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Journal of Molecular Cell Biology 2016年第2期8卷 174-177页

作者： Yi Yang Kepin Wang Han Wu Qin Jin Degong Ruan Zhen Ouyang Bentian Zhao Zhaoming Liu Yu Zhao Quanjun Zhang Nana Fan Qishuai Liu shimei guo Lei Bu Yong Fan Xiaofang Sun Xiaoping Li Liangxue Lai Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine South China Institute for Stem Cell Biology and Regenerative MedicineGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China School of Life Sciences University of Science and Technology of ChinaHefei 230027China Leon H Charney Division of Cardiology New York University School of Medicine522 First AvenueNew YorkNY 10016USA Key Laboratory for Major Obstetric Diseases of Guangdong Province Key Laboratory of Reproduction and Genetics of Guangdong Higher Education InstitutesThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150China Jilin Provincial Key Laboratory of Animal Embryo Engineering Institute of ZoonosisCollege of Veterinary MedicineJilin UniversityChangchun 130062China

Dear Editor,Type1diabetes(T1D)isa lifelong(chronic)disease and a major health problem throughout the *** disease can be treatedby either insulin injection or islet *** transplantation is considered as a better treatment for T1D patients,because islets can produce and release insulin at the appropriate time,resulting in tight blood glucose control.

关键词： islet injection expressing

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溅射沉积Cu-W合金薄膜的结构及力学性能

稀有金属 2010年第1期34卷 38-43页

作者：郭中正孙勇段林昆郭诗玫李玉阁昆明理工大学云南省新材料制备与加工重点实验室云南昆明650093 曲靖师范高等专科学校云南曲靖655000

用磁控共溅射法制备Cu-W合金薄膜,运用EDX,XRD,TEM,SEM和纳米压痕仪对薄膜成分、结构和力学性能及其关系进行了研究。结果表明,含W较低的Cu82.1W17.9(%,原子分数)和W浓度较高的Cu39.8W60.2薄膜为晶态结构且出现固溶度扩展,分别存在fccCu... 详细信息

用磁控共溅射法制备Cu-W合金薄膜,运用EDX,XRD,TEM,SEM和纳米压痕仪对薄膜成分、结构和力学性能及其关系进行了研究。结果表明,含W较低的Cu82.1W17.9(%,原子分数)和W浓度较高的Cu39.8W60.2薄膜为晶态结构且出现固溶度扩展,分别存在fccCu(W)亚稳过饱和固溶体(固溶度4.8%W)和bccW(Cu)亚稳过饱和固溶体(固溶度5.7%Cu),W含量为31.8%,45.7%,54.8%的Cu-W薄膜呈非晶态,表面粗糙度较晶态Cu-W薄膜低。总体上非晶Cu-W薄膜弹性模量E和硬度H值较低,fccCu-W膜实测E值介于Voigt和Reuss规则预测值之间,bcc和非晶Cu-W膜实测E值分别高于和低于预测值;晶态Cu-W膜实测H值与Voigt规则计算值的符合性优于非晶膜,薄膜结构对力学性能预测可靠性影响较大。

关键词： Cu-W合金薄膜微观结构非晶态力学性能

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Al/Pb纳米多层膜的组织结构

中国教育技术装备 2010年第21期 102-103页

作者：郭诗玫孙勇曲靖师范学院物理与电子工程学院云南曲靖655011 昆明理工大学新材料制备与加工重点实验室昆明650093

采用离子束溅射法制备Al/Pb纳米多层膜,其XRD图谱表明,仅有Pb的衍射峰出现,而无Al相或其他新相产生;经250℃退火或15天的时效后,样品中均同时出现Al和Pb的衍射峰,但仍然没有其他新相生成。SEM、TEM观察表明,Al/Pb纳米多层膜表面并非均... 详细信息

采用离子束溅射法制备Al/Pb纳米多层膜,其XRD图谱表明,仅有Pb的衍射峰出现,而无Al相或其他新相产生;经250℃退火或15天的时效后,样品中均同时出现Al和Pb的衍射峰,但仍然没有其他新相生成。SEM、TEM观察表明,Al/Pb纳米多层膜表面并非均匀一致,而是由颗粒和空隙组成,时效或热处理均能改善膜层的表面粗糙度,但也使得多层膜中的Pb膜发生碎化,进而使得Pb从Al膜中析出并发生团簇。

关键词： Al/Pb多层膜纳米材料离子束溅射

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库水位日降幅对白家包滑坡稳定性影响分析

人民长江 2017年第9期48卷 50-53,69页

作者：鲁芃王世梅郭振李正辉金来福三峡大学三峡库区地质灾害教育部重点实验室湖北宜昌443002

以三峡库区白家包滑坡为研究对象,通过野外勘察和资料收集,对比分析GPS监测曲线、库水位变动曲线和降雨历时曲线,并利用Geo-Studio的SEEP模块和FLAC^(3D)分别对各种不同库水位日降幅条件下滑坡渗流场及应力应变进行了数值模拟。结果表明... 详细信息

以三峡库区白家包滑坡为研究对象,通过野外勘察和资料收集,对比分析GPS监测曲线、库水位变动曲线和降雨历时曲线,并利用Geo-Studio的SEEP模块和FLAC^(3D)分别对各种不同库水位日降幅条件下滑坡渗流场及应力应变进行了数值模拟。结果表明,滑坡的应力场、位移场、塑性区均随库水位日降幅增大而变化,其变形量及塑性区范围均随库水位日降幅的增大而增大。综合分析认为,目前白家包滑坡处于欠稳定-不稳定状态,在增大库水位日降幅条件下滑坡稳定性将会进一步降低而导致失稳。研究成果可为三峡水库调度确定库水位日降幅标准及滑坡防治提供参考依据。

关键词：库水位日降幅渗流数值模拟滑坡稳定性白家包滑坡三峡库区

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紫藤茎结构解析

商丘师范学院学报 2013年第12期29卷 90-92页

作者：许自龙尤文婷宗梅郭仕妹安庆师范学院生命科学学院安徽安庆246011

利用石蜡切片技术在光学显微镜下观察紫藤幼茎和老茎的解剖学结构.根据观察可知,紫藤的幼茎为初生结构,主要由表皮、皮层和维管束三个结构组成.紫藤的老茎出现了次生韧皮部、次生木质部以及髓的结构.通过观察和实验,提高我们对茎的认识... 详细信息

利用石蜡切片技术在光学显微镜下观察紫藤幼茎和老茎的解剖学结构.根据观察可知,紫藤的幼茎为初生结构,主要由表皮、皮层和维管束三个结构组成.紫藤的老茎出现了次生韧皮部、次生木质部以及髓的结构.通过观察和实验,提高我们对茎的认识和了解,从而促进对茎的功能的开发及利用.

关键词：紫藤茎初生结构次生结构

Screening and characterization of proteases produced by deep-sea cold seep bacteria

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Journal of Oceanology and Limnology 2022年第2期40卷 678-689页

作者： Chenchen guo Chaomin SUN shimei WU College of Life Sciences Qingdao UniversityQingdao 266071China CAS Key Laboratory of Experimental Marine Biology Institute of OceanologyChinese Academy of SciencesQingdao 266071China

Fifty protease-producing strains were screened from sediment of deep-sea cold seep,and divided into four diff erent categories:Bacillus,Pseudoalteromonas,Vibrio,and Alteromonas according to the sequences of 16s *** abilities to produce protease,amylase,and lipase were determined,and a Bacillus strain gcc-1 displayed very strong alkaline protease activity and stability under different thermal and acidic *** purifi cation of the protease produced by strain gcc-1 was carried out by precipitation with ammonium sulfate,and sequentially chromatographed by anion exchange column and gel *** purifi ed protease showed a single band at the molecular weight of 28 kDa by *** characterization results show that the purified protease exhibited a considerable activity and stability in a wide thermal range of 10-80℃and a wide acidic range of pH 6.5-11.5,and displayed highest activity at 40℃ and pH ***,the protease still maintained high activity even at low to 10℃.Furthermore,the protease exhibited good stability in presence of diff erent surfactants,organic solvents,oxidizing agent H_(2)O_(2),and commercial ***,the protease produced by gcc-1 is a cold active and high stable enzyme,and has a promising potential in laundry detergent as an additive.

关键词： deep-sea Bacillus alkaline protease purification characterization

Monogenic gene therapy for glaucoma and optic nerve injury

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Neural Regeneration Research 2025年第3期20卷 815-816页

作者： Chikako Harada Xiaoli guo Takayuki Harada Visual Research Project Tokyo Metropolitan Institute of Medical ScienceTokyoJapan

The prevalence of glaucoma, the second leading cause of global blindness, is increasing due to aging populations. In glaucoma, degeneration of the optic nerve and retinal ganglion cells(RGCs) causes visual field defec... 详细信息

关键词： visual glaucoma degeneration

Asking one mechanism in glial cells during neuroinflammation

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Neural Regeneration Research 2025年第4期20卷 1077-1078页

作者： Xiaoli guo Chikako Harada Takayuki Harada Visual Research Project Tokyo Metropolitan Institute of Medical ScienceTokyoJapan

Multiple sclerosis(MS),which is characterized by inflammatory demyelination in the central nervous system(CNS),is the most common neurological disease in the young adult *** autoimmune encephalomyelitis(EAE),an animal model of MS,is often used in preclinical *** data indicate that in addition to immune cells such as T cells and dendritic cells,CNS resident microglia and astrocytes play important roles in demyelinating neuroinflammation(Healy et al.,2022).In particular,microglia are key immune-competent cells that can respond to environmental *** depletion of transforming growth factor-β-activated kinase 1,a mitogen-associated protein kinase kinase kinase,in microglia is reported to reduce CNS inflammation and diminish axonal and myelin damage *** suggests that elucidating the mechanisms of microglia-specific responses during pathologies may help in the development of treatments that reduce EAE/MS disease severity(Goldmann et al.,2013).

关键词： inflammation clinical

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru C.guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British Columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science Core Collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P GC-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Multiple Tin Compounds Modified Carbon Fibers to Construct Heterogeneous Interfaces for Corrosion Prevention and Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第1期17卷 507-527页

作者： Zhiqiang guo Di Lan Zirui Jia Zhenguo Gao Xuetao Shi Mukun He Hua guo Guanglei Wu Pengfei Yin College of Science Sichuan Agricultural UniversityYa’an 625014People’s Republic of China School of Materials Science and Engineering Hubei University of Automotive TechnologyShiyan 442002People’s Republic of China Institute of Materials for Energy and Environment State Key Laboratory of Bio‑Fibers and Eco‑TextilesCollege of Materials Science and EngineeringQingdao UniversityQingdao 266071People’s Republic of China Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China

Currently,the demand for electromagnetic wave(EMW)absorbing materials with specific functions and capable of withstanding harsh environments is becoming increasingly ***-component interface engineering is considered an effective means to achieve high-efficiency EMW ***,interface modulation engineering has not been fully discussed and has great potential in the field of EMW *** this study,multi-component tin compound fiber composites based on carbon fiber(CF)substrate were prepared by electrospinning,hydrothermal synthesis,and high-temperature thermal *** utilizing the different properties of different substances,rich heterogeneous interfaces are *** effectively promotes charge transfer and enhances interfacial polarization and conduction *** prepared SnS/SnS_(2)/SnO_(2)/CF composites with abundant heterogeneous interfaces have and exhibit excellent EMW absorption properties at a loading of 50 wt%in epoxy *** minimum reflection loss(RL)is−46.74 dB and the maximum effective absorption bandwidth is 5.28 ***,SnS/SnS_(2)/SnO_(2)/CF epoxy composite coatings exhibited long-term corrosion resistance on Q235 steel ***,this study provides an effective strategy for the design of high-efficiency EMW absorbing materials in complex and harsh environments.

关键词： Electrostatic spinning Component regulation Heterogeneous interfaces Electromagnetic wave absorption Corrosion protection