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Colonic diverticulitis with comorbid diseases may require elective colectomy

World Journal of Gastroenterology 2013年第39期19卷 6613-6617页

作者： Kevin CW Hsiao Joseph G Wann Chien-Sheng Lin chang-chieh Wu Shu-Wen Jao Ming-Hsin Yang Department of Surgery Tri-Service General HospitalNational Defense Medical Center Department of Physiology College of MedicineNational Taiwan University Department of Emergency and Critical Care Medicine Cheng Hsin Rehabilitation Medical Center Department of Emergency Tri-Service General HospitalNational Defense Medical Center

AIM:To investigate the comorbid disease could be the predictors for the elective colectomy in colonic ***:A retrospective chart review of 246 patients with colonic diverticulitis admitted between 2000and 2008 was conducted,and 19 patients received emergent operation were identified and *** were collected with regard to age,sex,albumin level on admission,left or right inflammation site,the history of recurrent diverticulitis,preoperative comorbidity,smoking habits,medication,treatment policy,morbidity,and *** comorbid diseases included cardiovascular disease,diabetes,pulmonary disease,peptic ulcer disease,gouty arthritis,and *** in use included non-steroidal anti-inflammatory drugs,acetylsalicylic acid(Aspirin),and *** and multivariate logistic regression analyses were performed to identify the relevant risk factors correlating to ***:The mean age of the 246 patients was 69.5years(range,24-94 years).Most diverticulitis could be managed with conservative treatment(n=227,92.3%),and urgent colectomy was performed in 19patients(7.7%).There were three deaths in the surgical group and four deaths in the nonsurgical *** overall mortality rate in the study was 1.7%among patients with conservative treatment and 15.7%among patients undergoing urgent *** logistic regression analysis indicated that comorbidities were risk factors for urgent colectomy for ***:To avoid high mortality and morbidity related to urgent colectomy,we suggest that patients with colonic diverticulitis and comorbid diseases may require elective colectomy.

关键词： Colonic diverticulitis Colectomy Comorbid disease

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Application of quantitative estimates of fecal hemoglobin concentration for risk prediction of colorectal neoplasia

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World Journal of Gastroenterology 2013年第45期19卷 8366-8372页

作者： Chao-Sheng Liao Yu-Min Lin Hung-Chuen chang Yu-Hung Chen Lee-Won Chong Chun-Hao Chen Yueh-shih Lin Kuo-Ching Yang Chia-Hui shih Division of Gastroenterology Department of Internal Medicine Shin Kong Wu Ho-Su Memorial Hospital Taipei 111 Taiwan School of Medicine Fu Jen Catholic University New Taipei City 24205 Taiwan Department of Family Medicine Shin Kong Wu Ho-Su Memorial Hospital Taipei 111 Taiwan Health Management Center Shin Kong Wu HoSu Memorial Hospital Taipei 111 Taiwan chang Gung Institute of Technology School of Nursing Tao-Yuan 333 Taiwan

AIM:To determine the role of the fecal immunochemical test(FIT),used to evaluate fecal hemoglobin concentration,in the prediction of histological grade and risk of colorectal ***:We enrolled 17881 individuals who attended the two-step colorectal cancer screening program in a single hospital between January 2010 and October *** was recommended to the participants with an FIT of≥12 ngHb/mL *** classified colorectal lesions as cancer(C),advanced adenoma(AA),adenoma(A),and others(O)by their colonoscopic and histological *** linear regression analysis adjusted for age and gender was used to determine the association between the FIT results and colorectal tumor *** risk of adenomatous neoplasia was estimated by calculating the positive predictive values for different FIT ***:The positive rate of the FIT was 10.9%(1948/17881).The attendance rate for colonoscopy was 63.1%(1229/1948).The number of false positive results was *** these 1229 cases,the numbers of O,A,AA,and C were 759,221,201,and 48,*** analysis revealed a positive association between histological grade and FIT concentration(β=0.088,P0.95,P<0.001).CONCLUSION:Higher FIT concentrations are associated with more advanced histological *** prediction for colorectal neoplasia based on individual FIT concentrations is significant and may help to improve the performance of screening programs.

关键词： Colorectal cancer Fecal immunochemical test Screening Risk prediction Performance

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巨噬细胞极化在组织修复过程中的可视化分析

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中国组织工程研究 2025年第7期29卷 1486-1496页

作者：常金霞刘羽飞牛少辉王唱曹建春北京中医药大学北京市100029 中国中医科学院西苑医院北京市100091 北京中医药大学东方医院北京市100078

背景:巨噬细胞在组织修复和再生过程的各个阶段展现出促炎、抗炎、促纤维化、促伤口愈合等多重活性,巨噬细胞的异质性及其平衡极化对器官修复具有决定性作用。目的:通过可视化分析方法探究巨噬细胞极化在组织修复领域的研究热点和发展趋... 详细信息

背景:巨噬细胞在组织修复和再生过程的各个阶段展现出促炎、抗炎、促纤维化、促伤口愈合等多重活性,巨噬细胞的异质性及其平衡极化对器官修复具有决定性作用。目的:通过可视化分析方法探究巨噬细胞极化在组织修复领域的研究热点和发展趋势,以及该领域全球科研与临床工作者的研究水平。方法:利用文献计量分析方法,采用Citespace文献可视化分析软件和VOSviewer工具,在Web of Science Core Collection的科学引文索引扩展(SCI-Expanded)和社会科学引文索引扩展(SSCI-Expanded)数据库中检索2013-2023年间的相关文献,通过动态图谱形式呈现分析结果,揭示研究的主要趋势和焦点。结果与结论:在2013-2023年,有关巨噬细胞极化在组织修复领域的发文量迅速增加,尤其从2017年增加显著;中国研究者的发文量居于第一位(642篇),美国研究者较早关注到该领域;Elisseeff Hennifer H教授对该领域研究有非常高的贡献;上海交通大学是发文量最多的机构;近年来“透明质酸”“调控”等关键词出现频率较高。巨噬细胞极化在组织修复领域的研究主要集中在其多功能性的调节机制、与其他细胞类型的相互作用以及在特定病理条件下的表现,研究热点涵盖了巨噬细胞在创面、心血管疾病、慢性炎症、肿瘤微环境及再生医学中的作用。通过深入理解巨噬细胞的多功能性和极化机制可以开发新的治疗策略,促进组织修复和再生,提高患者治疗效果。

关键词：文献计量学巨噬细胞极化组织修复 VOSviewer Citespace

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Repair of a giant inguinoscrotal hernia with herniation of the ileum and sigmoid colon:A case report

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World Journal of Clinical Cases 2023年第2期11卷 401-407页

作者： shih-Hung Liu Ching-Hen Yen Hsu-Ping Tseng Je-Ming Hu Ching-Han chang Ta-Wei Pu Department of Surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 11490Taiwan Division of Urological Surgery Department of SurgerySongshan BranchTri-Service General HospitalNational Defense Medical CenterTaipei 10581Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 11490Taiwan Department of Surgery Kaohsiung Armed Forces General HospitalKaohsiung 802Taiwan Division of Colon and Rectal Surgery Department of SurgerySongshan BranchTri-Service General HospitalNational Defense Medical CenterTaipei 10581Taiwan

BACKGROUND Giant inguinoscrotal hernias are huge inguinal hernias that extend below the midpoint of the inner thigh in the standing *** inguinoscrotal hernias are rare in developed countries because of their better medical resources and early ***,they can develop in patients who refuse surgery or ignore their *** is inevitable because strangulation and organ perforation can occur,leading to peritonitis and *** surgical approaches include open abdominal and inguinal approaches or a combination of *** SUMMARY We present the case of a 73-year-old man who visited our emergency department with a huge mass in his left scrotum and septic *** computed tomography revealed a large left inguinoscrotal hernia that contained small bowel loops and the *** surgical intervention was performed immediately because intestinal strangulation was highly *** operative repair was performed using a combination of mini-exploratory laparotomy and the inguinal *** incarcerated organs,which included the ileum and sigmoid colon,had relatively good intestinal perfusion without perforation or ischemic *** were successfully reduced into the abdomen,and bowel resection was not necessary.A tension-free prosthetic mesh was used for the hernia *** weeks after the initial surgery,and with adequate antimicrobial therapy,the patient recovered and was discharged from our *** evidence of hernia relapse was noted during the outpatient follow-up examination 3 mo after *** Emergency surgery involving combined mini-exploratory laparotomy and the inguinal approach should be performed for serious incarcerated giant inguinoscrotal hernias.

关键词： Inguinal hernia Ileum Sigmoid colon Sepsis Hernia repair Case report

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数字经济赋能养老服务业跨越“低水平均衡陷阱”

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河北学刊 2025年第1期45卷 152-161页

作者：夏杰长罗敬蔚中国社会科学院财经战略研究院中央财经大学法学院

中国养老服务业正面临低水平需求与高成本供给之间的矛盾,这直接导致养老服务业陷入“低水平均衡陷阱”。数字经济在优化养老资源配置、降低养老服务成本和完善养老生态系统等方面发挥了重要作用,是跨越养老服务业“低水平均衡陷阱”的... 详细信息

中国养老服务业正面临低水平需求与高成本供给之间的矛盾,这直接导致养老服务业陷入“低水平均衡陷阱”。数字经济在优化养老资源配置、降低养老服务成本和完善养老生态系统等方面发挥了重要作用,是跨越养老服务业“低水平均衡陷阱”的重要力量。借力数字经济推动养老服务实现高水平均衡,进而实现养老服务业高质量发展,需要综合施策:适当延长老年群体工作年限;对老年人口进行数字技术培训,助力他们跨越数字鸿沟;利用数字技术优化养老服务的资源配置;多渠道降低养老服务业成本;提升从业人员数字素养。

关键词： “低水平均衡陷阱” 老龄化数字经济养老服务业

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Asialo GM1-positive liver-resident CD8 T cells that express CD44 and LFA-1 are essential for immune clearance of hepatitis B virus

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Cellular & Molecular Immunology 2021年第7期18卷 1772-1782页

作者： Chi-chang Sung Jau-Hau Horng shih-Hong Siao I-Tsu Chyuan Hwei-Fang Tsai Pei-Jer Chen Ping-Ning Hsu Graduate Institute of Immunology College of MedicineNational Taiwan UniversityTaipeiChina Graduate Institute of Microbiology College of MedicineNational Taiwan UniversityTaipeiChina Department of Internal Medicine Cathay General HospitalTaipeiChina School of Medicine College of MedicineFu Jen Catholic UniversityNew Taipei CityChina Department of Internal Medicine Taipei Medical University Shuang Ho HospitalTaipeiChina Graduate Institute of Clinical Medicine College of MedicineNational Taiwan UniversityTaipeiChina Department of Internal Medicine National Taiwan University HospitalTaipeiChina

Persistent hepatitis B virus(HBV)infection results in chronic liver diseases that may progress to chronic hepatitis,liver cirrhosis,and subsequent hepatocellular *** studies demonstrated that adaptive immunity,in particular CD8 T cells,is critical in HBV *** studies have revealed a distinct tissue-localized T cell lineage,tissue-resident memory(TRM)cells,that is crucial for protective immunity in peripheral *** this study,we showed that treatment with an anti-asialo GM1(ASGM1)antibody(Ab),which depletes NK cells,led to impairment of HBV clearance in a mouse animal ***,the ability to clear HBV was not significantly impaired in NFIL3 KO mice,which are deficient in NK cells,implying that other non-NK ASGM1-positive immune cells mediate HBV *** isolated intrahepatic ASGM1-positive cells from NFIL3 KO mice and analyzed the immune phenotype of these *** results demonstrated a distinct population of CD44+LFA-1hi CD8 T cells that were the major intrahepatic ASGM1-positive immune cells in NFIL3 KO ***,transcriptome analysis revealed that these ASGM1-positive CD8 T cells had distinct gene profiles and shared a similar core gene signature with TRM *** addition to both transcriptional and phenotypic liver residency characteristics,ASGM1-positive CD8 T cells were able to home to and be retained in the liver after adoptive *** together,our study results indicate that these ASGM1-positive liver-resident CD8 T cells are the major effector immune cells mediating anti-HBV immunity.

关键词： asialo GM-1 liver-resident CD8 T cells HBV clearance

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Thorium distribution on the Moon:new insights from chang’E-2 gamma-ray spectrometer

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Research in Astronomy and Astrophysics 2019年第6期19卷 1-14页

作者： Meng-Hua Zhu Jin chang Tao Ma State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and Technology Taipa Macao China Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210034 China CAS Center for Excellence in Comparative Planetology Hefei 230026 China

We present the thorium distribution on the lunar surface derived from observations by the chang’E-2 gamma-ray spectrometer(CE-2 GRS). This new map shows a similar thorium distribution to previous observations. In combination with this new thorium map and impact cratering model, we investigate the origination of thorium on the Moon’s highlands, which was previously thought to be contributed from Imbrium ejecta. We found that the Imbrium ejecta has a small contribution(~20%–30%) to the thorium on the lunar highlands but most thorium is likely to be indigenous before the deposition of the Imbrium ejecta. This new thorium map also confirms that the eastern highlands have a relatively higher thorium concentration than the western highlands. We propose that the thin crust and large basins on the eastern highlands are responsible for this difference in thorium.

关键词： Moon-chang'E-2 Gamma-ray Spectrometer-Thorium distribution

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PPC-based Reactive Hot Melt Polyurethane Adhesive(RHMPA)--Efficient Glues for Multiple Types of Substrates

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Chinese Journal of Polymer Science 2018年第1期36卷 58-64页

作者： Zeng-He Liu Ji-Qing Huang Li-Jie Sun Dong Lei Jing Cao Shuo Chen Wen-chang shih Feng-Ling Qing Zheng-Wei You State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China Beijing Institute of Aerospace Testing Techn-ology Beijing 100074China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China Department of Chemical and Materials Engineering National Chin-Yi University of TechnologyTaichung 41170China Key Laboratory of Organofluorine Chemistry Shanghai Institute of Organic ChemistryChinese Academy of ScienceShanghai 200032China

Tens of billion metric tons of anthropogenic CO_2 discharged from the burning of fossil fuels lead to an enormous environmental and resource burden. It is charming to transform CO_2 to desirable, economical chemicals and materials. Poly（propylene carbonate）（PPC） is an emerging CO_2-based material. Herein, we report the design, synthesis and characterization of the reactive hot melt polyurethane adhesive（RHMPA） based on PPC polyol. The resultant RHMPAs exhibit good adhesion properties to multiple substrates including plastics（PC, PMMA, ABS） and metals（aluminium, steel）, which is comparable to or even better than conventional RHMPAs prepared from petro-based polyol. Furthermore, the PPC-based RHMPAs have tunable mechanical properties, and are thermally stable in the typical working range of bonding process（up to 270 °C）. The study is expected to expand the applications of PPC and provide a new type of CO_2-based renewable and eco-friendly materials.

关键词： CO_2-based poly(propylene carbonate) Reactive hot melt polyurethane adhesive Sustainable adhesive Adhesion property

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Generalized T-Product Tensor BernsteinBounds

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Annals of Applied Mathematics 2022年第1期38卷 25-61页

作者： shih Yu chang Yimin Wei Department of Applied Data Science San Jose State UniversitySan JoseCA 95192USA School of Mathematical Sciences and Shanghai Key Laboratory of Contemporary Applied Mathematics Fudan UniversityShanghai 200433China

Since Kilmer et *** the new multiplication method between two third-order tensors around 2008 and third-order tensors with such multiplication structure are also called as T-product tensors,T-product tensors have been applied to many fields in science and engineering,such as low-rank tensor approximation,signal processing,image feature extraction,machine learning,computer vision,and the multi-view clustering problem,***,there are very few works dedicated to exploring the behavior of random T-product *** work considers the problem about the tail behavior of the unitarily invariant norm for the summation of random symmetric T-product *** and antisymmetric Kronecker product tools are main techniques utilized to establish inequalities for unitarily norms of multivariate T-product *** Laplace transform method is integrated with these inequalities for unitarily norms of multivariate T-product tensors to provide us with Bernstein bound estimation of Ky Fan k-norm for functions of the symmetric random T-product tensors ***,we also apply T-product Bernstein inequality to bound Ky Fan norm of covariance T-product tensor induced by hypergraph signal processing.

关键词： T-product tensors T-eigenvalues T-singular values Bernstein bound Courant-Fischer theorem for T.product tensors.

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Comparative study and systematic review of laparoscopic liver resection for hepatocellular carcinoma

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World Journal of Hepatology 2015年第27期7卷 2765-2773页

作者： Wei Qi Leong Iyer Shridhar Ganpathi Alfred Wei chieh Kow Krishnakumar Madhavan Stephen Kin Yong chang Division of Hepatobiliary and Pancreatic Surgery Department of Surgery National University Health System Singapore

AIM: To compare the surgical outcomes between laparoscopic liver resection(LLR) and open liver resection(OLR) as a curative treatment in patients with hepatocellular carcinoma(HCC). METHODS: A Pub Med database search was performed systematically to identify comparative studies of LLR vs OLR for HCC from 2000 to 2014. An extensive text word search was conducted, using combinations of search headings such as "laparoscopy", "hepatectomy", and "hepatocellular carcinoma". A comparative study was also performed in our institution where we analysed surgical outcomes of 152 patients who underwent liver resection between January 2005 to December 2012, of which 42 underwent laparoscopic or hand-assisted laparoscopic resection and 110 underwent open resection. RESULTS: Analysis of our own series and a review of 17 high-quality studies showed that LLR was superior to OLR in terms of short-term outcomes, as patients in the laparoscopic arm were found to have less intraoperative blood loss, less blood transfusions, and a shorter length of hospital stay. In our own series, both LLR and OLR groups were found to have similar overall survival(OS) rates, but disease-free survival(DFS) rates were higher in the laparoscopic arm. CONCLUSION: LLR is associated with better short-term outcomes compared to OLR as a curative treatment for HCC. Long-term oncologic outcomes with regards to OS and DFS rates were found to be comparable in both groups. LLR is hence a safe and viable option for curative resection of HCC.

关键词： Hepatocellular carcinoma Laparoscopy Open liver re

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