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Analysis of chloramphenicol in honey by on-line pretreatment liquid chromatography-tandem mass spectrometry

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Chinese Chemical Letters 2015年第1期26卷 36-38页

作者： shin-ichi kawano Hong-Yuan Hao Yuki Hashi Jin-Ming Lin Department of Chemistry Beijing Key Laboratory of Microanalytical Methods and InstrumentationTsinghua University Shimadzu Global COE for Application & Technical Development Shimadzu(China)Co.Ltd.

hloramphenicol is an antibiotic and one of the potential contaminants in ***-phase extraction is the key pretreatment procedure for analysis of chloramphenicol in *** this work,an on-line pretreatment liquid chromatography-tandem mass spectrometer system for sensitive,reliable and higher throughput analysis was *** the methylcellulose-immobilized reversed-phase column,sugars in a honey sample were efficiently removed in 1 *** a result,the limit of quantitation of chloramphenicol was 20 pg/mL（0.2 μg/kg honey）.

关键词： On-line pretreatment Liquid chromatography-mass spectrometry Chloramphenicol Honey

Drug-induced mucosal alterations observed during esophagogastroduodenoscopy

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World Journal of Gastroenterology 2024年第16期30卷 2220-2232页

作者： Masaya Iwamuro Seiji kawano Motoyuki Otsuka Department of Gastroenterology and Hepatology Okayama University Graduate School of MedicineDentistryand Pharmaceutical SciencesOkayama 700-8558Japan

Several features of drug-induced mucosal alterations have been observed in the upper gastrointestinal tract,i.e.,the esophagus,stomach,and *** include pill-induced esophagitis,desquamative esophagitis,worsening of gastroesophageal reflux,chemotherapy-induced esophagitis,proton pump inhibitor-induced gastric mucosal changes,medication-induced gastric erosions and ulcers,pseudomelanosis of the stomach,olmesartan-related gastric mucosal inflammation,lanthanum deposition in the stomach,zinc acetate hydrate tabletinduced gastric ulcer,immune-related adverse event gastritis,olmesartan-associated sprue-like enteropathy,pseudomelanosis of the duodenum,and lanthanum deposition in the *** endoscopists,acquiring accurate knowledge regarding these diverse drug-induced mucosal alterations is crucial not only for the correct diagnosis of these lesions but also for differential diag-nosis of other *** minireview aims to provide essential information on druginduced mucosal alterations observed on esophagogastroduodenoscopy,along with representative endoscopic images.

关键词： Diagnosis Esophagogastroduodenoscopy Non-neoplastic lesions Esophageal lesions Gastric lesions Duodenal lesions

MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1

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Oncology Research 2024年第3期32卷 463-476页

作者： Hur SUN MASANORI kawano TATSUYA IWASAKI ICHRO ITONAGA YUTA KUBOTA HROSHI TSUMURA KAZUHRO TANAKA Department of Orthopaedic Surgery Faculty of MedicineOita UniversityOita879-5503Japan

An important factor in the emergence and progre sion of osteosarcoma(OS)is the dysregulated expression of microRNAs(miRNAs).Transcription factor 7-like 1(TCF7LI),a member of the T cell factor/lymphoid enhancer factor(TCF/LEF)transcription factor family,interacts with the Wnt signaling pathway regulator β-catenin and acts as a DNA-specific binding *** study sought to elucidate the impact of the interaction between miR 3293p and TCF7L1 *** growth and apoptosis of OS and analyze the regulatory expression relationship between miRNA and mRNA in osteosarcoma cells using a variety of ***329-3p was significantly downregulated,while TCF7L1 was considerably up-regulated in all examined OS cell ***,a clinical comparison study was performed using the TCGA ***,the regulatory relationship between miR-329-3p and TCF7L1 on the proliferation and apoptosis of OS cells was verified through in vitro and in vivo *** miR 329-3p was transfected into the OS cell line,the expression of TCF7L1 decreased,the proliferation of OS cells was inhibited,the cytoskeleton disintegrated,and the nucleus condensed to fom apoptotic *** expression of proteins that indicate apoptosis increased *** cell cycle was arrested in the G0/G1 phase,and the G1/S transition was *** introduction of miR 3293p also inhibited downstream Cyclin D1 of the Wnt *** experiments indicated that the overexpression of miR-329-3p signi ficanly inhibited the growth of OS xenografts in nude mice,and the expression of TCF7L1 and C-Myc in tumor tssues *** 329-3p was significantly reduced in OS cells and played a suppressive role in tumorigenesis and proliferation by targeting TCF7L1 both in vitro and in *** cell cycle arrest and pathway inhibition were observed upon the regulation of TCF7LI by miR *** these results,it can be inferred that miR.3293p exerts anticancer efects in osteosarcom

关键词： MiR-329-3p TCF7L1 Wnt/β-catenin pathway Osteosarcoma Proliferation

Correction: MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1

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Oncology Research 2024年第8期32卷 1369-1370页

作者： HUI SUN MASANORI kawano TATSUYA IWASAKI ichiRO ITONAGA YUTA KUBOTA HIROSHI TSUMURA KAZUHIRO TANAKA Department of Orthopaedic Surgery Faculty of MedicineOita UniversityOita879-5503Japan

In the article‘MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1’(Oncology Research,2024,Vol.32,No.3,pp.463−***:10.32604/or.2023.044085),there was an error in the compilation of *** have revised Fig.8D to correct this error.A corrected version of Fig.8 is *** correction does not change any results or conclusions of the *** apologize for any inconvenience caused.

关键词： osteosarcoma correction revised

Co-Sense for BA LC/MS系统对血浆中药物的直接分析

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Co-Sense for BA LC/MS系统对血浆中药物的直接分析

采用自动前处理LC/MS进行血浆中药物的快速分析

第十五次全国色谱学术报告会

作者：宋苑苑 Hashi Yuki 吕冬 Masatoshi Takahashi shin-ichi kawano Keiko Yamabe Eiichi Yamamoto Naoki Asakawa 岛津国际贸易(上海)有限公司北京分析中心岛津国际贸易(上海)有限公司北京分析中心岛津国际贸易(上海)有限公司北京分析中心 Shimadzu Corporation Japan Shimadzu Corporation Japan Shimadzu Corporation Japan Eisai Co．Ltd． Japan Eisai Co．Ltd． Japan

＜正＞本文介绍采用Co-Sense for BA LC/MS系统对血浆中药物进行直接分析。该系统运用柱切换技术、含有稀释旁路与前处理柱的自动在线前处理系统以及MS检测器（电喷雾接口）。在药代动力学及代谢研究中需要对血清、血浆等生物样品中的... 详细信息

＜正＞本文介绍采用Co-Sense for BA LC/MS系统对血浆中药物进行直接分析。该系统运用柱切换技术、含有稀释旁路与前处理柱的自动在线前处理系统以及MS检测器（电喷雾接口）。在药代动力学及代谢研究中需要对血清、血浆等生物样品中的药物进行分析。为防止柱子的堵塞、劣化,在保护LC/MS接口的同时提高药物的回收率,分析前需要对生物样品进行除蛋白的处理。自动在线前处理系统Co-Sense for BA使用反相前处理柱（Shim-pack MAYI-ODS）和在线稀释旁路,可实现对血清、血浆等生物样品的直接进样分析。

关键词： Co-Sense-LC/MS 在线前处理系统药物分析

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分析科学学报 2005年第3期21卷 313-315页

作者：端裕树山部惠子高桥雅俊河野慎一三上博久岛津国际贸易(上海)有限公司北京分析应用中心北京100020 岛津公司分析应用部

药物研究的发展对高通量的样品处理分析提出了越来越高的要求,减少样品制备时间和分析时间是解决问题的关键。我们新近发展了一种具有在线稀释旁路和新的样品预处理柱的ShimPackMAYIODS自动柱切换HPLC和LC/MS系统,该系统无需样品前处理... 详细信息

药物研究的发展对高通量的样品处理分析提出了越来越高的要求,减少样品制备时间和分析时间是解决问题的关键。我们新近发展了一种具有在线稀释旁路和新的样品预处理柱的ShimPackMAYIODS自动柱切换HPLC和LC/MS系统,该系统无需样品前处理,可直接进样进行血浆、血清中的药物分析。本文利用自动样品前处理LC/MS系统,用ODS整体柱实现了血浆中药物的快速分析。包括样品预处理,整个分析仅需1.2min完成。

关键词：高效液相色谱柱切换血浆 LC/MS 整体柱

Improving disease resistance to rice false smut without yield penalty by manipulating the expression of effector target

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Molecular Plant 2022年第12期15卷 1834-1837页

作者： Qiong Wang Yoji kawano School of Plant Protection Yangzhou UniversityYangzhou 225009China Institute of Plant Science and Resources Okayama UniversityOkayama 710-0046Japan Kihara Institute for Biological Research Yokohama City UniversityKanagawa 244-0813Japan

Rice grain production and quality are threatened by many devastating *** smut caused by Ustilaginoidea virens is emerging as a major fungal disease of rice,leading to a severe loss of *** invades only rice panicles at the late stage of booting and replaces grains with false smut balls containing mycotoxins,which endanger human and animal health(Sun et al.,2020).This successful colonization is accomplished through manipulating host immune responses by *** effectors.

关键词： false panicle resistance

The anti-oncogenic effect of 17-DMAG via the inactivation of HSP90 and MET pathway in osteosarcoma cells

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Oncology Research 2023年第5期31卷 631-643页

作者： MASANORI kawano KAZUHIRO TANAKA ichiRO ITONAGA TATSUYA IWASAKI YUTA KUBOTA HIROSHI TSUMURA Department of Orthopaedic Surgery Faculty of MedicineOita UniversityOita879-5593Japan

Heat shock protein(HSP)90 plays a crucial role in correcting the misfolded three-dimensional structure of proteins,assisting them in folding into proper ***90 is critical in maintaining the normal functions of various proteins within cells,as essential factors for cellular ***,HSP90 simultaneously supports the maturation of cancer-related proteins,including mesenchymal epithelial transition factor(MET)within tumor *** osteosarcoma cell lines had elevated MET expression in the cDNA array in our ***,a tyrosine kinase receptor,promotes proliferation and an anti-apoptotic state through the activation of the MET pathway constructed by *** this study,we treated osteosarcoma cells with an HSP90 inhibitor,17-demethoxygeldanamycin hydrochloride(17-DMAG),and assessed the changes in the MET signaling pathway and also the antitumor effect of the *** cell cycle in osteosarcoma cells administered 17-DMAG was found to be halted at the G2/M ***,treatment with 17-DMAG inhibited cell proliferation and induced *** of tumor cell proliferation was also observed in an in vivo model system,mice that were treated with *** on the results of this study,we were able to confirm that 17-DMAG promotes inhibition of osteosarcoma cell proliferation and induction of apoptosis by inhibition of MET,a protein highly expressed in osteosarcoma *** approach may be useful for the establishment of a new treatment strategy for patients resistant to the standard treatment for osteosarcoma.

关键词： Osteosarcoma MET HSP90 17-DMAG

Fine-tuning ROS homeostasis by ROD1 is a battleground between rice and Magnaporthe oryzae

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Molecular Plant 2021年第12期14卷 1979-1981页

作者： Yoji kawano CAS Center for Excellence in Molecular Plant Sciences Shanghai Center for Plant Stress BiologyChinese Academy of SciencesShanghai 201602China Kihara Institute for Biological Research Yokohama City UniversityYokohamaKanagawa 244-0813Japan Institute of Plant Science and Resources Okayama University2-20-1ChuoKurashikiOkayama 710-0046Japan

When plants recognize pathogens,reactive oxygen species(ROS)homeostasis is optimized to elicit immune *** also manipulate ROS homeostasis in host plants,which increases susceptibility to pathogens.A recent study found a novel regulation mechanism of ROS homeostasis through a rice susceptibility gene(ROD1)(Gao et al.,2021).The loss of function of ROD1 confers high resistance against three major rice pathogens but decreases yield,and an allele of ROD1 improves basal disease resistance without reducing *** current study sheds light on the fine-tuning of ROS ho-meostasis by ROD1 in rice and on how the Magnaporthe oryzae effector Avr-Piz-t highjacks on ROS homeostasis in rice.

关键词： homeostasis Magnaporthe susceptibility