Wound healing of intestinal epithelial cells

作     者：Masahiro Iizuka Shiho Konno 

作者机构：Akita Health Care CenterAkita Red Cross HospitalAkita 010-0001Japan 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2011年第17卷第17期

页      面：2161-2171页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：Supported by (in part) Health and Labour Sciences Research Grants for research on intractable diseases from Ministry of Health Labour and Welfare of Japan 

主　　题：Intestinal epithelial cell Wound healing Restitution Growth factors Toll-like receptor 

摘      要：The intestinal epithelial cells(IECs) form a selective permeability barrier separating luminal content from underlying *** injury,the intestinal epithelium undergoes a wound healing *** wound healing is dependent on the balance of three cellular events;restitution,proliferation,and differentiation of epithelial cells adjacent to the wounded *** studies have shown that various regulatory peptides,including growth factors and cytokines,modulate intestinal epithelial wound *** studies have revealed that novel factors,which include toll-like receptors(TLRs),regulatory peptides,particular dietary factors,and some gastroprotective agents,also modulate intestinal epithelial wound *** these factors,the activation of TLRs by commensal bacteria is suggested to play an essential role in the maintenance of gut *** studies suggest that mutations and dysregulation of TLRs could be major contributing factors in the predisposition and perpetuation of inflammatory bowel ***,studies have shown that specific signaling pathways are involved in IEC wound *** this review,we summarize the function of IECs,the process of intestinal epithelial wound healing,and the functions and mechanisms of the various factors that contribute to gut homeostasis and intestinal epithelial wound healing.