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Roles of N-cadherin in cerebral cortical development:cooperation with membrane trafficking and actin cytoskeletal regulation

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Neural Regeneration Research 2025年第1期20卷 188-190页

作者： shiho Ito Takeshi Kawauchi Department of Adaptive and Maladaptive Responses in Health and Disease Graduate School of MedicineKyoto UniversityKyotoJapan Department of Physiology Keio University School of MedicineTokyoJapan

Cell adhesion plays pivotal roles in the morphogenesis of multicellular *** cells form several types of cell-to-cell adhesion,including zonula occludens(tight junctions),zonula adhaerens(adherens junctions),and macula adhaerens(desmosomes).Although these adhesion complexes are basically observed only in epithelial cells,cadherins,which are the major cell adhesion molecules of adherens junctions,are expressed in both epithelial and non-epithelial tissues,including neural tissues(Kawauchi,2012).The cadherin superfamily consists of more than 100 members,but classic cadherins.

关键词： cerebral skeletal cooperation

A trial of simple and easy health monitoring for power poles by using ‘ipod’

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Science China(Technological Sciences) 2015年第4期58卷 712-719页

作者： ORAI Naoki ICHII Koji ISHII shiho Graduate School of Engineering Hiroshima University

At present,the regular inspection of power poles is just a visual inspection based on the inspector’s ***,overlook of the deteriorated poles can come *** order to avoid an accident due to the overlook of the deteriorated poles,the authors propose a simple and easy health monitoring method for power poles using‘i Pod’.Since the applicability of‘i Pod’as a vibration sensor in this purpose was not clear,it was examined in the following ***,the authors proposed a tool to fix the‘i Pod’to a power pole,and the performance of‘i Pod’as a vibration measurement device was compared with a conventional acceleration *** a result,it was confirmed that‘i Pod’could give almost the same response with the conventional sensor in terms of the observed predominant ***,vibration measurements were conducted at power poles in a *** a result,the observed predominant frequency corresponded to the calculated 2nd natural frequency of power *** some power poles were supported by some additional wires from the ground,the measurements were successful at almost all the ***,the authors confirmed that the‘i Pod’based health monitoring is possible.

关键词： iPod health monitoring power pole natural frequency

Characteristics of obese or overweight dogs visiting private Japanese veterinary clinics

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Asian Pacific Journal of Tropical Biomedicine 2016年第4期6卷 338-343页

作者： shiho Usui Hidemi Yasuda Yuzo Koketsu School of Agriculture Meiji University Department of Veterinary Research and Development Spectrum Lab Japan

Objective:To characterize obese or overweight dogs that visited private Japanese veterinary clinics located in humid subtropical climate ***:Dogs were categorized into four body condition score groups and five body size groups based on their *** logistic regression models were applied to the data.A Chi-squared test was used to examine whether the percentage of obese or overweight dogs differed between ***:There were 15.1% obese dogs and 39.8% overweight *** dogs were characterized by increased age and female sex,whereas overweight dogs were characterized by increased age and neuter status(P < 0.05).Peak probabilities of dogs being either obese or overweight were between 7 and 9 years of age,with the probabilities then declining as the dogs got *** example,in toy sized dogs,the probability of dogs being overweight increased from 33.4% to a peak of 55.1% as dog age rose from 1 to 8years ***,in medium,small and toy sized dogs,neutered dogs were more likely to be overweight than intact dogs,whereas neutered small sized dogs were more likely to be obese than intact small sized dogs(P < 0.05).Additionally,the percentages of obese or overweight dogs differed between the 10 selected breeds with the highest percentage of obese or overweight ***:By taking age,body size,sex and neuter status into account,veterinarians can advise owners about maintaining their dogs in ideal body condition.

关键词： Age Canine Factors Obesity Overweight

Efficacy of cytapheresis in patients with ulcerative colitis showing insufficient or lost response to biologic therapy

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World Journal of Gastroenterology 2022年第34期28卷 4959-4972页

作者： Masahiro Iizuka Takeshi Etou shiho Sagara Akita Health Care Center Akita Red Cross HospitalAkita 010-0001Japan Department of Gastroenterology Akita Red Cross HospitalAkita 010-1495Japan

For the optimal management of refractory ulcerative colitis(UC),secondary loss of response(LOR)and primary non-response to biologics is a critical *** article aimed to summarize the current literature on the use of cytapheresis(CAP)in patients with UC showing a poor response or LOR to biologics and discuss its advantages and ***,we summarized the efficacy of CAP in patients with UC showing insufficient response to thiopurines or immunomodulators(IM).Eight studies evaluated the efficacy of CAP in patients with UC with inadequate responses to thiopurines or *** were no significant differences in the rate of remission and steroid-free remission between patients exposed or not exposed to thiopurines or *** studies evaluated the efficacy of CAP in patients with UC showing an insufficient response to biologic *** remission rates of biologics exposed or unexposed patients were 29.4%and 44.2%,*** studies evaluated the efficacy of CAP in combination with biologics in patients with inflammatory bowel disease showing a poor response or LOR to *** rates of remission/response and steroid-free remission in patients with UC ranged 32%-69%(mean:48.0%,median:42.9%)and 9%-75%(mean:40.7%,median:38%),*** had the same effectiveness for remission induction with or without prior failure on thiopurines or IM but showed little benefit in patients with UC refractory to *** heterogeneity existed in the efficacy of the combination therapy with CAP and biologics,these combination therapies induced clinical remission/response and steroid-free remission in more than 40%of patients with UC refractory to biologics on *** the excellent safety profile of CAP,this combination therapy can be an alternative therapeutic strategy for UC refractory to *** prospective studies are needed to understand the efficacy of combination therapy with CAP and biologics.

关键词： Ulcerative colitis Inflammatory bowel disease Cytapheresis Granulocyte and monocyte adsorptive apheresis Anti-tumor necrosis factor-αantibody Combination therapy

Acute respiratory distress syndrome associated with severe ulcerative colitis

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World Journal of Gastroenterology 2010年第19期16卷 2440-2442页

作者： shiho Sagara Yasuo Horie Yumiko Anezaki Hideaki Miyazawa Masahiro Iizuka Health Care Center Akita Red Cross Hospital Akita 010-0001 Japan Department of Internal Medicine Akita University School of Medicine Akita 010-8543 Japan Department of Surgery Akita University School of Medicine Akita 010-8543 Japan

Various extraintestinal manifestations including pulmonary abnormalities have been reported in patients with ulcerative colitis. Acute respiratory distress syndrome (ARDS) is a serious and fatal pulmonary manifestation. We have experienced a 67-year-old male patient with ARDS associated with a severe type of ulcerative colitis (UC). Severe dyspnea symptoms occurred during the treatment of UC in a previous hospital and the patient was transferred to our hospital on June 27, 2007. Both blood and sputa cultures for bacteria and fungi were negative. Cytomega-lovirus antigenemia was also not detected. From the clinical and radiological [Chest X-ray, computed tomography (CT)] findings, the patient was diagnosed with ARDS on the basis of the def inition of ARDS developed by the European-American Consensus Conference on ARDS. Both colonic inflammations and ARDS symptoms of the patient were resistant to any medical treatment includingcorticosteroids and antibiotics. However, ARDS symptoms were dramatically improved after surgical colectomy. We believe that severe colonic inflammation from UC was closely associated with the onset of ARDS of the patient. Our case report suggests that a severe type of ulcerative colitis might be taken into consideration as one of the predisposing factors of ARDS.

关键词： Acute respiratory distress syndrome Ulcerative colitis Inflammatory bowel disease Extra-intestinal manifestation

Cytapheresis re-induces high-rate steroid-free remission in patients with steroid-dependent and steroid-refractory ulcerative colitis

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World Journal of Gastroenterology 2021年第12期27卷 1194-1212页

作者： Masahiro Iizuka Takeshi Etou Yosuke Shimodaira Takashi Hatakeyama shiho Sagara Akita Health Care Center Akita Red Cross HospitalAkita 010-0001Japan Department of Gastroenterology Akita Red Cross HospitalAkita 010-1495Japan Department of Gastroenterology and Neurology Akita University Graduate School of MedicineAkita 010-8543Japan akashi Hatakeyama Department of NephrologyAkita Red Cross HospitalAkita 010-1495Japan

BACKGROUND It is a crucial issue for patients with refractory ulcerative colitis(UC),including steroid-dependent and steroid-refractory patients,to achieve and maintain steroid-free ***,clinical studies focused on the achievement of steroid-free remission in refractory UC patients are ***(CAP)is a non-pharmacological extracorporeal therapy that is effective for active UC with fewer adverse *** study comprised UC patients treated with CAP and suggested the efficacy of CAP for refractory UC *** To clarify the efficacy of CAP in achieving steroid-free remission in refractory UC *** We retrospectively reviewed the collected data from 55 patients with refractory UC treated with *** analyzed the following points:(1)Efficacy of the first course of CAP;(2)Efficacy of the second,third,and fourth courses of CAP in patients who experienced relapses during the observation period;(3)Efficacy of CAP in colonic mucosa;and(4)Long-term efficacy of *** efficacy was evaluated using Lichtiger’s clinical activity index or Sutherland index(disease activity index).Mucosal healing was evaluated using Mayo endoscopic *** primary and secondary endpoints were the rate of achievement of steroidfree remission and the rate of sustained steroid-free remission,*** analysis was performed using the paired t-test and chi-squared *** The rates of clinical remission,steroid-free remission,and poor effectiveness after CAP were 69.1%,45.5%,and 30.9%,*** were no significant differences in rate of steroid-free remission between patients with steroiddependent and steroid-refractory *** mean disease activity index and Lichtiger’s clinical activity index scores were significantly decreased after CAP(P<0.0001).The rates of steroid-free remission after the second,third,and fourth courses of CAP in patients who achieved steroid-free remission after the first course of CAP were 8

关键词： Ulcerative colitis Cytapheresis Steroid-dependent Steroid-refractory Steroid-free remission Inflammatory bowel disease

Heat coma as an indicator of resistance to environmental stress and its relationship to ocean dynamics in the sea skaters, Halobates （Heteroptera： Gerridae）

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Insect Science 2011年第6期18卷 703-711页

作者： Tetsuo Harada shiho Takenaka Takero Sekimoto Mitsuru Nakajyo Takao Inoue Takamasa Ishibashi Chihiro Katagiri Laboratory of Environmental Physiology Graduate School of Integrated Sciences and Arts Kochi University Kochi Institute of Low Temperature Sciences Hokkaido University Sapporo Japan

The tolerance to temperature increase was tested for Halobates individuals collected during two cruises in the western tropical Pacific Ocean （MR-06-05-Leg 3, December 21, 2006-January 12, 2007, 0°N-8°N; KH-06-02-Leg 5, August 18-31, 2006, 12°N-17°N）. High temperature coma experiments were conducted on adults and 5th instar larvae. On average, H. sericeus （distributed in the wide latitude zone of 5°N-40°N）, H. germanus （distributed in the moderate latitude zone of 0°N-35°N） and H. micans （distributed mainly in the lower latitudes around the equator） were on average paralyzed at 35.6℃（SD： 0.89）, 32.9℃ （SD： 2.17） and 31.6℃ （SD： 2.60）, respectively （P = 0.035）. According to the current dynamics during the cruise, the colony ofH. sericeus at one station （5°N 137°E） may have been transferred from the northern area of 14°N by three currents （North Equatorial Current, Mindanao Current and North Equatorial Counter Current） to the area of 5°N 138°E. Extremely high heat resistance was shown by the adults of H. germanus in the sea area around the equator. Dynamic current and air movements in this area around the equator, that is a ＂warm seawater pool＂, could be hypothesized to be related to the high resistance to heat shown in this study.

关键词： currents distribution heat paralysis oceanic dynamics oceanic Halobates

A New Bis-iridoid Glucoside from Mussaenda incana

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Chinese Chemical Letters 2006年第10期17卷 1331-1334页

作者： Biswanath DINDA Sudhan DEBNATH Santanu MAJUMDER shiho ARIMA Nariko SATO Yoshihiro HARIGAYA Department of Chemistry Tripura University Suryamaninagar 799-130 Agartala India Department of Chemistry Belonia College Belonia 799-155 India School of Pharmaceutical Sciences Kitasato University Minato-ku Tokyo 108-8641 Japan

A new bis-iridoid glucoside, incaside 1 was isolated along with known iridoid, 6-0- veratroylcatalposide from the stem-bark of Mussaenda incana. The structure of the new iridoid was established mainly on the basis of ... 详细信息

关键词： Mussaenda incana Rubiaceae incaside bis-iridoid glucoside.

The Islamic Studies in China:Research in the Field of History

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Cultural and Religious Studies 2024年第6期12卷 329-337页

作者： Alimtohte shiho Tohoku University SendaiJapan

A history of the Islamic studies in China,not only includes studies on world Islam,it also includes research on Islam and Muslims in *** the Reform and Opening Up,China did not achieve much in this field,since then,the research field of Islam and Muslim in China has been expanding and the results have been published,forming a new *** this field,scholars such as Jin Yijiu,Li Xinghua,Qin Huibin,Zhou Guoli,Sha Qiuzhen,Zhou Xiefan,Wu Yungui,and Yang Huaizhong have made the most outstanding *** in the collation of reference books and historical materials,in the past 20 years,The Encyclopedia of the history of Islam,The Chinese Encyclopedia of Islam have emerged,and the Chinese and World Encyclopedia of Islamic Law and other important historical books have been *** paper focuses on the field of historical research and divided into academic research history at home and abroad,which is discussed from several fields such as general history,special history,national history,and regional history.

关键词： Islamic studies China the field of history Chinese Islam world Islam