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Optical tracking of picosecond coherent phonon pulse focusing inside a sub-micron object

Light(Science & Applications) 2016年第1期5卷 653-659页

作者： Thomas Dehoux Kenichi Ishikawa Paul H Otsuka Motonobu Tomoda Osamu Matsuda Masazumi Fujiwara shigeki takeuchi Istvan A Veres Vitalyi E Gusev Oliver B Wright Institut Lumière Matière UMR5306UniversitéLyon 1-CNRSUniversitéde Lyon69622 VilleurbanneFrance Division of Applied Physics Faculty of EngineeringHokkaido UniversitySapporo 060-8628Japan Research Institute for Electronic Science Hokkaido UniversitySapporo 001-0020Japan School of Science and Technology Kwansei Gakuin UniversitySandaHyogo 669-1337Japan Department of Electronic Science and Engineering Kyoto UniversityKyoto 615-8510Japan Research Centre for Non-Destructive Testing GmbH Altenberger Strasse 69A-4040 LinzAustria Laboratoire d'Acoustique de l'Université du MaineLe Mans 72085France

By means of an ultrafast optical technique,we track focused gigahertz coherent phonon pulses in objects down to sub-micron in *** light pulses illuminating the surface of a single metal-coated silica fibre generate longitudinal-phonon wave *** of visible probe light pulses from the fibre surface allows the vibrational modes of the fibre to be detected,and Brillouin optical scattering of partially transmitted light pulses allows the acoustic wavefronts inside the transparent fibre to be continuously *** thereby probe acoustic focusing in the time domain resulting from generation at the curved fibre *** analytical model,supported by three-dimensional simulations,suggests that we have followed the focusing of the acoustic beam down to a~150-nm diameter waist inside the *** work significantly narrows the lateral resolution for focusing of picosecond acoustic pulses,normally limited by the diffraction limit of focused optical pulses to~1μm,and thereby opens up a new range of possibilities including nanoscale acoustic microscopy and nanoscale computed tomography.

关键词： acoustic–optic fibre optical scattering picosecond ultrasonics

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Expression analyses of stress‑responsive genes in the hermatypic coral Acropora tenuis and its symbiotic dinofagellates after exposure to the herbicide Diuron

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Marine Life Science & Technology 2023年第3期5卷 289-299页

作者： Hiroshi Ishibashi Seigo Minamide Ichiro takeuchi Graduate School of Agriculture Ehime UniversityMatsuyamaEhime 790-8566Japan Center of Advanced Technology for the Environment Graduate School of AgricultureEhime UniversityMatsuyamaEhime 790-8566Japan

Diuron is one of the most frequently applied herbicides in sugarcane farming in southern Japan,and *** addition,it is used as a booster substance in copper-based antifouling *** to these various uses,Diuron is released into the marine environment;however,little information is available on gene expression in corals and their symbiotic algae exposed to *** investigated the efects of Diuron on stress-responsive gene expression in the hermatypic coral Acropora tenuis and its symbiotic *** seven days of exposure to 1µg/L and 10µg/L Diuron,no signifcant changes in the body colour of corals were ***,quantitative reverse transcription-polymerase chain reaction analyses revealed that the expression levels of stress-responsive genes,such as heat shock protein 90(HSP90),HSP70,and calreticulin(CALR),were signifcantly downregulated in corals exposed to 10µg/L of Diuron for seven ***,aquaglyceroporin was signifcantly downregulated in corals exposed to environmentally relevant concentrations of 1µg/L *** contrast,no such efects were observed on the expression levels of other stress-responsive genes,such as oxidative stress-responsive proteins,methionine adenosyltransferase,and green/red fuorescent *** exposure had no signifcant efect on the expression levels of HSP90,HSP70,or HSP40 in the symbiotic *** results suggest that stress-responsive genes,such as HSPs,respond diferently to Diuron in corals and their symbiotic dinofagellates and that *** HSPs and CALRs may be useful molecular biomarkers for predicting stress responses induced by the herbicide Diuron.

关键词： Acropora tenuis Calreticulin Coral bleaching Diuron Heat shock protein

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Disseminated carcinomatosis of the bone marrow caused by granulocyte colony-stimulating factor:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2022年第10期14卷 2077-2084页

作者： Kengo Fujita Ayaka Okubo Toshitsugu Nakamura Nobumichi takeuchi Department of Medical Oncology Ina Central HospitalNagano 396-8555Japan Department of Diagnostic Pathology Ina Central HospitalNagano 396-8555Japan

BACKGROUND Disseminated carcinomatosis of the bone marrow(DCBM)is a widespread metastasis with a hematologic disorder that is mainly caused by gastric *** it commonly occurs as a manifestation of recurrence long after curative treatment,the precise mechanism of relapse from dormant status remains *** colony-stimulating factor(G-CSF)can promote cancer progression and invasion in various ***,the potential of G-CSF to trigger recurrence from a cured malignancy has not been *** SUMMARY A 55-year-old Japanese woman was diagnosed with Ewing sarcoma localized on the fifth lumbar vertebrae 6 years after curative gastrectomy for T1 gastric *** palliative surgery to release nerve compression,pathological diagnosis of the resected specimen was followed by curative radiation and *** treatment,G-CSF was administered 32 times for severe neutropenia *** months after completing definitive treatment,she complained of severe back pain and was diagnosed as multiple bone metastases with DCBM from gastric *** palliative chemotherapy,she died of disseminated intravascular coagulation 13 d after the *** examination of the autopsied bone marrow confirmed a diffuse positive staining for the G-CSF receptor(G-CSFR)in the relapsed gastric cancer cell cytoplasm,whereas the primary lesion cancer cells showed negative staining for *** this case,G-CSF administration may have been the key trigger for the disseminated relapse of a dormant gastric *** administering G-CSF to cancer survivors,recurrence of a preceding cancer should be monitored even after curative treatment.

关键词： Disseminated bone marrow carcinomatosis Gastric cancer Granulocyte colony-stimulating factor Cancer survivor Immunostaining Case report

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A Delayed HIV Infection Model with the Homeostatic Proliferation of CD4^(+)T Cells

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Acta Mathematicae Applicatae Sinica 2022年第2期38卷 441-462页

作者： Qiang-hui XU Ji-cai HUANG Yue-ping DONG Yasuhiro takeuchi School of Mathematics and Statistics and Hubei Key Laboratory of Mathematical Sciences Central China Normal UniversityWuhan 430079China College of Science and Engineering Aoyama Gakuin UniversityKanagawa 252-5258Japan

In this paper,we investigate a delayed HIV infection model that considers the homeostatic prolif-eration of CD4^(+)T *** existence and stability of uninfected equilibrium and infected equilibria(smaller and larger ones)are studied by analyzing the characteristic equation of the *** intracellular delay does not affect the stability of uninfected equilibrium,but it can change the stability of larger positive equilibrium and Hopf bifurcation appears inducing stable limit ***,direction and stability of Hopf bifur-cation are well investigated by using the central manifold theorem and the normal form *** numerical simulation results show that the stability region of larger positive equilibrium becomes smaller as the increase of time ***,when the maximum homeostatic growth rate is very small,the larger positive equilibrium is always *** the contrary,when the rate of supply of T cells is very small,the larger positive equilibrium is always unstable.

关键词： HIV infection and persistence T cell homeostatic proliferation delayed model dynamics analysis Hopf bifurcation

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Drug-induced entero-colitis due to interleukin-17 inhibitor use;capsule endoscopic findings and pathological characteristics:A case report

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世界胃肠病学杂志:英文版 2023年第32期29卷 4912-4919页

作者： Keita Saito Kiichiro Yoza Shinichiro Takeda Yoshihiro Shimoyama Ken takeuchi Department of Gastroenterology Tsujinaka Hospital Kashiwano-HaKashiwa 277-0871Japan

BACKGROUND Interleukin-17(IL-17)inhibitors are known to cause exacerbation or new onset of inflammatory bowel disease upon ***,few reports have described characteristic endoscopic and histopathologic findings,and no small intestinal lesions have been reported so *** SUMMARY A woman in her 60s with psoriasis was administered ixekizumab(IXE),an anti-IL-17A antibody,for the treatment of *** months after commencing treatment,the patient visited our hospital because of persistent *** tests performed at the time of the visit revealed severe inflammation,and colonoscopy revealed multiple round ulcers throughout the colon.A tissue biopsy of the ulcer revealed infiltration of inflammatory cells and granuloma-like findings in the submucosal *** endoscopy revealed multiple jejunal *** the withdrawal of IXE,the symptoms gradually improved,and ulcer reduction and scarring of the colon were endoscopically *** To the best of our knowledge,17 reports have documented IL-17 inhibitorinduced entero-colitis with endoscopic images,endoscopic findings,and pathological characteristics,including the present *** of these cases showed diffuse loss of vascular pattern,coarse mucosa/ulcer formation in the left colon,and endoscopic findings similar to those of ulcerative *** the remaining eight cases,discontinuous erosions and ulcerations from the terminal ileum to the rectum were seen,with endoscopic findings similar to those of Crohn’s *** this case,the findings were confirmed by capsule endoscopy,which has not been previously reported.

关键词： Interleukin-17 inhibitor Ixekizumab Drug-induced entero-colitis Capsule endoscopy Case report

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Moving computational multi-domain method for modelling the flow interaction of multiple moving objects

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Advances in Aerodynamics 2022年第1期4卷 78-95页

作者： Momoha Nishimura Masashi Yamakawa Shinichi Asao Seiichi takeuchi Mehdi Badri Ghomizad Department of Mechanical and System Engineering Kyoto Institute of TechnologyKyotoJapan Department of Mechanical Engineering College of Industrial TechnologyHyogoJapan

This study proposes a method for modelling the flow interaction of multiple moving objects where the flow field variables are communicated between multiple separate moving computational *** of using the conventional approach with a single fixed computational domain covering the whole flow field,this method advances the moving computational domain(MCD)method in which the computational domain itself moves in line with the motions of an object *** computational domains created around each object move independently,and the flow fields of each domain interact where the flows *** eliminates the spatial restriction for simulating multiple moving ***,a shock tube test verifies that the overset implementation and grid movement do not adversely affect the results and that there is communication between the grids.A second test case is conducted in which two spheres are crossed,and the forces exerted on one object due to the other’s crossing at a short distance are *** results verify the reliability of this method and show that it is applicable to the flow interaction of multiple moving objects.

关键词： Crossing Moving boundary problems Compressible flow Moving mesh method

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Machine learning super-resolution of laboratory CT images in all-solid-state batteries using synchrotron radiation CT as training data

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Energy and AI 2023年第4期14卷 612-619页

作者： M.Kodama A.takeuchi M.Uesugi S.Hirai Tokyo Institute of Technology 2-12-1 OokayamaMeguro-kuTokyo 152-8550Japan Japan Synchrotron Radiation Research Institute(JASRI/SPring-8) 1-1-1 KoutoSayoHyogo 679-5198Japan

High-performance all-solid-state lithium-ion batteries require observation,control,and optimization of the electrode structure.X-ray computational tomography(CT)is an effective nondestructive method for observing the electrode structure in three ***,the limited availability of synchrotron radiation CT,which offers high-resolution imaging with a high signal-to-noise ratio,makes it difficult to conduct experiments and restricts the use of X-ray CT in battery ***,laboratory CT systems are widely available,but they use X-rays emitted from a metal target,resulting in lower image quality and resolution compared with synchrotron radiation *** study explores a method for achieving comparable resolution in laboratory CT images of all-solid-state batteries to that of synchrotron radiation *** method involves using the synchrotron radiation CT images as training data for machine learning *** results demonstrate that,by employing an appropriate machine learning algorithm and activation function,along with a sufficiently deep network,the image quality of laboratory CT becomes equivalent to that of synchrotron radiation CT.

关键词： All-solid-state lithium-ion battery X-ray CT Laboratory CT Synchrotron radiation CT Super-resolution Machine learning

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Association of anastomotic leakage with long-term oncologic outcomes of patients with esophagogastric junction cancer

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World Journal of Gastrointestinal Surgery 2022年第1期14卷 46-55页

作者： Masashi takeuchi Hirofumi Kawakubo Satoru Matsuda Shuhei Mayanagi Tomoyuki Irino Jun Okui Kazumasa Fukuda Rieko Nakamura Norihito Wada Hiroya takeuchi Yuko Kitagawa Department of Surgery Keio University School of MedicineTokyo 160-8582Japan Department of Preventive Medicine and Public Health Keio University School of MedicineTokyo 160-8582Japan Department of Surgery Hamamatsu University School of MedicineShizuoka 431-3192Japan

BACKGROUND Despite improvements in surgical procedures and peri-operative patients management,the postoperative complications in esophagogastric junction(EGJ)cancer remain high because of technical *** studies have indicated the negative influence of postoperative infectious complications on long-term survival after gastrointestinal ***,no study has shown the association between postoperative complications and long-term survival of patients with EGJ *** To elucidate influence of postoperative complications on the long-term outcomes of patients with EGJ *** A total of 122 patients who underwent surgery for EGJ cancer at the Keio University were included in this *** examined the association between complications and long-term oncologic *** In all patients,the 3-year overall survival(OS)rate was 71.9%,and the recurrencefree survival(RFS)rate was 67.5%.Compared with patients without anastomotic leakage,those with anastomotic leakage had poor median OS(8 mo vs not reached,P=0.028)and median RFS(5 mo vs not reached,P=0.055).Among patients with cervical anastomosis,there were not significant differences between patients with and without anastomotic ***,among patients who underwent intrathoracic anastomosis,patients with anastomotic leakage had significantly worse OS(P=0.002)and RFS(P=0.005).CONCLUSION Anastomotic leakage was significantly associated with long-term oncologic outcomes of patients with EGJ cancer,especially those who underwent intrathoracic *** anastomosis with subtotal esophagectomy may be an option for the patients who are at high risk for anastomotic leakage.

关键词： Esophagogastric junction cancer Complication Long-term outcome

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PPARα activator irbesartan suppresses the proliferation of endometrial carcinoma cells via SREBP1 and ARID1A

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Oncology Research 2023年第3期31卷 239-253页

作者： YU LU TSUTOMU MIYAMOTO HODAKA takeuchi FUMI TSUNODA NAOKI TANAKA TANRI SHIOZAWA Department of Obstetrics and Gynecology School of MedicineShinshu UniversityMatsumoto390-8621Japan Department of Global Medical Research Promotion School of MedicineShinshu University GraduateMatsumotoNagano390-8621Japan International Relations Office School of MedicineShinshu UniversityMatsumotoNagano390-8621Japan Research Center for Social Systems Shinshu UniversityMatsumotoNagano390-8621Japan

Endometrial carcinoma(EMC)is associated with obesity;however,the underlying mechanisms have not yet been *** proliferator-activated receptor alpha(PPARα)is a nuclear receptor that is involved in lipid,glucose,and energy ***αreportedly functions as a tumor suppressor through its effects on lipid metabolism;however,the involvement of PPARαin the development of EMC remains *** present study demonstrated that the immunohistochemical expression of nuclear PPARαwas lower in EMC than in normal endometrial tissues,suggesting the tumor suppressive nature of PPARα.A treatment with the PPARαactivator,irbesartan,inhibited the EMC cell lines,Ishikawa and HEC1A,by down-regulating sterol regulatory element-binding protein 1(SREBP1)and fatty acid synthase(FAS)and up-regulating the tumor suppressor genes p21 and p27,antioxidant enzymes,and AT-rich interaction domain 1A(ARID1A).These results indicate the potential of the activation of PPARαas a novel therapeutic approach against EMC.

关键词： Peroxisome proliferator-activated receptor alpha Sterol regulatory element-binding protein 1 Antioxidant Migration

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In-silico clearing approach for deep refractive index tomography by partial reconstruction and wave-backpropagation

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Light(Science & Applications) 2023年第5期12卷 877-893页

作者： Osamu Yasuhiko Kozo takeuchi Central Research Laboratory Hamamatsu Photonics K.K5000 HirakuchiHamakita-kuHamamatsu 434-8601 ShizuokaJapan

Refractive index(RI)is considered to be a fundamental physical and biophysical parameter in biological imaging,as it governs light-matter interactions and light propagation while reflecting cellular *** tomography enables volumetric visualization of RI distribution,allowing biologically relevant analysis of a ***,multiple scattering(MS)and sample-induced aberration(SIA)caused by the inhomogeneity in RI distribution of a thick sample make its visualization *** paper proposes a deep RI tomographic approach to overcome MS and SIA and allow the enhanced reconstruction of thick samples compared to that enabled by conventional linear-model-based RI *** proposed approach consists of partial RI reconstruction using multiple holograms acquired with angular diversity and their backpropagation using the reconstructed partial RI map,which unambiguously reconstructs the next partial *** this operation efficiently reconstructs the entire RI tomogram while suppressing MS and *** visualized a multicellular spheroid of diameter 140μm within minutes of reconstruction,thereby demonstrating the enhanced deep visualization capability and computational efficiency of the proposed method compared to those of conventional RI ***,we quantified the high-RI structures and morphological changes inside multicellular spheroids,indicating that the proposed method can retrieve biologically relevant information from the RI *** from the excellent biological interpretability of RI distributions,the label-free deep visualization capability of the proposed method facilitates a noninvasive understanding of the architecture and time-course morphological changes of thick multicellular specimens.

关键词： properties refractive overcome

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