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Region-specific microRNA signatures in the human epididymis

Asian Journal of Andrology 2018年第6期20卷 539-544页

作者： James A Browne shih-hsing leir Scott E Eggener Ann Harris Department of Genetics and Genome Sciences Case Western Reserve UniversityClevelandOH 44106USA Human Molecular Genetics Program Lurie Children＇s Research CenterChicagoIL 60614USA Department of Pediatrics Northwestern University Feinberg School of MedicineChicagoIL 60611USA Section of Urology University of Chicago Medical CenterChicagoIL 60611USA.

The epithelium of the human epididymis maintains an appropriate luminal environment for sperm maturation that is essential for male fertility. Regional expression of small noncoding RNAs such as microRNAs contributes to segment-specific gene expression and differentiated functions. MicroRNA profiles were reported in human epididymal tissues but not specifically in the epithelial cells derived from those regions. Here, we reveal miRNA signatures of primary cultures of caput, corpus, and cauda epididymis epithelial cells and of the tissues from which they were derived. We identify 324 epithelial cell-derived microRNAs and 259 tissue-derived microRNAs in the epididymis, some of which displayed regionalized expression patterns in cells and/or tissues. Caput cell-enriched miRNAs included miR-573 and miR-155. Cauda cell-enriched miRNAs included miR-1204 and miR-770. Next, we determined the gene ontology pathways associated with in silico predicted target genes of the differentially expressed miRNAs. The effect of androgen receptor stimulation on miRNA expression was also investigated. These data show novel epithelial cell-derived miRNAs that may regulate the expression of important gene networks that are responsible for the regionalized gene expression and function of the epididymis.

关键词： caput cauda corpus human epididymis microRNA

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Epidermal stem cells and skin tissue engineering in hair follicle regeneration

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World Journal of Stem Cells 2015年第4期7卷 711-727页

作者： María Eugenia Balaná Hernán Eduardo Charreau Gustavo Jose leirós Fundación Pablo Cassará-Instituto de Ciencia y Tecnología Dr.César Milstein Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Saladillo 2468 C1440FFXCiudad de Buenos AiresArgentina Technology Intelligence Unit ClarkeModet&C°Lavalle 1903°PisoC1047AAD Buenos AiresArgentina

The reconstitution of a fully organized and functional hair follicle from dissociated cells propagated under defined tissue culture conditions is a challenge stillpending in tissue engineering. The loss of hair follicles caused by injuries or pathologies such as alopecia not only affects the patients' psychological well-being, but also endangers certain inherent functions of the skin. It is then of great interest to find different strategies aiming to regenerate or neogenerate the hair follicle under conditions proper of an adult individual. Based upon current knowledge on the epithelial and dermal cells and their interactions during the embryonic hair generation and adult hair cycling, many researchers have tried to obtain mature hair follicles using different strategies and approaches depending on the causes of hair loss. This review summarizes current advances in the different experimental strategies to regenerate or neogenerate hair follicles, with emphasis on those involving neogenesis of hair follicles in adult individuals using isolated cells and tissue engineering. Most of these experiments were performed using rodent cells, particularly from embryonic or newborn origin. However, no successful strategy to generate human hair follicles from adult cells has yet been reported. This review identifies several issues that should be considered to achieve this objective. Perhaps the most important challenge is to provide threedimensional culture conditions mimicking the structure of living tissue. Improving culture conditions that allow the expansion of specific cells while protecting their inductive properties, as well as methods for selecting populations of epithelial stem cells, should give us the necessary tools to overcome the difficulties that constrain human hair follicle neogenesis. An analysis of patent trends shows that the number of patent applications aimed at hair follicle regeneration and neogenesis has been increasing during the last decade. This fiel

关键词： Adult stem cells Skin grafts Epidermis Multipotential differentiation Tissue regeneration Dermal papilla Epithelial-mesenchymal interactions

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Review on the management of cardiovascular risk factors in the elderly

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Journal of Geriatric Cardiology 2022年第11期19卷 894-927页

作者： Magali González-Colaço Harmand María del Mar García-Sanz Antònia Agustí Pablo César Prada-Arrondo Alberto Domínguez-Rodríguez Beatriz Grandal-leirós David Peña-Otero Natalia Negrín-Mena Jesús Javier López-Hernández Pablo Díez-Villanueva Department of Internal Medicine-Geriatric Medicine Hospital Universitario Nuestra Señora de CandelariaSanta Cruz de TenerifeSpain Universidad Europea de Canarias Faculty of Health SciencesLa OrotavaSpain Clinical Pharmacology Department Hospital Universitario Marqués de ValdecillaSantanderSpain Clinical Pharmacology Department.Hospital Vall d'Hebron BarcelonaSpain Cardiac Surgery Department Hospital Universitario de CanariasLa LagunaTenerifeSpain Cardiology Department Hospital Universitario de CanariasLa LagunaTenerifeSpain Ortogeriatric Department.Hospital Universitario de Canarias La LagunaTenerifeSpain Subdepartment of Health Care Hospital Universitario Marqués de ValdecillaServicio Cántabro de SaludSantanderSpain Instituto de Investigación Sanitaria Gregorio Marañón(liSGM)y Valdecilla(IDIVAL) Spain Hospital Universitario de Canarias Sistema Canario de SaludTenerifeSpain Primary Care Management Servicio Cántabro de SaludSpain Cardiology Department Hospital de la PrincesaMadridSpain

Cardiovascular risk factors(CVRF)are very prevalent in the elderly population and in addition to predisposing to cardiovascular disease they are related to functional decline,which limits the quality of life in this *** objective of this work is to offer a review of the current evidence in the management of CVRF in the elderly *** search strategy was executed in PubMed,*** and Embase,to search for clinical trials,observational cohort or cross-sectional studies,reviews,and clinical practice guidelines focused or including elderly *** results provided were refined after reading the title and abstract,as well as elimination of duplicates,and were finally identified and assessed following the GRADE methodology.A total of 136 studies were obtained for all predefined risk factors,such as sedentary lifestyle,smoking,obesity and metabolic syndrome,hypertension,diabetes mellitus,dyslipidemia and *** described the results of the studies identified and assessed according to their methodological quality in different recommendation sections:diagnostic and prevention,intervention,or treatment in the elderly *** the main limitation to the results of this review,there is the lack of quality studies whose target population is elderly *** issue limits the recommendations that can be made in this *** to this reason,comprehensive geriatric assessment seems the best tool currently available to implement the most appropriate treatment plans based on the baseline situation and comorbidity of each elderly patient.

关键词： prevention elderly finally

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利用FPGA实现的以太网分时复用机制及其在时间服务器中的应用设计

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电工技术 2023年第3期 188-190页

作者：杨磊殷仕佳南京科远智慧科技集团股份有限公司江苏南京211102 江苏省热工过程智能控制重点实验室江苏南京211102

介绍了一种利用FPGA实现的以太网分时复用机制,提出了将该机制应用到NT6000分散控制系统时间服务器中的思路,并最终实现了实际应用。首先分析了通用以太网技术的一些原理,包括TCP/IP五层模型的各个层实现方式,进而介绍了该以太网分时复... 详细信息

介绍了一种利用FPGA实现的以太网分时复用机制,提出了将该机制应用到NT6000分散控制系统时间服务器中的思路,并最终实现了实际应用。首先分析了通用以太网技术的一些原理,包括TCP/IP五层模型的各个层实现方式,进而介绍了该以太网分时复用机制的具体原理,进行了优缺点分析,最后介绍了该以太网分时复用机制在NT6000 DCS系统时间服务器中的实际应用案例。

关键词：以太网 FPGA 介质无关接口时间服务器 DCS

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