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世界核心医学期刊文摘（胃肠病学分册） 2005年第7期1卷 52-53页

作者： Nakamura M. shimizu- y.shida y. Takii y. 王铮 Department of Hepatology Natl. Hosp. Org. Nagasaki Med. Ctr. Nagasaki Univ. Grad. Sch. Biomed. S. Kubara 2- 1001- 1 Omura Nagasaki 856- 8562 Japan

Background/Aims: The presence of antibodies to the 210- kDa gly.oprotein of the nuclear pore complex (gp210) is highly.indicative of primary.biliary.cirrhos is (PBC). However, the significance of anti- gp210 antibody.titers for monitori ng PBC remains unresolved. Methods: We used an ELISA with a gp210 C- terminal p eptide as an antigen to assess serum antibody.titers in 71 patients with PBC. Re sults: Patients were classified into three groups: Group A in whom anti- gp210 titers were sustained at a high level, Group B in whom anti- gp210 status chang ed from positive to negative under ursodeoxy.holic acid (UDCA) therapy. Group C in whom anti- gp210 antibodies were negative at the time of diagnosis. The rate of progression to end- stage hepatic failure was significantly.higher in group A (60% ) as compared to groups B (0% ) and C (4.2% ). The sustained antibody.response to gp210 was closely.associated with the severity.of interface hepatit is. The significance of anti- gp210 antibody.was confirmed by.National Hospital Organization Study.Group for Liver Disease in Japan. Conclusions: The serial qu antitation of serum anti- gp210- C- terminal peptide antibodies is useful for monitoring the effect of UDCA and for the early.identification of patients at h igh risk for end- stage hepatic failure.

关键词： gp210-C端抗体滴度熊去氧胆酸血清抗体肝衰竭核孔复合物 UDCA 肝病研究抗体反应

足跖部表皮囊肿的临床病理学特征:与传统的表皮囊肿和毛发囊肿相比较

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世界核心医学期刊文摘(皮肤病学分册) 2005年第7期 61-62页

作者： shimizu y. Sakita K. Arai E. M.shimizu 李政霄 Saitama 3500495 Department of Pathology.Saitama Medical School Japan Dr. Moroy.ma-machi 38 Morohongo Iruma-gun

皮肤鳞状细胞癌:向罕见的基底鳞状细胞和梭形细胞变异的双重分化

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世界核心医学期刊文摘（皮肤病学分册） 2006年第6期2卷 8-9页

作者： Mitsuhashi T. Itoh T. shimizu y. 李政霄 Department of Pathology Saitama Medical School 38 Morohongo Moroyama-mach Iruma-gun Saitama 350-0495 Japan Dr.

Basosquamous carcinoma (BSC) is defined as a tumor containing the areas of both basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) with a transition zone linking the two. Spindle cell squamous carcinoma (SCSC) may.have a variable component of conventional SCC and spindle cells. We present a case of an 89-y.ar-old woman with an eruption on the scalp for several decades. Grossly. the lesion measured 8.5 ×6.0 ×1.8 cm and consisted of a gray.white and focally.black tumor. Microscopically. a non-ulcerated upper part of the tumor consisted of large poly.onal squamoid cells with occasional keratinization (SCC), trabecular growth of basaloid cells with peripheral palisading (BCC), and an area in which both the components were intermingled. The rest of the tumor was a my.oid area with elongated fusiform spindle cells, which appeared to arise from conventional SCC. Immunohistochemically. the tumor cells in the SCSC (both conventional and spindle cell) area co-expressed CAM5.2, and vimentin. Ber-EP4 was positive in the BCC area with the transition zone of SCC and BCC showing diminished staining. Epithelial membrane antigen was focally.positive in the conventional SCC area. To our knowledge, this is the first case report of SCC of the skin that has dual differentiations to BSC and SCSC.

关键词：基底鳞状细胞癌梭形细胞细胞变异皮肤鳞状细胞癌重分化皮肤鳞癌肿瘤细胞罕见阳性表达基底细胞癌

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空间乳胶室探测器的研制

天文学报 2008年第2期49卷 233-242页

作者：胡一鸣常进宫一忠张仁健王楠森唐和森 Torii S. Nishimura J. Kobay.shi T. shimizu y. Makino F. 中国科学院紫金山天文台南京210008 中国科学院研究生院北京100039 Advanced Research Institute for Science and Engineering Waseda UniversityTokyo Japan 169-8555 Institute of Space and Astronautical Science JAXA Japan Department of Phy.ics Aoyamagakuin University Japan

"实践八号"乳胶室探测器是我国首次用于空间观测高能电子及伽玛射线的乳胶室探测器.介绍"实践八号"乳胶室探测器的设计原理、数据分析方法、设计过程和初步观测结果等."实践八号"乳胶室探测器空间观测时间为15天,可探测的粒子能量范围为... 详细信息

"实践八号"乳胶室探测器是我国首次用于空间观测高能电子及伽玛射线的乳胶室探测器.介绍"实践八号"乳胶室探测器的设计原理、数据分析方法、设计过程和初步观测结果等."实践八号"乳胶室探测器空间观测时间为15天,可探测的粒子能量范围为100 GeV～5 TeV.

关键词：仪器探测器,仪器诸多方面,暗物质

Unsteady.Flow Condition of Contra-Rotating Small-Sized Axial Fan

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Journal of Thermal Science 2011年第6期20卷 495-502页

作者： T.Shigemitsu J.Fukutomi y.Okabe K.Iuchi H.shimizu Institute of Technology.and Science The University of Tokushima2-1 Minamijyosanjima-choTokushima 770-8506JAPAN Associate ProfessorDr.Eng. Institute of Technology.and Science The University of Tokushima2-1 Minamijyosanjima-choTokushima 770-8506JAPAN Graduate School of Advanced Technology.and Science The University of Tokushima2-1 Minamijyosanjima-choTokushima 770-8506JAPAN

Small-sized axial fans are used as air cooler for electric *** there is a strong demand for higher power of fans according to the increase of quantity.of heat from electric ***,higher rotational speed design is conducted,although,it causes the deterioration of efficiency.and the increase of ***,the adoption of contra-rotating rotors for the small-sized axial fan is proposed for the improvement of *** the case of contra-rotating rotors,it is necessary.to design the rotor considering the unsteady.flow condition of each front and rear *** the present paper,the fan performance of the contra-rotating small-sized axial fan with 100mm diameter at a designed and a partial flow rates is shown,and the unsteady.flow conditions at the inlet and the outlet of each front and rear rotor are clarified with unsteady.numerical ***,the relation between the performance and the unsteady.flow condition of the contra-rotating small-sized axial fan is discussed and the methods to improve the performance are considered.

关键词： Small-sized axial fan Contra-rotating rotor Performance Unsteady.flow condition

Comparison of Various Foods Intakes and Their Relationships with Body.Mass Index in Japanese Old Men and Women

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Food and Nutrition Sciences 2021年第6期12卷 591-601页

作者： A. Takada F. shimizu y. Ishii M. Ogawa T. Takao International Projects on Food and Health (NPO) Tokyo Japan Faculty.of Human Life and Environmental Sciences Showa Women’s University Tokyo Japan

Objective: Obesity.is an important health problem, leading to many.metabolic diseases such as ty.e2 diabetes mellitus, cardiovascular diseases, cancer etc. There are many.diet proposals to combat obesity. Since obesit... 详细信息

Objective: Obesity is an important health problem, leading to many metabolic diseases such as type2 diabetes mellitus, cardiovascular diseases, cancer etc. There are many diet proposals to combat obesity. Since obesity is relatively rare in Japan, we wanted to know what kinds of foods influence body mass index (BMI) in old Japanese people. Methods: Healthy participants were given self-administered diet history questionnaires and described answers on each item by recollection of diets they took (7 days dietary recall). We used a brief-type self-administered diet history questionnaire (BDHQ) by using which the Japanese Ministry of Health, Labour and Welfare reports national Nutrition Surveys. From these questionnaires, we calculated the intakes of energy, carbohydrate, fat, protein or other foods. Results: Meny.e="font-family."">y.e="font-family.Verdana;"> take more alcohol, salt fruit, beans, and eggs than women. Intakes of majo

关键词： Carbohy.rate Protein Fish Glucose Insulin BMI (Body.Mass Index) Obesity

Effects of Various Foods Intakes on Plasma Levels of Trans Fatty.Acids in Japanese Old Men

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Food and Nutrition Sciences 2018年第7期9卷 797-805页

作者： F. shimizu y. Ishii M. Ogawa T. Takao S. Koba A. Takada Faculty.of Life and Environmental Sciences Showa Women’s University Tokyo Japan Division of Cardiology Department of Medicine Showa University School of Medicine Tokyo Japan International Projects on Food and Health (NPO) Tokyo Japan

Background: Trans fatty.acids are said to be formed by.the partial hy.rogenation of vegetable oils. Some amounts are produced in digestive organs of ruminants and present in dairy.products or meat. In Japan, use of trans fatty.acids in the foods is prohibited, thus trans fatty.acids must come from foods or microbes in the digestive organs. Methods: Plasma levels of fatty.acids including trans forms of healthy.old men are measured by.gas chromatography.and correlations between various foods intakes and plasma levels of trans fatty.acids such as palmitoelaidic, elaidic and linoelaidic acids are examined. Results: No correlations between various foods intakes and trans fatty.acids were found except between intake of preference drinks such as tea or coffee and plasma levels of palmitoelaidic and linoelaidic acids. Conclusion: Since palmitoelaidic acid is cardioprotective, increase in plasma levels of palmitoelaidic acid may.indicate that intakes of tea and coffee may.be beneficial for heath by.increasing palmitoelaidic acids.

关键词： Fatty Acid Trans Fatty Acid Palmitoelaidic Acid Elaidic Acid Linoelaidic Acid Saturated Fatty Acid Unsaturated Fatty Acid ω Fatty Acid DHA (Docosahexanoic Acid) EPA (Eicosapentanoic Acid) AA (Arachidonic Acid)

The Development of Hi-Speed Punching Sy.tem Using A Couple of Rotating Bodies

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厦门大学学报（自然科学版） 2002年第S1期41卷 116-117页

作者： Shinichi Tay. Keiichi shimizu Technical Research Lab. Toyo Kohan Co.Technical Research Lab. Toyo Kohan Co. LTD JapanLTD Japan

Punched steel sheets (metal sheets or foils) as thi n as 0.1mm are quite useful in the field of filters and various precision instrume nts. Thus, we have to develop more accurate and speedy.techniques for punching t hin sheets. The traditional punching method uses an up-down pressing motion of a punch or a die on a strip of metal. The efficiency.of this method is determine d by.the speed of the motion. In the case of punching a sequence of tiny.holes w ith a few millimeters’ interval, the speed of feeding a strip of metal to the p unching machine cannot exceed only.a couple of meters per minute. We have de veloped a new technique for punching tiny.holes with a pair of rotating bodies i n order to increase the feeding speed up to 100 meters per minute. Our proposed technique is shown in Fig.1 where the female tool has a round blade and the male tool has an M-shape boss. In addition, the setting of two tools i s alternating. The interference between them cannot occur because the clearance between the front and the back edge of the male tool and the female tool in the rotating direction becomes infinite in this configuration. An appropriate cleara nce is given for the thickness of the sheet between the side edge of the male to ol and the female tool. The punching itself is done by.shearing. The side edge o f the male tool does contact with the female tool, but they.cannot be interferin g. Our technique has another advantage to the traditional up-down pressing mach ine where the stamped out chips are hard to be discharged. It is quite easy.in o ur proposed technique. Fig.2, 3 show a sample of punched material [TPP116A,+39mm88mm,y.PZ#]Fig.1 The configuration of the punching parts using the sequential punching sy.tem.[TPP116B,+43mm155mm,X,BP#]Fig.2 A sample of punched material using the continuous punch ing lineFig.3 A exterior picture of a piece of punched steel foil(coi l) using the continuous punching For our developed high speed punching sy.tem, it is shown for (1) th

关键词： The Development of Hi-Speed Punching Sy.tem Using A Couple of Rotating Bodies

Numerical modeling for the coupled thermo-mechanical processes and spalling phenomena in sp Pillar Stability.Experiment (APSE)

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Journal of Rock Mechanics and Geotechnical Engineering 2013年第1期5卷 58-72页

作者： T.Koy.ma M.Chijimatsu H.shimizu S.Nakama T.Fujita A.Kobay.shi y.Ohnishi Department of Urban Management Kyoto University Hazama Corporation Institute of Fluid Science Tohoku University Japan Atomic Energy.Agency.(JAEA) Faculty.of Environmental and Urban Engineering Kansai University Ky.to University

In this paper, the coupled thermo-mechanical （TM） processes in the AEspoe Pillar Stability.Experiment （APSE） carried out by.the Swedish Nuclear Fuel and Waste Management Company.（SKB） were simulated using both continuum and discontinuum based numerical methods. Two-dimensional （2D） and three- dimensional （3D） finite element method （FEM） and 2D distinct element method （DEM） with particles were used. The main objective for the large scale in situ experiment is to investigate the y.elding strength of cry.talline rock and the formation of the excavation disturbed/damaged zone （EDZ） during excavation of two boreholes, pressurizing of one of the boreholes and heating. For the DEM simulations, the heat flow algorithm was newly.introduced into the original code. The calculated stress, displacement and temperature distributions were compared with the ones obtained from in situ measurements and FEM simulations. A parametric study.for initial microcracks was also performed to reproduce the spalling phenomena observed in the APSE.

关键词： Coupled thermo-mechanical (TM)processesAspoe Pillar Stability.Experiment (APSE)Excavation disturbed/damaged zone (EDZ)Finite element method (FEM)Distinct element method (DEM)