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Material basis and pharmacodynamic mechanism of YangshenDingzhi granules in the intervention of viral pneumonia:Based on serum pharmacochemistry and network pharmacology

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Animal Models and Experimental Medicine 2024年第3期7卷 259-274页

作者： Huirong Xu Meiyue Dong Ruikun Du chengcheng Zhang Zinuo chen Guangyu Tian Qinghua Cui Kejian Li College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinanChina Innovative Institute of Chinese Medicine and Pharmacy Shandong University of Traditional Chinese MedicineJinanChina Qingdao Academy of Chinese Medical Sciences Shandong University of Traditional Chinese MedicineQingdaoChina College of Pharmacy Shandong University of Traditional Chinese MedicineJinanChina

Background:YangshenDingzhi granules(YSDZ)are clinically effective in preventing and treating *** present study elucidates the underlying mechanism of YSDZ intervention in viral pneumonia by employing serum pharmacochemistry and network ***:The chemical constituents of YSDZ in the blood were examined using ultraperformance liquid chromatography-quadrupole/orbitrap high-resolution mass spectrometry(UPLC-Q-Exactive Orbitrap MS).Potential protein targets were obtained from the SwissTargetPrediction database,and the target genes associated with viral pneumonia were identified using GeneCards,DisGeNET,and Online Mendelian Inheritance in Man(OMIM)*** intersection of blood component-related targets and disease-related targets was determined using Venny ***-protein interaction networks were constructed using the STRING *** Metascape database was employed to perform enrichment analyses of Gene Ontology(GO)functions and Kyoto Encyclopedia of Genes and Genomes(KEGG)signaling pathways for the targets,while the Cytoscape 3.9.1 software was utilized to construct drug-component-disease-target-pathway ***,in vitro and in vivo experiments were performed to establish the therapeutic effectiveness of YSDZ against viral ***:Fifteen compounds and 124 targets linked to viral pneumonia were detected in *** these,MAPK1,MAPK3,AKT1,EGFR,and TNF play significant *** vitro tests revealed that the medicated serum suppressed the replication of H1N1,RSV,and SARS-CoV-2 ***,in vivo testing analysis shows that YSDZ decreases the viral load in the lungs of mice infected with RSV and ***:The chemical constituents of YSDZ in the blood may elicit therapeutic effects against viral pneumonia by targeting multiple proteins and pathways.

关键词： network pharmacology pharmacodynamical material basis serum pharmacochemistry viral pneumonia YangshenDingzhi granules

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An analysis of the transcriptional landscape in hypoxia-treated primary nucleus pulposus cells

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Genes & Diseases 2024年第2期11卷 558-560页

作者： Zhicai Peng Zhuo Wang Shuaichi Guo Bing Tan Ruichao Cao Shengqiang cheng Jun chen Chunwang Xie Dehong Mao Zhenming Hu Department of Orthopaedics Yongchuan Traditional Chinese Medicine Hospital of ChongqingChongqing 402160China Department of Orthopaedic Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Department of Spine Surgery The Third Hospital of MianyangSichuan Mental Health CenterMianyangSichuan 621000China

Intervertebral disc degeneration(IDD)is the main cause of lower back *** back pain places a huge burden on society,and all current treatments for IDD cannot restore the original function of the intervertebral *** new treatments for IDD requires clarifying the mechanisms of *** hypoxia is an important feature of the nucleus pulposus because of its special anatomical *** RNA sequencing(RNA-seq),we obtained the whole transcriptome of nucleus pulposus cells(NPCs)under hypoxia and hypoxia-inducible factor(HIF1A)*** demonstrated possible effects of oxygen concentration and HIF1A on *** addition,our results showed that hypoxia can affect lipid metabolism in NPCs.

关键词： structure metabolism degeneration

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Celastrol regulates the oligomeric state and chaperone activity of αB-crystallin linked with protein homeostasis in the lens

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Fundamental Research 2024年第2期4卷 394-400页

作者： Huaxia Wang Qing Tian Ying Zhang Yibo Xi Lidan Hu Ke Yao Jingyuan Li Xiangjun chen Eye Center of the Second Affiliated Hospital Zhejiang University School of Medicine88 Jiefang RoadHangzhou 310009China Institute of Translational Medicine Zhejiang University School of Medicine268 Kaixuan RoadHangzhou 310020China. State Key Laboratory of Membrane Biology School of Life SciencesTsinghua UniversityBeijing 100084China The Children’s Hospital Zhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Zhejiang Province Key Laboratory of Quantum Technology and Device Department of PhysicsZhejiang UniversityZheda Road 38Hangzhou 310027China

Protein misfolding and aggregation are crucial pathogenic factors for cataracts,which are the leading cause of visual impairment worldwide.α-crystallin,as a small molecular chaperone,is involved in preventing protein misfolding and maintaining lens *** chaperone activity of α-crystallin depends on its oligomeric *** previous work identified a natural compound,celastrol,which could regulate the oligomeric state of α*** this work,based on the UNcle and SEC analysis,we found that celastrol induced𝛼αB-crystallin to form large *** oligomer formation enhanced the chaperone activity of αB-crystallin and prevented aggregation of the cataract-causing mutant α*** interactions between𝛼αB-crystallin and celastrol were detected by the FRET(Fluorescence Resonance Energy Transfer)technique,and verified by molecular *** least 9 binding patterns were recognized,and some binding sites covered the groove structure of α***,αB-R120G,a cataract-causing mutation located at the groove structure,and celastrol can decrease the aggregates of α***,our results suggested celastrol not only promoted the formation of large αB-crystallin oligomers,which enhanced its chaperone activity,but also bound to the groove structure of its α-crystallin domain to maintain its structural *** might serve as a chemical and pharmacological chaperone for cataract treatment.

关键词： αB-crystallin Celastrol Interactions Oligomeric state Chaperone activity Structural stability

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Delicate chemical structure regulation of nonfullerene acceptor for efficient and large thickness organic solar cells

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Science China Chemistry 2024年第5期67卷 1596-1604页

作者： Zhe Zhang Wanying Feng Yunxin Zhang Shaohui Yuan Yuyang Bai Peiran Wang Zhaoyang Yao chenxi Li Tainan Duan Xiangjian Wan Bin Kan Yongsheng chen State Key Laboratory and Institute of Elemento-Organic Chemistry Frontiers Science Center for New Organic MatterThe Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer MaterialsRenewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai UniversityTianjin 300071China School of Materials Science and Engineering National Institute for Advanced MaterialsNankai UniversityTianjin 300350China Chongqing Institute of Green and Intelligent Technology Chongqing SchoolUniversity of Chinese Academy of Sciences(UCAS Chongqing)Chinese Academy of SciencesChongqing 400722China

Inspired by the success of CH-series acceptors, a small-molecular acceptor, CH-Tz was reported by adopting a new conjugationextended electron-deficient unit([1,2,5]thiadiazolo[3,4-b]pyrazine) on the central core. Owing to the enhanced inter-/intramolecular interactions, CH-Tz exhibited near-infrared absorption and an effective three-dimensional molecular packing network in its single crystal. When blended with polymer donor PM6, the binary device achieved a high power conversion efficiency(PCE) of 18.54%, with a notable short-circuit current density(J_(sc)) of 27.54 m A cm-2and an excellent fill factor(FF) over 80%,which can be partly ascribed to the balanced charge transport properties in the blend film. After employing D18-Cl as the third component, an enhanced PCE of 18.85% was achieved due to a more obvious fiber network. Impressively, the CH-Tz-based OSC devices show excellent thermal stability and thickness insensitivity. Record-breaking Jscof 28.92 m A cm-2was reached for PM6:D18-Cl:CH-Tz ternary device with a thickness of 560 nm. Besides, CH-Tz shows potential in fabricating multicomponent high-performance organic solar cells, where over 19% efficiency could be realized in the quaternary device. Our work advances the strong influence of electron-deficient central units on molecular photovoltaic properties and guides the design of acceptors for stable and large-thickness organic solar cells.

关键词： organic solar cells non-fullerene acceptor central unit large thickness molecular packing

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Hetero-phase zirconia encapsulated with Au nanoparticles for boosting electrocatalytic nitrogen reduction

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Chinese Chemical Letters 2024年第5期35卷 509-513页

作者： Xue Xin Qiming Qu Islam E.Khalil Yuting Huang Mo Wei Jie chen Weina Zhang Fengwei Huo Wenjing Liu Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech UniversityNanjing 211816China

Electrocatalytic nitrogen reduction reaction(NRR)is considered as an attractive approach for ammonia synthesis under mild conditions.A bottleneck of NRR is the exploration of efficient catalysts for accelerating reaction kinetics,among which heterogeneous structures possessing distinct atomic arrangement could modify electronic structure,and therefore altering their NRR ***,we report a facile strategy for fabricating hetero-phase metal oxides derived from metal organic framework that are further integrated with Au nanoparticles as NRR *** phase composition of zirconia can be easily adjusted by simply changing the reaction temperature,where the monoclinic and tetragonal phases with the roughly close proportions have a distinct interface,leading to a strong interaction between Au and ZrO_(2).The enhanced interaction renders Au to be more electropositive and facilitates stronger binding to N_(2).As a result,a remarkable ammonia yield of 22.32μg h^(-1)mg_(cat.)^(-1) and a Faradaic efficiency of 31.92%can be achieved at low *** work is expected to pave the way for the design of heterogeneous structures and the exploration of hetero-phase nanostructures in boosting the electrocatalytic NRR.

关键词： Hetero-phase Metal-organic framework derivatives Zirconia Nitrogen reduction reaction Electrochemistry

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Sedimentary architecture of submarine channel-lobe systems under different seafloor topography:Insights from the Rovuma Basin offshore East Africa

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Petroleum Science 2024年第1期21卷 125-142页

作者： Mei chen Sheng-He Wu Rui-Feng Wang Jia-Jia Zhang Peng-Fei Xie Min Wang Xiao-Feng Wang Ji-Tao Yu Qi-Cong Xiong State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China College of Geosciences China University of Petroleum(Beijing)Beijing102249China Faculty of Geosciences University of BremenBremen28359Germany MARUM-Center for Marine and Environmental Sciences University of BremenBremen28359Germany Research institute of Petroleum Exploration and Development PetroChinaBeijing10083China School of Geosciences Yangtze UniversityWuhan 100083HubeiChina CNODC Mozambique Ltd. Beijing 100034China

Seafloor topography plays an important role in the evolution of submarine ***,it is still not so clear how the shape of slope affects the three-dimensional(3-D)architecture of submarine *** this study,we analyze the effect of topography factors on different hierarchical lobe architectures that formed during Pliocene to Quaternary in the Rovuma Basin offshore East *** characterize the shape,size and growth pattern of different hierarchical lobe architectures using 3-D seismic *** find that the relief of the topographic slope determines the location of preferential deposition of lobe complexes and single *** the topography is irregular and presents topographic lows,lobe complexes first infill these *** lobes are deposited preferentially at positions with higher longitudinal(***-slope)slope *** the longitudinal slope becomes higher,the aspect ratio of the single lobes ***(***-slope)topography does not seem to have a strong influence on the shape of single lobe,but it seems to affect the overlap of single *** the lateral slope gradient is relatively high,the single lobes tend to have a larger overlap ***,as the average of lateral slope and longitudinal slope gets greater,the width/thickness ratio of the single lobe is smaller,*** tend to accumulate *** results demonstrate that the shape of slopes more comprehensively influences the 3-D architecture of lobes in natural deep-sea systems than previously other lobe deposits and analogue experiments,which helps us better understand the development and evolution of the distal parts of turbidite systems.

关键词： Submarine fan Seafloor topography Sedimentary architecture Slope system SW Indian ocean

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使用全局自注意Teager能量倒谱系数检测重放欺骗语音

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声学学报 2024年第5期49卷 1122-1130页

作者：陈铭陈雪勤苏州大学电子信息学院苏州215006

提出了一种基于能量的前端特征提取方法,旨在应对自动说话人验证系统中面临的重放攻击威胁。该方法实现了全频段上的可变分辨率,以充分利用重放语音与真实语音在子带能量上的高鉴别非线性信息。首先,通过采用F-ratio方法统计分析了多种... 详细信息

提出了一种基于能量的前端特征提取方法,旨在应对自动说话人验证系统中面临的重放攻击威胁。该方法实现了全频段上的可变分辨率,以充分利用重放语音与真实语音在子带能量上的高鉴别非线性信息。首先,通过采用F-ratio方法统计分析了多种录音和播放设备。接着,根据统计结果在全频段上设计了一组滤波器,旨在捕获高鉴别能量信息。最后,利用Teager能量算子计算子带滤波信号的能量,提出了全局自注意Teager能量倒谱系数(GSTECC)。为了验证所提方法的有效性,采用高斯混合模型作为分类器,在ASVspoof 2017 V2和ASVspoof 2021 PA数据库上进行了一系列测试实验。实验结果表明,相对于其他先进特征提取方法,所提GSTECC特征在检测重放攻击方面表现出更优异的性能。

关键词：说话人验证重放攻击检测全局自注意特征 Teager 能量倒谱系数非线性滤波器组

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The Catastrophe of Civilization:The Destruction of the Grandeur of the Old Summer Palace

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China Book International 2024年第2期 18-21页

作者： chen Wenping An Su Shanghai University China Overseas Cultural Relics Research Center expert review committee for the China National Arts Fund(CNAF) Collection Department of the Tsinghua University Art Museum sub-project group for the“Research on the Standard System of China's Intangible Cultural Heritage”under the National Social Science Fund project

The first part of this book follows the thread of ten major events involving the dispersal of cultural relics,unveiling the complex truths behind the loss of national *** latter part meticulously selects 108 precious relics overseas,ranging from the Neolithic era to the Qing Dynasty,covering Dunhuang relics,calligraphy,ceramics,bronzes,jades,lacquerware,sculptures,and oracle bone scriptures,*** interprets the historical background,craftsmanship,color details,aesthetic design,and symbolic meanings,encompassing exquisite collections from dozens of institutions abroad,offering a glimpse into the rare treasures of Chinese heritage.

关键词： oracle struction offering

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Review on laser directed energy deposited aluminum alloys

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International Journal of Extreme Manufacturing 2024年第2期6卷 84-131页

作者： Tian-Shu Liu Peng chen Feng Qiu Hong-Yu Yang Nicholas Tan Yew Jin Youxiang Chew Di Wang Ruidi Li Qi-Chuan Jiang Chaolin Tan Singapore Institute of Manufacturing Technology(SIMTech) Agency for ScienceTechnology and Research(A∗STAR)5 Cleantech LoopSingapore 636732Singapore State Key Laboratory of Automotive Simulation and Control Jilin UniversityChangchun 130025People’s Republic of China Key Laboratory of Automobile Materials Ministry of Education and Department of Materials Science and EngineeringJilin UniversityChangchun 130025People’s Republic of China School of Mechanical&Automotive Engineering South China University of TechnologyGuangzhou 510640People’s Republic of China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083People’s Republic of China

Lightweight aluminum(Al)alloys have been widely used in frontier fields like aerospace and automotive industries,which attracts great interest in additive manufacturing(AM)to process high-value Al *** a mainstream AM technique,laser-directed energy deposition(LDED)shows good scalability to meet the requirements for large-format component manufacturing and ***,LDED Al alloys are highly challenging due to their inherent poor printability(*** laser absorption,high oxidation sensitivity and cracking tendency).To further promote the development of LDED high-performance Al alloys,this review offers a deep understanding of the challenges and strategies to improve printability in LDED Al *** porosity,cracking,distortion,inclusions,element evaporation and resultant inferior mechanical properties(worse than laser powder bed fusion)are the key challenges in LDED Al *** parameter optimizations,in-situ alloy design,reinforcing particle addition and field assistance are the efficient approaches to improving the printability and performance of LDED Al *** underlying correlations between processes,alloy innovation,characteristic microstructures,and achievable performances in LDED Al alloys are *** benchmark mechanical properties and primary strengthening mechanism of LDED Al alloys are *** review aims to provide a critical and in-depth evaluation of current progress in LDED Al *** opportunities and perspectives in LDED high-performance Al alloys are also outlined.

关键词： additive manufacturing laser directed energy deposition(LDED) aluminum alloys printability aluminum matrix composite auxiliary fields mechanical properties

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Asymmetric orbital hybridization in Zn-doped antiperovskite Cu_(1-x)Zn_(x)NMn_(3)enables highly efficient electrocatalytic hydrogen production

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Journal of Energy Chemistry 2024年第2期89卷 304-312,I0008页

作者： Yuxiang Yan Yuxin Cao Zhichao Wang Ka Wang Hengdong Ren Shaoqi Zhang Yi Wang Jian chen Yong Zhou Lizhe Liu Jun Dai Xinglong Wu National Laboratory of Solid States Microstructures and School of Physics Nanjing UniversityNanjing 210093JiangsuChina College of Engineering and Applied Sciences Nanjing UniversityNanjing 210093JiangsuChina National Laboratory of Solid States Microstructures and Research Institute of Superconductor Electronics Nanjing UniversityNanjing 210093JiangsuChina School of Mathematics&Physics Jiangsu University Science&TechnologyZhenjiang 212003JiangsuChina

Rational design of efficient and robust earth-abundant alkaline hydrogen evolution reaction(HER)catalysts is a key factor for developing energy conversion ***,antiperovskite nitride CuNMn_(3)has garnered significant interest due to its remarkable properties such as negative/zero thermal expansion and magnetocaloric ***,when utilized as hydrogen evolution catalysts,it encounters large challenge resulting from excessively strong/weak interactions with adsorbed H on Mn/Cu active sites,which leads to low HER *** this study,we introduce an asymmetric orbital hybridization strategy in Zn-doped Cu_(1-x)Zn_(x)NMn_(3)by leveraging the localization of Zn electronic states to reconfigure the electronic structures of Cu and Mn,thereby reducing the energy barrier for water dissociation and optimizing Cu and Mn active sites for hydrogen adsorption and H_(2)*** evaluations reveal that Cu_(0.85)Zn_(0.15)NMn_(3)with x=0.15 demonstrates exceptional electrocatalytic activity in alkaline electrolytes.A low overpotential of 52 mV at 10 mA cm^(-2)and outstanding stability over a 150-h test period are achieved,surpassing commercial Pt/*** research offers a novel strategy for enhancing HER performance by modulating asymmetric hybridization of electron orbitals between multiple metal atoms within a material structure.

关键词： Cu_(1-x)ZnxNMn_(3) Asymmetric orbital hybridization Hydrogen adsorption Hydrogen production

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