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The Number of Positive Tumor Marker Status Is Beneficial for the Selection of Therapeutic Modalities in Patients with Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2017年第2期5卷 165-168页

作者： Toru Beppu shigeki nakagawa Hidetoshi Nitta Hirohisa Okabe Takayoshi Kaida Katsunori Imai Hiromitsu Hayashi Yuki Koga Kunitaka Kuramoto Daisuke Hashimoto Yo-ichi Yamashita Akira Chikamoto Takatoshi Ishiko Hideo Baba Department of Surgery Yamaga City Medical Center Kumamoto Japan Department of Gastroenterological Surgery Graduate School of Life Sciences Kumamoto University Kumamoto Japan Department of Gastroenterological Surgery Graduate School of Life Sciences Kumamoto University Kumamoto Japan

Hepatic resection (HR) and radiofrequency ablation (RFA) are popular local therapies for early-stage hepatocellular carcinoma (HCC).Alpha-fetoprotein,Lens culinaris agglutininreactive fraction of alpha-fetoprotein,and des-c-carboxy prothrombin are well-known and useful tumor markers for *** positive number status of these tumor markers has recently been demonstrated as beneficial for predicting outcome for HCC patients treated with local *** the normal ranges reported have differed by institution,the positivity of tumor markers is consistent and can easily be *** and Wakayama's group clearly demonstrated the following:1) Regardless of the degree of tumor stage,a triple-positive tumor marker profile can predict poor outcome in HCC patients undergoing HR;2) For RFA alone,HCC patients with double-and triple-positive status,having less than three lesions and lesions ≤3 cm in diameter show comparably insufficient outcomes;3) For HCC patients with lesions ≤5 cm in Child-Pugh grade A,HR is preferred over RFA;4) Microvascular invasion rates increased even in the double-positive patients,while poorly differentiated HCC was frequently observed only in the triple-positive patients;and 5) RFA with chemoembolization,anatomical liver resection,and postoperative adjuvant chemoembolization or hepatic arterial chemotherapy might improve the outcome for patients with highly malignant HCC with multiple positive tumor ***,the impacts of these therapies still need to be evaluated in prospective comparative studies.

关键词： Triple-positive tumor markers Double-positive tumor markers Hepatocellular carcinoma Hepatic resection Radiofrequency ablation Alpha-fetoprotein Des-γ-carboxy prothrombin Lens culinaris agglutinin reactive fraction of alpha-fetoprotein

Risk factors for lymph node metastasis in patients with pancreatic neuroendocrine neoplasms

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World Journal of Clinical Oncology 2022年第6期13卷 520-528页

作者： Yosuke Nakao Hiromitsu Hayashi Yo-ichi Yamashita Ofuchi Takashi Kazuki Matsumura Norio Uemura Fumimasa Kitamura Rumi Itoyama Toshihiko Yusa Katsunobu Taki Tatsunori Miyata Takaaki Higashi shigeki nakagawa Hirohisa Okabe Katsunori Imai Hideo Baba Department of Gastroenterological Surgery Kumamoto UniversityKumamoto 860-8556Japan

BACKGROUND Although PNENs generally have a better prognosis than pancreatic cancers,some PNENs display malignant behavior including lymph node(LN)*** tumor resection can be the only potentially curative treatment for patients with resectable ***,the indications for LN dissection are still *** the last decade,minimally invasive surgery such as laparoscopic pancreatic surgery(LPS)has been increasingly performed for pancreatic tumors including *** To investigate the risk factors for LN metastasis in PNENs and to select appropriate patients for limited surgery by *** From April 2001 to December 2019,92 patients underwent pancreatic resection for PNENs at Kumamoto University ***,82 patients were enrolled in this *** perioperative factors,we examined the predictive factors for LN metastasis in *** Among the 82 patients,the percentage of LN metastasis according to the pathological findings was 12%(10/82 cases).The median tumor size was 12 mm(range:5-90 mm).The median tumor size in the LN-positive group(37 mm)was significantly larger than that in the LN-negative group(12 mm)(P=0.0001).Multivariate analyses revealed that larger tumor size(≥20 mm)was an independent risk factor for LN metastasis(odds ratio 16.8,P=0.0062).In patients with small tumors(≤10 mm),LN metastasis was not *** Larger tumor size(≥20 mm)is an independent risk factor for LN metastasis in *** smaller PNENs(≤10 mm),we may be able to choose limited surgery without LN dissection.

关键词： Lymph node metastasis Pancreatic neuroendocrine neoplasms Risk factor Tumor size

纳米级半金属薄膜Fe_3O_4(001)的外延生长及晶向测定

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化学分析计量 2014年第5期23卷 19-23页

作者：王梅玲王海高思田宋小平中川茂树中国计量科学研究院北京100029 东京工业大学

半金属材料Fe3O4具有理论上100%的自旋极化率,其居里温度高达860 K,具有室温操作的可能。此外,Fe3O4与Mg O晶格具有较低的失配率(0.3%),将二者结合起来有利于磁阻的进一步提高,因此Fe3O4材料成为制备磁阻器件的候选材料。采用对靶磁控... 详细信息

半金属材料Fe3O4具有理论上100%的自旋极化率,其居里温度高达860 K,具有室温操作的可能。此外,Fe3O4与Mg O晶格具有较低的失配率(0.3%),将二者结合起来有利于磁阻的进一步提高,因此Fe3O4材料成为制备磁阻器件的候选材料。采用对靶磁控溅射的方法,实现了低温制备纳米级别Fe3O4(001)薄膜。利用X射线衍射测量,采用小角掠射(掠射角为2o)、2θ/θ联动模式、步进扫描方式,成功获得其择优取向的图谱。通过XRD与TEM截面样品暗场选区电子衍射相结合的方法,可以定性区分各层薄膜的择优取向。

关键词：半金属 (001)择优取向外延生长缓冲层

On the Numerical Modeling of the Deep Mantle Water Cycle in Global-Scale Mantle Dynamics:The Effects of the Water Solubility Limit of Lower Mantle Minerals

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Journal of Earth Science 2017年第4期28卷 563-577页

作者： Takashi nakagawa Department of Mathematical Science and Advanced Technology Japan Agency for Marine-Earth Science and TechnologyYokohama 236-0001Japan

Water is the most important component in Earth system evolution. Here, I review the current understanding of the fate of water in the mantle dynamics system based on high-pressure and temperature experiments, geochemical analyses, seismological and geomagnetic observations, and nu- merical modeling of both regional- and giobal-scale mantle dynamics. In addition, as a numerical ex- ample, I show that the water solubility of the deep mantle is strongly sensitive to global-scale water cir- culation in the mantle. In a numerical example shown here, water solubility maps as functions of tem- perature and pressure are extremely important for revealing the hydrous structures in both the mantle transition zone and the deep mantle. Particularly, the water solubility limit of lower mantle minerals should be not so large as ~100 ppm for the mantle transition zone to get the largest hydrous reservoir in the giobal-scale mantle dynamics system. This result is consistent with the current view of mantle water circulation provided by mineral physics, which is also found as a hydrous basaltic crust in the deep mantle and the water enhancement of the mantle transition zone simultaneously. In this paper, I also discuss some unresolved issues associated with mantle water circulation, its influence on the onset and stability of plate motion, and the requirements for developing Earth system evolution in mantle dy- namics simulations.

关键词： numerical modeling mantle convection water cycle water solubility limit.

A weeding-duration model for Abies sachalinensis plantations in Hok-kaido, northern Japan

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Journal of Forestry Research 2013年第1期24卷 131-136页

作者： Masahiko nakagawa Doto Station Forestry Research InstituteHokkaido Research OrganizationShintoku-choHokkaido081-0038Japan

I developed a weeding-duration model for Sakhalin fir （Abies sachalinensis （Fr. Schmidt） Masters） plantations that employs a generalized linear model. The number of years following planting that weeding is necessary is the response variable, and elevation, slope steepness, maximum snow depth, annual precipitation, geology, soil, site index, slope aspect, and vegetation type are explanatory variables. Among the explanatory variables, geology, soil, slope aspect, and vegetation type are categorical data. A Poisson distribution is assumed for the response variable, with a log-link function. Elevation, slope steepness, maximum snow depth, annual precipitation, site index, and vegetation type had a significant effect on weeding duration. Among the eight models with the smallest Akaike information criterion （AIC）, I chose the model with no multicollinearity among the explanatory variables. The weeding-duration model includes site index, maximum snow depth, slope steepness （angle） and vegetation type as explanatory variables; elevation and annual precipitation were not included in the selected model because of multicollinearity with maximum snow depth. This model is useful for cost-benefit analyses of afforestation or reforestation with Abies sachalinensis.

关键词： Abies sachalinensis plantation snow depth site index weeding

Lateral pelvic lymph nodes for rectal cancer:A review of diagnosis and management

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World Journal of Gastrointestinal Oncology 2021年第10期13卷 1412-1424页

作者： Shimpei Ogawa Michio Itabashi Yuji Inoue Takeshi Ohki Yoshiko Bamba Kurodo Koshino Ryosuke nakagawa Kimitaka Tani Hisako Aihara Hiroka Kondo shigeki Yamaguchi Masakazu Yamamoto Department of Surgery Institute of GastroenterologyTokyo Women's Medical UniversityTokyo 162-8666Japan

The current status and future prospects for diagnosis and treatment of lateral pelvic lymph node(LPLN)metastasis of rectal cancer are described in this *** resonance imaging(MRI)is recommended for the diagnosis of LPLN metastasis.A LPLN-positive status on MRI is a strong risk factor for metastasis,and evaluation by MRI is important for deciding treatment *** dissection(LPLD)has an advantage of reducing recurrence in the lateral pelvis but also has a disadvantage of complications;therefore,LPLD may not be appropriate for cases that are less likely to have LPLN *** therapy(RT)and chemoradiation therapy(CRT)have limited effects in cases with suspected LPLN metastasis,but a combination of preoperative CRT and LPLD may improve the treatment ***,RT and CRT plus selective LPLD may be a rational strategy to omit unnecessary LPLD and produce a favorable treatment outcome.

关键词： Diagnosis Treatment Rectal cancer Lateral pelvic lymph node metastasis Lateral pelvic lymph node dissection Radiotherapy

Promoting functional recovery by inhibition of repulsive guidance molecule-a after spinal cord injury

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Neural Regeneration Research 2018年第6期13卷 981-982页

作者： Hiroshi nakagawa Masahiko Takada Sobell Department of Motor Neuroscience and Movement Disorders Institute of Neurology University College London Systems Neuroscience Section Primate Research Institute Kyoto University

Spinal cord injury（SCI）leads to permanent disability with motor and sensory *** mature mammalian central nervous system（CNS）possesses a limited capacity to regenerate/regrow after injury.

关键词： Promoting functional recovery by inhibition of repulsive guidance molecule-a after spinal cord injury SCI

Taming heterogeneous rhenium catalysis for the production of biomass-derived chemicals

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Chinese Chemical Letters 2020年第5期31卷 1071-1077页

作者： Keiichi Tomishige Yoshinao nakagawa Masazumi Tamura Department of Applied Chemistry School of EngineeringTohoku UniversityMiyagi 980-857Japan

Rhenium is one of important components for heterogeneous catalysts,which has been recently used for the catalytic reactions related to the production of biomass-derived chemicals such as deoxydehydration of vicinal OH groups,C-O hydrogenolysis,and hydrogenation of carboxylic acids,and so *** oxidation state of Re as a catalytic active species is strongly dependent on the catalytic *** control of the oxidation state of Re species on the catalysts is crucial on the catalyst development.

关键词： Rhenium Oxidation state Deoxydehydration Hydrogenolysis Hydrogenation

Prediction of Photosynthetic Carbon Assimilation Rate of Individual Rice Leaves under Changes in Light Environment Using BLSTM-Augmented LSTM

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Computer Modeling in Engineering & Sciences 2022年第12期133卷 557-577页

作者： Masayuki Honda Kenichi Tatsumi Masaki nakagawa Graduate School of Bio-Applications and Systems Engineering Tokyo University of Agriculture and TechnologyKoganei City184-8588Japan Institute of Agriculture Tokyo University of Agriculture and TechnologyFuchu City183-0054Japan Institute of Engineering Tokyo University of Agriculture and TechnologyKoganei City184-8588Japan

A model to predict photosynthetic carbon assimilation rate(A)with high accuracy is important for forecasting crop yield and *** short-term memory(LSTM),a neural network suitable for time-series data,enables prediction with high accuracy but requires mesophyll *** addition,for practical use,it is desirable to have a technique that can predict A from easily available *** this study,we propose a BLSTM augmented LSTM(BALSTM)model,which utilizes bi-directional LSTM(BLSTM)to indirectly reproduce the mesophyll variables required for *** most significant feature of the proposed model is that its hybrid architecture uses only three relatively easy-to-collect external environmental variables—photosynthetic photon flux density(Q_(in)),ambient CO_(2) concentration(C_(a)),and temperature(T_(air))—to generate mesophyll CO_(2) concentration(C_(i))and stomatal conductance to water vapor(g_(sw))as intermediate ***,A is predicted by applying the obtained intermediate outputs to the learning ***,in this study,1)BALSTM(Q_(in),C_(a),T_(air))had a significantly higher A prediction accuracy than LSTM(Q_(in),C_(a),T_(air))in case of using only Q_(in),C_(a),and T_(air);2)BALSTMC_(i),g_(sw),which had C_(i) and g_(sw) as intermediate products,had the highest A prediction accuracy compared with other candidates;and 3)for samples where LSTM(Q_(in),C_(a),T_(air))had poor prediction accuracy,BALSTMC_(i),g_(sw)(Q_(in),C_(a),T_(air))clearly improved the ***,it was found that incorrect predictions may be formed when certain factors are not reflected in the data(e.g.,timing,cultivar,and growth stage)or when the training data distribution that accounts for these factors differs from the predicted data ***,a robust model should be constructed in the future to improve the prediction accuracy of A by conducting gasexchange measurements(including a wide range of external environmental values)and by increasing the

关键词： Hybrid prediction model assimilation rate leaf internal variables recurrent neural network fluctuating light environments rice