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Pan-TRK positive uterine sarcoma in immunohistochemistry without neurotrophic tyrosine receptor kinase g.ne fusions:A case report

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World Journal of Clinical Cases 2025年第2期13卷 39-49页

作者： Seung.ee Lee Yu-Ra Jeon Chang.in shin Sun-Young.Kwon Sojin shin Department of Obstetrics and g.necolog. Keimyung University School of MedicineDaegu 42601South Korea Department of Patholog. and Institute for Cancer Research Keimyung University School of MedicineDaegu 42601South Korea

BACKg.OUND The classification of uterine sarcomas is based on distinctive morpholog.cal and immunophenotypic characteristics,increasing.y supported by molecular g.netic *** on neurotrophic tyrosine receptor kinase(NTRK)g.ne fusionpositive uterine sarcoma,potentially ag.ressive and morpholog.cally similar to fibrosarcoma,are limited due to its recent ***-TRK immunohistochemistry(IHC)analysis serves as an effective screening.tool with hig. sensitivity and specificity for NTRK-fusion *** SUMMARY We report a case of a malig.ant mesenchymal tumor orig.nating.from the uterine cervix,which was pan-TRK IHC-positive but lacked NTRK g.ne fusions,accompanied by a brief literature review.A 55-year-old woman presented to the emerg.ncy department with abdominal pain and distension,exhibiting.sig.ificant ascites and multiple solid pelvic *** examination revealed a tumor encompassing.the uterine cervix,extending.to the vag.na and uterine corpus.A punch biopsy of the cervix indicated NTRK sarcoma with positive immunochemical pan-TRK ***,subsequent next g.neration sequencing.revealed no NTRK g.ne fusion,leading.to a diag.osis of poorly differentiated,advanced-stag. *** The clinical sig.ificance of NTRK g.ne fusion lies in potential treatment with TRK inhibitors for positive *** such rare tumors is crucial due to the potential applicability of tropomyosin receptor kinase inhibitor treatment.

关键词： Uterine sarcoma Cervical sarcoma Neurotrophic tyrosine receptor kinase g.ne fusion Next g.neration sequencing Case report

Micronization of curcumin with biodeg.adable polymer by supercritical anti-solvent using.micro swirl mixer

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Frontiers of Chemical Science and Eng.neering 2018年第1期12卷 184-193页

作者： Kimthet Chhouk Wahyudiono Hideki Kanda shin-Ichro Kawasaki Motonobu goto Department of Chemical Eng.neering Nagoya University Nagoya 464-8603 Japan Department of Chemical Eng.neering.and Food Technolog. Institute of Technology of Cambodia Phnom Penh Cambodia Department of Materials Process Eng.neering Nagoya University Nagoya 464-8603 Japan Research Institute for Chemical Eng.neering.Process Technolog. National Institute of Advanced Industrial Science and Technology Sendai 983-8551 Japan

Curcumin is a hydrophobic polyphenol compound exhibiting.a wide rang. of biolog.cal activities such as anti-inflammatory, anti-bacterial, anti-fung.l, anti-carcinog.nic, anti-human immunodeficiency virus, and antimicrobial activity. In this employed to produce the work, a swirl mixer was micronized curcumin with polyvinylpyrrolidone （PVP） by the supercritical antisolvent process to improve the bioavailability of curcumin. The effects of operating.parameters such as curcumin/PVP ratio, feed concentration, temperature, pressure, and CO2 flow rate were investig.ted. The characterization and solubility of particles were determined by using.scanning.electron microscopy, Fourier Transform Infrared spectroscopy, and ultra-violet-visible spectroscopy. The result shows that the optimal condition for the production of curcumin/PVP particles is at curcumin/PVP ratio of 1：30, feed concentration of 5 mg.mL^-1, temperature of 40 ℃, pressure of 15 MPa, and CO2 flow rate of 15 mL·min^-1. Moreover, the dissolution of curcumin/PVP particles is faster than that of raw curcumin.

关键词： micronization curcumin polyvinylpyrrolidone supercritical anti-solvent swirl mixer

NAD＋ Accumulation during.Pollen Maturation in Arabidopsis Reg.lating.Onset of g.rmination

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Molecular Plant 2013年第1期6卷 216-225页

作者： shin-nosuke Hashida Hideyuki Takahashi Kentaro Takahara Maki Kawai-Yamada Kazuyoshi Kitazaki Kazuhiro Shoji Fumiyuki goto Toshihiro Yoshihara Hirofumi Uchimiya Institute of Molecular and Cellular Biosciences (IMCB) University of Tokyo 1-1-1 Yayoi Bunkyo-ku Tokyo 113-0032 Japan Environmental Science Research Laboratory Central Research Institute of Electric Power Industry (CRIEPI) 1646 Abiko Chiba 270-1194 Japan Iwate Biotechnolog. Research Center (IBRC) Kitakami Iwate 024-0003 Japan Department of Environmental Science and Human Eng.neering Saitama University Sakura-ku Saitama 338-0825 Japan Institute for Environmental Science and Technolog. Saitama University 255 Shimo-Okubo Sakura-ku Saitama 338-8570 Japan

Althoug. the nicotinamide nucleotides NAD（H） and NADP（H） are essential for various metabolic reactions that play major roles in maintenance of cellular homeostasis, the sig.ificance of NAD biosynthesis is not well under- stood. Here, we investig.ted the dynamics of pollen nicotinamide nucleotides in response to imbibition, a representative g.rmination cue. Metabolic analysis with capillary electrophoresis electrospray ionization mass spectrometry revealed that excess amount of NAD＊ is accumulated in freshly harvested dry pollen, whereas it dramatically decreased immedi- ately after contact with water, importantly, excess of NAD~ impaired pollen tube g.owth. Moreover, NAD~ accumulation was retained after pollen was imbibed in the presence of NAD^-consuming.reaction inhibitors and pollen g.rmination was g.eatly retarded. Pollen deficient in the nicotinate/nicotinamide mononucleotide adenyltransferase （NMNAT） g.ne, encoding.a key enzyme in NAD biosynthesis, and a lack of NAD＊ accumulation in the g.metophyte, showed precocious pollen tube g.rmination inside the anther Iocule and vig.rous tube g.owth under hig.-humidity conditions. Hence, the accumulation of excess NAD＊ is not essential for pollen g.rmination, but instead participates in reg.lating.the timing.of g.rmination onset. These results indicate that NAD＋ accumulation acts to neg.tively reg.late g.rmination and a decrease in NAD＋ plays an important role in metabolic state transition.

关键词： Arabidopsis nicotinamide adenine dinucleotide (NAD) NAD biosynthesis NAD consumption NMNAT polleng.rmination pollen long.vity.

Characteristics of Hig. Speed Electro-thermal Jet Activated by Pulsed DC Discharg.

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Chinese Journal of Aeronautics 2010年第5期23卷 518-522页

作者： Jichul shin Department of Aerospace Eng.neering University of Ulsan

Experimental study of synthetic jet produced by pulsed direct current （DC） discharg. is presented. Hig. velocity jet is acti- vated electro-thermally by hig. frequency pulsed DC discharg. in small cavity. A cavity of 2.38 mm diameter cylinder bounded by circular electrode is made in a ceramic plate and a small orifice of 1.78 mm diameter is drilled in the middle of cavity. Hig. frequency pulsed DC discharg. instantaneously heats air in the cavity and produces hig. velocity jet at the exit of the orifice. Schlieren imag.ng.at hig. framing.rate of 100 kHz reveals the presence of supersonic precursor shock followed by the jet emerg. ing.from the orifice. The jet velocity reaches as hig. as about 300 m/s. Jet with smaller cavity volume produces lesser effect and jet velocity reaches maximum at certain cavity volume with g.ven discharg. current and orifice size. As duty time of pulse increases from 5 to 20 μs at fixed frequency of 5 kHz, the jet velocity also increases and becomes nearly constant with further increase in duty time. At fixed duty time of 20 μs, hig.er frequency pulsing.of 10 kHz produces deg.adation of the jet as the discharg. pulse continues. The jet developed in this study is demonstrated to be strong.enoug. to penetrate deep into supersonic boundary layer and to produce a bow shock when the jet is issued into Mach 3 supersonic flow.

关键词： synthetic jet pulsed DC plasma supersonic flow actuation

Joint Operation of Atomic Force Microscope and Advanced Laser Confocal Microscope for Observing.Surface Processes in a Protein Crystal

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Journal of Surface Eng.neered Materials and Advanced Technolog. 2012年第3期2卷 210-214页

作者： shin-ichiro Yanag.ya Nobuo goto Institute of Technolog. and Science University of Tokushima Tokushima Japan.

We demonstrated the insitu observation of a moving.atomic force microscope (AFM) cantilever using.a laser confocal microscope combined with a differential interference microscope (LCM-DIM). The AFM cantilever scanned or indented the {110} surface of a hen eg.-white lysozyme crystal in a supersaturated solution. Using.a soft cantilever, we could observe the step g.owth with hig. time resolution by LCM-DIM and perform quantitative measurements of the step heig.t by AFM simultaneously. In addition, a hard cantilever was used with LCM-DIM to observe the dynamics of crystal surface scratching.and indentation. In the supersaturated solution, the small steps g.nerated from the scratched line ag.reg.ted to macro steps, and subsequently flattened the surface.

关键词： Laser Confocal Microscopy Atomic Force Microscopy Surface Process Protein Crystal

Facial Expression Recog.ition of Various Internal States via Manifold Learning

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Journal of Computer Science & Technolog. 2009年第4期24卷 745-752页

作者： Young.Suk shin IEEE Department of Information and Communication Eng.neering Chosun University

Emotions are becoming.increasing.y important in human-centered interaction architectures. Recog.ition of facial expressions, which are central to human-computer interactions, seems natural and desirable. However, facial expressions include mixed emotions, continuous rather than discrete, which vary from moment to moment. This paper represents a novel method of recog.izing.facial expressions of various internal states via manifold learning. to achieve the aim of humancentered interaction studies. A critical review of widely used emotion models is described, then, facial expression features of various internal states via the locally linear embedding.（LLE） are extracted. The recog.ition of facial expressions is created with the pleasure-displeasure and arousal-sleep dimensions in a two-dimensional model of emotion. The recog.ition result of various internal state expressions that mapped to the embedding.space via the LLE alg.rithm can effectively represent the structural nature of the two-dimensional model of emotion. Therefore our research has established that the relationship between facial expressions of various internal states can be elaborated in the two-dimensional model of emotion, via the locally linear embedding.alg.rithm.

关键词： manifold learning locally linear embedding dimension model pleasure-displeasure dimension arousal-sleep dimension

Improving.Application Launch Performance on Solid State Drives

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Journal of Computer Science & Technolog. 2012年第4期27卷 727-743页

作者： Yong.oo Joo Junhee Ryu Sang.oo Park Kang.g.shin Department of Computer Science and Eng.neering Ewha Womans University IEEE Department of Computer Science and Eng.neering Seoul National University Department of Electrical Eng.neering.and Computer Science University of Michigan

Application launch performance is of g.eat importance to system platform developers and vendors as it g.eatly affects the deg.ee of users＇ satisfaction. The sing.e most effective way to improve application launch performance is to replace a hard disk drive （HDD） with a solid state drive （SSD）, which has recently become affordable and popular. A natural question is then whether or not to replace the traditional HDD-aware application launchers with a new SSD-aware optimizer. We address this question by analyzing.the inefficiency of the HDD-aware application launchers on SSDs and then proposing.a new SSD-aware application prefetching.scheme, called the Fast Application STarter （FAST）. The key idea of FAST is to overlap the computation （CPU） time with the SSD access （I/O） time during.an application launch. FAST is composed of a set of user-level components and system debug.ing.tools provided by Linux OS （operating.system）. Hence, FAST can be easily deployed in any recent Linux versions without kernel recompilation. We implement FAST on a desktop PC with an SSD running.Linux 2.6.32 OS and evaluate it by launching.a set of widely-used applications, demonstrating.an averag. of 28% reduction of application launch time as compared to PC without a prefetcher.

关键词： application launch performance I/O prefetch solid state drive

A characterization of Burniat surfaces with K^2 = 4 and of non nodal type

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Science China Mathematics 2016年第5期59卷 839-848页

作者： shin Yong.oo Shang.ai Center for Mathematical Sciences Fudan University

Let S be a minimal surface of g.neral type with pg.S) = 0 and K_S^2= 4. Assume the bicanonical map ψ of S is a morphism of deg.ee 4 such that the imag. of ψ is smooth. Then we prove that the surface S is a Burniat ... 详细信息

关键词： bicanonical map Burniat surface surface of g.neral type

NOON-state interference in the frequency domain

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Lig.t(Science & Applications) 2024年第5期13卷 843-851页

作者： Dong.in Lee Woncheol shin Sebae Park Junyeop Kim Heedeuk shin Department of Physics Pohang University of Science and Technology(POSTECH)Pohang 37673South Korea

The examination of entang.ement across various deg.ees of freedom has been pivotal in aug.enting.our understanding.of fundamental physics,extending.to hig. dimensional quantum states,and promising.the scalability of quantum *** this paper,we demonstrate the photon number path entang.ement in the frequency domain by implementing.a frequency beam splitter that converts the sing.e-photon frequency to another with 50%probability using.Brag. scattering.four-wave *** two-photon NOON state in a sing.e-mode fiber is g.nerated in the frequency domain,manifesting.the two-photon interference with two-fold enhanced resolution compared to that of sing.e-photon interference,showing.the outstanding.stability of the *** successful translation of quantum states in the frequency domain will pave the way toward the discovery of fascinating.quantum phenomena and scalable quantum information processing.

关键词： quantum state showing