World Journal of Gastroenterology 2016年第9期22卷 2855-2860页

作者： Satoshi Asai Koutarou Takeshita Yuki Kano Eisuke nakao Takumi ichinona Naoki Fujimoto Eisuke Akamine Takuji Mori Atsuhiro Ogawa Department of Gastroenterology Tane General Hospital

A case in which implantation of esophageal squamous cell carcinoma onto a post-dissection gastric ulcer was strongly suspected is presented. A 72-yearold man with alcoholic liver cirrhosis underwent esophagogastroduodenoscopy(EGD). Esophageal cancer(EC)(Mt, 20 mm, 0-Is) and gastric cancer(GC)(antrum, 15 mm, 0-Ⅱc) were identified. Biopsy specimens revealed moderately differentiated squamous cell carcinoma(SCC) and differentiated adenocarcinoma, respectively. The GC was resected by endoscopic submucosal dissection(ESD) [14 mm × 9 mm, type 0-Ⅱc, tub1, p T1a(M), ly0, v0, HM(-), VM(-)]. Two months after ESD, radiation therapy was started for the EC, and an almost complete response was obtained. Nine months after the ESD, a follow-up EGD showed a submucosal tumor-like lesion with ulceration, located immediately under the post-ESD scar, and biopsy specimens showed moderately differentiated SCC. There were no similar lesions suggesting hematogenous or lymphatic metastasis in the stomach.

关键词： Implantation Esophageal cancer Gastric cancer Endoscopic submucosal dissection Postdissection ulcer

Chemotherapy as a component of multimodal therapy for gastric carcinoma

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World Journal of Gastroenterology 2006年第13期12卷 2000-2005页

作者： Yasuhiro Kodera Michitaka Fujiwara Masahiko Koike Akimasa nakao Department of Surgery Ⅱ Nagoya University Graduate School of Medicine 65Tsurumai-choShowa-kuNagoyaAichi 466-8550Japan

Prognosis of locally advanced gastric cancer remains poor, and several multimodality strategies involving surgery, chemotherapy, and radiation have been tested in clinical trials. Phase Ⅲ trial testing the benefit of postoperative adjuvant chemotherapy over treatment with surgery alone have revealed little impact on survival, with the exception of some small trials in Western nations. A large trial from the United States exploring postoperative chemoradiation was the first major success in this category. Results from Japanese trials suggest that moderate chemotherapy with oral fluoropyrimidines may be effective against less-advanced （T2-stage） cancer, although another confirmative trial is needed to prove this point. Investigators have recently turned to neoadjuvant chemotherapy, and some promising results have been reported from phase Ⅱ trials using active drug combinations. In 2005, a large phase Ⅲ trial testing preand postoperative chemotherapy has proven its survival benefit for resectable gastric cancer. Since the rate of pathologic complete response is considered to affect treatment results of this strategy, neoadjuvant chemoradiation that further increases the incidence of pathologic complete response could be a breakthrough, and phase Ⅲ studies testing this strategy may be warranted in the near future.

关键词： Surgery Radiation Anticancer drug Adjuvant chemotherapy Neoadjuvant chemotherapy

Developmental and Reproductive Performance of the Tobacco Thrips, <i>Frankliniella fusca</i>(Hinds) (Insecta: Thysanoptera), on Leaves of Nicotiana spp.

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Agricultural Sciences 2014年第6期5卷 555-559页

作者： Shiro nakao Chisako Chikamori School of Life and Environmental Sciences Kyoto Prefectural University Kyoto Japan

Tobacco thrips, Frankliniella fusca, which is a vector of Tospovirus, is a serious pest of tobacco, peanuts, and cotton in the United States. It was said that immigration of the adult thrips from weed hosts into crop fields is a cause of TSWV epidemy in the field. Recently this pest thrips was introduced into Japan. We investigated survival rate, developmental time, and fecundity of a Japanese strain of F. fusca on leaves of tobacco, peanut, and green bean at 18°C. Thrips could not complete larval development on 3 Nicotiana species, N. tabacum, N. gossei, and N. rustica. On the other hand, survival rate from hatching to adult emergence on peanut and green bean is 78% and 86%, respectively. A female adult thrips lived during about 25 days and deposited 101 eggs on green bean, but died within 10 days without ovipositing on Nicotiana spp. The tobacco is not a reproductive host plant that permits tobacco thrips to propagate, but an adult food source that is susceptible of TSWV.

关键词： Tobacco Thrips Groundnut Green Bean Fecundity Survival Rate

Study of Rectangular Underexpanded Microjets

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Open Journal of Fluid Dynamics 2023年第2期13卷 122-131页

作者： Shota Yoshimi shinichiro nakao Yoshiaki Miyazato Department of Mechanical Systems Engineering The University of Kitakyushu Fukuoka Japan

The underexpanded microjet emerging from a rectangular convergent nozzle with a high aspect ratio at the nozzle exit is investigated numerically using the Reynolds-averaged Navier-Stokes (RANS) simulation with the Menter’s shear stress transport (SST) k-ω turbulence model. The simulation is performed at the nozzle pressure ratio of 5.0 to produce a strong shock and it is validated by a comparison with a rainbow schlieren picture of the microjet. The three-dimensional structure of the shock-containing rectangular microjet is demonstrated using the isopycnic surface and bright-field schlieren representations.

关键词： Microjets Rainbow Schlieren RANS Simulation Rectangular Nozzle Shock Waves