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中药诱导干细胞在骨组织工程学中应用的研究概况

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中医药临床杂志 2024年第6期36卷 1191-1196页

作者：赵军朱欢徐世红王小强王培鑫李屿璠张辰甘肃省中医院甘肃兰州730050 甘肃中医药大学甘肃兰州730000

随着组织工程学的飞速发展以及科研人员的不断深入研究发现,用中药诱导干细胞在组织工程学中修复骨缺损具有一定的优势。骨组织工程学因具有良好的组织相容性、生物降解材料降解性而成为了研究的热点。近年来,骨组织工程技术的不断发展... 详细信息

随着组织工程学的飞速发展以及科研人员的不断深入研究发现,用中药诱导干细胞在组织工程学中修复骨缺损具有一定的优势。骨组织工程学因具有良好的组织相容性、生物降解材料降解性而成为了研究的热点。近年来,骨组织工程技术的不断发展为修复骨缺损带来了希望,而干细胞移植是组织工程学中非常重要的环节之一,因其具有能够在特定条件下分化为不同类型细胞的能力,所以对于组织器官的损伤修复具有重要意义。而单纯利用干细胞治疗骨缺损疾病则存在治疗周期延长、靶向性不高等缺陷。中药参与治疗可促进干细胞增殖、诱导干细胞定向分化、促进移植后的干细胞定向迁移,从而缩短治疗周期并增强靶向性,可大大提高临床治疗效果。基于此,文章以中药诱导干细胞在骨组织工程学中应用的最新研究进展为契入点进行综述,探讨中药诱导干细胞在骨组织工程学中发挥的重要作用。

关键词：中药干细胞骨组织工程学骨缺损综述

Successful transplantation of cryopreserved spermatogonia in Sebastes schlegelii:A simple and suitable alternative approach for conservation of viviparous fish

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Water Biology and Security 2023年第3期2卷 75-86页

作者： Li Zhou xueying Wang Shuran Du shihong xu Yanfeng Wang Zongcheng Song Qinghua Liu Jun Li The Key Laboratory of Experimental Marine Biology Center for Ocean Mega-ScienceInstitute of OceanologyChinese Academy of SciencesQingdao266071China College of Life Science Ningde Normal UniversityEngineering Research Center of Mindong Aquatic Product Deep-ProcessingFujian Province UniversityNingde352100China Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdao266071China Weihai Shenghang Aquatic Product Science and Technology Co.Ltd. Weihai264200China

Black rockfish(Sebastes schlegelii)is one of the most important marine economic viviparous ***,germplasm degradation and genetic diversity reduction have occurred due to overfishing and long-term artificial *** cell transplantation combined with cryopreservation may be an alternative way to protect genetic ***,in viviparous fish that undertake fertilization and embryo development in vivo,transplantation is more difficult than in oviparous fish,including selection of transplantation stage,isolation of germ stem cells,and preparation of sterile *** seriously restricts the development of viviparous ***,in this study,we aimed to explore a transplantation method suitable for these *** cells were isolated from cryopreserved whole testes of 300–400g male Sebastes schlegelii in May,labeled by PKH26,and intra-peritoneally transplanted into allogeneic larvae at 5–10 days ***,the development of donor-derived cells in recipients were continuously detected by fluorescence labeling,histology,microsatellite markers,and fecundity *** results showed that donors were rich in spermatogonia(75%)and recipients maintained a high survival rate after transplantation,with a rate of>20%at sexual ***,donor-derived cells successfully migrated(100%),colonized,and incorporated into the developing recipient gonad(93.33%).Finally,transplanted recipients could normally develop and differentiate into male and female individuals,with donor-derived gametes found in 65.38%of mature *** the present study,we first establish a simple and suitable transplantation method for Sebastes schlegelii using immature males and specific larvae,which will serve as a promising tool in the protection of germplasm resources for this transplantation-restricted marine viviparous species.

关键词： Allogeneic transplantation Spermatogonia Sebastes schlegelii Germ cells Germplasm

肠道菌群调节软骨代谢及其对骨性关节炎治疗的作用

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生命的化学 2024年第8期44卷 1338-1346页

作者：秦启顺徐世红姜朝阳姜登宸党泽亮彭培王兴盛甘肃中医药大学兰州730000 甘肃省中医院兰州730050

本文介绍了骨性关节炎的病理特征与关节软骨代谢的关系,并简述了近年来肠道菌群在骨性关节炎发病与进展中的关键作用。通过回顾近年来肠道菌群与关节软骨代谢之间的相关研究,本文分析了肠道菌群调节关节软骨代谢的潜力,以及其在骨性关... 详细信息

本文介绍了骨性关节炎的病理特征与关节软骨代谢的关系,并简述了近年来肠道菌群在骨性关节炎发病与进展中的关键作用。通过回顾近年来肠道菌群与关节软骨代谢之间的相关研究,本文分析了肠道菌群调节关节软骨代谢的潜力,以及其在骨性关节炎治疗中的重要性。本文指出通过调节肠道菌群来治疗骨性关节炎的新思路,并提出了相关领域未来研究的方向,包括深入探索肠道菌群与骨性关节炎之间的具体互作机制,以及开发新的益生菌或预生菌等调节肠道菌群的干预措施,强调了个性化的肠道菌群调节策略的重要性,同时展望了肠道菌群作为调节关节软骨代谢和治疗骨性关节炎的新兴靶点所展现的巨大潜力。

关键词：骨性关节炎肠道菌群软骨代谢应激

从巨噬细胞极化角度浅析中医药治疗骨质疏松症的治疗思路

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数理医药学杂志 2024年第9期37卷 695-700页

作者：党泽亮王兴盛王芳徐世红姜朝阳姜登宸秦启顺彭培甘肃中医药大学研究生院兰州730000 甘肃省中医院创伤中心兰州730050 甘肃省第二人民医院体检科兰州730099

骨质疏松症(osteoporosis,OP)是一种全身性骨微观环境代谢疾病。巨噬细胞极化是指巨噬细胞响应某些微环境改变后的一种活化状态,这种状态下形成的M1、M2型巨噬细胞分别从增加骨吸收、破骨细胞形成及成骨细胞形成方面发挥作用,影响骨微... 详细信息

骨质疏松症(osteoporosis,OP)是一种全身性骨微观环境代谢疾病。巨噬细胞极化是指巨噬细胞响应某些微环境改变后的一种活化状态,这种状态下形成的M1、M2型巨噬细胞分别从增加骨吸收、破骨细胞形成及成骨细胞形成方面发挥作用,影响骨微环境。中医药治疗OP也是通过调节骨微环境代谢,从而增加骨吸收、破骨细胞形成。本文从巨噬细胞极化角度出发,阐释中医药在抑制M1型巨噬细胞及促进M2型巨噬细胞上发挥作用,进而抑制骨吸收,抑制破骨细胞形成,增加成骨细胞形成,以发挥调节OP骨微环境代谢的治疗作用。

关键词：骨质疏松症巨噬细胞极化中医药治疗思路

Biomaterials and tissue engineering in traumatic brain injury:novel perspectives on promoting neural regeneration

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Neural Regeneration Research 2024年第10期19卷 2157-2174页

作者： shihong Zhu Xiaoyin Liu Xiyue Lu Qiang Liao Huiyang Luo Yuan Tian xu Cheng Yaxin Jiang Guangdi Liu Jing Chen Department of Neurosurgery West China HospitalWest China Medical SchoolSichuan UniversityChengduSichuan ProvinceChina National Engineering Research Center for Biomaterials College of Biomedical EngineeringSichuan UniversityChengduSichuan ProvinceChina Department of Anesthesiology West China HospitalWest China Medical SchoolSichuan UniversityChengduSichuan ProvinceChina Department of Pharmacy West China HospitalWest China Medical SchoolSichuan UniversityChengduSichuan ProvinceChina Out-patient Department West China HospitalWest China Medical SchoolSichuan UniversityChengduSichuan ProvinceChina Department of Respiratory and Critical Care Medicine West China HospitalWest China Medical SchoolSichuan UniversityChengduSichuan ProvinceChina

Traumatic brain injury is a serious medical condition that can be attributed to falls, motor vehicle accidents, sports injuries and acts of violence, causing a series of neural injuries and neuropsychiatric symptoms. However, limited accessibility to the injury sites, complicated histological and anatomical structure, intricate cellular and extracellular milieu, lack of regenerative capacity in the native cells, vast variety of damage routes, and the insufficient time available for treatment have restricted the widespread application of several therapeutic methods in cases of central nervous system injury. Tissue engineering and regenerative medicine have emerged as innovative approaches in the field of nerve regeneration. By combining biomaterials, stem cells, and growth factors, these approaches have provided a platform for developing effective treatments for neural injuries, which can offer the potential to restore neural function, improve patient outcomes, and reduce the need for drugs and invasive surgical procedures. Biomaterials have shown advantages in promoting neural development, inhibiting glial scar formation, and providing a suitable biomimetic neural microenvironment, which makes their application promising in the field of neural regeneration. For instance, bioactive scaffolds loaded with stem cells can provide a biocompatible and biodegradable milieu. Furthermore, stem cells-derived exosomes combine the advantages of stem cells, avoid the risk of immune rejection, cooperate with biomaterials to enhance their biological functions, and exert stable functions, thereby inducing angiogenesis and neural regeneration in patients with traumatic brain injury and promoting the recovery of brain function. Unfortunately, biomaterials have shown positive effects in the laboratory, but when similar materials are used in clinical studies of human central nervous system regeneration, their efficacy is unsatisfactory. Here, we review the characteristics and properties

关键词： bioactive materials biomaterials exosomes neural regeneration scaffolds stem cells tissue engineering traumatic brain injury

Characterization and differential expression of three GnRH forms during reproductive development in cultured turbot Schophthalmus maximus

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Journal of Oceanology and Limnology 2018年第4期36卷 1360-1373页

作者： ZHAO Chunyan xu shihong FENG Chengcheng LIU Yifan YANG Yang WANG Yanfeng XIAO Yongshuang SONG Zongcheng LIU Qinghua LI Jun Key Laboratory of Experimental Marine Biology Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China University of Chinese Academy of Sciences Beijing 100049 China Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and Technology Qingdao 266237 China Weihai Shenghang Aquatic Product Science and Technology Co. Ltd. Weihai 264200 China

Turbots( Schophthalmus maximus), one of the most important economic marine flatfish species, fail to undergo final spawning and spermiation naturally under artificial farming conditions. In vertebrates, reproduction is regulated by the brain-pituitary-gonadal axis(BPG-axis), and gonadotropin releasing hormone(GnRH) is one of its key components. Therefore, to better understand the physiology of reproduction in the turbot, three of the genes encoding GnRH subtypes— sbGnRH, c GnRH-II and sGnRH —were cloned and sequenced by isolating the cDNA sequences. The localizations and patterns of expression of their mRNAs were also evaluated during seasonal gonadal development. All three mRNAs were expressed abundantly in the brain; sbGnRH and sGnRH mRNAs were also detected in the gonads and pituitary gland, and sbGnRH expression was much higher than that of sGnRH, indicating the critical role of sbGnRH in regulating the BPG-axis. Moreover, the brain expression patterns of sbGnRH and sGnRH mRNAs showed an increased trend during gonadal development, peaking in mature stages. This indicated the direct regulation of gonadal development by the GnRH system. In addition, c GnRH-II mRNA expression showed no significant variations, suggesting that c GnRH-II is not critically involved in the control of reproduction. Further, the mRNA abundances of the three GnRH forms in the breeding season were significantly higher than those in immature and post-breeding stages in all analyzed brain areas. Therefore, we propose that sbGnRH is the most important hormone for the regulation of reproduction in turbot via the BPG-axis. These results will help in better understanding the reproductive endocrine mechanisms of turbots and lay the groundwork for additional studies aimed at comparing the reproductive physiology of wild individuals with those raised under artificial conditions.

关键词： turbot GnRH brain gonad reproductive development

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百年回顾:出土法律文献与秦汉令研究

上海师范大学学报（哲学社会科学版） 2011年第5期40卷 69-79页

作者：徐世虹中国政法大学法律古籍整理研究所北京100088

令作为中国古代法律重要的法源形式之一,自中国法制史研究之始即为学者关注。以沈家本、程树德为代表的早期辑佚复原、考证研究,开启了秦汉令的研究领域,为秦汉律令体系的构建奠定了基础。此后中田薰又将汉令研究推向一个新阶段。百年... 详细信息

令作为中国古代法律重要的法源形式之一,自中国法制史研究之始即为学者关注。以沈家本、程树德为代表的早期辑佚复原、考证研究,开启了秦汉令的研究领域,为秦汉律令体系的构建奠定了基础。此后中田薰又将汉令研究推向一个新阶段。百年来出土简牍的不断问世,丰富了秦汉令的资料来源,人们对汉令的形式、结构、性质及令的分化、律令转化、令的立法程序予以全面探讨,成果迭见,秦汉令研究呈现一个新局面。但由于对出土文献的认识及基本概念的解析各不相同,有关秦汉时有无令典,挈令的形态究竟如何,干支令、挈令、事项令的关系如何,令分甲乙丙的标准为何,对秦汉令的法律地位应当如何判断,如何定位它在中国法律史发展过程的作用,仍有待新资料的披露及研究的进一步深入。

关键词：出土法律文献简牍秦汉令研究历程

西汉末期法制新识--以张勋主守盗案牍为对象

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历史研究 2018年第5期 4-20,189页

作者：徐世虹中国政法大学法律古籍整理研究所北京100088

湖南益阳兔子山遗址J3出土的两方木牍,记录了汉平帝元始二年张勋主守盗一案的判决结果,反映了较为丰富的西汉末期的法制状况:"鞫"除"认定犯罪事实"的程序之义外,也具有指代诉讼全部程序的涵义;计赃等级有250以上一级,与秦及汉初有所不... 详细信息

湖南益阳兔子山遗址J3出土的两方木牍,记录了汉平帝元始二年张勋主守盗一案的判决结果,反映了较为丰富的西汉末期的法制状况:"鞫"除"认定犯罪事实"的程序之义外,也具有指代诉讼全部程序的涵义;计赃等级有250以上一级,与秦及汉初有所不同;"衣服如法",表明囚衣之服有法律规定;对主守盗有加倍追赃、令同居承担赔偿责任的要求;对处髡钳城旦的刑徒,执行收入司空、从事劳役的刑罚。牍文所见的"爵减",在现有史料的范围内指向回避刑等;此案的审判权在益阳县,"论决言"的含义是将审判结果报府,但未必是履行程序上的复核。

关键词：兔子山J3木牍西汉末期刑罚爵减

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秦汉简牍中的不孝罪诉讼

华东政法学院学报 2006年第3期 124-129页

作者：徐世虹中国政法大学

20世纪70年代以来,一大批重要的简牍、帛书文献在我国相继出土,给学术界带来了接连不断的惊喜。这些文献在价值上足以和王国维先生所谓“中国学问上之最大发现”相媲美,其对法律史研究之巨大价值亦不言而喻。众多失传已久的古代律令、... 详细信息

20世纪70年代以来,一大批重要的简牍、帛书文献在我国相继出土,给学术界带来了接连不断的惊喜。这些文献在价值上足以和王国维先生所谓“中国学问上之最大发现”相媲美,其对法律史研究之巨大价值亦不言而喻。众多失传已久的古代律令、流沙掩没的司法文书、深藏墓穴的先秦佚籍,它们的再现每每成为海内外学者关注的焦点所在;在法律史学界,对出土文献的整理与研究同样受到广泛重视。目前文献之出土仍呈方兴未艾之势,屡有重大发现见诸报端。本期特组稿件对此问题予以研讨,并以之纪念华东政法学院法律古籍整理研究所成立20周年。法律古籍整理研究所的张伯元教授抱病为本刊撰写专稿,在此特致谢意。

关键词：刑事诉讼简牍秦汉孝古代法律张家山汉简二年律令家长权研究者见解