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Mitophagy in neurodegenerative disease pathogenesis

Neural Regeneration Research 2024年第5期19卷 998-1005页

作者： Kan Yang Yuqing Yan Anni Yu Ru Zhang Yuefang Zhang Zilong Qiu Zhengyi Li Qianlong Zhang shihao wu Fei Li Department of Developmental and Behavioural Pediatric&Child Primary Care Brain and Behavioural Research Unit of Shanghai Institute for Pediatric Research and MOE-Shanghai Key Laboratory for Children’s Environmental HealthXinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Center for Excellence in Brain Science and Intelligence Technology Institute of NeuroscienceState Key Laboratory of NeuroscienceCAS Key Laboratory of Primate NeurobiologyChinese Academy of SciencesShanghaiChina College of Materials and Chemical Engineering Hunan Institute of EngineeringXiangtanHunan ProvinceChina School of Medicine Yunnan UniversityKunmingYunnan ProvinceChina Songjiang Research Institute Shanghai Jiao Tong University School of MedicineShanghaiChina Neurosurgery Department Kunming Yenan HospitalKunmingYunnan ProvinceChina

Mitochondria are critical cellular energy resources and are central to the life of the neuron.Mitophagy selectively clears damaged or dysfunctional mitochondria through autophagic machinery to maintain mitochondrial quality control and homeostasis.Mature neurons are postmitotic and consume substantial energy,thus require highly efficient mitophagy pathways to turn over damaged or dysfunctional mitochondria.Recent evidence indicates that mitophagy is pivotal to the pathogenesis of neurological diseases.However,more work is needed to study mitophagy pathway components as potential therapeutic targets.In this review,we briefly discuss the characteristics of nonselective autophagy and selective autophagy,including ERphagy,aggrephagy,and mitophagy.We then introduce the mechanisms of Parkin-dependent and Parkin-independent mitophagy pathways under physiological conditions.Next,we summarize the diverse repertoire of mitochondrial membrane receptors and phospholipids that mediate mitophagy.Importantly,we review the critical role of mitophagy in the pathogenesis of neurodegenerative diseases including Alzheimer’s disease,Parkinson’s disease,and amyotrophic lateral sclerosis.Last,we discuss recent studies considering mitophagy as a potential therapeutic target for treating neurodegenerative diseases.Together,our review may provide novel views to better understand the roles of mitophagy in neurodegenerative disease pathogenesis.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis autophagy mitochondria mitophagy mitophagy receptor Parkin Parkinson’s disease PINK1

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Aberrant epithelial cell interaction promotes esophageal squamous-cell carcinoma development and progression

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Signal Transduction and Targeted Therapy 2024年第1期9卷 279-294页

作者： Liping Chen shihao Zhu Tianyuan Liu Xuan Zhao Tao Xiang Xiao Hu Chen wu Dongxin Lin Department of Etiology and Carcinogenesis National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Key Laboratory of Cancer Genomic Biology Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical UniversityNanjing 211166China CAMS Oxford Institute Chinese Academy of Medical SciencesBeijing 100006China Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaGuangzhou 510060China

Epithelial-mesenchymal transition(EMT)and proliferation play important roles in epithelial cancer formation and progression,but what molecules and how they trigger EMT is largely unknown.Here we performed spatial transcriptomic and functional analyses on samples of multistage esophageal squamous-cell carcinoma(ESCC)from mice and humans to decipher these critical issues.By investigating spatiotemporal gene expression patterns and cell–cell interactions,we demonstrated that the aberrant epithelial cell interaction via EFNB1-EPHB4 triggers EMT and cell cycle mediated by downstream SRC/ERK/AKT signaling.The aberrant epithelial cell interaction occurs within the basal layer at early precancerous lesions,which expands to the whole epithelial layer and strengthens along the cancer development and progression.Functional analysis revealed that the aberrant EFNB1-EPHB4 interaction is caused by overexpressedΔNP63 due to TP53 mutation,the culprit in human ESCC tumorigenesis.Our results shed new light on the role of TP53-TP63/ΔNP63-EFNB1-EPHB4 axis in EMT and cell proliferation in epithelial cancer formation.

关键词： esophageal TP53 squamous

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Three-dimensional constrained gravity inversion of Moho depth and crustal structural characteristics at Mozambique continental margin

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Acta Oceanologica Sinica 2024年第2期43卷 120-129页

作者： shihao Yang Zhaocai wu Yinxia Fang Mingju Xu Jialing Zhang Fanlin Yang College of Geodesy and Geomatics Shandong University of Science and TechnologyQingdao 266590China Key Laboratory of Submarine Geoscience Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China School of Geomatics and Municipal Engineering Zhejiang University of Water Resources and Electric PowerHangzhou 310018China Ocean College Zhejiang UniversityZhoushan 316021China

Mozambique's continental margin in East Africa was formed during the break-off stage of the east and west Gondwana lands. Studying the geological structure and division of continent-ocean boundary(COB) in Mozambique's continental margin is considered of great significance to rebuild Gondwana land and understand its movement mode. Along these lines, in this work, the initial Moho was fit using the known Moho depth from reflection seismic profiles, and a 3D multi-point constrained gravity inversion was carried out. Thus, highaccuracy Moho depth and crustal thickness in the study area were acquired. According to the crustal structure distribution based on the inversion results, the continental crust at the narrowest position of the Mozambique Channel was detected. According to the analysis of the crustal thickness, the Mozambique ridge is generally oceanic crust and the COB of the whole Mozambique continental margin is divided.

关键词： 3D constrained gravity inversion continent-ocean boundary Mozambique continental margin Moho depth

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Power-efficient programmable integrated multiport photonic interferometer in CMOS-compatible silicon nitride

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Photonics Research 2024年第3期12卷 I0011-I0020页

作者： SHUQING LIN YANFENG ZHANG ZHAOYANG wu shihao ZENG QING GAO JIAQI LI XIAOQUN YU SIYUAN YU State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologySun Yat-sen UniversityGuangzhou 510275China Hefei National Laboratory Hefei 230088China

Silicon nitride(SiNx)is an appealing waveguide material choice for large-scale,high-performance photonic integrated circuits(PICs)due to its low optical loss.However,SiNx PICs require high electric power to realize optical reconfiguration via the weak thermo-optic effect,which limits their scalability in terms of device density and chip power dissipation.We report a 6-mode programmable interferometer PIC operating at the wavelength of 1550 nm on a CMOS-compatible low-temperature inductance coupled plasma chemical vapor deposition(ICP-CVD)silicon nitride platform.By employing suspended thermo-optic phase shifters,the PIC achieves 2×improvement in compactness and 10×enhancement in power efficiency compared to conventional devices.Reconfigurable 6-dimensional linear transformations are demonstrated including cyclic transformations and arbitrary unitary matrices.This work demonstrates the feasibility of fabricating power-efficient large-scale reconfigurable PICs on the low-temperature ICP-CVD silicon nitride platform.

关键词： unitary arbitrary figuration

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Polyimide covalent organic frameworks as efficient solid-state Li^(+) electrolytes

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Science China Chemistry 2024年第5期67卷 1647-1652页

作者： Xu Liu Shi Wang Siqi Liu Chengfang Liu Xiangchun Li Jian wu Dazhi Li shihao Xu Chongyang Liu Wen-Yong Lai State Key Laboratory of Organic Electronics and Information Displays(SKLOEID) Institute of Advanced Materials(IAM)School of Chemistry and Life SciencesNanjing University of Posts&TelecommunicationsNanjing 210023China

Covalent organic frameworks(COFs) are attractive porous crystalline materials with extremely high stability, easy functionalization, and open channels, which are expected to be unique ion conductors/transporters in lithium ion batteries(LIBs). Despite recent advances, low ion conductivity and low transference number, resulting in low charging/discharging rate, low energy density, and short battery life, are the main issues that limit their direct application as solid electrolytes in LIBs. Here, we designed and synthesized a novel polyimide COF, namely, TAPA-PDI-COF, with abundant C=O groups, which has been successfully employed as high-performance solid electrolytes by doping TAPA-PDI-COF and succinonitrile(SN). Both the well-defined nanochannels of COFs and SN confined in the well-aligned channels restricted the free migration of anions, while C=O on COFs and CN groups of SN enhanced Li^(+) transport, thus achieving a high ion conductivity of 0.102 m S cm^(-1)at 80 °C and a high lithium-ion transference number of 0.855 at room temperature. According to density functional theory(DFT)calculations, Li-ion migration mainly adopted in-plane transport rather than the axial pathway, which may be due to the shorter hopping distances in the planar pathway. The results suggest an effective strategy for the design and development of all-solidstate ionic conductors for achieving high-performance LIBs.

关键词： lithium ion batteries(LIBs) covalent organic frameworks(COFs) solid-state ion conductors solid-state electrolytes ion conductivity

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Antioxidant and Hypoglycemic Ability of Ardisia gigantifolia Stapf Parts

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Medicinal Plant 2024年第1期15卷 88-91页

作者： Chaohao GU shihao LIANG Yuexuan wu Zhiren YAO Jiaojiao LI Kaimei ZHU Guilin Medical University Guilin 541000China Second Affiliated Hospital of Guilin Medical University Guilin 541000China

[Objectives]To study the antioxidant and hypoglycemic effects of different parts of Ardisia gigantifolia Stapf.[Methods]The hydroxyl radical scavenging activity,DPPH radical scavenging activity and total antioxidant capacity of ABTS of 75%ethanol extract of A.gigantifolia Stapf and the petroleum ether,ethyl acetate,n-butanol,chloroform and aqueous extract were measured with Vc as positive control.At the same time,acarbose was used as reference substance to determine the inhibitory effect of each polar site onα-glucosidase.[Results]All parts of A.gigantifolia Stapf had antioxidant activity,among which ethyl acetate had the strongest antioxidant activity,and the scavenging rate of hydroxyl radical and DPPH radical was higher than that of positive control.The results showed that petroleum ether,ethyl acetate and chloroform had a good inhibitory effect onα-glucosidase(better than acarbose).[Conclusions]The ethyl acetate part of A.gigantifolia Stapf had the best antioxidant activity and inhibitory effect onα-glucosidase.It provides a basis for further research and development of A.gigantifolia Stapf.

关键词： Ardisia gigantifolia Stapf Antioxidants Free radicals Hypoglycemic effect

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赣南马尾松林地表细小死可燃物含水率动态及模型

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林业科学 2024年第5期60卷 158-168页

作者：朱诗豪吴志伟李政杰李顺江西师范大学地理与环境学院、江西师范大学鄱阳湖湿地与流域研究教育部重点实验室、江西省自然灾害监测预警与评估重点实验室南昌330022

[目的]建立森林地表细小死可燃物(枯落叶、细枯枝、枯草等)含水率预测模型,预警区域森林火灾引燃的可能性及其潜在火行为。[方法]基于野外长期定位观测的赣南地区典型植被类型马尾松林地表细小死可燃物含水率数据,在不同地形条件和时间... 详细信息

[目的]建立森林地表细小死可燃物(枯落叶、细枯枝、枯草等)含水率预测模型,预警区域森林火灾引燃的可能性及其潜在火行为。[方法]基于野外长期定位观测的赣南地区典型植被类型马尾松林地表细小死可燃物含水率数据,在不同地形条件和时间段进行气象因子随机森林相对重要性排序和皮尔逊相关性分析,建立地表细小死可燃物含水率随机森林模型和气象要素回归模型,比较不同模型精度指标,筛选适合赣南地区的森林火灾预测模型。[结果]赣南地区马尾松林地表细小死可燃物含水率具有明显变异性,阴坡含水率显著高于阳坡,在防火期初期最明显。地表细小死可燃物含水率与各气象要素(温度、相对湿度、风速、光照强度)具有极显著相关性(P<0.001);随机森林模型预测精度高于气象要素回归模型,阴坡2种模型精度均高于阳坡;具有滞后效应的光照强度因子对地表细小死可燃物含水率影响最大,影响地表细小死可燃物含水率的关键因素在阳坡是相对湿度、阴坡是风速。[结论]具有滞后效应的气象因子对赣南地区马尾松林地表细小死可燃物含水率有显著影响,考虑增加这些因素能更好预测地表细小死可燃物含水率变化,为火险预警提供可靠依据。

关键词：地表细小死可燃物含水率预测模型气象要素回归模型随机森林赣南地区

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QNE1 is a key flowering regulator determining the length of the vegetative period in soybean cultivars

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Science China(Life Sciences) 2022年第12期65卷 2472-2490页

作者： Zhengjun Xia Hong Zhai Yanfeng Zhang Yaying Wang Lu Wang Kun Xu Hongyan wu Jinglong Zhu Shuang Jiao Zhao Wan Xiaobin Zhu Yi Gao Yingxiang Liu Rong Fan shihao wu Xin Chen Jinyu Liu Jiayin Yang Qijian Song Zhixi Tian Key Laboratory of Soybean Molecular Design Breeding Northeast Institute of Geography and AgroecologyInnovation Academy for Seed DesignChinese Academy of SciencesHarbin 150081China Hybrid Rapeseed Research Center of Shaanxi Province Yangling 712100China College of Life Science Northeast Agricultural UniversityHarbin 150030China Institute of Industrial Crops Jiangsu Academy of Agricultural SciencesNanjing 210014China Huaiyin Institute of Agricultural Science of Xuhuai Region Jiangsu Academy of Agricultural SciencesHuai’an 223001China USDA ARS Soybean Genome&Improvement LabBeltsville 20705USA State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyInnovation Academy for Seed DesignChinese Academy of SciencesBeijing 100101China

The soybean E1 gene is a major regulator that plays an important role in flowering time and maturity.However,it remains unclear how cultivars carrying the dominant E1 allele adapt to the higher latitudinal areas of northern China.We mapped the novel quantitative trait locus QNE1(QTL near E1) for flowering time to the region proximal to E1 on chromosome 6 in two mapping populations.Positional cloning revealed Glyma.06G204300,encoding a TCP-type transcription factor,as a strong candidate gene for QNE1.Association analysis further confirmed that functional single nucleotide polymorphisms(SNPs) at nucleotides 686 and 1,063 in the coding region of Glyma.06G204300 were significantly associated with flowering time.The protein encoded by the candidate gene is localized primarily to the nucleus.Furthermore,soybean and Brassica napus plants overexpressing Glyma.06G204300 exhibited early flowering.We conclude that despite their similar effects on flowering time,QNE1 and E4 may control flowering time through different regulatory mechanisms,based on expression studies and weighted gene co-expression network analysis of flowering time-related genes.Deciphering the molecular basis of QNE1 control of flowering time enriches our knowledge of flowering gene networks in soybean and will facilitate breeding soybean cultivars with broader latitudinal adaptation.

关键词： QNE1 soybean TCP flowering time vegetative period maturity Zhonghuang 13

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斜齿轮时变啮合刚度改进算法及影响因素分析

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机械强度 2024年第2期46卷 312-319页

作者：吴鲁纪杨世豪冯伟杨林杰郑州机械研究所有限公司郑州450001 同济大学机械与能源工程学院上海201804 河南工业大学机电工程学院郑州450001

在势能法基础上,基于切片积分原理,考虑齿根过渡曲线方程,提出一种改进的斜齿时变啮合刚度计算方法。该方法考虑了真实齿根过渡曲线参数方程,修正了渐开线齿廓的积分区间,与有限元方法的对比结果验证了算法的有效性,减小了时变啮合刚度... 详细信息

在势能法基础上,基于切片积分原理,考虑齿根过渡曲线方程,提出一种改进的斜齿时变啮合刚度计算方法。该方法考虑了真实齿根过渡曲线参数方程,修正了渐开线齿廓的积分区间,与有限元方法的对比结果验证了算法的有效性,减小了时变啮合刚度的计算误差。在此方法基础上,分析了齿宽、螺旋角、齿数和模数对时变啮合刚度的影响。结果表明,时变啮合刚度均值受齿宽影响较大,近似成线性关系;受螺旋角、齿数影响较小;螺旋角增大,均值以较小幅度波动性变化;中心距一定时,齿数增大,时变啮合刚度缓慢增大;齿轮参数改变会影响重合度;轴向重合度为整数时,时变啮合刚度波动值较小。

关键词：斜齿轮重合度改进势能法时变啮合刚度

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江西省赣州市南康区松材线虫病发生特征

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应用生态学报 2024年第2期35卷 507-515页

作者：袁佳玉熊立吴志伟朱诗豪康平李顺江西师范大学鄱阳湖湿地与流域研究教育部重点实验室南昌330022 江西师范大学江西省自然灾害监测预警与评估重点实验室南昌330022 江西师范大学地理与环境学院南昌330022 江西省减灾备灾中心南昌330022

松材线虫病是我国南方森林面临的主要灾害之一。本文基于野外调查和高分一号(GF⁃1)卫星WFV影像数据,采用随机森林模型构建松材线虫病空间识别模型,探究地形、人类活动和林分因子等对病害发生的影响,监测病害空间分布,并采用空间自相关... 详细信息

松材线虫病是我国南方森林面临的主要灾害之一。本文基于野外调查和高分一号(GF⁃1)卫星WFV影像数据,采用随机森林模型构建松材线虫病空间识别模型,探究地形、人类活动和林分因子等对病害发生的影响,监测病害空间分布,并采用空间自相关性分析评估江西省赣州市南康区松材线虫病发生特征。结果表明:构建模型对松材线虫病的识别效果良好(AUC值=0.99,总体精度=0.96),可以实现对区域松材线虫病空间分布情况的有效监测;归一化差异绿度指数(NDGI)、距高速公路的距离、归一化植被指数(NDVI)是重要的建模因子;空间自相关性分析表明,松材线虫病的发生存在明显的空间正相关性即空间聚集性特征;南康区松材线虫病高发生区集中于赤土乡、朱坊镇和十八塘乡,低发生区集中于蓉江街道附近;分析变量的边际效应发现,离高速公路远、离县道近的低海拔地段是松材线虫病易发区域。研究结果可服务于区域松材线虫病分布的快速监测,对该病害防治和管理具有一定的指导意义。

关键词：松材线虫病监测模型随机森林多光谱数据 GF⁃1 WFV

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