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乳腺癌循环肿瘤细胞微流控芯片检测研究进展

中国普通外科杂志 2023年第11期32卷 1804-1812页

作者：尉卓凡宁智文胡波袁时芳中国人民解放军空军军医大学第一附属医院甲乳血管外科陕西西安710032 西安电子科技大学生命科学技术学院陕西西安710126

乳腺癌是女性最常见的恶性肿瘤。不可预测的转移性复发是乳腺癌患者治疗失败、复发乃至死亡的主要原因。循环肿瘤细胞(CTC)被定义为从原发肿瘤处脱落并进入循环或淋巴系统的肿瘤细胞。研究证实,CTC的检测可以为乳腺癌的诊断、治疗策略... 详细信息

乳腺癌是女性最常见的恶性肿瘤。不可预测的转移性复发是乳腺癌患者治疗失败、复发乃至死亡的主要原因。循环肿瘤细胞(CTC)被定义为从原发肿瘤处脱落并进入循环或淋巴系统的肿瘤细胞。研究证实,CTC的检测可以为乳腺癌的诊断、治疗策略的制定和预后评估提供重要的临床信息。作为液体活检的重要检测对象之一,CTC能够简单地通过抽取患者的血液来收集。然而,大多数CTC在循环中死亡,只有极少数存活并侵犯远处器官。数量上的稀缺、CTC的异质性以及血液中复杂成分的干扰使得CTC的准确检测成为一个巨大的挑战。针对CTC的生物和物理特性开发的各种检测方法往往需要在检测前对CTC进行分离和富集,但吸附、洗脱和转移等预处理过程不可避免地会造成CTC的损失,而耗时、操作复杂、设备昂贵等问题也限制了CTC的临床应用,因此迫切需要开发新的检测技术。以微加工结构为特征的微流控技术近年来受到了广泛关注与研究,微流控技术可以精确控制微米级的流体和细胞,因而成为一种特别适合检测稀有CTC的方法。微流控芯片具有成本低、操作简单、低耗材、高通量、实时检测等优势,其小型化的特点可将多种检测技术集成于微尺度中,为CTC的分离、鉴定和表征提供了一个高效的平台,有助于对肿瘤患者进行个体化分析与治疗。最近,三维(3D)打印技术的兴起为微流控芯片的制造提供了更高效、个性化的方式,避免了传统微流体器件制作方法步骤复杂、耗时等问题。逐层打印出的3D结构将促进微流控芯片实现更高效率和更高通量,并将推动实验室技术成功应用于临床,为肿瘤的生物学和临床研究开辟新视野,为乳腺癌的诊断治疗提供前所未有的机会。本文中,笔者分析了近年来CTC的不同检测手段的特点,阐述了微流控技术在乳腺癌CTC检测中的应用研究,以及3D打印微流控芯片技术前沿,并对3D打印微流控芯片技术在乳腺癌CTC检测中的应用前景进行了展望。

关键词：乳腺肿瘤肿瘤细胞循环芯片实验室装置综述

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同核双金属烯烃聚合催化剂

化学进展 2019年第12期31卷 1737-1748页

作者：袁世芳闫艺山西大学应用化学研究所太原030006 山西大学化学化工学院太原030006

与单核金属配合物催化剂相比,双核金属配合物催化剂所具的双金属活性中心对烯烃聚合催化活性和所得聚合物的性能(包括聚合物微结构、分子量大小和分子量分布)产生了重要影响。本文综述了双金属配合物作为均相催化剂催化乙烯聚合及共聚... 详细信息

与单核金属配合物催化剂相比,双核金属配合物催化剂所具的双金属活性中心对烯烃聚合催化活性和所得聚合物的性能(包括聚合物微结构、分子量大小和分子量分布)产生了重要影响。本文综述了双金属配合物作为均相催化剂催化乙烯聚合及共聚合的最新研究,归纳思路包括不同的金属类型,即基于前过渡金属(Zr,Ti,Hf)和后过渡金属(Ni,Fe,Co)的双核金属组合;不同的配体化合物,即CGC配体、酚氧亚胺配体、氮杂环胺配体、α-二亚胺和亚胺吡啶配体等。这些研究表明,前过渡金属催化剂不仅解决了乙烯自聚还实现了乙烯与α-烯烃共聚;后过渡金属催化剂高效催化乙烯自聚合,其中铁和钴催化剂获得高度线性聚乙烯,镍催化剂则产生多支链聚乙烯。

关键词：双金属配合物同核催化活性聚烯烃微结构特征

Collective Molecular Machines: Multidimensionality and Reconfigurability

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Nano-Micro Letters 2024年第8期16卷 309-340页

作者： Bin Wang yuan Lu Department of Chemical Engineering Tsinghua UniversityBeijing 100084People’s Republic of China Key Laboratory of Industrial Biocatalysis Ministry of EducationTsinghua UniversityBeijing 100084People’s Republic of China

Molecular machines are key to cellular activity where they are involved in converting chemical and light energy into efficient mechanical *** the last 60 years,designing molecular structures capable of generating unidirectional mechanical motion at the nanoscale has been the topic of intense *** progress has been made,attributed to advances in various fields such as supramolecular chemistry,biology and nanotechnology,and ***,individual molecular machines are only capable of producing nanometer work and generally have only a single *** order to address these problems,collective behaviors realized by integrating several or more of these individual mechanical units in space and time have become a new *** this review,we comprehensively discuss recent developments in the collective behaviors of molecular *** particular,collective behavior is divided into two *** is the appropriate integration of molecular machines to efficiently amplify molecular motions and deformations to construct novel functional *** other is the construction of swarming modes at the supramolecular level to perform nanoscale or microscale *** discuss design strategies for both modes and focus on the modulation of features and ***,in order to address existing challenges,the idea of transferring experience gained in the field of micro/nano robotics is presented,offering prospects for future developments in the collective behavior of molecular machines.

关键词： Molecular machines Collective control Collective behaviors DNA Biomolecular motors

Least Squares Hermitian Problem of Matrix Equation (AXB, CXD) = (E, F) Associated with Indeterminate Admittance Matrices

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Journal of Applied Mathematics and Physics 2018年第6期6卷 1199-1214页

作者： Yanfang Liang shifang yuan Yong Tian Mingzhao Li School of Mathematics and Computational Science Wuyi University Jiangmen China KaiQiao Middle School in KaiPing City Jiangmen China

For A∈CmΧn, if the sum of the elements in each row and the sum of the elements in each column are both equal to 0, then A is called an indeterminate admittance matrix. If A is an indeterminate admittance matrix and a Hermitian matrix, then A is called a Hermitian indeterminate admittance matrix. In this paper, we provide two methods to study the least squares Hermitian indeterminate admittance problem of complex matrix equation (AXB,CXD)=(E,F), and give the explicit expressions of least squares Hermitian indeterminate admittance solution with the least norm in each method. We mainly adopt the Moore-Penrose generalized inverse and Kronecker product in Method I and a matrix-vector product in Method II, respectively.

关键词： Matrix Equation Least Squares Solution Least Norm Solution Hermitian Indeterminate Admittance Matrices

MAUN:Memory-Augmented Deep Unfolding Network for Hyperspectral Image Reconstruction

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1139-1150页

作者： Qian Hu Jiayi Ma yuan Gao Junjun Jiang Yixuan yuan Electronic Information School Wuhan UniversityWuhan 430072China School of Computer Science and Technology Harbin Institute of TechnologyHarbin 150001China Department of Electronic Engineering Chinese University of Hong KongHong Kong 999077China

Spectral compressive imaging has emerged as a powerful technique to collect the 3D spectral information as 2D *** algorithm for restoring the original 3D hyperspectral images(HSIs)from compressive measurements is pivotal in the imaging *** approaches painstakingly designed networks to directly map compressive measurements to HSIs,resulting in the lack of interpretability without exploiting the imaging *** some recent works have introduced the deep unfolding framework for explainable reconstruction,the performance of these methods is still limited by the weak information transmission between iterative *** this paper,we propose a Memory-Augmented deep Unfolding Network,termed MAUN,for explainable and accurate HSI ***,MAUN implements a novel CNN scheme to facilitate a better extrapolation step of the fast iterative shrinkage-thresholding algorithm,introducing an extra momentum incorporation step for each iteration to alleviate the information ***,to exploit the high correlation of intermediate images from neighboring iterations,we customize a cross-stage transformer(CSFormer)as the deep denoiser to simultaneously capture self-similarity from both in-stage and cross-stage features,which is the first attempt to model the long-distance dependencies between iteration *** experiments demonstrate that the proposed MAUN is superior to other state-of-the-art methods both visually and *** code is publicly available at https://***/HuQ1an/MAUN.

关键词： Deep folding iteration

Gradient microstructure and superior strength-ductility synergy of AZ61 magnesium alloy bars processed by radial forging with different deformation temperatures

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Journal of Materials Science & Technology 2024年第3期170卷 65-77页

作者： Jingfeng Zou Lifeng Ma Yanchun Zhu Ling Qin yuan yuan School of Mechanical Engineering Taiyuan University of Science and TechnologyTaiyuan 030024China Heavy Machinery Engineering Research Center of the Ministry Education Taiyuan University of Science and TechnologyTaiyuan 030024China Department of Engineering University of HullCottingham RdHull HU67RXUK National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China

Gradient microstructure modification is a cost-efficient strategy for high strength without compromising ductility,which is urgently needed in the fundamental science of engineering *** this study,heterogeneous structures of AZ61 alloy bars with anisotropic gradients(with different grain size distributions from the surface to the center)were observed to exhibit strong strength-ductility synergies under different deformation tem *** results reveal that the grain refinement process under mediumlow temperature deformation conditions(≤350℃)consists of four transition stages along the radial direction,i.e.,twin activations and deformation band formations,dislocation cells and pile-ups,ultrafine sub-grains,and randomly orientated quasi-micron *** deformation temperatures have a great influence on twin activations and deformation band formations,and the high temperature can easily provoke the initiation of non-basal *** deformation bands were determined as a primary nucleation site due to their highly unstable dislocation hindrance *** in combination with the Radial forging(RF)deformation process,the differences of dynamic precipitates can be attributed to microstructural difference and solubility limit of Al at different tem *** summarizing the tensile test results,the sample forged at 350℃exhibited the best strength-ductility synergy,exhibiting the highest elongation(EL)of 23.2%with a 251 MPa yield strength(YS)and 394 MPa ultimate tensile strength(UTS)in center region,and combined with the highest strength value of 256 MPa YS and 420 MPa UTS in the center region,while the EL was slightly degraded to 19.8%.

关键词： Gradient microstructure Radial forging Strength-ductility synergy Magnesium alloy Strengthening mechanism

Pyrolysis Empirical Modeling of Polyester Glass Fiber Reinforced Plastics Using Sestak-Berggren Model Method

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Journal of Thermal Science 2024年第2期33卷 725-738页

作者： NAN Wei JI Wenhui yuan Yanping yuan Zhongyuan SUN Yong School of Mechanical Engineering Southwest Jiaotong UniversityChengdu610031China CRRC Changchun Railway Vehicles Co. LtdChangchun130062China

Polyester Glass Fiber Reinforced Plastic(Polyester GFRP),a thermosetting plastic comprised of glass fiber and polyester polymer compounds,is extensively utilized in high-speed *** its pyrolysis mechanism is crucial as it significantly influences the combustion characteristics and fire safety ***,kinetic research on polyester GFRP primarily focuses on employing the Coats-Redfern method to derive a theoretical kinetic ***,the pyrolysis process of polyester GFRP is complex and the aforementioned theoretical model fails to accurately describe the pyrolysis ***,this study seeks to utilize the Sestak and Berggren(SB) model as a methodological approach to reveal the complex reaction mechanism during the pyrolysis *** on thermogravimetric analysis,the entire pyrolysis process of polyester GFRP is divided into two primary ***,model-free methods are employed to ascertain the activation energy and pre-exponential *** results show that the fitted empirical models of the two main pyrolysis stages are f(α)=(1-α)^(1.47)[-ln(1-α)]^(1.50) and f(α)=(1-α)^(1.77)[-ln(1-α)]^(1.72),*** predicted results are in good agreement with experimental data under different heating rates,which indicates that the empirical model can sufficiently describe the pyrolysis process of polyester GFRP.

关键词： polyester GFRP model-fitting methods empirical models pyrolysis

Pseudomonotonicity of Nonlinear Transformations on Euclidean Jordan Algebras

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 192-204页

作者： yuan-Min Li School of Mathematics and Statistics Xidian UniversityXi’an710071China

In this paper, we have introduced the concepts of pseudomonotonicity properties for nonlinear transformations defined on Euclidean Jordan algebras. The implications between this property and other P-properties have been studied. More importantly, we have solved the solvability problem of the nonlinear pseudomonotone complementarity problems over symmetric cones.

关键词： Euclidean Jordan algebra nonlinear transformation complementarity problem pseudomonotone

Perspective of alkaline zinc-based flow batteries

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Science China Chemistry 2024年第1期67卷 260-275页

作者： Zhizhang yuan Xianfeng Li Division of Energy Storage Dalian National Laboratory for Clean Energy(DNL)Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 110623China

Energy storage technologies have been identified as the key in constructing new electric power systems and achieving carbon neutrality,as they can absorb and smooth the renewables-generated *** zinc-based flow batteries are well suitable for stationary energy storage applications,since they feature the advantages of high safety,high cell voltage and low ***,many alkaline zinc-based flow batteries have been proposed and developed,e.g.,the alkaline zinc–iron flow battery and alkaline zinc–nickel flow *** development and application are closely related to advanced materials and battery *** this perspective,we will first provide a brief introduction and discussion of alkaline zinc-based flow *** we focus on these batteries from the perspective of their current status,challenges and *** bottlenecks for these batteries are briefly *** with the practical requirements and development trends of alkaline zinc-based flow battery technologies,their future development and research direction will be summarized.

关键词： energy storage alkaline zinc-based flow batteries advanced materials battery structure