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Journal of Northeast Agricultural University(English Edition) 2017年第1期24卷 48-53页

作者： Li Chang-qing Alatengdalai Xue Shu-yuan Atsushi Asano Atsushi tajima Naoto Ishikawa Faculty of Life and Environment Science University of TsukubaTsukubaIbaraki 305-8572Japan Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences Hohhot 010031China

The present experiment was conducted to determine the effects of Molasses-Urea Supplementation （MUS） on weight gain, ruminal fermentation and major microbial populations in sheep on a winter grazing regime in Inner Mongolia. Total 40 sheep, allowed free consumption of MUS after grazing, served as a treatment group, while 30 sheep, fed only by pasture grazing, served as a control group. Ruminal fermentation parameters, consisted of pH, Bacterial Crude Protein （BCP） and ammonia nitrogen （NH3-N） were measured. In addition, numbers of five symbiotic bacteria were investigated. The results showed as follows： the average daily weight gain, concentration of NH3-N and numbers of protozoa were significantly higher （p〈0.05） in the treatment group than those in the control group. Contrastingly, no significant difference was found in BCP concentration and pH between the two groups. At the end of the experiment, the populations of Selenomonas ruminantium, Anaerovibrio lipolytica, Fibrobacter succinogenes, Ruminococcus flaveciens and Ruminococcus albus in the treatment group were significantly higher than those of the control group （p〈0.05）. These results demonstrated that greater weight gain could be induced during winter in Inner Mongolia by improved nutritional status through promotion of microbial populations using urea and sugar.

关键词： Molasses-Urea Supplementation (MUS) weight gain ruminal bacteria grazing sheep Inner Mongolia

Inflammatory cytokines promote inducible nitric oxide synthase-mediated DNA damage in hamster gallbladder epithelial cells

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World Journal of Gastroenterology 2007年第47期13卷 6379-6384页

作者： Amane Kitasato Yoshitsugu tajima Tamotsu Kuroki Ryuji Tsutsumi Tomohiko Adachi Takehiro Mishima Takashi Kanematsu Department of Surgery Nagasaki University Graduate School of Biomedical Sciences1-7-1 SakamotoNagasaki 852-8501Japan

AIM: To investigate the link between chronic biliary inflammation and carcinogenesis using hamster gallbladder epithelial cells. METHODS: Gallbladder epithelial cells were isolated from hamsters and cultured with a mixture of inflammatory cytokines including interleukin-1β,interferon-γ,and tumor necrosis factor-α. Inducible nitric oxide synthase (iNOS) expression,nitric oxide (NO) generation,and DNA damage were evaluated. RESULTS: NO generation was increased significantly following cytokine stimulation,and suppressed by an iNOS inhibitor. iNOS mRNA expression was demonstrated in the gallbladder epithelial cells during exposure to inflammatory cytokines. Furthermore,NO-dependent DNA damage,estimated by the comet assay,was significantly increased by cytokines,and decreased to control levels by an iNOS inhibitor. CONCLUSION: Cytokine stimulation induced iNOS expression and NO generation in normal hamster gallbladder epithelial cells,which was sufficient to cause DNA damage. These results indicate that NO-mediated genotoxicity induced by inflammatory cytokines through activation of iNOS may be involved in the process of biliary carcinogenesis in response to chronic inflammation of the biliary tree.

关键词：胆囊癌症状细胞因子氮氧化物

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铁路斜拉桥和吊桥(上)

铁道建筑 1991年第4期31卷 33-36页

作者： Jiro tajima M.Ohashi A.Matsuura 张锻

一、前言在本州—四国连络线上有3座吊桥和2座斜拉桥。它们是公铁两用结构,是濑户内港的主要景观。这些桥梁采用桁式加劲梁,桥梁上面是公路,下面为铁路,如图1所示。

关键词：铁路桥斜拉桥吊桥

Distal gastric tube resection with vascular preservation for gastric tube cancer:A case report and review of literature

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World Journal of Gastrointestinal Surgery 2020年第9期12卷 397-406页

作者： Masahiro Yura Kazuo Koyanagi Kiyohiko Adachi Asuka Hara Keita Hayashi Yuki tajima Yasushi Kaneko Hiroto Fujisaki Akira Hirata Kiminori Takano Kumiko Hongo Kikuo Yo Kimiyasu Yoneyama Reiko Dehari Motohito Nakagawa Department of Surgery Hiratsuka City HospitalKanagawa 2540065Japan Department of Gastroenterological Surgery Tokai University School of MedicineIsehara 2591193Japan Department of Surgical Pathology Hiratsuka City HospitalKanagawa 2540065Japan

BACKGROUND Survival rates in patients with esophageal cancer undergoing esophagectomy have improved,but the prevalence of gastric tube cancer(GTC)has also *** resection of the gastric tube with lymph node dissection is considered a radical treatment,but GTC surgery is more invasive and involves a higher risk of severe complications or death,particularly in elderly *** SUMMARY We report an elderly patient with early GTC that had invaded the duodenum who was successfully treated with resection of the distal gastric tube and Roux-en-Y(R-Y)*** tumor was a type 0-IIc lesion with ulcer scars surrounding the pyloric *** submucosal resection was not indicated because the primary lesion was submucosally invasive,was undifferentiated type,surrounded the pyloric ring,and had invaded the *** of distal gastric tube with R-Y reconstruction was safely performed,with preservation of the right gastroepiploic artery(RGEA)and right gastric artery(RGA).CONCLUSION Distal resection of the gastric tube with preservation of the RGEA and RGA is a good treatment option for elderly patients with cT1bN0 GTC in the lower part of the gastric tube.

关键词： Gastric tube cancer Distal resection Preservation of right gastroepiploic artery and right gastric artery Elderly patients Duodenal invasion Case report Posterior mediastinal reconstruction

Sonodynamic Antitumor Effect of Benzoporphyrin Derivative Monoacid Ring A on KLN205 Cells

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Journal of Cancer Therapy 2011年第2期2卷 99-104页

作者： Tomohiro Osaki Motoshi tajima Yoshiharu Okamoto Satoshi Takagi Takeshi Tsuka Tomohiro Imagawa Saburo Minami 不详

Sonodynamic therapy is a new cancer treatment based on the synergetic effect of ultrasound and a drug. In this study, ultrasonically induced antitumor effects of benzoporphyrin derivative monoacid ring A (BPD-MA) on KLN205 cells were investigated. KLN205 cells were irradiated at an ultrasonic frequency of 3 MHz with 10 μg/ml BPD-MA. The ultrasonically induced cell damage significantly increased as an ultrasonic intensity and ultrasound exposure time increased. Confocal microscopic examination revealed that the irradiated cells were induced chromatin condensation and phosphatidylserine exposure. The synergistic effect of the ultrasound exposure and BPD-MA on the tumor cell adhesion rate was significant.

关键词： BPD-MA Cell Damage Sonodynamic Therapy Sonosensitizer Ultrasound

Successful Extracorporeal Membranous Oxygenation with Possible Transfusion-Related Acute Lung Injury after Pulmonary Endarterectomy

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Open Journal of Thoracic Surgery 2018年第3期8卷 57-62页

作者： Kayo Sugiyama Hirotaka Watanuki Masaho Okada Yasuhiro Futamura Atomu tajima Rokuki Kiyosawa Katsuhiko Matsuyama Department of Cardiac Surgery Aichi Medical University Hospital Nagakute Japan

Transfusion-related acute lung injury (TRALI) is characterized by acute severe hypoxemia with bilateral noncardiogenic pulmonary edema after transfusion of a plasma-containing blood component. In patients undergoing cardiac surgery, the incidence of TRALI is high;however, the detailed clinical course is unknown. Here, we report a case of life-threatening TRALI following pulmonary thrombectomy, which was successfully treated with extracorporeal membranous oxygenation (ECMO).

关键词： Transfusion-Related Acute Lung Injury Extracorporeal Membrane Oxygenation Acute Pulmonary Emboli

超短脉冲强激光与固体靶相互作用中Kα射线的实验研究

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物理学报 2007年第1期56卷 353-358页

作者：徐妙华陈黎明李玉同远晓辉刘运全 Kazuhisa Nakajima Toshi tajima 王兆华魏志义赵卫张杰中国科学院物理研究所光物理实验室北京100080 Advanced Photon Research Center Japan Atomic Energy Research InstituteKyotoJapan619-0215 中国科学院西安光机所瞬态光学国家重点实验室西安710068

在相对论激光强度下,对p偏振30fs激光与固体Cu靶相互作用中产生的Kα射线进行了实验研究.采用刀边成像技术和单光子计数X射线CCD相结合的探测装置,在单发激光脉冲打靶时同时得到X射线源的尺寸、能谱以及Kα光子的转换效率等多种信息.实... 详细信息

在相对论激光强度下,对p偏振30fs激光与固体Cu靶相互作用中产生的Kα射线进行了实验研究.采用刀边成像技术和单光子计数X射线CCD相结合的探测装置,在单发激光脉冲打靶时同时得到X射线源的尺寸、能谱以及Kα光子的转换效率等多种信息.实验结果与Reich等人的理论计算结果有明显的差异,Kα光子的能量转换效率在激光功率密度为1·6×1018W/cm2的条件下达到最大值7·08×10-6/sr.根据这一结果并结合蒙特卡罗程序,推断出在这一聚焦光强下激光能量转换为前向超热电子的效率约为10%.

关键词：超短脉冲激光与等离子体相互作用 Kα射线转换效率

CYP1A1 , GSTM1 , GSTT1 and NQO1 polymorphisms and colorectal adenomas in Japanese men

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World Journal of Gastroenterology 2013年第25期19卷 4023-4030页

作者： Tadamichi Hamachi Osamu tajima Kousaku Uezono Shinji Tabata Hiroshi Abe Keizo Ohnaka Suminori Kono Department of Preventive Medicine Graduate School of Medical Sciences Kyushu University Self Defense Forces Fukuoka Hospital Kasuga-shi Self Defense Forces Kumamoto Hospital Department of Geriatric Medicine Graduate School of Medical Sciences Kyushu University

AIM: To investigate the role of functional genetic poly-morphisms of metabolic enzymes of tobacco carcinogens in the development of colorectal adenomas. METHODS: The study subjects were 455 patients with colorectal adenomas and 1052 controls with no polyps who underwent total colonoscopy in a preretirement health examination at two Self Defense Forces hospitals. The genetic polymorphisms studied wereCYP1A1*2A (rs 4646903), CYP1A1*2C (rs 1048943), GSTM1 (null or non-null genotype), GSTT1 (null or non-null genotype) and NQO1 C609T (rs 1800566). Genotypes were determined by the polymerase chain reaction (PCR)-restriction fragment length polymorphism or PCR method using genomic DNA extracted from the buffy coat. Cigarette smoking and other life-style factors were ascertained by a self-administered questionnaire. The associations of the polymorphisms with colorectal adenomas were examined by means of OR and 95%CI, which were derived from logistic regression analysis. Statistical adjustment was made for smoking, alcohol use, body mass index and other factors. The gene-gene interaction and effect modification of smoking were evaluated by the likelihood ratio test. RESULTS: None of the five polymorphisms showed a significant association with colorectal adenomas, nor was the combination of GSTM1 and GSTT1 . A borderline significant interaction was observed for the combination of CYP1A1*2C and NQO1 (P = 0.051). The OR associated with CYP1A1*2C was significantly lower than unity among individuals with the NQO1 609CC genotype. The adjusted OR for the combination of the CYP1A1*2C allele and NQO1 609CC genotype was 0.61 (95%CI: 0.42-0.91). Although the interaction was not statistically significant (P = 0.24), the OR for individuals carrying the CYP1A1*2C allele and GSTT1 null genotype decreased significantly compared with those who had neither CYP1A1*2C allele nor GSTT1 null genotype (adjusted OR: 0.69, 95%CI: 0.49-0.97). Smoking did not modify the associations of the individual

关键词： Colorectal adenoma Smoking Polymorphism CYP1A1 GSTM1 GSTT1 NQO1

Parental perceptions and childhood overweight/obesity: A population-based study among school children in Japan

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Health 2012年第8期4卷 506-513页

作者： Takako Shirasawa Hirotaka Ochiai Tadahiro Ohtsu Rimei Nishimura Takaya Shimizu Hiromi Hoshino Naoko tajima Akatsuki Kokaze Department of Public Health Showa University School of Medicine Tokyo Japan Division of Diabetes Metabolism and Endocrinology Department of Internal Medicine Jikei University School of Medicine Tokyo Japan Jikei University School of Medicine Tokyo Japan

The lifestyle of children is primarily controlled by their parents, and that childhood obesity is related to family variables. The aim of this study was to investigate the relationship between parental perceptions on childhood obesity and their child’s overweight/obesity in Japan. The study subjects were 3168 school children (aged 9 or 10 years) and their parents in the town of Ina, Saitama Prefecture, Japan, between 2002 and 2009. Information regarding parental perceptions about childhood obesity and the lifestyle factors of their children was collected using self-administered questionnaires completed by the participants and their parents. Childhood over-weight was defined according to the International Obesity Task Force cutoffs. Parental perceptions on childhood obesity were significantly associated with their child’s overweight status. Specifically, low perceptions regarding childhood obesity significantly increased the odds ratio (OR) for the child’s overweight status (OR: 1.86, 95% CI: 1.32 - 2.62). However, when the analysis was limited to children with both parents being overweight, there was no statistically significant difference between levels of parental perceptions and the overweight status of their children. Accordingly, the present study suggests that, when both parents are obese, not only is raising parental awareness important, but also encouraging parents to prevent themselves from becoming overweight, leads to improvements in the lifestyle habits of children, which may contribute to the prevention of childhood overweight.

关键词： Children Childhood Obesity Parental Perceptions Parental Obesity Japan

A case of mucin producing liver metastases with intrabiliary extension

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World Journal of Gastroenterology 2006年第30期12卷 4918-4921页

作者： Hirotaka Tokai Yujo Kawashita Susumu Eguchi Yukio Kamohara Mitsuhisa Takatsuki Sadayuki Okudaira Yoshitsugu tajima Tomayoshi Hayashi Takashi Kanematsu Department of Transplantation and Digestive Surgery Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan Department of Pathology Nagasaki University Hospital. Nagasaki Japan

一个 75 岁的人从结肠癌与肝转移的诊断进入我们的医院。他八年以前为盲肠的癌症经历了正确的半结肠切除术，并且在片断 8 有一个变形的肝肿瘤(S8 ) ，它是通过手术 resected 在起始的操作以后的大约 4 年。从两操作的 resected 标本的... 详细信息

一个 75 岁的人从结肠癌与肝转移的诊断进入我们的医院。他八年以前为盲肠的癌症经历了正确的半结肠切除术，并且在片断 8 有一个变形的肝肿瘤(S8 ) ，它是通过手术 resected 在起始的操作以后的大约 4 年。从两操作的 resected 标本的组织病理学说的检查与 mucinous 揭示了区分得好的腺癌。在第二操作以后的四个月，计算断层摄影术在残余肝的切割表面表明了低密度的损害。尽管是煽动性的液体的一个手术后的集合被认为，它形成了一种膀胱的配置并且在直径在尺寸增加了到约 5 厘米。与变形癌症的复发的临时诊断， S8 的部分肝切除术被执行。resected 标本的组织学的检查也揭示了粘蛋白的腺癌，它入侵了进胆管，沿着它的上皮代替并且延长。Immunohistochemically，肿瘤房间为 cytokeratin (CK ) 是积极的 20，但是为 CK7 否定。因此，肿瘤从结肠的癌症作为变形腺癌被诊断。颜色的肝转移表面的腺癌有时入侵 Glisson 的三个一组并且沿着胆管成长。

关键词：粘液素肝疾病治疗临床