Sonodynamic Antitumor Effect of Benzoporphyrin Derivative Monoacid Ring A on KLN205 Cells

作     者：Tomohiro Osaki Motoshi Tajima Yoshiharu Okamoto Satoshi Takagi Takeshi Tsuka Tomohiro Imagawa Saburo Minami 

作者机构：不详 

出 版 物：《Journal of Cancer Therapy》 (癌症治疗（英文）)

年 卷 期：2011年第2卷第2期

页      面：99-104页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：BPD-MA Cell Damage Sonodynamic Therapy Sonosensitizer Ultrasound 

摘      要：Sonodynamic therapy is a new cancer treatment based on the synergetic effect of ultrasound and a drug. In this study, ultrasonically induced antitumor effects of benzoporphyrin derivative monoacid ring A (BPD-MA) on KLN205 cells were investigated. KLN205 cells were irradiated at an ultrasonic frequency of 3 MHz with 10 μg/ml BPD-MA. The ultrasonically induced cell damage significantly increased as an ultrasonic intensity and ultrasound exposure time increased. Confocal microscopic examination revealed that the irradiated cells were induced chromatin condensation and phosphatidylserine exposure. The synergistic effect of the ultrasound exposure and BPD-MA on the tumor cell adhesion rate was significant.