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Pharmacology & Pharmacy 2015年第10期6卷 461-470页

作者： shigeko fujimoto sakata Koichi Matsuda Yoko Horikawa Yasuto Sasaki Faculty of Nutrition Kobe Gakuin University Kobe Japan

An increase in total homocysteine (Hcy) levels (protein-bound and free Hcy in the serum) has been identified as a risk factor for vascular diseases. Hcy is a product of the methionine cycle and is a precursor of glutathione in the transsulfuration pathway. The methionine cycle mainly occurs in the liver, with Hcy being exported out of the liver and subsequently bound to serum proteins. When the non-specific adenosine receptor agonist 5’-N-ethylcarboxamide-adenosine (NECA;0.1 or 0.3 mg/kg body weight) was intraperitoneally administered to mice that had been fasted for 16 h, total Hcy levels in the serum significantly increased 1 h after its administration. The NECA treatment may have inhibited transsulfuration because glutathione levels were significantly decreased in the liver. After the intraperitoneal administration of a high dose of NECA (0.3 mg/kg body weight), elevations in total Hcy levels in the serum continued for up to 10 h. The mRNA expression of methionine metabolic enzymes in the liver was significantly reduced 6 h after the administration of NECA. NECA-induced elevations in total serum Hcy levels may be maintained in the long term through the attenuated expression of methionine metabolic enzymes.

关键词： Adenosine 5’-N-Ethylcarboxamide-Adenosine Glutathione Homocysteine

The Adenosine Receptor Agonist 5’-<i>N</i>-Ethylcarboxamide-Adenosine Increases Glucose 6-Phosphatase Expression and Gluconeogenesis

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Pharmacology & Pharmacy 2014年第1期5卷 19-23页

作者： Koichi Matsuda Yoko Horikawa Yasuto Sasaki shigeko F. sakata Faculty of Nutrition Kobe Gakuin University Kobe Japan.

Intraperitoneal administration of the non-selective adenosine receptor agonist 5’-N-ethylcarboxamide-adenosine (NECA) (0.1 or 0.3 mg/kg) increased fasting serum glucose levels in mice. To clarify the mechanism responsible for this, the expression of liver glucose 6-phosphatase (G6Pase: a gluconeogenic enzyme) was analyzed, and it was found that G6Pase mRNA was increased by NECA treatment. Administration of 0.3 mg/kg NECA resulted in elevated serum glucose levels at 1 h and were further elevated at 6 h. Administration of 0.1 mg/kg NECA increased serum glucose levels at 1 h and had returned to control levels by 6 h. The increase in fasting serum glucose levels induced by NECA are thought to be caused, in part, by elevated G6Pase expression.

关键词： 5’-N-Ethylcarboxamide-Adenosine Glucose 6-Phosphatase Gluconeogenesis

The social life of the Japanese language

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The social life of the Japanese language

Serum Levels of Testosterone in Patients with Polycythemia Vera

作者： shigeko Okamoto and Janet S. Shibamoto-Smith

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Open Journal of Blood Diseases 2016年第2期6卷 17-22页

作者： Hiroshi Fujita Akira Ohwada shigeko Nishimura Department of Transfusion Medicine Tokyo Metropolitan Bokutoh Hospital Tokyo Japan Department of Internal Medicine Tokyo Metropolitan Bokutoh Hospital Tokyo Japan

Despite its association with vascular events such as myocardial and cerebral infarction, polycythemia vera (PV) is characterized by low serum total cholesterol levels. Because several sex hormones are derived from cholesterol, statins may induce hypogodanism in male patients. Therefore, we assessed the relationship between serum total cholesterol and sex hormone levels according to gender. Medical records of 41 patients with erythrocytosis (hemoglobin concentrations: men >18.5 g/dL;women >16.5 g/dL) collected between August 2005 and December 2014 were reviewed for patient age, and gender, as well as clinical hematology, biochemistry, and endocrinology laboratory findings. Serum levels of testosterone were lower in men with PV than in patients with reactive erythrocytosis (RE) (PV: 385 ± 78 ng/mL versus RE: 529 ± 46 ng/mL). However, serum levels of testosterone in women with PV were comparable to those in patients in the nonerythrocytic group (PV: 20.5 ± 3.5 ng/mL versus non-erythrocytic group: 21.0 ± 4.3 ng/mL). Serum levels of testosterone were not related to serum levels of cholesterol. Therefore, we speculated that lower testosterone levels were not due to lower serum levels of cholesterol, a known adverse effect of statin. In conclusion, we report for the first time that serum levels of testosterone were lower in male PV patients than in those with RE;however, serum levels of testosterone in female patients with PV were not lower.

关键词： Polycythemia Vera JAK2 V617F Mutation Hypocholesterolemia Testosterone

Evaluation of Flooding Risk in Greater Dhaka District Using Satellite Data and Geomorphological Land Classification Map

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Journal of Geoscience and Environment Protection 2016年第9期4卷 110-127页

作者： Marju Ben Sayed shigeko Haruyama Graduate School of Bioresources Mie University Tsu City Japan

Flood is a common feature in rapidly urbanizing Dhaka city and its surrounding areas. In this research, evaluation of flood risk of Greater Dhaka in Bangladesh has been developed by using an integrated approach of GIS and remote sensing. The objective of the study is to measure the flooding risk based on the satellite data and geomorphological land classification map under the land use/land cover change from 1995 to 2015 related with the urbanization of Dhaka city. Comparing with each landform, land cover unit and historical rainfall data the flooding return period has been calculated. Terrace, natural levee and back swamp has been divided into three sub categories. Especially the built-up zone which is closer to the river channel, former river course and the back swamps are mostly vulnerable to flood inundation. This study revealed that, 70% of Greater Dhaka district within moderate to very high hazard zone, especially surrounding city like Manikganj Sadar Upazila areas. It is expected that, this study could contribute to effective flood forecasting, relief and emergency management for future flood event.

关键词： Land Use/Land Cover Change Manikganj Sadar Upazila Greater Dhaka GIS Flood

Dynamics of Land Use/Cover Change in Manikganj District, Bangladesh: A Case Study of Manikganj Sadar Upazila

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Journal of Geographic Information System 2015年第6期7卷 579-587页

作者： Marju Ben Sayed shigeko Haruyama Department of Environment Science and Technology Mie University Tsu Japan

This study revealed land use/cover change of Manikganj Sadar Upazila concerning with urbanization of Dhaka city. The study area also offers better residential opportunity and food support for Dhaka city. The major focus of this study is to find out the spatial and temporal changes of land use/cover and its effects on urbanization while Dhaka city is an independent variable. For analyzing land use/cover change GIS and remote sensing technique were used. The maps showed that, between 1989 and 2009 built-up areas increased approximately +12%, while agricultural land decreased -7%, water bodies decreased about -2% and bare land decreased about -2%. The significant change in agriculture land use is observed in the south-eastern and north eastern site of the city because of nearest distance and better transportation facilities with Dhaka city. This study will contribute to the both the development of sustainable urban land use planning decisions and also for forecasting possible future changes in growth patterns.

关键词： Land Use/Cover Change Manikganj Sadar Upazila Union Urban Sprawl Remote Sensing

Evaluation of a Possible Effect of In-House Cryoprecipitate Transfusion on Outcome of Severe Upper Gastrointestinal Bleeding: A Retrospective Cohort Study

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Open Journal of Blood Diseases 2019年第1期9卷 20-29页

作者： Hiroshi Fujita shigeko Nishimura Kazuhiro Sugiyama Department of Transfusion Medicine Tokyo Metropolitan Bokutoh Hospital Tokyo Japan Tertiary Emergency Medical Center Tokyo Metropolitan Bokutoh Hospital Tokyo Japan

Purposes: Hypofibrinogenemia is usually complicated with severe and massive upper gastrointestinal (GI) bleeding, especially in liver cirrhosis. In Japan, neither fibrinogen concentrate nor cryoprecipitate (CRYO) is available for cases of acquired hypofibrinogenemia to recover the hemostatic level of fibrinogen rapidly. We prepared and produced in-house CRYO from fresh frozen plasma, and compared mortality between pre-implementation and post-implementation of CRYO. Methods: We performed a retrospective cohort study of patients admitted to our single tertiary medical center with upper GI bleeding from January 2011 to December 2016. The observational control period was from January 2011 to February 2013. From March 2013 to December 2016, we implemented the transfusion of CRYO, which was prepared and produced in our hospital. Clinical outcomes were compared between the patients in the two periods. Patients: Eleven patients in the control period and 10 in the intervention period were eligible for analysis. Results: In-hospital mortality (55% vs. 20%, P = 0.238) and mortality within 24 hour after admission (27% vs. 0%, P = 0.246) tended to be lower in the intervention period than in the control period, although the patients had more severe coagulation on admission than those in the control period. The plasma fibrinogen level before the treatment of hemostasis in the intervention period was higher than that in the control period (80 ± 9 mg/dL vs. 127 ± 15 mg/dL, P Conclusion: Implementation of in-house CRYO transfusion may reduce the rate of mortality due to severe upper GI bleeding.

关键词： Esophageal Varix Resuscitation Mortality Hypofibrinogenemia

High Contact Pressure Resulting from Bone Marrow Puncture

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Open Journal of Blood Diseases 2012年第3期2卷 56-58页

作者： Hiroshi Fujita Junji Tomiyama shigeko Nishimura Department of Internal Medicine Tokyo Metropolitan Bokutoh Hospital Tokyo Japan Department of Transfusion Medicine Tokyo Metropolitan Bokutoh Hospital Tokyo Japan

Cardiac tamponade following sternal puncture is fatal and is caused by an anomaly such as foramen sterni, fragility of the bone, or high pressure exerted by doctors on the bone. Contact pressure associated with bone marrow aspiration is unknown;therefore, we examined the contact pressure resulting from bone marrow puncture for aspiration. Prescale, a pressure-sensitive film, was used for measurements. Contact pressure on wood surface at 2 heights, the knee and hip positions of the hematologists, was examined and was approximately 15 - 21 megapascals. The magnitude of the con-tact pressure did not change with the type of puncture needle. However, the contact pressure in the needle area at the hip position was higher than that at the knee position height, when doctors aspirated the bone marrow. Contact pressure resulting from bone marrow puncture was found to be high;therefore, hematologists should be aware of this force when dealing with patients.

关键词： Bone Marrow Aspiration Cardiac Tamponade Contact Pressure Iatrogenic Accident

Linking uric acid metabolism to diabetic complications

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World Journal of Diabetes 2014年第6期5卷 787-795页

作者： Akifumi Kushiyama Kentaro Tanaka shigeko Hara Shoji Kawazu Division of Diabetes and Metabolism The Institute for Adult DiseasesAsahi Life Foundation2-2-6

Hyperuricemia have been thought to be caused by the ingestion of large amounts of purines, and prevention or treatment of hyperuricemia has intended to prevent gout. Xanthine dehydrogenase/xanthine oxidase(XDH/XO) is rate-limiting enzyme of uric acid generation, and allopurinol was developed as a uric acid(UA) generation inhibitor in the 1950 s and has been routinely used for gout prevention since then. Serum UA levels are an important risk factor of disease progression for various diseases, including those related to lifestyle. Recently, other UA generation inhibitors such as febuxostat and topiroxostat were launched. The emergence of these novel medications has promoted new research in the field. Lifestyle-related diseases, such as metabolic syndrome or type 2 diabetes mellitus, often have a common pathological foundation. As such, hyperuricemia is often present among these patients. Many in vitro and animal studies have implicated inflammation and oxidative stress in UA metabolism and vascular injury because XDH/XO act as one of the major source of reactive oxygen species Many studies on UA levels and associated diseases implicate involvement of UA generation in disease onset and/or progression. Interventional studies for UA generation, not UA excretion revealed XDH/XO can be the therapeutic target forvascular injury and renal dysfunction. In this review, the relationship between UA metabolism and diabetic complications is highlighted.

关键词： Uric acid Xanthine dehydrogenase/xanthine oxidase Diabetes mellitus Diabetic complications Xanthine oxidase inhibitor Metabolism

Relative Monocytosis in Patients with Erythrocytosis

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Open Journal of Blood Diseases 2013年第1期3卷 21-24页

作者： Hiroshi Fujita Akira Ohwada Naoko Handa shigeko Nishimura Department of Internal Medicine Tokyo Metropolitan Bokutoh Hospital Tokyo Japan. Department of Transfusion Medicine Tokyo Metropolitan Bokutoh Hospital Tokyo Japan

Polycythemia vera (PV) is characterized by leukocytosis, thrombocytosis, and low mean capsular volume (MCV). No specific hematological findings are observed in patients with erythrocytosis of other origins. However, recombinant erythropoietin (EPO) increases the number of mononuclear cells in the peripheral blood. Therefore, we hematologically examined monocytes in patients with erythrocytosis. The medical records of 48 erythrocytosis patients (hemoglobin: men, >18.5 g/dL;women, >16.5 g/dL) collected between August 2005 and July 2012 were reviewed for age, gender, hematology, and serum erythropoietin level. Patients were divided into 3 groups: PV (N = 17), reactive erythrocytosis (RE, N = 25), and EPO-elevated erythrocytosis (EPO-E, N = 6). We compared monocytes in the hemogram among the 3 groups and examined the correlation between hematological data and serum EPO level. The percent monocytes in the hemogram were 3.4% ± 0.3%, 7.4% ± 0.4%, and 12.3% ± 1.1% for the PV, RE, and EPO-E groups, respectively, which were significant (p 1.0 ′ 109/L) in the PV, RE, and EPO-E groups, respectively. A significant correlation was observed between percent monocyte or absolute monocyte count and serum EPO level. In conclusion, monocyte count in hemograms may be useful for diagnosing EPO-elevated erythrocytosis.

关键词： Erythropoietin Monocyte Erythrocytosis