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基于比特重组快速模约简的高面积效率椭圆曲线标量乘法器设计

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电子与信息学报 2024年第1期46卷 344-352页

作者：刘志伟张琦黄海杨晓秋陈冠百赵石磊于斌哈尔滨理工大学计算机科学与技术学院哈尔滨150080

针对现有椭圆曲线密码标量乘法器难以兼顾灵活性和面积效率的问题,该文设计了一种基于比特重组快速模约简的高面积效率标量乘法器。首先,根据椭圆曲线标量乘的运算特点,设计了一种可实现乘法和模逆两种运算的硬件复用运算单元以提高硬... 详细信息

针对现有椭圆曲线密码标量乘法器难以兼顾灵活性和面积效率的问题,该文设计了一种基于比特重组快速模约简的高面积效率标量乘法器。首先,根据椭圆曲线标量乘的运算特点,设计了一种可实现乘法和模逆两种运算的硬件复用运算单元以提高硬件资源使用率,并采用Karatsuba-Ofman算法提高计算性能。其次,设计了基于比特重组的快速模约简算法,并实现了支持secp256k1, secp256r1和SCA-256(SM2标准推荐曲线)快速模约简计算的硬件架构。最后,对点加和倍点的模运算操作调度进行了优化,提高乘法与快速模约简的利用率,降低了标量乘计算所需的周期数量。所设计的标量乘法器在55 nm CMOS工艺下需要275 k个等效门,标量乘运算速度为48 309次/s,面积时间积达到5.7。

关键词：椭圆曲线密码硬件实现 Secp256k1 标量乘快速模约简

Modeling the epidemic dynamics and control of COVID-19 outbreak in China

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Quantitative Biology 2020年第1期8卷 11-19页

作者： shilei zhao Hua Chen CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China China National Center for Bioinformation Beijing 100101China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China CAS Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650223China

Background:The coronavirus disease 2019(COVID-19)is rapidly spreading in China and more than 30 countries over last two ***-19 has multiple characteristics distinct from other infectious diseases,including high infectivity during incubation,time delay between real dynamics and daily observed number of confirmed cases,and the intervention effects of implemented quarantine and control ***:We develop a Susceptible,Un-quanrantined infected,Quarantined infected,Confirmed infected(SUQC)model to characterize the dynamics of COVID-19 and explicitly parameterize the intervention effects of control measures,which is more suitable for analysis than other existing epidemic ***:The SUQC model is applied to the daily released data of the confirmed infections to analyze the outbreak of COVID-19 in Wuhan,Hubei(excluding Wuhan),China(excluding Hubei)and four first-tier cities of *** found that,before January 30,2020,all these regions except Beijing had a reproductive number R>\,and after January 30,all regions had a reproductive number/?<1,indicating that the quarantine and control measures are effective in preventing the spread of *** confirmation rate of Wuhan estimated by our model is 0.0643,substantially lower than that of Hubei excluding Wuhan(0.1914),and that of China excluding Hubei(0.2189),but it jumps to 0.3229 after February 12 when clinical evidence was adopted in new diagnosis *** number of unquarantined infected cases in Wuhan on February 12,2020 is estimated to be 3,509 and declines to 334 on February 21,*** fitting the model with data as of February 21,2020,we predict that the end time of COVID-19 in Wuhan and Hubei is around late March,around mid March for China excluding Hubei,and before early March 2020 for the four tier-one cities.A total of 80,511 individuals are estimated to be infected in China,among which 49,510 are from Wuhan,17,679 from Hubei(excluding Wuhan),and the rest 13,322 from other regi

关键词： coronavirus disease 2019 SARS-CoV-2 epidemic model

BDNF与5-HTT基因启动子区多态性的交互作用对精神分裂症暴力攻击行为的影响

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精神医学杂志 2024年第3期37卷 286-291页

作者：王立峰赵世磊赵慧高秀花石家庄市第八医院河北石家庄050000 广州中医药大学基础医学院中西医结合基础研究中心

目的探讨脑源性神经营养因子(BDNF)与5-羟色胺转运体基因启动子区多态性(5-HTTLPR)的交互作用对精神分裂症暴力攻击行为(SCZ-AB)的影响。方法选取169例精神分裂症患者,根据是否有暴力攻击行为分为A组(有暴力攻击行为,n=87)与B组(无暴力... 详细信息

目的探讨脑源性神经营养因子(BDNF)与5-羟色胺转运体基因启动子区多态性(5-HTTLPR)的交互作用对精神分裂症暴力攻击行为(SCZ-AB)的影响。方法选取169例精神分裂症患者,根据是否有暴力攻击行为分为A组(有暴力攻击行为,n=87)与B组(无暴力攻击行为,n=82)。比较两组一般资料、BDNF与5-HTTLPR基因分型及等位基因频率分布、A组BDNF与5-HTTLPR基因型间Buss&Perry攻击量表和Barratt冲动量表评分,Logistic回归分析不同BDNF基因型和5-HTTLPR基因型对SCZ-AB的影响。运用MDR统计分析不同基因型间交互作用。结果A组与B组间Val和Met频率比较,差异有统计学意义(P<0.05),A组Val/Val频率低于B组(P<0.05),Val/Met和Met/Met基因型频率高于B组(P<0.05);Buss&Perry攻击量表和Barratt冲动量表比较发现:A组Met/Met基因型的各项分值均高于Val/Val、Val/Met基因型(P<0.05);控制性别因素,携带Met等位基因有暴力攻击行为的精神分裂患者的相对危险度是不携带Met等位基因患者的2倍(P<0.05)。Buss&Perry攻击量表和Barratt冲动量表比较发现:L/L基因型患者的各项分值均显著高于S/S基因型(P<0.05)。同时携带Met和L等位基因者的相对危险度是不携带Met和L等位基因者的2倍(P<0.05)。结论同时携带BDNF Met和5-HTTLPR L等位基因患者有暴力攻击行为的危险度较高,BDNF Met等位基因发挥主要作用,Met/Met基因型患者病情更严重。

关键词：脑源性神经营养因子 5-羟色胺转运体基因启动子区多态性基因多态性精神分裂症暴力攻击行为

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陕南茶园绿盲蝽发生为害规律

中国植保导刊 2024年第4期44卷 37-40,96页

作者：文家富杨雪竹赵世垒李慧玲陈花枝陕西省商洛市植保植检站陕西商洛726000 陕西省商南县农业技术服务中心陕西商南726300

2020—2022年连续3年对陕南商洛茶园绿盲蝽发生为害情况进行了大田普查和系统监测调查,结果表明,在商洛茶园绿盲蝽1年发生5代,第1代若虫始见于4月中下旬,5月上旬始见第1代成虫,茶园内第1、4、5代成虫虫量较大,第4代成虫8月下旬回迁茶园... 详细信息

2020—2022年连续3年对陕南商洛茶园绿盲蝽发生为害情况进行了大田普查和系统监测调查,结果表明,在商洛茶园绿盲蝽1年发生5代,第1代若虫始见于4月中下旬,5月上旬始见第1代成虫,茶园内第1、4、5代成虫虫量较大,第4代成虫8月下旬回迁茶园,是秋季回迁茶园的主体;冬季绿盲蝽主要以卵在当年剪口髓部越冬,在靠近坡边和水渠的中茶108和中黄2号品种上,有卵枝率和百枝卵量较大。

关键词：茶园绿盲蝽发生规律为害特点

茶树CsTRPS基因的鉴定及豌豆-茶树间作条件下表达分析

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绿色科技 2024年第7期26卷 211-216,220页

作者：赵石磊聂云菲马青平聊城大学农学与农业工程学院山东聊城252000

TRPs(tryptophan synthase beta chain 1)基因调控合成的色氨酸,作为吲哚乙酸合成的前体,广泛存在于各种植物中,并通过调控生长素的合成影响植物的生长。但关于茶树中TRPs基因研究尚未报道。因此,以茶树为试验材料,克隆了茶树CsTRPS基因... 详细信息

TRPs(tryptophan synthase beta chain 1)基因调控合成的色氨酸,作为吲哚乙酸合成的前体,广泛存在于各种植物中,并通过调控生长素的合成影响植物的生长。但关于茶树中TRPs基因研究尚未报道。因此,以茶树为试验材料,克隆了茶树CsTRPS基因,对CsTRPS基因进行了生物信息学分析,并通过转录组数据探究了豌豆-茶树间作条件下基因的表达情况。结果表明:CsTRPS基因全长1425bp,编码474个氨基酸,CsTRPS蛋白分子量为51.552865KDa,理论等电点(PI)为6.52,甘氨酸(Gly)残基含量最高,占比10.1%,为亲水性蛋白,无信号肽及跨膜结构。CsTRPS蛋白二级结构中α-螺旋占比38.19%,β-转角占比7.59%,延伸链占比17.09%,无规则卷曲占比37.13%。亚细胞定位预测结果表明,CsTRPS蛋白主要集中在线粒体中表达。系统进化树显示,茶树CsTRPS蛋白与红马银花RvTRPS蛋白,猕猴桃AcTRPS蛋白,君迁子DlTRPS蛋白进化关系最近。转录组数据显示,茶树CsTRPS基因在豌豆-茶树间作条件下下调表达。

关键词：茶树 CsTRPS基因生物信息学分析豌豆-茶树间作

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Will the large-scale vaccination succeed in containing the COVID-19 pandemic and how soon?

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Quantitative Biology 2021年第3期9卷 304-316页

作者： shilei zhao Tong Sha Chung-I Wu Yongbiao Xue Hua Chen Beijing Institute of Genomics Chinese Academy of SciencesBeijing 100101China China National Center for Bioinformation Beijing 100101China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Biocontrol School of Life SciencesSun Yat-sen UniversityGuangzhou 510275China Department of Ecology and Evolution University of ChicagoChicagoIL 60637USA CAS Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650223China

Background:The availability of vaccines provides a promising solution to contain the COVID-19 ***,it remains unclear whether the large-scale vaccination can succeed in containing the COVID-19 pandemic and how *** developed an epidemiological model named SUVQC(Suceptible-Unquarantined-Vaccined-Quarantined-Conflrmed)to quantitatively analyze and predict the epidemic dynamics of COVID-19 under ***:In addition to the impact of non-pharmaceutical interventions(NPIs),our model explicitly parameterizes key factors related to vaccination,including the duration of immunity,vaccine efficacy,and daily vaccination rate *** model was applied to the daily reported numbers of confirmed cases of Israel and the USA to explore and predict trends under vaccination based on their current epidemic statuses and intervention *** further provided a formula for designing a practical vaccination strategy,which simultaneously considers the effects of the basic reproductive number of COVID-19,intensity of NPIs,duration of immunological memory after vaccination,vaccine efficacy and daily vaccination ***:In Israel,53.83%of the population is fully vaccinated,and under the current NPI intensity and vaccination scheme,the pandemic is predicted to end between May 14,2021,and May 16,2021,assuming immunity persists for 180 days to 365 *** NPIs are not implemented after March 24,2021,the pandemic will end later,between July 4,2021,and August 26,*** the USA,if we assume the current vaccination rate(0.268%per day)and intensity of NPIs,the pandemic will end between January 20,2022,and October 19,2024,assuming immunity persists for 180 days to 365 ***,assuming immunity persists for 180 days and no NPIs are implemented,the pandemic will not end and instead reach an equilibrium state,with a proportion of the population remaining actively ***:Overall,the daily vaccination rate should be decided according to vaccine effica

关键词： COVID-19 vaccination pandemic epidemic dynamics epidemiological model

单孔胸腔镜下肺段与肺叶切除术治疗早期非小细胞肺癌患者的效果比较

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中国当代医药 2024年第24期31卷 52-55页

作者：卫锐狮冯利赵士磊顾春东江苏省常州市肿瘤医院江苏省常州市第四人民医院胸外科江苏常州213002 大连医科大学附属第一医院胸外科辽宁大连116000

目的比较单孔胸腔镜下肺段、肺叶切除术治疗早期非小细胞肺癌患者的效果、并发症发生率。方法回顾性分析2021年9月至2023年3月常州市肿瘤医院收治的78例早期非小细胞肺癌患者的临床资料,根据治疗方案不同分为参照组和研究组,每组各39例... 详细信息

目的比较单孔胸腔镜下肺段、肺叶切除术治疗早期非小细胞肺癌患者的效果、并发症发生率。方法回顾性分析2021年9月至2023年3月常州市肿瘤医院收治的78例早期非小细胞肺癌患者的临床资料,根据治疗方案不同分为参照组和研究组,每组各39例。参照组开展单孔胸腔镜下肺叶切除术治疗,研究组开展单孔胸腔镜下肺段切除术治疗。比较两组患者的手术开展情况、并发症发生率及肺功能、肿瘤标志物指标。结果两组患者的手术时间比较,差异无统计学意义(P>0.05)。研究组的胸腔引流量、术中出血量少于参照组,住院时间短于参照组,并发症总发生率低于参照组,术后1个月时的第1秒用力呼气量占预计值百分比(FEV_(1)%)、用力肺活量占预计值的百分比(FVC%)、最大自主通气量占预计值的百分比(MVV%)、深吸气量(IC)、FEV_(1)/FVC等指标高于参照组,糖类抗原50(CA50)、癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)等指标低于参照组,差异有统计学意义(P<0.05)。结论相较于单孔胸腔镜下肺叶切除术,对早期非小细胞肺癌患者开展单孔胸腔镜下肺段切除术治疗,治疗效果更佳,术后并发症发生率更低,且术后肺功能改善更为明显,效果显著。

关键词：单孔胸腔镜下肺段切除术肺叶切除术早期非小细胞肺癌并发症发生率肺功能

Population Genetics of SARS-CoV-2: Disentangling Effects of Sampling Bias and Infection Clusters

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Genomics, Proteomics & Bioinformatics 2020年第6期18卷 640-647页

作者： Qi Liu shilei zhao Cheng-Min Shi Shuhui Song Sihui Zhu Yankai Su Wenming zhao Mingkun Li Yiming Bao Yongbiao Xue Hua Chen Beijing Institute of Genomics Chinese Academy of SciencesBeijing 100101China China National Center for Bioinformation Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650223China

A novel RNA virus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is responsible for the ongoing outbreak of coronavirus disease 2019(COVID-19).Population genetic analysis could be useful for investigating the origin and evolutionary dynamics of ***,due to extensive sampling bias and existence of infection clusters during the epidemic spread,direct applications of existing approaches can lead to biased parameter estimations and data *** this study,we first present robust estimator for the time to the most recent common ancestor(TMRCA)and the mutation rate,and then apply the approach to analyze 12,909 genomic sequences of *** mutation rate is inferred to be 8.69×10^(−4) per site per year with a 95%confidence interval(CI)of[8.61×10^(−4),8.77×10^(−4)],and the TMRCA of the samples inferred to be Nov 28,2019 with a 95%CI of[Oct 20,2019,Dec 9,2019].The results indicate that COVID-19 might originate earlier than and outside of Wuhan Seafood *** further demonstrate that genetic polymorphism patterns,including the enrichment of specific haplotypes and the temporal allele frequency trajectories generated from infection clusters,are similar to those caused by evolutionary forces such as natural *** results show that population genetic methods need to be developed to efficiently detangle the effects of sampling bias and infection clusters to gain insights into the evolutionary mechanism of *** for implementing VirusMuT can be downloaded at https://***/biocode/tools/BT007081.

关键词： COVID-19 SARS-CoV-2 Phylogenetic divergence Infection cluster Sampling bias

Ongoing Positive Selection Drives the Evolution of SARS-CoV-2 Genomes

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Genomics, Proteomics & Bioinformatics 2022年第6期20卷 1214-1223页

作者： Yali Hou shilei zhao Qi Liu Xiaolong Zhang Tong Sha Yankai Su Wenming zhao Yiming Bao Yongbiao Xue Hua Chen Beijing Institute of Genomics Chinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650223China

SARS-CoV-2 is a new RNA virus affecting humans and spreads extensively throughout the world since its first outbreak in December,*** the transmissibility and pathogenicity of SARS-CoV-2 in humans after zoonotic transfer are actively evolving,and driven by adaptation to the new host and environments is still under *** the evolutionary mechanism underlying epidemiological and pathological characteristics of COVID-19 is essential for predicting the epidemic trend,and providing guidance for disease control and *** novel strategies for identifying natural selection using within-species polymorphisms and 3,674,076 SARSCoV-2 genome sequences of 169 countries as of December 30,2021,we demonstrate with population genetic evidence that during the course of SARS-CoV-2 pandemic in humans,1)SARS-CoV-2 genomes are overall conserved under purifying selection,especially for the 14 genes related to viral RNA replication,transcription,and assembly;2)ongoing positive selection is actively driving the evolution of 6 genes(e.g.,S,ORF3a,and N)that play critical roles in molecular processes involving pathogen–host interactions,including viral invasion into and egress from host cells,and viral inhibition and evasion of host immune response,possibly leading to high transmissibility and mild symptom in SARS-CoV-2 *** to an established haplotype phylogenetic relationship of 138 viral clusters,a spatial and temporal landscape of 556 critical mutations is constructed based on their divergence among viral haplotype clusters or repeatedly increase in frequency within at least 2 clusters,of which multiple mutations potentially conferring alterations in viral transmissibility,pathogenicity,and virulence of SARS-CoV-2 are highlighted,warranting attention.

关键词： COVID-19 SARS-CoV-2 Viral evolution Natural selection Darwinian selection